Dimethylbenz[α]anthracene induces oxidative stress and reduces the binding capacity of the mitochondrial 18-kDa translocator protein in rat aorta

References

• Albert, R., Vanderlaan, M., Burns, F., Nishizumi, M. (1977). Effect of carcinogens on chicken atherosclerosis. Cancer Res 37:2232–2235.
   PubMed Web of Science ®Google Scholar
• Awad, M, Gavish M. (1987). Binding of [3H] Ro5-4864 and [3H]PK 11195 to cerebral cortex and peripheral tissues of various species: species differences and heterogeneity in peripheral benzodiazepine binding sites. J Neurochem 495:1407–1414.
   Google Scholar
• Baker, D. G., Taylor, H. W., Lee, S. P., Barker, S. A., Goad, M. E. P., Means, J. C. (2001). Hepatic toxicity and recovery of Fischer 344 rats following exposure to 2-aminoanthracene by intraperitoneal injection. Toxicol Pathol 29:328–332.
   PubMed Web of Science ®Google Scholar
• Barros, A. C. S. D., Muranaka, E. N. K., Jo Mori, L., Pelinzon, C. H. T., Giocondo, G., Pinotti, J. A. (2004). Induction of experimental mammary carcinogenesis in rats with 7,12-dimethylbenz [a]anthracene. Rev Hosp Clin Fac Med S Paulo 59:257–261.
   PubMedGoogle Scholar
• Batastini, G., Penn, A. (1984). An ultrastructural comparison of carcinogen-associated and spontaneous aortic lesions in the cockerel. Am J Pathol 114:403–409.
   PubMed Web of Science ®Google Scholar
• Canat, X., Carayon, P., Bouaboula, M., Cahard, D., Shire, D., Roque, C., et al. (1993). Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells. Life Sci 52:107–118.
   PubMed Web of Science ®Google Scholar
• Carter, J. H., Carter, H. W. (1988). Adrenal regulation of mammary tumorigenesis in female Sprague-Dawley rats: histopathology of mammary tumors. Cancer Res 48:3808–3815.
   PubMed Web of Science ®Google Scholar
• Catanzaro, D. F., Zhou, Y., Chen, R., Yu, F., Catanzaro, S. E., De Lorenzo, M. S., et al. (2007). Potentially reduced exposure cigarettes accelerate atherosclerosis: evidence for the role of nicotine. Cardiovasc Toxicol 7:192–201.
   PubMed Web of Science ®Google Scholar
• Costopoulos, C., Liew, T. V., Bennet, M. (2008). Ageing and atherosclerosis: mechanisms and therapeutic options. Biochem Pharamcol 75:1251–1261.
   PubMed Web of Science ®Google Scholar
• Curfs, D. M., Beckers, L., Godschalk, R. W., Gijbels, M. J., VanSchooten, F. J. (2003). Modulation of plasma lipid level affects benzo[a]pyrene-induced DNA damage in tissues of two hyperlipidemic mouse models. Environ Mol Mutagen 42:243–249.
   PubMed Web of Science ®Google Scholar
• Curfs, D. M. J., Lutgens, E., Gijbels, M. M. J., Kockx, M. M., Daemen, M. J. A. P., van Schooten, F. J. (2004). Chronic exposure to the carcinogenic compound benzo[α]pyrene induces larger and phenoltypically different atherosclerotic plaques in ApoE-knockout mice. Am J Pathol 164:101–108.
   PubMed Web of Science ®Google Scholar
• Curfs, D. M. J., Knaapen, A. M., Pachen, D. M. F. A., Gijbels, M. M. J., Lutgens, E., Smook, M. L. F., et al. (2005). Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties. FASEB J 19:1290–1292.
   PubMed Web of Science ®Google Scholar
• Danovich, l., Veenman, L., Leschiner, S., Lahav, M., Shuster, V., Weizman, A., et al. (2008). The influence of clozapine treatment and other antipsychotics on the 18-kDa translocator protein, formerly named the peripheral-type benzodiazepine receptor, and steroid production. Eur Neuropsychopharmacol 18:24–33.
   PubMed Web of Science ®Google Scholar
• Delavoie, F., Li, H., Hardwick, M., Robert, J., Giatzakis, C., Peranzi, G., et al. (2003). In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: functional significance in drug ligand and cholesterol binding. Biochemistry 42:4506–4519.
   PubMed Web of Science ®Google Scholar
• Demerle-Pallardy, C., Duverger, D., Spinnewyn, B., Pirotzky, E., Braquet, P. (1991). Peripheral-type benzodiazepine binding sites following transient forebrain ischemia in the rat: effect of neuroprotective drugs. Brain Res 565:312–320.
   PubMed Web of Science ®Google Scholar
• Draper, H. H., Hadley, M. (1990). Malondialdehyde determination as index of lipid peroxidation. Meth Enzymol 186:421–431.
