Cysteine-String Protein's Neuroprotective Role

REFERENCES

• Boal, F., Zhang, H., Tessier, C., Scotti, P., Lang, J. (2004). The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions. Biochemistry, 43, 16212–16223.
   PubMedGoogle Scholar
• Bonini, N.M., Fortini, M.E. (2003). Human neurodegenerative disease modeling using Drosophila. Annu Rev Neurosci, 26, 627–656.
   PubMed Web of Science ®Google Scholar
• Bowyer, J.F., Davies, D.L. (1999). Changes in mRNA levels for heat-shock/stress proteins (Hsp) and a secretory vesicle associated cysteine-string protein (Csp1) after amphetamine (AMPH) exposure. Ann. N. Y. Acad. Sci. 890, 314–329.
   PubMedGoogle Scholar
• Braun, J., Wilbanks, S.M., Scheller, R.H. (1996). The cysteine string secretory vesicle protein activates Hsc70 ATPase. J. Biol. Chem. 271, 25989–25993.
   PubMed Web of Science ®Google Scholar
• Braun, J.E.A., Scheller, R.A. (1995). Cysteine string protein, a DnaJ family member, is present on diverse secretory vesicles. Neuropharmacology, 34, 1361–1369.
   PubMedGoogle Scholar
• Bronk, P., Nie, Z., Klose, M.K., Dawson-Scully, K., Zhang, J., Robertson, R.M., Atwood, H.L., Zinsmaier, K.E. (2005). The multiple functions of cysteine-string protein analyzed at Drosophila nerve terminals. J. Neurosci. 25, 2204–2214.
   PubMed Web of Science ®Google Scholar
• Bronk, P., Wenniger, J.J., Dawson-Scully, K., Guo, X., Hong, S., Atwood, H.L., Zinsmaier, K.E. (2001). Drosophila Hsc70-4 is critical for neurotransmitter exocytosis in vivo. Neuron, 30, 475–488.
   PubMed Web of Science ®Google Scholar
• Brown, H., Larsson, O., Branstrom, R., Yang, S.N., Leibiger, B., Leibiger, I., Fried, G., Moede, T., Deeney, J.T., Brown, G.R., (1998). Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. EMBO J. 17, 5048–5058.
   PubMedGoogle Scholar
• Buchner, E., Bader, R., Buchner, S., Cox, J., Emson, P.C., Flory, E., Heizmann, C.W., Hemm, S., Hofbauer, A., Oertel, W.H. (1988). Cell-specific immuno-probes for the brain of normal and mutant Drosophila melanogaster. I. Wildtype visual system. Cell Tissue Res. 253, 357–370.
   PubMed Web of Science ®Google Scholar
• Buchner, E., Gundersen, C.B. (1997). The DnaJ-like cysteine string protein and exocytotic neurotransmitter release. Trends Neurosci, 20, 223–227.
   PubMed Web of Science ®Google Scholar
• Bukau, B., Horwich, A.L. (1998). The Hsp70 and Hsp60 chaperone machines. Cell 92, 351–366.
   PubMed Web of Science ®Google Scholar
• Burgoyne, R.D., Fisher, R.J., Graham, M.E., Haynes, L.P., Morgan, A. (2001). Control of membrane fusion dynamics during regulated exocytosis. Biochem. Soc. Trans. 29, 467–472.
   PubMedGoogle Scholar
• Burnashev, N., Rozov, A. (2005). Presynaptic Ca2+ dynamics, Ca2+ buffers and synaptic efficacy. Cell Calcium, 37, 489–495.
   PubMedGoogle Scholar
• Caplan, A.J., Cyr, D.M., Douglas, M.G. (1993). Eukaryotic homologues of Escherichia coli dnaJ: A diverse protein family that functions with hsp70 stress proteins [review]. Mol. Biol. Cell 4, 555–563.
   PubMed Web of Science ®Google Scholar
• Chamberlain, L.H., Burgoyne, R.D. (1996b). Identification of a novel cysteine string protein variant and expression of cysteine string proteins in non-neuronal cells. J. Biol. Chem. 271, 7320–7323.
   PubMedGoogle Scholar
• Chamberlain, L.H., Burgoyne, R.D. (1997a). The molecular chaperone function of the secretory vesicle cysteine string proteins. J. Biol. Chem. 272, 31420–31426.
