The relationship of maternal age to molar pregnancy incidence, risks for chemotherapy and subsequent pregnancy outcome

References

• Altieri A, Franceschi S, Ferlay J, Smith J, La Vecchia C. 2003. Epidemiology and aetiology of gestational trophoblastic diseases. Lancet Oncology 4:670–678.
   PubMed Web of Science ®Google Scholar
• Ayhan A, Tuncer ZS, Halilzade H, Küçükali T. 1996. Predictors of persistent disease in women with complete hydatidiform mole. Journal of Reproductive Medicine 441:591–594.
   Google Scholar
• Baasanjav B, Usui H, Kihara M, Kaku H, Nakada E, Tate S, et al. 2010. The risk of post-molar gestational trophoblastic neoplasia is higher in heterozygous than in homozygous complete hydatidiform moles. Human Reproduction 25:1183–1191.
   PubMed Web of Science ®Google Scholar
• Bagshawe KD, Dent J, Webb J. 1986. Hydatidiform mole in England and Wales 1973–1983. Lancet 2:673–677.
   PubMed Web of Science ®Google Scholar
• Bagshawe KD, McDonald JM. 1960. Treatment of choriocarcinoma with a combination of cytotoxic drugs. British Medical Journal 2:426–431.
   PubMedGoogle Scholar
• Bandy LC, Clarke-Pearson DL, Hammond CB. 1984. Malignant potential of gestational trophoblastic disease at the extreme ages of reproductive life. Obstetrics and Gynecology 64:395–399.
   PubMed Web of Science ®Google Scholar
• Berkowitz RS, Im SS, Bernstein MR, Goldstein DP. 1998. Gestational trophoblastic disease. Subsequent pregnancy outcome, including repeat molar pregnancy. Journal of Reproductive Medicine 43:81–86.
   PubMed Web of Science ®Google Scholar
• Constable JD, Hatch MC. 1985. Reproductive effects of herbicide exposure in Vietnam: recent studies by the Vietnamese and others. Teratogenesis, Carcinogenesis, and Mutagenesis 5:231–250.
   PubMedGoogle Scholar
• El-Helw LM, Coleman RE, Everard JE, Tidy JA, Horsman JM, Elkhenini HF et al. 2009. Impact of the revised FIGO/WHO system on the management of patients with gestational trophoblastic neoplasia. Gynecologic Oncology 113:306–311.
   PubMed Web of Science ®Google Scholar
• Fülöp V, Szigetvári I, Szepesi J, Végh G, Bátorfi J, Nagymányoki Z et al. 2010. 30 years’ experience in the treatment of low-risk gestational trophoblastic neoplasia in Hungary. Journal of Reproductive Medicine 55:253–257.
   PubMed Web of Science ®Google Scholar
• Hertz R, Li MC, Spencer DB. 1956. Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma. Proceedings of the Society for Experimental Biology and Medicine 93:361–366.
   PubMed Web of Science ®Google Scholar
• Hoekstra AV, Lurain JR, Rademaker AW, Schink JC. 2008. Gestational trophoblastic neoplasia: treatment outcomes. Obstetrics and Gynecology 112:251–258.
   PubMedGoogle Scholar
• Jacobs PA, Szulman AE, Funkhouser J, Matsuura JS, Wilson CC. 1982. Human triploidy: relationship between parental origin of the additional haploid complement and development of partial hydatidiform mole. Annals of Human Genetics 46:223–231.
   PubMed Web of Science ®Google Scholar
• Kim SJ, Lee C, Kwon SY, Na YJ, Oh YK, Kim CJ. 2004. Studying changes in the incidence, diagnosis and management of GTD: the South Korean model. Journal of Reproductive Medicine 49:643–654.
   PubMedGoogle Scholar
• Lawler SD, Fisher RA, Pickthall VJ, Povey S, Evans MW. 1982. Genetic studies on hydatidiform moles. I. The origin of partial moles. Cancer Genetics and Cytogenetics 5:309–320.
   PubMedGoogle Scholar
• Lawler SD, Pickthall VJ, Fisher RA, Povey S, Evans MW, Szulman AE. 1979. Genetic studies of complete and partial hydatidiform moles. Lancet 2:580.
   PubMed Web of Science ®Google Scholar
• Matsui H, Iitsuka Y, Suzuka K, Seki K, Sekiya S. 2001. Subsequent pregnancy outcome in patients with spontaneous resolution of HCG after evacuation of hydatidiform mole: comparison between complete and partial mole. Human Reproduction 16:1274–1277.
   PubMed Web of Science ®Google Scholar
• McNeish IA, Strickland S, Holden L, Rustin GJ, Foskett M, Seckl MJ et al. 2002. Low-risk persistent gestational trophoblastic disease: outcome after initial treatment with low-dose methotrexate and folinic acid from 1992 to 2000. Journal of Clinical Oncology 20:1838–1844.