   PubMed Web of Science ®Google Scholar
• Drugan, R. C., Basile, A. S., Crawley, J. N., Paul, S. M., Skolnick, P. (1988). Characterization of stress-induced alterations in [3H] Ro5-4864 binding to peripheral benzodiazepine receptors in rat heart and kidney. Pharmacol Biochem Behav 30:1015–1020.
   PubMed Web of Science ®Google Scholar
• Esterbauer, H., Chessman, K. H. (1990). Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Meth Enzymol 186:407–421.
   PubMed Web of Science ®Google Scholar
• French, J. F., Matlib, M. A. (1988). Identification of a high-affinity peripheral-type benzodiazepine-binding site in rat aortic smooth muscle membranes. J Pharmacol Exp Ther 247:23–28.
   PubMed Web of Science ®Google Scholar
• Gairola, C. G., Drawdy, M. L., Block, A. E., Daugherty, A. (2001). Sidetream cigarette smoke accelerates atherogenesis in ApoE–/–mice. Atherosclerosis 1:49–55.
   Google Scholar
• Gao, J., Lauer, F. T., Mitchell, L. A., Burchiel, S. W. (2007). Microsomal epoxide hydrolase is required for 7,12-dimethylbenz[a]anthracene DMBA-induced immunotoxicity in mice. Toxicol Sci 98:137–144.
   PubMed Web of Science ®Google Scholar
• Gavish, M., Bar-Ami, S., Weizman, R. (1992). The endocrine system and mitochondrial benzodiazepine receptors. Mol Cell Endocrinol 88:1–13.
   PubMed Web of Science ®Google Scholar
• Gavish, M., Bachman, I., Shoukrun, R., Katz, Y., Veenman, L., Weisinger, G., et al. (1999). Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev 51:630–646.
   Google Scholar
• Hakkak, R., Holley, A. W., Macleod, S. L., Simpson, P. M., Fuchs, G. J., Jo, C. H., et al. (2005). Obesity promotes 7,12-dimethylbenzaanthracene-induced mammary tumor development in female Zucker rats. Breast Cancer Res 5:R627–R633.
   Google Scholar
• Harrigan, J. A., Vezina, C. M., McGarrigle, B. P., Ersing, N., Box, H. C., Maccubbin, A. E., et al. (2004). DNA adduct formation in precision-cut rat liver and lung slices exposed to benzoapyrene. Toxicol Sci 77:307–314.
   PubMed Web of Science ®Google Scholar
• Harrison, H. H., Levit, M. H. (1987). Serum protein electrophoresis: basic principles, interpretations, practical consideration. ASCI. Check sample. Core chemistry no. PTS 87-7 (PTS-25). ASCP. In:Wallach, J. (Ed.), Interpretation of diagnostic tests (pp 77–81). Chicago, Illinois, USA: Wolters Kluwer, Lippincot Williams & Wilkins, 2007.
   Google Scholar
• Huberman, E., Chou, M. W., Yang, S. K. (1979). Identification of 7,12-dimethylbenz[α]antracene metabolites that lead to mutagenesis in mammalian cells. Proc Natl Acad Sci U S A 76:862–866.
   PubMed Web of Science ®Google Scholar
• Huggins, C., Grand, L., Fukunishi, R. (1964). Aromatic influences on the yields of mammary cancers following administration of 7,12-dimethylbenzanthracene. Pathology 51:737–742.
   Google Scholar
• Iwano, S., Shibahara, N., Saito, T., Kamataki, T. (2006). Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons. FEBS Lett 580:890–893.
   PubMed Web of Science ®Google Scholar
• Izzotti, A., Balansky, R.M., Dagostini, F., Bennicelli, C., Myers, S.R., Grubbs, C.J., Lubet, R.A., Kelloff, G.J., De Flora, S. (2001). Modulation of biomarkers by chemopreventive agents in smoke-exposed rats. Cancer Res 61:2472–2479.
   PubMed Web of Science ®Google Scholar
• Krueger, K. E., Papadopoulos, V. (1990). Peripheral-type bezodizaepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells. J Biol Chem 265:15015–15022.
   PubMed Web of Science ®Google Scholar
• Kugler, W., Veenman, L., Shandalov, Y., Leschiner, S., Spanier, I., Lakomek, M., et al. (2008). Ligands of the mitochondrial 18-kDa translocator protein attenuate apoptosis in human glioblastoma cells exposed to erucylphosphohomocholine. Cell Oncol 30:435–450.
   PubMedGoogle Scholar
• Kunduzova, O. R., Escourrou, G., De La Farge, F., Salvayre, R., Seguelas, M. H., Leducq, N., et al. (2004). Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion. J Am Soc Nephrol 15:2152–2160.
