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The fetal safety of thiopurines for the treatment of inflammatory bowel disease in pregnancy

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Pages 1-8 | Published online: 21 Dec 2012

References

  • Alstead EM, Ritchie JK, Lennard-Jones JE, Farthing MJ, Clark ML. 1990. Safety of azathioprine in pregnancy in inflammatory bowel disease. Gastroenterology 99:443–446.
  • Angelberger S, Reinisch W, Messerschmidt A, Miehsler W, Novacek G, Vogelsang H. 2011. Long-term follow-up of babies exposed to azathioprine in utero and via breastfeeding. Journal of Crohn's and Colitis 5:95–100.
  • Ardizzone S, Maconi G, Russo A, Imbesi V, Colombo E, Bianchi Porro G. 2006. Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis. Gut 55:47–53.
  • Baiocco PJ, Korelitz BI. 1984. The influence of inflammatory bowel disease and its treatment on pregnancy and fetal outcome. Journal of Clinical Gastroenterology 6:211–216.
  • Baird DD, Narendranathan M, Sandler RS. 1990. Increased risk of preterm birth for women with inflammatory bowel disease. Gastroenterology 99:987–994.
  • Bortoli A, Saibeni S, Tatarella M, Prada A, Beretta L. 2007. Pregnancy before and after the diagnosis of inflammatory bowel diseases: retrospective case-control study. Journal of Gastroenterology and Hepatology 22:542–549.
  • Campbell S, Ghosh S. 2000. Safety of azathioprine use in pregnancy. Gut 46: A13.
  • Cleary BJ, Kallen B. 2009. Early pregnancy azathioprine use and pregnancy outcomes. Birth Defects Research. Part A, Clinical and Molecular Teratology 85:647–654.
  • Coelho J, Beaugerie L, Colombel JF, Hebuterne X, Lerebours E, Lemann M. 2011. Pregnancy outcome in patients with inflammatory bowel disease treated with thiopurines: cohort from the CESAME Study. Gut 60:198–203.
  • Cooper GS, Stroehla BC. 2003. The epidemiology of autoimmune diseases. Autoimmunity Reviews 2:119–125.
  • Cornish J, Tan E, Teare J, Teoh TG, Rai R, Clark SK. 2007. A meta-analysis on the influence of inflammatory bowel disease on pregnancy. Gut 56:830–837.
  • Davis AR, Miller L, Tamimi H, Gown A. 1999. Methotrexate compared with mercaptopurine for early induced abortion. Obstetrics and Gynecology 93:904–909.
  • Dejaco C, Angelberger S, Waldhoer T, Meihsler W, Wenzl H, Haas T. 2005. Pregnancy and birth outcome under thiopurine therapy for inflammatory bowel disease (IBD). Gastroenterology 128: A12.
  • Dominitz JA, Young JC, Boyko EJ. 2002. Outcomes of infants born to mothers with inflammatory bowel disease: a population-based cohort study. American Journal of Gastroenterology 97:641–648.
  • Fedorkow DM, Persaud D, Nimrod CA. 1989. Inflammatory bowel disease: a controlled study of late pregnancy outcome. American Journal of Obstetrics and Gynecology 160:998–1001.
  • Francella A, Dyan A, Bodian C, Rubin P, Chapman M, Present DH. 2003. The safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study. Gastroenterology 124:9–17.
  • Goldstein LH, Dolinsky G, Greenberg R, Schaefer C, Cohen-Kerem R, Diav-Citrin O. 2007. Pregnancy outcome of women exposed to azathioprine during pregnancy. Birth Defects Research. Part A, Clinical and Molecular Teratology 79:696–701.
  • Hanauer SB. 1999. Updating the approach to Crohn's disease. Hospital Practice (Minneapolis) 34:77–78, 81–83, 87–93.
  • Jain V, Gordon C. 2011. Managing pregnancy in inflammatory rheumatological diseases. Arthritis Research and Therapy 13:206.
  • Khan ZH, Mayberry JF, Spiers N, Wicks AC. 2000. Retrospective case series analysis of patients with inflammatory bowel disease on azathioprine. A district general hospital experience. Digestion 62:249–254.
