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Archives of Andrology
Journal of Reproductive Systems
Volume 7, 1981 - Issue 2
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Original Article

Androgen Transport Proteins: Physical Properties, Hormonal Regulation, and Possible Mechanism of TeBG and ABP Action

Pages 133-151 | Received 01 Jan 1981, Published online: 09 Jul 2009

References

  • Boffa GA., Martin B., Winchenne JJ., Ozon R. Interactions steroides-prote ines dans le serum de l'homme, d'un amphibien et d'un cyclostome. Chromatographie analytique sur echangeurs d'ion. Biochimie 1972; 54: 1137–1145
  • Britton TC, Lobl TJ, Campbell JA, Tindall DJ, Cunningham GR, Means AR. The synthesis and affinity of A-ring fused heterocyclic steroids to rat androgen binding protein and rat cytoplasmic androgen receptor. Procedings 179th American Chemical Society National Meeting, Houston, Texas, March 24–27, 1980, Abstract MEDI-7. (Manuscript in preparation)
  • Burke WR, Aten RF, Eisenfeld AJ, Lytton B. Androgen binding in human testis. J Urology 1977; 118: 52–57
  • Chen C, Hiipakka RA, Liao S. Receptors: non-genome aspects. Prostate α-protein: subunit structure, polyamine binding, and inhibition of nuclear chromatin binding of androgen-receptor complex. J Steroid Biochem 1979; 11: 401–405
  • Cheng SL, Musto NA., Gunsalus GL, Bardin CW. Purification and characterization of rabbit epididymal androgen binding protein (rbABP): comparison with rat ABP. Procedings 62nd Annual Meeting Endocrine Society, Washington, D.C., June 18–20, 1980, 136, Abstract #246
  • Cooper TG, Waites GMH. Steroid entry into rete testis fluid and the blood-testis barrier. J Endocrinol 1975; 65: 195–205
  • Cooper TG, Waites GMH. Factors affecting the entry of testosterone into the lumen of cauda epididymidis of the anesthetized rat. J Reprod Fertil 1979; 56: 165–174
  • Corvol P, Bardin CW. Species distribution of testosterone-binding globulin. Biol Reprod 1973; 8: 277–282
  • Cunningham GR, Tindall DJ, Lobl TJ, Campbell J, Means AR. Characterization and comparison of the steroid specificity of human testosterone-estrogen binding globulin (TeBG) and rat cytoplasmic receptor (CR). Procedings VI International Congress of Endocrinology, MelbourneAustralia, Feb. 10–16, 1980, abstract #802
  • Cunningham GR, Tindall DJ, Means AR. Differences in steroid specificity for rat androgen binding protein and the cytoplasmic receptor. Steroids 1979; 33: 261–276
  • Danzo BJ, Eller BC. Steroid binding proteins in rabbit plasma: separation of testosterone-binding globulin (TeBG) from corti-costeroid-binding globulin (CBG). Preliminary characterization of TeBG, and changes in TeBG concentration during sexual maturation. Molec Cell Endocrinol 1975; 2: 351–368
  • Danzo BJ, Eller BC, Orgebin-Crist M-C. Studies on the site of origin of the androgen binding protein present in epididymal cytosol from mature intact rabbits. Steroids 1974; 24: 107–122
  • Elkington JSH, Sanborn BM, Steinberger E. The effect of testosterone propionate on the concentration of testicular and epididymal androgen binding activity in the hypophysectomised rat. Mol Cell Endocrinol 1975; 2: 157–170
  • Ewing LL, Chubb CE, Robaire B. Macro-molecules, steroid binding and testosterone secretion by rabbit testis. Nature 1976; 264: 84–86
  • Ewing LL, Davis JC, Zirkin BR. Regulation of testicular function: a spatial and temporal view. Reproductive Physiology 3, International Reviews of Physiology, RO Greep. University Park, Baltimore, MD 1980; 22: 41–115
  • Fang S, Liao. Androgen receptors. Steroid and tissue specific retention of a 17β-Hy-droxy-5α-androstan-3-one-protein complex by the cell nuclei of ventral prostate. J Biol Chem 1971; 246: 16–24
  • Fawcett DW, Hoffer AP. Failure of exogenous androgen to prevent regression of the initial segments of the rat epididymis after efferent duct ligation or orchidectomy. Biol Reprod 1979; 20: 162–181
  • Forest MG, Rivarola MA, Migeon CJ. Percentage binding of testosterone, androstenedione and dehydroisoandrosterone in human plasma. Steroids 1968; 12: 323–343