   PubMedGoogle Scholar
• Chamberlain, L.H., Burgoyne, R.D. (1997b). Activation of the ATPase activity of heat-shock proteins Hsc70/Hsp70 by cysteine-string protein. Biochem. J. 322, 853–858.
   PubMedGoogle Scholar
• Chamberlain, L.H., Burgoyne, R.D. (1998a). Cysteine string protein functions directly in regulated exocytosis. Mol. Biol. Cell 9, 2259–2267.
   PubMed Web of Science ®Google Scholar
• Chamberlain, L.H., Burgoyne, R.D. (2000). Cysteine string protein: The chaperone at the synapse. J. Neurochem. 74, 1781–1789.
   PubMed Web of Science ®Google Scholar
• Chamberlain, L.H., Graham, M.E., Kane, S., Jackson, J.L., Maier, V.H., Burgoyne, R.D. (2001). The synaptic vesicle protein, cysteine-string protein, is associated with the plasma membrane in 3T3-L1 adipocytes and interacts with syntaxin 4. J. Cell Sci. 114, 445–455.
   PubMedGoogle Scholar
• Chamberlain, L.H., Henry, J., Burgoyne, R.D. (1996a). Cysteine string proteins are associated with chromaffin granules. J. Biol. Chem. 271, 19514–19517.
   PubMedGoogle Scholar
• Chandra, S., Gallardo, G., Fernandez-Chacon, R., Schluter, O.M., Sudhof, T.C. (2005). Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123, 383–396.
   PubMed Web of Science ®Google Scholar
• Cheetham, M.E., Caplan, A.J. (1998). Structure, function and evolution of DnaJ: Conservation and adaptation of chaperone function. Cell Stress Chaperones, 3, 28–36.
   PubMed Web of Science ®Google Scholar
• Chen, S., Zheng, X., Schulze, K.L., Morris, T., Bellen, H., Stanley, E.F. (2002). Enhancement of presynaptic calcium current by cysteine string protein. J Physiol 538, 383–389.
   PubMedGoogle Scholar
• Chin, H., Lyu, M.S., Kwon, O.J., Kozak, C.A. (1997). Genetic mapping of the gene encoding cysteine string protein. Mamm. Genome 8, 456–457.
   PubMedGoogle Scholar
• Coppola, T., Gundersen, C. (1996). Widespread expression of human cysteine string proteins. FEBS Lett. 391, 269–272.
   PubMedGoogle Scholar
• Cordeiro, M.L., Gundersen, C.B., Umbach, J.A. (2003). Dietary lithium induces regional increases of mRNA encoding cysteine string protein in rat brain. J. Neurosci. Res. 73, 865–869.
   PubMedGoogle Scholar
• Cordeiro, M.L., Gundersen, C.B., Umbach, J.A. (2004). Convergent effects of lithium and valproate on the expression of proteins associated with large dense core vesicles in NGF-differentiated PC12 cells. Neuropsychopharmacology, 29, 39–44.
   PubMedGoogle Scholar
• Cordeiro, M.L., Umbach, J.A., Gundersen, C.B. (2000a). Lithium ions enhance cysteine string protein gene expression in vivo and in vitro. J. Neurochem. 74, 2365–2372.
   PubMedGoogle Scholar
• Cordeiro, M.L., Umbach, J.A., Gundersen, C.B. (2000b). Lithium ions up-regulate mRNAs encoding dense-core vesicle proteins in nerve growth factor-differentiated PC12 cells. J. Neurochem. 75, 2622–2625.
   PubMed Web of Science ®Google Scholar
• Cyr, D.M., Langer, T., Douglas, M.G. (1994). DnaJ-like proteins: Molecular chaperones and specific regulators of Hsp70. Trends Biochem. Sci. 19, 176–181.
   PubMedGoogle Scholar
• Dawson-Scully, K., Bronk, P., Atwood, H.L., Zinsmaier, K.E. (2000). Cysteine-string protein increases the calcium sensitivity of neurotransmitter exocytosis in Drosophila. J. Neurosci. 20, 6039–6047.
   PubMedGoogle Scholar
• Dawson-Scully, K., Lin, Y., Imad, M., Zhang, J., Marin, L., Horne, J.A., Meinertzhagen, I.A., Karunanithi, S., Zinsmaier, K.E., Atwood, H.L. (2007). Morphological and functional effects of altered cysteine string protein at the Drosophila larval neuromuscular junction. Synapse 61, 1–16.
