60
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Assessment of cytotoxic and clastogenic effects of nimesulide: an NSAID drug in somatic cells of BALB/c mice in vivo

&
Pages 204-208 | Received 29 Jun 2009, Accepted 05 Oct 2009, Published online: 22 Mar 2010

References

  • Bernareggi. A. (1998). Clinical pharmacokinetics of nimesulide. Clin Pharmacokinet 35:247–274.
  • Cullen, L., Kelly, L., Connor, S. O., Fitzgerald, D. J. (1998). Selective cyclooxygenase-2 inhibition by nimesulide in man. J Pharmacol Exp Ther 287:578–582.
  • de Leval X., Dogne, J. M, Neven, P., Labasse, A.J, Delarge, J., Reginster, J.Y., et al. (1999). Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study. J Pharm (Belg) 54:89–90.
  • Fabiola, G. F., Pattabhi, V., Nagarajan, K. (1998). Structural basis for selective inhibition of COX-2 by nimesulide. Bioorg Med Chem 6:2337–2344.
  • Fukutake, M., Nakatsugi, S., Isoi, T., Takahashi, M., Ohta, T., Mamiya, S., et al. (1998). Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice. Carcinogenesis 19:1939–1942.
  • Fusetti, G., Magni, E., Armandola, M. C. (1993). Tolerability of nimesulide. Epidemiological data. Drugs 46(Suppl 1): 277–280.
  • Khan, P. K., Amod, K., Haque, M., Nath, A. (2003). Genotoxicity of nimesulide in murine bone marrow cells. In Vivo 17:439–440.
  • Köseoğlu, B. G., Öztürk, S., Koçak, H., Palanduz, S., Çefle, K. (2008). The effects of etodolac, nimesulide, and naproxen sodium on the frequency of sister chromatid exchange after enclused third molars surgery. Yonsei Med J 49:742–747.
  • Kotsinas, A., Gorgoulis, V., Zacharatos, P., Zioris, H., Triposkiadis, F., Donta, I., et al. (1999). Antioxidant agent, nimesulide, and beta-blocker, metoprolol, do not exert protective effects against rat mitochondrial DNA alterations in adriamycin-induced cardiotoxicity. Biochem Biophys Res Commun 254:651–656.
  • Kullich, W., Klein, G. (1986). Investigations of the influence of nonsteroidal antirheumatic drugs on the rates of sister chromatid exchange. Mutat Res 174:131–134.
  • Lee, S. H., Norppa, H. (1995). Effects of indomethacin and arachidonic acid on sister chromatid exchange induction by styrene and styrene-7,8-oxide. Mutat Res 348:175–181.
  • Macia, M. A., Carvajal, A., Del Pozo, J.G., Vera, E., Del Pino, A., (2002). Hepatotoxicity associated with nimesulide: data from the Spanish pharmacovigilence system. Clin Pharmacol Ther 72:596–597.
  • Nakatsugi, S., Fukutake, M., Takahashi, M., Fukuda, K., Isoi, T., Taniguchi, Y., et al. (1997). Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice. Jpn J Cancer Res 88:1117–1120.
  • Ozkul, Y., Erenmemisoglu A., Ekecik, A., Saatci C., Ozdzmar, S., Demiratas, H. (1996). Do non-steroidal anti-inflammatory drugs induce sister chromatid exchanges in T lymphocytes? J Int Med Res 24:84–87.
  • Philipose, B., Singh R., Khan, K. A., Giri A. K. (1997). Comparative mutagenic and genotoxic effects of three propionic acid derivatives ibuprofen, ketoprofen and naproxen. Mutat Res 393:123–131.
  • Rodrigo, L., De Franciscco, R. Perez, Pariente, J. M. (2002). Nimesulide-induced severe hemolytic anemia and acute liver failure leading to liver transplantation. Scand J Gastrontrol 37:1341–1343.
  • Scott, R., Ellis, E., 3rd, Upton, L. G. (1986). Double-blind evaluation of etodolac (200 mg, 400 mg) compared with zomepirac (100 mg) and placebo on third molar extraction pain. Oral Surg Oral Med Oral Pathol 62:638–642.
  • Takahashi, M., Fukutake, M., Yokota, S., Ishida, K., Wakabayashi, K., Sugimura, T. (1996). Suppression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase 2. J Cancer Res Clin Oncol 122:219–222.
  • Tardieu, D., Jaeg, J-P., Deloly, A., Corpet, D. E., Cadet, J., Petit, C. R. (2000). The COX-2 inhibitor, nimesulide, suppresses superoxide and 8-hydroxy deoxyguanosine formation and stimulates apoptosis in mucosa during early colonic inflammation in rats. Carcinogenesis 21:973–976.
  • Tice, R. R., Boucher, R., Luke, C. A., Shelby, M. (1987). Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F mice by multiple exposure to gaseous 1,3- butadiene. Environ Mutagen 9:235–250.
  • Umezawa, N., Arakane, K., Ryu, A., Mashiko, S. (1997). Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents. Arch Biochem Biophys 342:275–281.
  • World Health Organization. (1985). Environmental Health Criteria 51. Guide to short-term tests for detecting mutagenic and carcinogenic chemicals (pp 100–114). Geneva, Switzerland: WHO.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.