   PubMed Web of Science ®Google Scholar
• Messerli ML, Lilienfeld AM, Parmley I, Woodruff JD, Rosenshein NB. 1985. Risk factors for gestational trophoblastic neoplasia. American Journal of Obstetrics and Gynecology 153:294–300.
   PubMed Web of Science ®Google Scholar
• Murad TM, Longley JV, Lurain JR, Brewer JI. 1990. Hydatidiform mole: clinicopathologic associations with the development of postevacuation trophoblastic disease. International Journal of Gynaecology and Obstetrics 32:359–367.
   PubMedGoogle Scholar
• Nakano R, Sasaki K, Yamoto M, Hata H. 1980. Trophoblastic disease: analysis of 342 patients. Gynecologic and Obstetric Investigation 11:237–242.
   PubMedGoogle Scholar
• Niemann I, Hansen ES, Sunde L. 2007. The risk of persistent trophoblastic disease after hydatidiform mole classified by morphology and ploidy. Gynecologic Oncology 104:411–415.
   PubMed Web of Science ®Google Scholar
• Palmer JR. 1994. Advances in the epidemiology of gestational trophoblastic disease. Journal of Reproductive Medicine 39:155–162.
   PubMed Web of Science ®Google Scholar
• Parazzini F, La Vecchia C, Mangili G, Caminiti C, Negri E, Cecchetti G, Fasoli M. 1988. Dietary factors and the risk of trophoblastic disease. American Journal of Obstetrics and Gynecology 158:93–100.
   PubMedGoogle Scholar
• Parazzini F, La Vecchia C, Pampallona S. 1986. Parental age and risk of complete and partial hydatidiform mole. British Journal of Obstetrics and Gynaecology 93:582–585.
   PubMedGoogle Scholar
• Savage P, Williams J, Wong SL, Short D, Casalboni S, Catalano K et al. 2010. The demographics of molar pregnancies in England and Wales from 2000–2009. Journal of Reproductive Medicine 55:341–345.
   PubMed Web of Science ®Google Scholar
• Sebire NJ, Fisher RA, Foskett M, Rees H, Seckl MJ, Newlands ES. 2003. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. British Journal of Obstetrics and Gynaecology 110:22–26.
   Google Scholar
• Sebire NJ, Foskett M, Fisher RA, Rees H, Seckl M, Newlands E. 2002. Risk of partial and complete hydatidiform molar pregnancy in relation to maternal age. British Journal of Obstetrics and Gynaecology 109:99–102.
   Google Scholar
• Seckl MJ, Fisher RA, Salerno G, Rees H, Paradinas FJ, Foskett M et al. 2000. Choriocarcinoma and partial hydatidiform moles. Lancet 356:36–39.
   PubMed Web of Science ®Google Scholar
• Seckl MJ, Sebire NJ, Berkowitz RS. 2010. Gestational trophoblastic disease. Lancet 376:717–729.
   PubMed Web of Science ®Google Scholar
• Sekharan PK, Sreedevi NS, Radhadevi VP, Beegam R, Raghavan J, Guhan B. 2006. Management of postmolar gestational trophoblastic disease with methotrexate and folinic acid: 15 years of experience. Journal of Reproductive Medicine 51:835–840.
   PubMedGoogle Scholar
• Stone M, Bagshawe KD. 1979. An analysis of the influences of maternal age, gestational age, contraceptive method, and the mode of primary treatment of patients with hydatidiform moles on the incidence of subsequent chemotherapy. British Journal of Obstetrics and Gynaecology 86:782–792.
   PubMedGoogle Scholar
• Szulman AE, Surti U. 1978. The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. American Journal of Obstetrics and Gynecology 131:665–671.
   PubMed Web of Science ®Google Scholar
• Tangtrakul S, Srisupundit S, Linasmita V, Bullangpoti S, Bhamarapravati Y. 1990. The risk factors in the development of persistent trophoblastic disease following hydatidiform mole. Journal of the Medical Association 73:33–36.
   Google Scholar
• Tsukamoto N, Iwasaka T, Kashimura Y, Uchino H, Kashimura M, Matsuyama T. 1985. Gestational trophoblastic disease in women aged 50 or more. Gynecologic Oncology 20:53–61.
   PubMedGoogle Scholar
• UK National Statistics. Topic guide to: Maternity and pregnancy services. Available at: www.statistics.gov.uk/hub/health-social-care/specialist-health-services/maternity-and-pregnancies-services.
   Google Scholar
• Wake N, Fujino T, Hoshi S, Shinkai N, Sakai K, Kato H et al. 1987. The propensity to malignancy of dispermic heterozygous moles. Placenta 8:319–326.
   PubMed Web of Science ®Google Scholar