   PubMed Web of Science ®Google Scholar
• Eberle, K.K., Zinsmaier, K.E., Buchner, S.M.G., Jenni, M., Arnold, C., Leibold, C., Reisch, D., Walter, N., Hafen, E., (1998). Wide distribution of cysteine string protein in Drosophila tissues revealed by targeted mutagenesis. Cell Tissue Res, 294, 203–217.
   PubMedGoogle Scholar
• Eisenberg, E., Greene, L.E. (2007). Multiple roles of auxilin and hsc70 in clathrin-mediated endocytosis. Traffic 8, 640–646.
   PubMed Web of Science ®Google Scholar
• Evans, G.J., Barclay, J.W., Prescott, G.R., Jo, S.R., Burgoyne, R.D., Birnbaum, M.J., Morgan, A. (2006). Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. J. Biol. Chem. 281, 1564–1572.
   PubMedGoogle Scholar
• Evans, G.J., Morgan, A. (2002). Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I. Biochem. J. 364, 343–347.
   PubMedGoogle Scholar
• Evans, G.J., Morgan, A. (2003). Regulation of the exocytotic machinery by cAMP-dependent protein kinase: Implications for presynaptic plasticity. Biochem. Soc. Trans. 31, 824–827.
   PubMedGoogle Scholar
• Evans, G.J., Morgan, A. (2005). Phosphorylation of cysteine string protein in the brain: Developmental, regional and synaptic specificity. Eur. J. Neurosci. 21, 2671–2680.
   PubMedGoogle Scholar
• Evans, G.J., Morgan, A., Burgoyne, R.D. (2003). Tying everything together: The multiple roles of cysteine string protein (CSP) in regulated exocytosis. Traffic 4, 653–659.
   PubMed Web of Science ®Google Scholar
• Evans, G.J., Wilkinson, M.C., Graham, M.E., Turner, K.M., Chamberlain, L.H., Burgoyne, R.D., Morgan, A. (2001). Phosphorylation of cysteine string protein by protein kinase A. Implications for the modulation of exocytosis. J. Biol. Chem. 276, 47877–47885.
   PubMedGoogle Scholar
• Eybalin, M., Renard, N., Aure, F., Safieddine, S. (2002). Cysteine-string protein in inner hair cells of the organ of Corti: Synaptic expression and upregulation at the onset of hearing. Eur. J. Neurosci. 15, 1409–1420.
   PubMedGoogle Scholar
• Fernandez-Chacon, R., Wolfel, M., Nishimune, H., Tabares, L., Schmitz, F., Castellano-Munoz, M., Rosenmund, C., Montesinos, M.L., Sanes, J.R., Schneggenburger, R., Sudhof, T.C. (2004). The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron 42, 237–251.
   PubMed Web of Science ®Google Scholar
• Fujita, S.C. (1988). Use of hybridoma libraries in the study of the genetics and development of Drosophila. Annu. Rev. Entomol. 33, 1–15.
   PubMedGoogle Scholar
• Fujita, S.C., Zipursky, S.L., Benzer, S., Ferrus, A., Shotwell, S.L. (1982). Monoclonal antibodies against the Drosophila nervous system. Proc. Natl. Acad. Sci. U. S. A. 79, 7929–7933.
   PubMed Web of Science ®Google Scholar
• Galli, T., Haucke, V. (2004). Cycling of synaptic vesicles: How far? How fast! Sci STKE, 2004, re19.
   PubMedGoogle Scholar
• Ghijsen, W.E., Leenders, A.G. (2005). Differential signaling in presynaptic neurotransmitter release. Cell Mol Life Sci, 62, 937–954.
   PubMedGoogle Scholar
• Graham, M.E., Burgoyne, R.D. (2000). Comparison of cysteine string protein (Csp) and mutant a-SNAP overexpression reveals a role for Csp in late steps of membrane fusion in Dense-Core granule exocytosis in adrenal chromaffin cells. J. Neurosci. 20, 1281–1289.
   PubMedGoogle Scholar
• Gundersen, C.B., Umbach, J.A. (1992). Suppression cloning of the cDNA for a candidate subunit of a presynaptic calcium channel. Neuron 9, 527–537.
   PubMedGoogle Scholar
• Hartl, F.U., Hayer-Hartl, M. (2002). Molecular chaperones in the cytosol: From nascent chain to folded protein. Science 295, 1852–1858.