  • Fostier A., Breton B. Binding of Steroids by plasma of a teleost: The rainbow trout, Salmo gaidnerii. J Steroid Biochem 1975; 6: 345–351
  • Freeman HC, Idler DR. Binding affinities of blood proteins for sex hormones and corticosteroids in fish. Steroids 1971; 17: 233–250
  • Giorgi EP. Studies on androgen transport into canine prostate in vitro. J Endocrinol 1976; 68: 109–119
  • Gunsalus GL, Musto NA, Bardin CW. Factors affecting blood levels of androgen binding protein in the rat. Intern J Androl Suppl 1978; 2: 482–493
  • Gunsalus GL., Musto NA., Bardin CW. Bidirectional release of a Sertoli cell product, androgen binding protein, into the blood and seminiferous tubule. Testicular Development. Structure and Function, A Steinberger, E Steinberger. Raven Press, New York 1980; 291–297
  • Gunsalus GL, Musto NA, Bardin CW. Immunoassay of androgen binding protein in blood: a new approach for study of the seminiferous tubule. Science 1978; 200: 65–66
  • Hannouche N, Thieulant M-L, Samperez S, Jouan P. Androgens binding proteins in the cytosol from prepubertal male rat hypothal-mus, preoptic area and brain cortex. J Steroid Biochem 1978; 9: 147–151
  • Hansson V, Ritzen EM, French FS, Nayfeh SN. Androgen transport and receptor mechanisms in testis and epididymis. Handbook of Physiology, DW Hamilton, RO Greep. American Physiological Society, Washington 1975; Vol. 5: 173–201, Sec 7
  • Hansson V, Ritzen EM, Weddington SC, McLean WS, Tindall DJ, Nayfeh SN, French FS. Preliminary characterization of a binding protein for androgen in rabbit serum. Comparison with the testosterone-binding globulin (TeBG) in human serum. Endocrinology 1974; 95: 690–700
  • Hansson V, Trygstad O, French FS, McLean WS, Smith AA, Tindall DJ, Weddington SC, Petousz P, Nayfeh SN, Ritzen EM. Androgen transport and receptor mechanisms in testis and epididymis. Nature 1974; 250: 387–391
  • Heap RB, Symons AM, Watkins JC. Steroids and their interactions with phospholipids: solubility, distribution coefficient and effect on potassium permeability of liposomes. Biochem Biophys Acta 1970; 218: 482–495
  • Heyns W. The steroid-binding β-globulin of human plasma. Adv Steroid Biochem Pharmacol 1977; 6: 59–79
  • Heyns W, DeMoor P. Prostatic binding protein. A steroid-binding protein secreted by rat prostate. Eur J Biochem 1977; 78: 221–230
  • Heyns W, Van Damme B, DeMoor P. Secretion of Prostatic binding protein by rat ventral prostate: influence of age and androgen. Endocrinology 1978; 103: 1090–1095
  • Heyns W, Van Baelen H, DeMoor P. Study of the specificity of the steroid binding β-globulin in human plasma. J Endocrinol 1969; 43: 67–71
  • Hsu A-F, Troen P. An androgen binding protein in the testicular cytosol of human testis. J Clin Invest 1978; 61: 1611–1619
  • Kato T, Horton R. Studies of Testosterone Binding Globulin. J Clin Endocrin 1968; 28: 1160–1168
  • Krichhoff J, Soffie M, Rousseau GG. Differences in the steroid-binding site specificities of rat prostate androgen receptor and epididymal androgen-binding protein (ABP). J Steroid Biochem 1979; 10: 487–497
  • Lipshultz LI, Tsai Y-H, Sanborn BM, Steinberger E. Androgen binding activity in the human testis and epididymis. Fertil Steril 1977; 28: 947–951
  • Lobl TJ, Campbell JA, Tindall DJ, Cunningham GR, Means AR. A model for the mechanism for androgen binding, transport and translocation to the nucleus. Testicular Development, Structure, and Function, E Steinberger, A Steinberger. Raven Press, New York 1980; 323–330
  • Lobl TJ, Gunsalus G, Musto N, Bardin CW. Modulation of testicular, epididymal and serum androgen binding protein (ABP) levels by three heterocyclic exfoliating antispermatogenic agents. Procedings 4th Annual Meeting Amer Soc Androl, Houston, Texas, March 13–16, 1979, 27
  • Lobl TJ, Bardin CW, Gunsalus GL, Musto NA. Effects of lonidamine (AF1890) and its analogues on FSH, LH, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey 1980, in press
