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The International Journal on Orbital Disorders, Oculoplastic and Lacrimal Surgery
Volume 15, 1996 - Issue 3
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Original Article

In situ studies of orbital tissue from patients with thyroid-associated ophthalmopathy

Pages 147-158 | Accepted 20 Feb 1996, Published online: 08 Jul 2009

References

  • Wall J R, Salvi M, Bernard N F, Boucher A, Haegert D. Thyroidassociated ophthalmopathy-a model for the association of organ-specific autoimmune disorders. Immunol Today 1991; 12: 150–153
  • Weetman A P. Thyroid-associated eye disease: Pathophysiology. Lancet 1991; 338: 25–28
  • Gorman C A. Pathogenesis of Graves' ophthalmopathy. Thyroid 1994; 4: 379–383
  • Hiromatsu Y, Tanaka K, Ishisaka N, et al. Human histocompatibility leukocyte antigen-DR and heat shock protein-70 expression in eye muscle tissue in thyroid-associated ophthalmopathy. J Clin Endocrinol Metabol 1995; 80: 685–691
  • Dong Q, Ludgate M, Vassart G. Cloning and sequencing of a novel 64 kDa autoantigen recognized by patients with autoimmune thyroid disease, expressed in the thyroid and extraocular muscle. J Clin Endocrinol Metabol 1991; 72: 1375–1381
  • Yoshikawa K, Higashide T, Nakase Y, Inoue T, Inoue Y, Shiga H. Role of rectus muscle enlargement in clinical profile of dysthyroid ophthalmopathy. Jpn J Ophthalmol 1991; 35: 175–181
  • Hiromatsu Y, Kojima K, Ishisaka N, et al. Role of magnetic resonance imaging in thyroid-associated ophthalmopathy: its predictive value for therapeutic outcome of immunosup-pressive therapy. Thyroid 1992; 2: 299–305
  • Rieber E P. T-cell section report. Leukocyte Typing IV: White Cell Differentiation Antigens, W Knapp, B Dorken, W R Gilks, et al. Oxford University Press, New York 1989; 229–249
  • Gross B, Misrahi M, Sar S, Milgrom E. Composite structure of the human thyrotropin receptor gene. Biochem Biophys Res Commun 1991; 177: 679–687
  • Tanaka K, Hiromatsu Y, Sato M, Inoue Y, Nonaka K. Localization of heat shock protein in orbital tissue from patients with Graves' ophthalmopathy using in situ hybridization. Life Sci 1994; 54: 355–359
  • Chomczynski P, Sacchi N. Singlestep method of RNA isolation by acid guanidium thiocyanate-phenolchloroform extraction. Anal Biochem 1987; 162: 156–159
  • Tokunaga K, Nakamura Y, Sakata K, et al. Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res 1987; 47: 5616–5619
  • Fox R I, Kang H-I, Ando D, et al. Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome. J Immunol 1994; 152: 5532–5539
  • Huang X, Yuan J, Goddark A, et al. Interferon expression in the pancreas of patients with type I diabetes. Diabetes 1995; 44: 558–664
  • Watson P F, Pickerill A P, Davies R, Weetman A P. Analysis of cytokine gene expression in Graves' disease and multinodular goiter. J Clin Endocrinol Metabol 1994; 79: 355–360
  • Weetman A P, Cohen S, Gatter K C, Fells P, Shine B. Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy. Clin Exp Immunol 1989; 75: 222–227
  • Tallstedt L, Norberg R. Immunohistochemical staining of normal and Graves' extraocular muscle. Invest Ophthalmol Vis Sci 1988; 29: 175–184
  • Kroll A J, Kuwabara T. Dysthyroid ocular myopathy: anatomy, histology and electron microscopy. Arch Ophthalmol 1966; 76: 244–257
  • Heufelder A E, Bahn R S. Detection and localization of cytokine immunoreactivity in retro-ocular connective tissue in Graves' ophthalmopathy. Eur J Clin Invest 1993; 23: 10–17
  • McLachlan S M, Prummel M F, Rapoport B. Cell-mediated or humoral immunity in Graves' ophthalmopathy? Profiles of T-cell cytokines amplified by polymerase chain reaction from orbital tissue. J Clin Endocrinol Metabol 1994; 78: 1070–1074