   PubMed Web of Science ®Google Scholar
• Heckmann, M., Adelsberger, H., Dudel, J. (1997). Evoked transmitter release at neuromuscular junctions in wild type and cysteine string protein null mutant larvae of Drosophila. Neurosci L, 228, 167–170.
   PubMedGoogle Scholar
• Hennessy, F., Nicoll, W.S., Zimmermann, R., Cheetham, M.E., Blatch, G.L. (2005). Not all J domains are created equal: Implications for the specificity of Hsp40-Hsp70 interactions. Protein Sci. 14, 1697–1709.
   PubMed Web of Science ®Google Scholar
• Hofbauer, A., Buchner, E. (1989). Does Drosophila have seven eyes? Naturwissenschaften, 76, 335–336.
   Web of Science ®Google Scholar
• Hofbauer, A., Ebel, T., Waltenspiel, B., Oswald, P., Chen, Y.C., Halder, P., Biskup, S., Lewandrowski, U., Winkler, C., Sickmann, A., (2009). The Wuerzburg hybridoma library against Drosophila brain. J. Neurogenet. 23, 78–91.
   PubMed Web of Science ®Google Scholar
• Hohfeld, J., Jentsch, S. (1997). GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J. 16, 6209–6216.
   PubMed Web of Science ®Google Scholar
• Jahn, R., Lang, T., Sudhof, T.C. (2003). Membrane fusion. Cell, 112, 519–533.
   PubMed Web of Science ®Google Scholar
• Kelley, W.L. (1998). The J-domain family and the recruitment of chaperone power. Trends Biol Sci, 23, 222–227.
   PubMed Web of Science ®Google Scholar
• Kelley, W.L. (1999). Molecular chaperones: How J domains turn on Hsp70s. Curr. Biol. 9, R305–R308.
   PubMed Web of Science ®Google Scholar
• Kennedy, M.B. (2000). Signal-processing machines at the postsynaptic density. Science, 290, 750–754.
   PubMed Web of Science ®Google Scholar
• Kobayashi, Y., Sobue, G. (2001). Protective effect of chaperones on polyglutamine diseases. Brain Res. Bull. 56, 165–168.
   PubMed Web of Science ®Google Scholar
• Kohan, S.A., Pescatori, M., Brecha, N.C., Mastrogiacomo, A., Umbach, J.A., Gundersen, C.B. (1995). Cysteine string protein immunoreactivity in the nervous system and adrenal gland of rat. J. Neurosci. 15, 6230–6238.
   PubMedGoogle Scholar
• Leveque, C., Pupier, S., Marqueze, B., Geslin, L., Kataoka, M., Takahashi, M., De Waard, M., Seagar, M. (1998). Interaction of cysteine string proteins with the alpha1A subunit of the P/Q-type calcium channel. J. Biol. Chem. 273, 13488–13492.
   PubMedGoogle Scholar
• Levine, M.S., Cepeda, C., Hickey, M.A., Fleming, S.M., Chesselet, M.F. (2004). Genetic mouse models of Huntington's and Parkinson's diseases: Illuminating but imperfect. Trends Neurosci. 27, 691–697.
   PubMedGoogle Scholar
• Magga, J.M., Jarvis, S.E., Arnot, M.I., Zamponi, G.W., Braun, J.E.A. (2000). Cysteine string protein regulates G protein modulation of N-type calcium channels. Neuron 28, 195–204.
   PubMed Web of Science ®Google Scholar
• Marsh, J.L., Thompson, L.M. (2004). Can flies help humans treat neurodegenerative diseases? Bioessays 26, 485–496.
   PubMed Web of Science ®Google Scholar
• Mastrogiacomo, A., Gundersen, C.B. (1995). The nucleotide and deduced amino acid sequence of a rat cysteine string protein. Brain Res. Mol. Brain Res. 28, 12–18.
   PubMedGoogle Scholar
• Mastrogiacomo, A., Kornblum, H.I., Umbach, J.A., Gundersen, C.B. (1998). A Xenopus cysteine string protein with a cysteine residue in the J domain. Biochim. Biophys. Acta 1401, 239–241.
   PubMedGoogle Scholar
• Mastrogiacomo, A., Parsons, S.M., Zampighi, G.A., Jenden, D.J., Umbach, J.A., Gundersen, C.B. (1994). Cysteine string proteins—A potential link between synaptic vesicles and presynaptic Ca2+ channels. Science 263, 981–982.