  • Lobl TJ, Gunsalus GL, Musto NA, Bardin CW. The effects of medroxyprogesterone acetate on androgen binding protein in the rat. J Androl 1980; 1: 87
  • Lobl TJ, Stein SJ, Gunsalus GL, Musto NA. The effects of α-chlorohydrin on androgen binding protein in the rat. Biol Reprod 1979; 20: 90A, Suppl 1
  • Louis BG, Fritz IB. Follicle-stimulating hormone and testosterone independently increase the production of androgen binding protein by Sertoli cells in culture. Endocrinology 1979; 104: 454–461
  • Mainwaring WIP. Androgen receptors and biologic responses: a survey. Receptors and Hormone Action, BW O'Malley, L Birnbaumer. Academic Press, New York 1978; Vol 2: 105–120
  • Mainwaring WIP. The Mechanism of Action of Androgens. Monographs in Endocrinology. Springer-Verlag, New York 1977; Vol 10
  • Martin B. Steroid-protein interactions in nonmammalion vertebrates. Gen Comp Endocorinol. 1975; 25: 42–51
  • Mercier-Bodard C, Marchut M, Perrot M, Picard M-T, Baulieu E-E, Robel P. Influence of purified plasma proteins on testosterone uptake and metabolism by normal and hyperplastic human prostate in “constant-flow organ culture.”. J Clin Endocrinol Metab 1976; 43: 374–386
  • Musto NA, Bardin CW. Decreased levels of androgen binding protein in the reproductive tract of the restricted (Hrc) rat. Steroids 1976; 28: 1–11
  • Musto NA, Gunsalus GL, Miljkovic M, Bardin CW. A novel affinity column for isolation of androgen binding protein from rat epididymis. Endocrine Res Commun 1977; 4: 142–157
  • Nisula BC, Loriaux DL., Wilson YA. Solid phase method for measurement of the binding capacity of testosterone-estradiol binding globulin in human serum. Steroids 1978; 31: 681–690
  • Pardridge WM, Mietus LJ. Transport of protein-bound steroid hormones into liver in vivo. Am J Physicol 1979; 237: E367–E372
  • Parvinen L-M, Parvinen M. A “living cell method” for testing the early effects of anti-spermatogenic compounds: Model experiments with two alkylating agents thio-Tepa and nitrogen mustard. Intern J Androl Suppl 1978; 2: 523–537
  • Parvinen M, Marana R, Robertson DM, Hansson V, Ritzen EM. Functional cycle of rat Sertoli cells: Differential binding and action of follicle-stimulating hormone at various stages of the spermatogenic cycle. Testicular Development, Structure, and Function, A Steinberger, E. Steinberger. Raven Press., New York 1980; 425–437
  • Pelliniemi LJ., Dym M, Durand M., Gunsalus GL., Musto NA, Bardin CW, Fawcett DW. Localization of immunoreactive androgen binding protein in caput epididymis of the rat. Abstracts of 4th Annual Meeting, Amer Soc Androl, Houston, Texas, March 13–16, 1979
  • Petra PH. The serum sex steroid binding protein. Purification, characterization, and immunological properties of the human and rabbit proteins. J Steroid Biochem 1979; 11: 245–252
  • Purvis K, Calandra R., Haug E., Hansson V. 5α-reduced androgens and testicular function in the immature rat: Effects of 5α-an-drostan-17β-ol-3-one (DHT) propionate and 5α-androstan-3α,17β-diol. Mol Cell Endocrinol 1977; 7: 203–219
  • Rao ML, Rao GS, Breuer H. Uptake of estrone, estradiol-17β and testosterone by isolated rat liver cells. Biochem Biophys Res Commun 1977; 77: 566–572
  • Renoir J-M, Fox LL, Baulieu E-E, Mercier-Bodard C. An antiserum specific for human sex steroid-binding plasma protein (SBP). FEBS Lett 1977; 75: 83–88
  • Ritzen EM, French FS, Weddington SC, Nayfeh SN, Hansson V. Steroid binding in poly-acrylamide gels. J Biol Chem 1974; 249: 6597–6604
  • Rommerts FFG, Grootegoed JA, Van der Molen HJ. Physiological role for androgen binding protein-steroid complex in testis. Steroids 1976; 28: 43–49
  • Rommerts FFG, Kruger B. Ch., Grootegoed JA, Van der Molen HJ. Reversible interaction between androgen binding protein and testicular macromolecules causing inhibition of androgen binding activity. Steroids 1979; 33: 659–673
  • Rosner W. The binding of steroid hormones in human serum in Trace Components of Plasma: Isolation and Clinical Significance, GA Jamieson, TJ Greenwalt. Alan R Liss. 1976; Vol V: 377–395
