Publication Cover
Archives of Andrology
Journal of Reproductive Systems
Volume 22, 1989 - Issue 3
437
Views
16
CrossRef citations to date
0
Altmetric
Original Article

Reproductive Effects of the Anticancer Drug Cyclophosphamide in Male Rats at Different Ages

, , , , &
Pages 251-263 | Received 19 Nov 1988, Published online: 09 Jul 2009

References

  • Adams P M., Fabricant J D., Legator M S. Cyclophosphamide induced spermatogenetic effects detected in the F1, generation by behavioral test. Science 1981; 211: 80–82
  • Botta J A., Halukins H C., Weikel J H. Effects of cyclophosphamide on fertility and general reproductive performance of rats. Toxicol Appl Pharmacol 1974; 21: 602–611
  • Brittinger D. Die mutagene wirkung von Endoxan bei der mans. Hum Genet 1966; 3: 156
  • Buchanan J D., Fairley K F., Barrie J U. Return of spermatogenesis after stopping cyclophosphamide therapy. Lancet 1975; i: 568–569
  • Chapman R M. Gonadal injury resulting from chemotherapy. Am J Indust Med 1983; 4: 149–161
  • De Groot C W., Faiman C, Winter J SD. Cyclophosphamide and the prepubertal gonad: A negative report. J Pediatr 1974; 84: 123–125
  • Etteldorf I N., West C D., Pitcock J A., Williams D L. Gonadal function, testicular histology and meiosis following cyclophosphamide therapy in patients with nephrotic syndrome. J Pediatr 1976; 88: 206–212
  • Fairley K F., Barrie J U., Johnson W. Sterility and testicular atrophy related to cyclophosphamide therapy. Lancet 1972; i: 568–569
  • Freireich E J., Gehan E A., Rall D P., Schmidt L H., Skipper H E. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother Rep 1966; 50: 219–244
  • Fukutani K, Ishida H, Shinohara M, Minowada S, Nijima T, Hijikata K, Izawa Y. Suppression of spermatogenesis in patients with Behert's disease treated with cyclophosphamide and colchicine. Fertil Steril 1981; 36: 76–80
  • Garnier D H., Cotta Y, Terqui M. Androgen radioimmunoassay in the ram: Results of direct plasma testosterone and dehydroepiandrosterone measurement and physiological evaluation. Ann Biol Anim Biochim Biophys 1978; 18265–281
  • Glode L M., Robinson J, Gould S F. Protection from cyclophospharnide-induced testicular damage with an analogue of Gonadotrophin-releasing hormone. Lancet 1981; i: 1132–1133
  • Gould S F., Powell D, Nett T, Glode L M. A rat model for chemotherapy-induced male infertility. Arch Androl 1983; 11: 141–150
  • Hilscher W, Reichert P. Effect of cyclophosphamide and procarbazine on the seminiferous epithelium in the rat. Beitr Pathol Anat 1968; 137: 452–478
  • Hoffer A P. Effects of gossypol on the seminiferous epithelium in the rat: A light and electron microscope study. Biol Reprod 1983; 28: 1007–1020
  • Hyman L R., Gilbert E F. Testicular atrophy in a prepubescent male after cyclophosphamide therapy. Lancet 1972; i: 568
  • Kumar R, Biggart J D., McEvoy J, McGrown M G. Cyclophosphamide and reproductive function. Lancet 1972; i: 1212–1214
  • Lee I P., Dixon R L. Effects of procarbazine on spermatogenesis determined by velocity sedimentation cell separations technique and serial mating. J Pharmacol Exp Ther 1972; 181: 219–226
  • Lendon M, Hann I M., Palmer M K., Shalet S M., Morris-Jones P H. Testicular histology after combination chemotherapy in childhood for acute lymphoblastic leukaemia. Lancet 1978; ii: 439–441
  • Moreland F M., Sheu C W., Springer J A., Green S K. Effects of prolonged chemical treatment with cyclophosphamide and 6-mercaptopurine in the dominant lethal test system. Mutat Res 1981; 90: 193–199
  • Pennisi A J., Grushkin C M., Lieberman E. Gonadal function in children with nephrosis treated with cyclophosphamide. Am J Dis Child 1975; 129: 315–318
  • Qureshi M SA, Goldsmith H J., Pennington J H., Cox P E. Cyclophosphamide therapy and sterility. Lancet 1972; II: 1290–1291
  • Ritzén E M., French F S., Weddington S C., Nayfech S N., Hansson V. Steroid binding in polyacrylamide gels. J Biol Chem 1974; 249: 6597–6604
  • Robb G W., Amann R P., Killiam J M. Daily sperm production and epididymal sperm reserves of pubertal and adult rats. J Reprod Fertil 1978; 54: 103–107
  • Roeser H P., Stochs A E., Smith A J. Testicular damage due to cytotoxic drugs and recovery after cessation of therapy. Aust NZ J Med 1978; 8: 250–254
  • Shalet S M. Disorders of the endocrine system due to radiations and cytotoxic chemotherapy. Clin Endocrinol 1983; 18: 637–659
  • Shalet S M., Hann I M., Lendon M, Morris-Jones P H., Beardwell C G. Testicular function after combination chemotherapy in childhood for acute lymphoblastic leukaemia. Arch Dis Child 1981; 56: 275–278
  • Sherins R J., DeVita V T. Effect of drug treatment for lymphom ma on male reproductive capacity. Ann InternMed 1973; 79: 216–220
  • Trasler J M., Hales B F., Robaire B. Paternal cyclophosphamide treatment of rats causes fetal loss and malformations without affecting male fertility. Nature 1985; 316: 144–146
  • Trasler J M., Hales B F., Robaire B. Chronic low dose cyclophosphamide treatments of adult male rats: Effect on fertility, pregnancy outcome and progenity. Biol Reprod 1986; 34: 275–283
  • Vigil P, Bustos-Obregon E. Alkylating agents and mouse spermatogenesis. Effects of a single dose of cyclophosphamide. Andrologia 1985; 17: 276–282

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.