   PubMed Web of Science ®Google Scholar
• Levine, R. L., Garland, D., Oliver, C. N., Amici, A., Climent,I., Lenz, A. G., et al. (1990). Determination of carbonyl content in oxidatively modified proteins. Meth Enzymol 186:464–478.
   PubMed Web of Science ®Google Scholar
• Limón-Pacheco, J., Gonsebatt, M. E. (2009). The role of antioxidant-related enzymes in protective responses to environmentally induced oxidative stress. Mutat Res 674:137–147.
   PubMed Web of Science ®Google Scholar
• Löscher, W. (2001). Do cocarcinogenic effects of ELF electromagnetic field require repeated long-term interaction with carcinogens? Characteristics of positive studies using the DMBA breast cancer model in rats. Bioelectromagnetics 22:603–614.
   PubMed Web of Science ®Google Scholar
• Löscher, W., Mevissen, M., Lehmacher, W., Stamm, A. (1993). Tumor promotion in a breast cancer model by exposure to a weak alternating magnetic field. Cancer Lett 71:75–81.
   PubMed Web of Science ®Google Scholar
• Lowry, O. H., Rosenbrough, A. L., Randall, R. J. (1951). Protein measurement with Folin’s phenol reagent. J.Biol Chem 193:265–275.
   PubMed Web of Science ®Google Scholar
• Maeda, S, Miyawaki, T., Nakanishi, T., Takigawa, M., Shimada, M. (1998). Peripheral-type benzodiazepine receptor in T-lymphocyte-rich preparation. Life Sci 63:1423–1430.
   PubMed Web of Science ®Google Scholar
• Majesky, M. W., Reidy, M. A., Benditt, E. P., Juchau, M. R. (1985). Focal smooth muscle proliferation in the aortic intima produced by an initiation-promotion sequence. Proc Natl Acad Sci 82:3450–3454.
   PubMed Web of Science ®Google Scholar
• Meffert, G., Gellerich, F. N., Margreiter, R., Wyss, M. (2005). Elevated creatine kinase activity in primary hepatocellular carcinoma. BMC Gastroeneterol 5:9.
   PubMedGoogle Scholar
• Meisinger, C., Koenig, W., Baumert, J., Döring, A. (2008). Uric acid levels are associated with all-cause and coronary artery disease mortality independent of systemic inflammation in men from general population. The MONICA/ KORA Kohort study. Arterioscler Thromb Vasc Biol 28:1186–1192.
   PubMed Web of Science ®Google Scholar
• Mevissen, M., Lerchl, A., Löscher, W. (1996). Study on pineal function and DMBA-induced breast cancer formation in rats during exposure to a 100-mG, 50-Hz magnetic field. J Toxicol Environ Health 48:101–117.
   Google Scholar
• Moorthy, B., Miller, K. P., Jiang, W., Ramos, K. S. (2002). The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1. Cardiovasc Res 53:1002–1009.
   PubMed Web of Science ®Google Scholar
• Motoyama, J., Yamashita, N., Morina, T., Tanaka, M., Kobayashi, T., Honda, H. (2008). Hyperthermic treatment of DMBA-induced rat mammary cancer using magnetic nanoparticles. Biomagn Res Technol 6:2.
   PubMedGoogle Scholar
• Myers, R., Manjil, L. G., Frackowiak, R. S., Cremer, J. E. (1991). [3H] PK11195 and the localisation of secondary thalamic lesions following focal ischaemia in rat motor cortex. Neurosci Lett 133:20–24.
   PubMed Web of Science ®Google Scholar
• Netto, L. E., Kowaltowsky, A. J., Castilho, R. F., Vercesi, A. E. (2002). Thiol enzymes protecting mitochondria against oxidative damage. Meth Enzymol 348:260–270.
   PubMed Web of Science ®Google Scholar
• National Toxicology Program. (2006). NTP technical report on the toxicology and carcinogenesis studies of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin TCDD Cas.No1746-01-06 in female Harlan-Sprague-Dawley rats gavage studies. Natl Toxicol Prog Tech Rep Ser 521:4–232.
   PubMedGoogle Scholar
• O’Beirne, G. B., Woods, M. J., Williams, D. C. (1990). Two subcellular locations for peripheral-type benzodizepine receptors in rat liver. Eur J Biochem 188:131–138.
   PubMedGoogle Scholar
• Ohkawa, H., Ohishi, N., Yagi, K. (1978). Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358.
   Web of Science ®Google Scholar
• Oliveira, C. P., Coelho, A. M., Barbeiro, H. V., Lima, V. M., Soriano, F., Ribeiro, C., et al. (2006). Liver mitochondrial dysfunction and oxidative stress in the pathogenesis of experimental nonalcoholic fatty liver disease. Braz J Med Biol Res 39:189–194.