  • Botazzo G F, Pujol-Borrell R, Hanafusa T, Feldmann M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 1983; ii: 1115–1119
  • Gimmi C D, Freeman G J, Gribben J G, Gray G, Nadler L M. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc Natl Acad Sci USA 1993; 90: 6586–6590
  • Asuma M, Ito D, Yagita H, et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 1993; 366: 76–78
  • Weetman A P. Antigen presentation in the pathogenesis of autoimmune endocrine disease. J Autoimmunity 1995; 8: 305–312
  • Hiromatsu Y, Fukazawa H, How J, Wall J R. Antibody-dependent cell-mediated cytotoxicity against human eye muscle cells and orbital fibro-blasts in Graves' ophthalmopathy-roles of class II MHC antigen expression and γ-interferon action on effector and target cells. Clin Exp Immunol 1987; 70: 597–603
  • Heufelder A E, Wenzel B E, Bahn R S. Cell surface localization of a 72 kilodalton heat shock protein in retro-ocular fibroblasts from patients with Graves' ophthalmopathy. J Clin Endocrinol Metabol 1992; 74: 732–736
  • Heufelder A E, Goellner J R, Wenzel B E, Bahn R S. Immunohistochemical detection and localization of a 72-kilodalton heat shock protein in autoimmune thyroid disease. J Clin Endocrinol Metabol 1992; 74: 724–731
  • Heufelder A E, Bahn R S. Modulation of intercellular adhesion molecule-1 (ICAM-1) by cytokines and Graves' IgGs in cultured Graves' retroocular fibroblasts. Ear J Clin Invest 1992; 22: 529–537
  • Heufelder A E, Bahn R S, Boergen K P, Scriba P C. Nachweis, Lokalisation und Modulation der CD44/Hyaluronsäure-Rezeptor Expression bei Patienten mit endocriner Orbitopathie. Med Klinik 1993; 88: 181–185
  • Heufelder A E, Bahn R S. Soluble intercellular adhesion molecule-1 (sICAM-1) in sera of patients with Graves' ophthalmopathy and thyroid diseases. Clin Exp Immunol 1993; 92: 296–302
  • Kodama K, Sikorska H, Bandy-Dafoe P, Bayly R, Wall J R. Demonstration of a circulating autoantibody against soluble eye muscle antigen in Graves' ophthalmopathy. Lancet 1982; ii: 1353–1356
  • Kendall-Taylor P, Atkinson S, Holcombe M. A specific IgG in Graves' ophthalmopathy and its relation to retro-orbital and thyroid autoimmunity. Br Med J 1984; 288: 1183–1186
  • Mengistu M, Laryea E A, Miller A, Wall J R. Clinical significance of a new autoantibody against a human eye muscle soluble antigen detected by immunofluorescence. Clin Exp Immunol 1986; 65: 19–27
  • Hiromatsu Y, Fukazawa H, Guinard F, Salvi M, How J, Wall J R. A thyroid cytotoxic antibody that cross-reacts with an eye muscle cell surface antigen may be the cause of thyroid-associated ophthalmopathy. J Clin Endocrinol Metabol 1986; 67: 565–570
  • Salvi M, Miller A, Wall J R. Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in serum of patients with thyroidassociated ophthalmopathy. FEBS Lett 1988; 232: 135–139
  • Ahmann A, Baker J R, Weetman A P, Wartofsky L, Nutman T B, Burman K D. Antibodies to porcine eye muscle in patients with Graves' ophthalmopathy; identification of serum immunoglobulins directed against unique determinants by immunoblotting and enzyme-linked immunosorbent assay. J Clin Endocrinol Metabol 1987; 64: 454–460
  • Hiromatsu Y, Sato M, Tanaka K, et al. Significance of anti-eye muscle antibody in patients with thyroidassociated ophthalmopathy by quantitative western blot. Autoimmunity 1992; 14: 9–16
  • Kendler D L, Rootman J, Huber G K, Davies T F. A 64 kDa membrane antigen is a recurrent epitope for natural autoantibodies in patients with Graves' thyroid and ophthalmic disease. Clin Endocrinol (Oxf) 1991; 35: 539–547