  • Rosner W, Darmstadt RA. Demonstration and partial characterization of a rabbit serum protein which binds testosterone and dihydro-testosterone. Endocrinology 1973; 92: 1700–1707
  • Rosner W, Deakins SM. Testosterone binding globulins in human plasma: studies on sex distribution and specificity. J Clin Invest 1968; 47: 2109–2116
  • Rosner W, Smith RN. Isolation and characterization of the testosterone-estradiol-binding globulin from human plasma. Use of a novel affinity column. Biochemistry 1975; 14: 4813–4820
  • Rosseau GG, Quivy JI, Kirchhoff J, Bui X-H, Devis R. Nonsteroidal compounds which bind epididymal androgen-binding protein but not the androgen receptor. Nature 1980; 284: 458–459
  • Salhanick AR, Callard IP. Sex steroid binding proteins in non-mammalian vertebrates. Steroid Hormone Receptor Systems, WW Leavitt, JN Clark. Plenum Press. Adv Exp Med Biol, New York 1979; 117: 441–459
  • Sanborn BM, Elkington JSH, Tcholakian RK, Steinberger E. Some properties of androgen-binding activity in rat testis. Mol Cell Endocrinol 1975; 3: 129–142
  • Sandberg AA, Slaunwhite WR, Jr, Antoniades HN. The binding of steroids and steroid conjugates to human plasma proteins. Recent Prog Horn Res 1957; 13: 209–267
  • Samperez S, Thieulant M-L, Mercier L, Jouan P. A specific testosterone receptor in the cytosol of rat anterior hypophysis. J Steroid Biochem 1974; 5: 911–915
  • Setchell BP, Laurie MS, Main SJ, Goats GC. The mechanism of transport of testosterone through the walls of the seminiferous tubules of the rat testis. Interin J Androl Suppl 1978; 2: 506–512
  • Steinberger A, Heindel JJ, Lindsey JN, Elkington JSH, Sanborn BM, Steinberger E. Isolation and culture of FSH responsive Sertoli cells. Endocrin Res Commun 1975; 2: 261–272
  • Steins P, Krieg M, Hollmann HJ, Voigt KD. In vitro studies of testosterone and 5α-dihydrotestosterone binding in benign prostatic hypertrophy. Acta Endocrinol 1974; 75: 773–784
  • Stratico D, Hsu A-F, Oshima H, Troen P. Multiple forms of rat testicular androgen binding protein: physiochemical properties and the effect of Ca++. J Androl 1980; 1: 33–39
  • Taylor CA, Jr, Smith HE, Danzo BJ. Photoaffinity labeling of rat androgen binding protein. Proc Natl Acad Sci USA 1980; 77: 234–238
  • Tindall DJ, Cunningham GR, Means AR. 5α-Dihydrotestosterone binding to androgen binding protein. Effects of testosterone and other compounds in vivo and in vitro on the number of binding sites measured. J Biol Chem 1978; 253: 166–169
  • Tindall DJ, Mena CR, Means AR. Hormonal regulation of androgen-binding protein in hypophysectomized rats. Endocrinology 1978; 103: 589–594
  • Thomas MJ, Gordan RD, Smid JR. Physiological variations in plasma testosterone in normal adult male subjects measured by a competitive protein-binding technique. J Steroid Biochem 1974; 5: 45–53
  • Vermeulen A, Verdonch L. Studies on the binding of testosterone to human plasma. Steroids 1968; 11: 609–635
  • Vigersky RA, Loriaux DL, Howards SS, Hodgen GB, Lipsett MB, Chrambach A. Androgen binding proteins of testis, epididydmis and plasma in man and monkey. J Clin Invest 1976; 58: 1061–1068
  • Wagner RK. Extracellular and intracellular steroid binding proteins. Properties, discrimination, assay and clinical application. Acta Endocrinologica (Kbh) 1978; 88: 1–73, Suppl 218
  • Weddington SC, Brandtzaeg P, Sletten K, Christensen T, Hansson V, French FS, Petrusz P, Nayfeh SN, Ritzen EM. Purification and characterization of rabbit testicular androgen binding protein (ABP). Hormonal Regulation of Spermatogenesis, FS French, V Hansson, EM Ritzen, SN Nayfeh. Plenum Press, New York 1975; 433–451
  • Weddington SC, Hansson V, Purvis K, Varaas T, Verjans HL, Eik-Nes KB, Ryan WH, French FS, Ritzen EM. Biphasic effect of testosterone propionate on Sertoli cell secretory function. Mol Cell Endocrinol 1976; 5: 137–145
  • Westphal U. Steroid-Protein Interactions. Monographs on Endocrinology. Springer-Verlag, Berlin 1971; Vol 4

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