   PubMed Web of Science ®Google Scholar
• Miller, L.C., Swayne, L.A., Chen, L., Feng, Z.P., Wacker, J.L., Muchowski, P.J., Zamponi, G.W., Braun, J.E. (2003a). Cysteine string protein (CSP) inhibition of N-type calcium channels is blocked by mutant huntingtin. J. Biol. Chem. 278, 53072–53081.
   PubMed Web of Science ®Google Scholar
• Miller, L.C., Swayne, L.A., Kay, J.G., Feng, Z.P., Jarvis, S.E., Zamponi, G.W., Braun, J.E. (2003b). Molecular determinants of cysteine string protein modulation of N-type calcium channels. J. Cell Sci. 116, 2967–2974.
   PubMed Web of Science ®Google Scholar
• Muchowski, P.J. (2002). Protein misfolding, amyloid formation, and neurodegeneration: A critical role for molecular chaperones? Neuron 35, 9–12.
   PubMed Web of Science ®Google Scholar
• Muchowski, P.J., Wacker, J.L. (2005). Modulation of neurodegenration by molecular chaperones. Nat Rev Neurosci, 6, 11–22.
   PubMed Web of Science ®Google Scholar
• Natochin, M., Campbell, T.N., Barren, B., Miller, L.C., Hameed, S., Artemyev, N.O., Braun, J.E. (2005). Characterization of the G alpha(s) regulator cysteine string protein. J. Biol. Chem. 280, 30236–30241.
   PubMedGoogle Scholar
• Nie, Z., Ranjan, R., Wenniger, J.J., Hong, S.N., Bronk, P., Zinsmaier, K.E. (1999). Overexpression of cysteine string protein in Drosophila reveals interactions with syntaxin. J. Neurosci. 19, 10270–10279.
   PubMed Web of Science ®Google Scholar
• Ohki, R., Kawamata, T., Katoh, Y., Hosoda, F., Ohki, M. (1992). Escherichia coli dnaJ deletion mutation results in loss of stability of a positive regulator, CRP. J. Biol. Chem. 267, 13180–13184.
   PubMedGoogle Scholar
• Ohtsuka, K., Hata, M. (2000). Mammalian HSP40/DNAJ homologs: Cloning of novel cDNAs and a proposal for their classification and nomenclature. Cell Stress Chaperones 5, 98–112.
   PubMedGoogle Scholar
• Poage, R.E., Meriney, S.D., Gundersen, C.B., Umbach, J.A. (1999). Antibodies against cysteine string proteins inhibit evoked neurotransmitter release at Xenopus neuromuscular junctions. J. Neurophysiol. 82, 50–59.
   PubMedGoogle Scholar
• Pupier, S., Leveque, C., Marqueze, B., Kataoka, M., Takahashi, M., Seagar, M.J. (1997). Cysteine string proteins associated with secretory granules of the rat neurohypophysis. J. Neurosci. 17, 2722–2727.
   PubMedGoogle Scholar
• Qiu, X.B., Shao, Y.M., Miao, S., Wang, L. (2006). The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. Cell. Mol. Life Sci. 63, 2560–2570.
   PubMed Web of Science ®Google Scholar
• Ramon y Cajal, S. (1911). Histologie du systeme nerveux de l'homme & des vertebres (Vol. 2). Paris: Maloine.
   Google Scholar
• Ranjan, R., Bronk, P., Zinsmaier, K.E. (1998). Cysteine string protein is required for calcium secretion coupling of evoked neurotransmission in Drosophila but not for vesicle recycling. J. Neurosci. 18, 956–964.
   PubMed Web of Science ®Google Scholar
• Redecker, P., Pabst, H., Grube, D. (1998). Munc-18-1 and cysteine string protein (csp) in pinealocytes of the gerbil pineal gland. Cell Tissue Res. 293, 245–252.
   PubMedGoogle Scholar
• Rizo, J., Rosenmund, C. (2008). Synaptic vesicle fusion. Nat Struct Mol Biol 15, 665–674.
   PubMed Web of Science ®Google Scholar
• Rohrbough, J., Broadie, K. (2005). Lipid regulation of the synaptic vesicle cycle. Nat Rev Neurosci 6, 139–150.
   PubMed Web of Science ®Google Scholar
• Rowling, J.K. (1998). Harry Potter and the sorcerer's stone. New York: Scholastic Press.
   Google Scholar
• Ruiz, R., Casanas, J.J., Sudhof, T.C., Tabares, L. (2008). Cysteine string protein-alpha is essential for the high calcium sensitivity of exocytosis in a vertebrate synapse. Eur. J. Neurosci. 27, 3118–3131.
