258
Views
43
CrossRef citations to date
0
Altmetric
Research Article

General pharmacological properties, developmental toxicity, and analgesic activity of gambogic acid, a novel natural anticancer agent

, , , , &
Pages 88-96 | Received 18 Mar 2009, Accepted 08 Jul 2009, Published online: 14 Dec 2009

References

  • Amagaya, S., Iizuka, A., Makino, B., Kubo, M., Komatsu, Y., Cheng, F. C., et al. (2001). General pharmacological properties of Sho-seiryu-to (TJ-19) extracts. Phytomedicine 8:338–347.
  • Asano, J., Chiba, K., Tada, M., Yoshii, T. (1996). Cytotoxic xanthones from Garcinia hanburyi. Phytochemistry 41:815–820.
  • Carpiniello, B., Baita, A., Carta, M. G., Sitzia, R., Macciardi, A. M., Murgia, S., et al. (2002). Clinical and psychosocial outcome of patients affected by panic disorder with or without agoraphobia: results from a naturalistic follow-up study. Eur Psychiatry 17:394–398.
  • Deraedt, R., Jouquey, S., Delevallee, F., Flahaut, M. (1980). Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur J Pharmacol 61:17–24.
  • Dubuisson, D., Dennis, S. G. (1977). The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4:161–174.
  • Gu, H., You, Q., Liu, W., Yang, Y., Zhao, L., Qi, Q., et al. (2008). Gambogic acid–induced tumor cell apoptosis by T-lymphocyte activation in H22 transplanted mice. Int Immunopharmacol 8:1493–1502.
  • Guo, Q., Qi, Q., You, Q., Gu, H., Zhao, L., Wu, Z. (2006a). Toxicological studies of gambogic acid and its potential targets in experimental animals. Basic Clin Pharmacol Toxicol 99:178–184.
  • Guo, Q. L., Zhao, L., You, Q. D., Wu, ZQ, Gu, H. Y. (2004b). Gambogic acid inducing apoptosis in human gastric adenocarcinoma SGC-7901 cells. Chin J Nat Med 2:106–110.
  • Guo, Q. L., Lin, S. S., You, Q. D., Gu, H. Y., Yu, J., Zhao, L., et al. (2006b). Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells. Life Sci 78:1238–1245.
  • Guo, Q. L., You, Q. D., Wu, Z. Q., Yuan, S. T., Zhao, L. (2004a). General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice. Acta Pharmacol Sin 25:769–774.
  • Inoue, K., Motonaga, A., Nishimura, T., Yokota, M., Miki, N., Fujisawa, H., et al. (1991). Mechanism of anti- inflammatory action of etodolac. Arzneimittelforschung 41:235–239.
  • Lin, L. J., Lin, L. Z., Pezzuto, J. M., Cordell, G. A., Ruangrungsi, N. (1993). Isogambogic acid and isomorellinol from Garcinia hanburyi. Magn Reson Chem 31:340–347.
  • Muller, J. C., Botelho, G. G., Bufalo, A. C., Boareto, A. C., Rattmann, Y. D., Martins, E. S., et al. (2009). Morinda citrifolia Linn (Noni): in vivo and in vitro reproductive toxicology. J Ethnopharmacol 121:229–233. Epub 2008 Oct 30.
  • Ollis, W. D., Ramsay, M. V. J., Sutherland, I. O., Mongkolsuk, S. (1965). Constitution of gambogic acid. Tetrahedron 21:1453–1470.
  • Ortiz-Sanchez, E., Daniels, T. R., Helguera, G., Martinez-Maza, O., Bonavida, B., Penichet, M. L. (2009). Enhanced cytotoxicity of an antitransferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor, and reactive oxygen species. Leukemia 23:59–70. Epub 2008 Oct 23.
  • Qi, Q., Gu, H., Yang, Y., Lu, N., Zhao, J., Liu, W., et al. (2008a). Involvement of matrix metalloproteinases 2 and 9 in gambogic acid–induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis. J Mol Med 86:1367–1377.
  • Qi, Q., Lu, N., Wang, X. T., Gu, H. Y., Yang, Y., Liu, W., et al. (2008b). Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells. Biochem Cell Biol 86:386–395.
  • Qi, Q., You, Q., Gu, H., Zhao, L., Liu, W., Lu, N., et al. (2008c). Studies on the toxicity of gambogic acid in rats. J Ethnopharmacol 117:433–438.
  • Qiang, L., Yang, Y., You, Q. D., Ma, Y. J., Yang, L., Nie, F. F., et al. (2008). Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study. Biochem Pharmacol 75:1083–1092.
  • Rosland, J. H., Tjolsen, A., Maehle, B., Hole, K. (1990). The formalin test in mice: effect of formalin concentration. Pain 42:235–242.
  • Staples, R. E., Schnell, V. L. (1964). Refinements in rapid clearing technic in the KOH-alizarin red S method for fetal bone. Stain Technol 39:61–63.
  • Weakley, T. J. R., Cai S-X., Zhang, H-Z., Keana, J. F. W. (2002). Crystal structure of the pyridine salt of gambogic acid. J Chem Crystallogr 31:501–505.
  • Wilson, J. G. (1965). Embryological considerations in teratology. Ann N Y Acad Sci 123:219–227.
  • Wu, Z. Q., Guo, Q. L., You, Q. D., Zhao, L., Gu, H. Y. (2004). Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells. Biol Pharm Bull 27:1769–1774.
  • Yamauchi, H., Nishimura, K., Nakata, K., Suda, H., Iso, T., Shimizu, M., et al. (1987). General pharmacological properties of the potent angiotensin converting enzyme inhibitor rentiapril. Arzneimittelforschung 37(2):157–164.
  • Yang, Y., Yang, L., You, Q. D., Nie, F. F., Gu, H. Y., Zhao, L., et al. (2007). Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes. Cancer Lett 256:259–266.
  • Yi, T., Yi, Z., Cho, S. G., Luo, J., Pandey, M. K., Aggarwal, B. B., et al. (2008). Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling. Cancer Res 68(6):1843–1850.
  • Yongna, Z., Wantana, R., Pisit, B., Zhongkun, L., Rongping, Z. (2005). Analgesic and antipyretic activities of the aqueous extract of Urtica macrorrhiza in experimental animals. Fitoterapia 76:91–95.
  • Zhai, D., Jin, C., Shiau, C. W., Kitada, S., Satterthwait, A. C., Reed, J. C. (2008). Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins. Mol Cancer Ther 7:1639–1646.
  • Zhao, J., Qi, Q., Yang, Y., Gu, H. Y., Lu, N., Liu, W., et al. (2008). Inhibition of alpha(4) integrin-mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with gambogic acid. Eur J Pharmacol 589(1–3):127–131.
  • Zhao, L., Guo, Q. L., You, Q. D., Wu, Z. Q., Gu, H. Y. (2004). Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. Biol Pharm Bull 27:998–1003.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.