Pelvic organ prolapse is associated with alteration of sphingosine-1-phosphate/Rho-kinase signalling pathway in human vaginal wall

References

• Bai SW, Jeon MJ, Kim JY, Chung KA, Kim SK, Park KH. 2002. Relationship between stress urinary incontinence and pelvic organ prolapse. International Urogynecology Journal and Pelvic Floor Dysfunction 13:256–260.
   PubMed Web of Science ®Google Scholar
• Boreham MK, Wai CY, Miller RT, Schaffer JI, Word RA. 2002. Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse. American Journal of Obstetrics and Gynecology 187:56–63.
   PubMed Web of Science ®Google Scholar
• Boreham MK, Wai CY, Miller RT, Schaffer JI, Word RA. 2002. Morphometric properties of the posterior vaginal wall in women with pelvic organ prolapse. American Journal of Obstetrics and Gynecology 187:1501–1508.
   PubMed Web of Science ®Google Scholar
• Boyles SH, Weber AM, Meyn L. 2003. Procedures for pelvic organ prolapse in the United States, 1979–1997. American Journal of Obstetrics & Gynecology 188:108–115.
   PubMed Web of Science ®Google Scholar
• Chun J, Goetzl EJ, Hla T, Igarashi Y, Lynch KR, Moolenaar W et al. 2002. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews 54:265–269.
   PubMed Web of Science ®Google Scholar
• Connell KA. 2011. Elastogenesis in the vaginal wall and pelvic-organ prolapse. New England Journal of Medicine 364:2356–2358.
   PubMed Web of Science ®Google Scholar
• de LL, Blacher S, Munaut C, Nusgens B, Rubod C, Noel A et al. 2014. Changes in elastin density in different locations of the vaginal wall in women with pelvic organ prolapse. International Urogynecology Journal 25:1673–1681
   Web of Science ®Google Scholar
• Downing KT, Strube FA, Mikhail MS, DiSanto ME. 2013. Pregnancy with and without birth trauma modulates the gene expression of proteins involved in elastic fiber homeostasis in the rat vagina. Open Journal of Obstetrics and Gynecology 3: 603–608.
   Google Scholar
• Edsall LC, Cuvillier O, Twitty S, Spiegel S, Milstien S. 2001. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. Journal of Neurochemistry 76:1573–1584.
   PubMed Web of Science ®Google Scholar
• Guo S, Yu Y, Zhang N, Cui Y, Zhai L, Li H et al. 2014. Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen. Biochimica et Biophysica Acta 1841:836–846.
   PubMed Web of Science ®Google Scholar
• Han L, Wang L, Wang Q, Li H, Zang H. 2014. Association between pelvic organ prolapse and stress urinary incontinence with collagen. Experimental and Therapeutic Medicine 7:1337–1341.
   PubMed Web of Science ®Google Scholar
• Handa VL, Blomquist JL, Knoepp LR, Hoskey KA, McDermott KC, Munoz A. 2011. Pelvic floor disorders 5–10 years after vaginal or cesarean childbirth. Obstetrics and Gynecology 118: 777–784.
   PubMed Web of Science ®Google Scholar
• Hemmings DG, Xu Y, Davidge ST. 2004. Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats. British Journal of Pharmacology 143:276–284.
   PubMed Web of Science ®Google Scholar
• Hu W, Huang J, Mahavadi S, Li F, Murthy KS. 2006. Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle. Biochemical and Biophysical Research Communications 343:1038–1044.
   PubMed Web of Science ®Google Scholar
• Igarashi J, Erwin PA, Dantas AP, Chen H, Michel T. 2003. VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors. Proceedings of the National Academy of Sciences of the United States America 100:10664–10669.
   PubMed Web of Science ®Google Scholar
• Ishii I, Fukushima N, Ye X, Chun J. 2004. Lysophospholipid receptors: signaling and biology. Annual Review of Biochemistry 73:321–354.
   PubMed Web of Science ®Google Scholar
• Ishii I, Ye X, Friedman B, Kawamura S, Contos JJ, Kingsbury MA et al. 2002. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. Journal of Biological Chemistry 277:25152–25159.
   PubMed Web of Science ®Google Scholar
• Lensen EJ, van den Berg-van Erp SH, Stoutjesdijk JA, Hasaart TH, Withagen MI, Kluivers KB et al. 2013. Does the method of dissecting in anterior colporraphy lead to a difference in thickness of removed vaginal tissue? European Journal of Obsteterics, Gynecology, and Reproductive Biology 168:112–116.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402–408.
   PubMed Web of Science ®Google Scholar
• Lockman K, Hinson JS, Medlin MD, Morris D, Taylor JM, Mack CP. 2004. Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. Journal of Biological Chemistry 279:42422–42430.