  • Wall J R, Scalise D, Hayes M, et al. Native gel electrophoresis of the 64 kDa protein shows that it is eye muscle specific and an important target for autoantibodies in patients with thyroid-associated ophthalmopathy. Thyroid 1994; 4(Suppl 1)S-92
  • Kiljanski J, Nebes V, Wall J R. The ocular cell is a target of the immune system in endocrine ophthalmopathy. Int Arch Allergy Immunol 1995; 106: 204–212
  • Teng C S, Smith B R, Anderson J, Hall R. Comparison of thyrotropin receptors in membranes prepared from fat and thyroid tissue. Biochem Biophys Res Commun 1975; 66: 836–841
  • Perros P, Kendall-Taylor P. Demonstration of thyrotropin binding sites in orbital connective tissue: possible role in the pathogenesis of thyroidassociated ophthalmopathy. J Endocrinol Invest 1994; 17: 163–170
  • Pekonen F, Weintraub B D. Thyrotropin binding to cultured lymphocytes and thyroid cells. Endocrinology 1978; 103: 1668–1677
  • Roselli-Rehfuss L, Robbins L S, Cone R D. Thyrotropin receptor messenger ribonucleic acid is expressed in most brown and white adipose tissues in the guinea pig. Endocrinology 1992; 130: 1857–1861
  • Paschke R, Ellsei R, Vassart G, Ludgate M. Lack of evidence supporting the presence of mRNA for thyrotropin receptor in extraocular muscle. J Endocrinol Invest 1993; 16: 329–332
  • Feliciello A, Porcellini A, Ciullo I, Bonavolontà G, Avvedimento E V, Fenzi G. Expression of thyrotropinreceptor mRNA in healthy and Graves' disease retro-orbital tissue. Lancet. 1993; 342: 337–338
  • Endo T, Ohno M, Kotani S, Gunji K, Onaya T. Thyrotropin receptor in non-thyroid tissues. Biochem Biophys Res Commun 1993; 190: 774–779
  • Heufelder A E, Dutton C M, Sarkar G, Donovan K A, Bahn R S. Detection of TSH receptor RNA in cultured fibroblasts from patients with Graves' ophthalmopathy and pretibial dermopathy. Thyroid. 1993; 3: 297–300
  • Mengistu M, Lukses Y G, Nagy E V, et al. TSH receptor gene expression in retroocular fibroblasts. J Endocrinol Invest 1994; 17: 437–441
  • Hiromatsu Y, Tanaka K, Koga M, et al. Significance of thyrotropin receptor mRNA expression in orbital fat tissue from patients with thyroid-associated ophthalmopathy. J Endocrinol Invest 1994; 17(Suppl 1 to 6)44
  • Francis T, Burch H B, Cai W-Y, et al. Lymphocytes express thyrotropin receptor-specific mRNA as detected by the PCR technique. Thyroid 1991; 1: 223–228
  • Wall J R, Strakosch C R, Fang S L, Ingbar S H, Braverman L H. Thyroid binding antibodies and other immunological abnormalities in patients with Graves' ophthalmopathy: effect of treatment with cyclophosphamide. Clin Endocrinol 1979; 10: 79–91
  • Benker G, Kotulla P, Kendall-Taylor P, Emrich D, Reinwein D. TSH binding-inhibiting antibodies in hyperthyroidism: relationship to clinical signs and hormone levels. Clin Endocrinol 1989; 30: 19–28
  • Chang T C, Huang K H, Chang T J, Lin S L. Correlation of orbital computed tomography and antibodies in patients with hyperthyroid Graves' disease. Clin Endocrinol 1990; 32: 551–555
  • Feldt-Rasmussen U, Kemp A, Bech K, Madsen S N, Date J. Serum thyroglobulin, its autoantibody and thyroid stimulating antibodies in endocrine exophthalmos. Acta Endocrinol 1981; 96: 192–198
  • Nishikawa M, Yoshimura M, Toyoda N, et al. Correlation of orbital muscle changes evaluated by magnetic resonance imaging and thyroidstimulating antibody in patients with Graves' ophthalmopathy. Acta Endocrinol 1993; 129: 213–219
  • Miyake I, Koga M, Nagasawa N, et al. Clinical significance of antithyrotropin receptor antibodies in thyroid-associated ophthalmopathy. Thyroid 1995; 5(Suppl 1)S185

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