  • Kwan LY, Mahadevan U. 2010. Inflammatory bowel disease and pregnancy: An update. Expert Review of Clinical Immunology 6:643–657.
  • Landy HJ, Isada NB, McGinnis J, Ratner R, Grossman JH 3rd. 1988. The effect of chronic steroid therapy on glucose tolerance in pregnancy. American Journal of Obstetrics and Gynecology 159:612–615.
  • Langagergaard V, Pedersen L, Gislum M, Norgard B, Sorensen HT. 2007. Birth outcome in women treated with azathioprine or mercaptopurine during pregnancy: A Danish nationwide cohort study. Alimentary Pharmacology and Therapeutics 25:73–81.
  • Levy N, Roisman I, Teodor I. 1981. Ulcerative colitis in pregnancy in Israel. Diseases of the Colon and Rectum 24:351–354.
  • Ludvigsson JF, Ludvigsson J. 2002. Inflammatory bowel disease in mother or father and neonatal outcome. Acta Paediatrica 91:145–151.
  • Mountifield RE, Prosser R, Bampton P, Muller K, Andrews JM. 2010. Pregnancy and IBD treatment: This challenging interplay from a patients’ perspective. Journal of Crohn's and Colitis 4:176–182.
  • Mowat C, Cole A, Windsor A, Ahmad T, Arnott I, Driscoll R. 2011. Guidelines for the management of inflammatory bowel disease in adults. Gut 60:571–607.
  • Nørgård B, Pedersen L, Fonager K, Rasmussen SN, Sørensen HT. 2003. Azathioprine, mercaptopurine and birth outcome: a population-based cohort study. Alimentary Pharmacology and Therapeutics 17:827–834.
  • Norgard B, Pedersen L, Christensen LA, Sorensen HT. 2007. Therapeutic drug use in women with Crohn's disease and birth outcomes: A Danish nationwide cohort study. American Journal of Gastroenterology 102:1406–1413.
  • Osting VC, Carter JD. 2010. A safety assessment of tumor necrosis factor antagonists during pregnancy. Expert Opinion on Drug Safety 9: 421–429.
  • Park-Wyllie L, Mazzotta P, Pastuszak A, Moretti ME, Beique L, Hunnisett L. 2000. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology 62:385–392.
  • Peyrin-Biroulet L, Oussalah A, Roblin X, Sparrow MP. 2011. The use of azathioprine in Crohn's disease during pregnancy and in the post-operative setting: a worldwide survey of experts. Alimentary Pharmacology and Therapeutics 33:707–713.
  • Platzek T, Bochert G. 1996. Dose-response relationship of teratogenicity and prenatal-toxic risk estimation of 6-mercaptopurine riboside in mice. Teratogenesis, Carcinogenesis, and Mutagenesis 16:169–181.
  • Polifka JE, Friedman JM. 2002. Teratogen update: azathioprine and 6-mercaptopurine. Teratology 65:240–261.
  • Present DH, Meltzer SJ, Krumholz MP, Wolke A, Korelitz BI. 1989. 6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity. Annals of Internal Medicine 111:641–649.
  • Rahimi R, Nikfar S, Rezaie A, Abdollahi M. 2008. Pregnancy outcome in women with inflammatory bowel disease following exposure to 5-aminosalicylic acid drugs: a meta-analysis. Reproductive Toxicology 25:271–275.
  • Schatz M, Dombrowski MP, Wise R, Momirova V, Landon M, Mabie W. 2004. The relationship of asthma medication use to perinatal outcomes. Journal of Allergy and Clinical Immunology 113:1040–1045.
  • Shim L, Eslick GD, Simring AA, Murray H, Weltman MD. 2011. The effects of azathioprine on birth outcomes in women with inflammatory bowel disease (IBD). Journal of Crohn's and Colitis 5:234–238.
  • Tennenbaum R, Marteau P, Elefant E, Rambaud JC, Modigliani R, Gendre JP. 1999. [Pregnancy outcome in inflammatory bowel diseases]. Gastroenterologie Clinique et Biologique 23:464–469.
  • Timmer A, McDonald JW, Macdonald JK. 2007. Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis. Cochrane Database of Systematic Reviews (1):CD000478.
  • Woolfson K, Cohen Z, McLeod RS. 1990. Crohn's disease and pregnancy. Diseases of the Colon and Rectum 33:869–873.

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