   PubMed Web of Science ®Google Scholar
• Maher CM, Feiner B, Baessler K, Glazener CM. 2011. Surgical management of pelvic organ prolapse in women: the updated summary version Cochrane review. International Urogynecology Journal 22:1445–1457.
   PubMed Web of Science ®Google Scholar
• Meyer zu HD, Lass H, Alemany R, Laser KT, Neumann E, Zhang C et al. 1998. Sphingosine kinase-mediated Ca2 + signalling by G-protein-coupled receptors. EMBO Journal 17:2830–2837.
   PubMed Web of Science ®Google Scholar
• Moalli PA, Shand SH, Zyczynski HM, Gordy SC, Meyn LA. 2005. Remodeling of vaginal connective tissue in patients with prolapse. Obstetrics and Gynecology 106:953–963.
   PubMed Web of Science ®Google Scholar
• Ohmori T, Yatomi Y, Osada M, Kazama F, Takafuta T, Ikeda H et al. 2003. Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. Cardiovascular Research 58:170–177.
   PubMed Web of Science ®Google Scholar
• Olsen AL, Smith VJ, Bergstrom JO, Colling JC, Clark AL. 1997. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstetrics and Gynecology 89:501–506.
   PubMed Web of Science ®Google Scholar
• Phillips CH, Anthony F, Benyon C, Monga AK. 2006. Collagen metabolism in the uterosacral ligaments and vaginal skin of women with uterine prolapse. BJOG 113:39–46.
   PubMed Web of Science ®Google Scholar
• Salomone S, Yoshimura S, Reuter U, Foley M, Thomas SS, Moskowitz MA, Waeber C. 2003. S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. European Journal of Pharmacology 469:125–134.
   PubMed Web of Science ®Google Scholar
• Sandhu KS, Chua RG, Zhang X, Kanika ND, Collins SA, Mikhail M et al. 2009. Regional heterogeneity in expression of the sphingosine- 1-phosphate pathway in the female rat lower urinary tract. American Journal of Obstetrics and Gynecology 200:576–577.
   PubMed Web of Science ®Google Scholar
• Sukocheva OA, Wang L, Albanese N, Pitson SM, Vadas MA, Xia P. 2003. Sphingosine kinase transmits estrogen signaling in human breast cancer cells. Molecular Endocrinology 17:2002–2012.
   PubMed Web of Science ®Google Scholar
• Takacs P, Gualtieri M, Nassiri M, Candiotti K, Medina CA. 2008. Vaginal smooth muscle cell apoptosis is increased in women with pelvic organ prolapse. International Urogynecology Journal and Pelvic Floor Dysfunction 19:1559–1564.
   PubMed Web of Science ®Google Scholar
• Takacs P, Nassiri M, Candiotti K, Yang J, Yavagal S, Medina CA. 2010. Differential expression of fibulins in the uterosacral ligaments of women with uterine prolapse. Archives of Gynecology and Obstetrics 282:389–394.
   PubMed Web of Science ®Google Scholar
• Van Brocklyn JR, Lee MJ, Menzeleev R, Olivera A, Edsall L, Cuvillier O et al. 1998. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and Intracellular to regulate proliferation and survival. The Journal of Cell Biology 142:229–240.
   PubMed Web of Science ®Google Scholar
• van Koppen CJ, Meyer zu HD, Alemany R, Jakobs KH. 2001. Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors. Life Sciences 68:2535–2540.
   PubMed Web of Science ®Google Scholar
• Wang L, Han LY, Li HL. 2013. [Etiological study of pelvic organ prolapse and stress urinary incontinence with collagen status and metabolism]. Zhonghua Yi Xue Za Zhi 93:500–503.
   PubMedGoogle Scholar
• Wang X, Li Y, Chen J, Guo X, Guan H, Li C. 2014. Differential expression profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases in females with or without pelvic organ prolapse. Molecular Medicine Reports 10:2004–2008
   Web of Science ®Google Scholar
• Zhang G, Contos JJA, Weiner JA, Fukushima N, Chun J. 1999. Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene 227:89–99.
   PubMed Web of Science ®Google Scholar
• Zhao BH, Zhou JH. 2012. Decreased expression of elastin, fibulin-5 and lysyl oxidase-like 1 in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse. Journal of Obstetrics and Gynaecology Research 38:925–931.
   PubMed Web of Science ®Google Scholar
• Zhou H, Murthy KS. 2004. Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. American Journal of Physiology. Cell Physiology 286: C1130–C1138.
   PubMed Web of Science ®Google Scholar