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Research Article

Low pregnancy associated plasma protein-A in the 1st trimester: Is it a predictor of poor perinatal outcome?

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Pages 351-354 | Published online: 08 May 2013

References

  • Dugoff L, Hobbins JC, Malone FD, Porter F, Luthy D, Christine H et al. 2004. First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: A population-based screening study (The FASTER Trial). American Journal of Obstetrics and Gynecology 191:1446–1451.
  • Irwin JC, Suen LF, Martina NA, Mark SP, Giudice LC. 1999. Role of the IGF system in trophoblast invasion and pre-eclampsia. Human Reproduction 14(suppl):90–96.
  • Johnson MR, Riddle AF, Grudzinskas JG, Sharma V, Collins WP, Nicolaides KH. 1998. Reduced circulating placental protein concentrations during the first trimester are associated with preterm labour and low birth weight. Human Reproduction 8:1942–1947.
  • Krantz D, Goetzl L, Simpson JL, Thom E, Zachary J, Hallahan T et al. 2004. Association of extreme first-trimester free human chorionic gonadotropin-B, pregnancy-associated plasma protein A, and nuchal translucency with intrauterine growth restriction and other adverse pregnancy outcomes. American Journal of Obstetrics and Gynecology 191:1452–1458.
  • Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG et al. 1999. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy- associated plasma protein-A. Proceedings of the National Academy of Science 96:3149–3153.
  • Morssink LP, Kornman LH, Hallahan TW, Kloosterman MD, Beekhuis JR, de Wolf BT et al.1998. Maternal serum levels of free beta-hCG and PAPP-A in the first trimester of pregnancy are not associated with subsequent fetal growth retardation or preterm delivery. Prenatal Diagnosis 18:147–152.
  • Ong CYT, Liao AW, Spencer K, Munim S, Nicolaides KH. 2000. First trimester maternal serum free B human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications. British Journal of Obstetrics and Gynaecology 107:1265–1270.
  • Poon LC, Maiz N, Valencia C, Plasencia W, Nicolaides KH. 2009. First- trimester maternal serum pregnancy-associated plasma protein-A and pre-eclampsia. Ultrasound in Obstetrics and Gynecology 33:23–33.
  • Poon LC, Stratieva V, Piras S, Piri S, Nicolaides KH. 2010. Hypertensive disorders in pregnancy: combined screening by uterine artery Doppler, blood pressure and serum PAPP-A at 11–13 weeks. Prenatal Diagnosis 30:216–223.
  • Smith GCS, Crossley JA, Aitken DA, Pell JP, Cameron AD, Connor JM et al. 2004. First-trimester placentation and the risk of antepartum stillbirth. Journal of the American Medical Association 29:2249–2254.
  • Smith GCS, Shah I, Crossley JA, Aitken DA, Pell JP, Nelson SM et al. 2006. Pregnancy-associated plasma protein A and alpha-fetoprotein and prediction of adverse perinatal outcome. Obstetrics and Gynecology 107:161–166.
  • Smith GCS, Stenhouse EJ, Crossley JA, Aitken DA, Cameron AD, Connor MJ. 2002. Early pregnancy levels of pregnancy-associated plasma protein A and the risk of intrauterine growth restriction, premature birth, preeclampsia and stillbirth. Journal of Clinical Endocrinology and Metabolism 87:1762–1767.
  • Spencer K, Cowans NJ, Avgidou K, Nicolaides KH. 2006. First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of impending fetal death. Ultrasound in Obstetrics and Gynecology 28:637–643.
  • Spencer K, Cowans NJ, Avgidou K, Molina F, Nicolaides KH. 2008a. First-trimester biochemical markers of aneuploidy and the prediction of small-for-gestational age fetuses. Ultrasound in Obstetrics and Gynecology 31:15–19.
  • Spencer K, Cowans NJ, Molina F, Kagan KO, Nicolaides KH. 2008b. First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of preterm or early preterm delivery. Ultrasound in Obstetrics and Gynecology 31:147–152.
  • Spencer K, Cowans NJ, Nicolaides KH. 2008c. Low levels of maternal serum PAPP-A in the first trimester and the risk of pre-eclampsia. Prenatal Diagnosis 28:7–10.
  • Spencer K, Souter V, Tul N, Snijders R, Nicolaides KH. 1999. A screening program for trisomy 21 at 10–14 weeks using fetal nuchal translucency, maternal serum free β human chorionic gonadotropin and pregnancy-associated plasma protein-A. Ultrasound in Obstetrics and Gynecology 13:231–237.
  • Tul N, Pusenjak S, Osredkar J, Spencer K, Novak-Antolic Z. 2003. Predicting complications of pregnancy with first-trimester maternal serum free-BhCG, PAPP-A and inhibin-A. Prenatal Diagnosis 23:990–996.
  • Yaron Y, Heifetz S, Ochshorn Y, Lehavi O, Orr-Urtreger A. 2002. Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome. Prenatal Diagnosis 22:778–782.

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