   PubMed Web of Science ®Google Scholar
• Paigen, B., Holmes, P. A., Morrow, A., Mitchell, D. (1986). Effect of 3-methylcholanthrene on atherosclerosis in two congenic strains of mice with different susceptibilites to methylcholanthrene-induced tumors. Cancer Res 46:3321–3324.
   PubMed Web of Science ®Google Scholar
• Papadopoulos, V., Amri, H., Boujrad, N., Cascio, C., Culty, M., Garnier, M., et al. (1997). Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids 62:21–28.
   PubMed Web of Science ®Google Scholar
• Papadopoulos, V., Baraldi, M., Guilarte, T. R., Knudsen, T. B., Lacapère, J. J., Lindemann, P., et al. (2007). Translocator protein (18-kDa). New nomenclature for the peripheral-typebenzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 27:402–409.
   Web of Science ®Google Scholar
• Raa, A., Stansberg, C., Steen, V. M., Bjerkvig, R., Reed, R. K., Stuhr, L. E. B. (2007). Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors. BMC Cancer 7:23.
   PubMed Web of Science ®Google Scholar
• Revis, N. W., Bull, R., Laurie, D., Schiller, C. A. (1984). The effectiveness of chemical carcinogens to induce atheroslcerosis in the white Carneau pigeon. Toxicology 32:215–227.
   PubMed Web of Science ®Google Scholar
• Ross, R. (1999). Atherosclerosis—an inflammatory disease. NEJM 340:115–126.
   PubMed Web of Science ®Google Scholar
• Salvetti, F., Chelli, B., Gesi, M., Pellegrini, A., Giannaccini, G., Lucacchini, A., et al. (2000). Effect of noise exposure on rat cardiac peripheral benzodiazepine receptors. Life Sci 66:1165–1175.
   PubMed Web of Science ®Google Scholar
• Stoebner, P. E., Carayon, P., Penarier, G., Frechin, N., Barneon, G., Casellas, P., et al. (1999). The expression of peripheral benzodiazepine receptors in human skin: the relationship with epidermal cell differentiation. Br J Dermatol 140:1010–1016.
   PubMed Web of Science ®Google Scholar
• Szeto, H. H. (2006). Cell permeable, mitochondrial-targeted, peptide antioxidants. AAPS J 8:E277–E283.
   PubMed Web of Science ®Google Scholar
• Taniguchi, T., Wang, J. K., Spector, S. (1980). Properties of [3H] diazepam binding to rat peritoneal mast cells. Life Sci 27:171–178.
   PubMed Web of Science ®Google Scholar
• Veenman, L., Gavish, M. (2006). The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development. Pharmacol Ther 110:503–524.
   PubMed Web of Science ®Google Scholar
• Veenman, L., Leschiner, S., Spanier, I., Weisinger, G., Weizman, A., Gavish, M. (2002). PK11195 attenuates kainicacid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain. J Neurochem 80:917–927.
   PubMed Web of Science ®Google Scholar
• Veenman, L., Papadopoulos, V., Gavish, M. (2007). Channel-like functions of the 18-kDa translocator protein TSPO regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharm Des 13:2385–2405.
   PubMed Web of Science ®Google Scholar
• Veenman, L., Shandalov, Y., Gavish, M. (2008). VDAC activation by the 18-kDa translocator protein (TSPO): implications for apoptosis. J Bioenerg Biomembr 40:199–205.
   PubMed Web of Science ®Google Scholar
• Veenman, L, Weizman, A., Weisinger, G., Gavish, M. (2009; In press). Expression and functions of the 18-kDa mitochondrial translocator protein, TSPO, in health and disease. Targ Drug Deliv Cancer Ther
   Google Scholar
• Wakabayashi, K. (1990). International commision for protection against environmental mutagens and carcinogens. ICPEMC working paper 7/1/3. Animal studies suggesting involvement of mutagen carciongen exposure in atherosclerosis. Mutat Res 239:181–187.
   PubMedGoogle Scholar
• Whitsett, T., Carpenter, M., Lamartiniere, C. A. (2006). Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats. J Carcinog 5:15.
   PubMedGoogle Scholar
• Witko-Sarsat, V., Friedlander, M., Capeille`re-Blandin, C., Nguyen-Khoa, T., Nguyen, A. T., Zingraff, J., et al. (1996). Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 49:1304–1305.
   PubMed Web of Science ®Google Scholar
• Yousef, M. I., Awad, T. I., Mohamed, E. H. (2006). Deltamethrin-induced oxidative damage and biochemical alterations in rat and its attenuation by vitamin E. Toxicology 227:240–247.
   PubMed Web of Science ®Google Scholar
• Zeno, S., Zaaroor, M., Leschiner, S., Veenman, L., Gavish, M. (2009). CoCl(2) induces apoptosis via the 18-kDa translocator protein in U118MG human glioblastoma cells. Biochemistry 48:4652–4661.
   PubMed Web of Science ®Google Scholar