   PubMedGoogle Scholar
• Salinas, P.C. (2005). Signaling at the vertebrate synapse: New roles for embryonic morphogens? J. Neurobiol. 64, 435–445.
   PubMedGoogle Scholar
• Scheufler, C., Brinker, A., Bourenkov, G., Pegoraro, S., Moroder, L., Bartunik, H., Hartl, F.U., Moarefi, I. (2000). Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell 101, 199–210.
   PubMed Web of Science ®Google Scholar
• Schiavo, G., Matteoli, M., Montecucco, C. (2000). Neurotoxins affecting neuroexocytosis. Physiol. Rev. 80, 717–766.
   PubMed Web of Science ®Google Scholar
• Schmitz, F., Tabares, L., Khimich, D., Strenzke, N., de la Villa-Polo, P., Castellano-Munoz, M., Bulankina, A., Moser, T., Fernandez-Chacon, R., Sudhof, T.C. (2006). CSPalpha-deficiency causes massive and rapid photoreceptor degeneration. Proc. Natl. Acad. Sci. U. S. A. 103, 2926–2931.
   PubMedGoogle Scholar
• Sherrington, C. (1947). The integrative action of the nervous system (2nd ed.). New Haven: Yale University Press.
   Google Scholar
• Sondermann, H., Scheufler, C., Schneider, C., Hohfeld, J., Hartl, F.U., Moarefi, I. (2001). Structure of a Bag/Hsc70 complex: Convergent functional evolution of Hsp70 nucleotide exchange factors. Science 291, 1553–1557.
   PubMed Web of Science ®Google Scholar
• Swayne, L.A., Beck, K.E., Braun, J.E. (2006). The cysteine string protein multimeric complex. Biochem Biophys Res Commun, 348, 83–91.
   PubMed Web of Science ®Google Scholar
• Takayama, S., Reed, J.C. (2001). Molecular chaperone targeting and regulation by BAG family proteins. Nat Cell Biol 3, E237–241.
   PubMed Web of Science ®Google Scholar
• Tobaben, S., Thakur, P., Fernandez-Chacon, R., Sudhof, T.C., Rettig, J., Stahl, B. (2001). A trimeric protein complex functions as a synaptic chaperone machine. Neuron 31, 987–999.
   PubMed Web of Science ®Google Scholar
• Tobaben, S., Varoqueaux, F., Brose, N., Stahl, B., Meyer, G. (2003). A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein. J. Biol. Chem. 278, 38376–38383.
   PubMedGoogle Scholar
• Umbach, J.A., Mastrogiacomo, A., Gundersen, C.B. (1995). Cysteine string proteins and presynaptic function. J. Physiol. Paris 89, 95–101.
   PubMedGoogle Scholar
• Umbach, J.A., Zinsmaier, K.E., Eberle, K.K., Buchner, E., Benzer, S., Gundersen, C.B. (1994). Presynaptic dysfunction in Drosophila csp mutants. Neuron 13, 899–907.
   PubMed Web of Science ®Google Scholar
• Ungewickell, E., Ungewickell, H., Holstein, S.E., Lindner, R., Prasad, K., Barouch, W., Martin, B., Greene, L.E., Eisenberg, E. (1995). Role of auxilin in uncoating clathrin-coated vesicles. Nature 378, 632–635.
   PubMed Web of Science ®Google Scholar
• Ungewickell, E.J., Hinrichsen, L. (2007). Endocytosis: Clathrin-mediated membrane budding. Curr. Opin. Cell Biol. 19, 417–425.
   PubMed Web of Science ®Google Scholar
• van deGoor, J., Kelly, R.B. (1996). Association of Drosophila cysteine string proteins with membranes. FEBS Lett. 380, 251–256.
   PubMedGoogle Scholar
• van deGoor, J., Ramaswami, M., Kelly, R. (1995). Redistribution of synaptic vesicles and their proteins in temperature-sensitive shibire(ts1) mutant Drosophila. Proc Natl Acad Sci U S A 92, 5739–5743.
   PubMedGoogle Scholar
• Walsh, P., Bursac, D., Law, Y.C., Cyr, D., Lithgow, T. (2004). The J-protein family: Modulating protein assembly, disassembly and translocation. EMBO Rep 5, 567–571.
   PubMed Web of Science ®Google Scholar
• Wilbur, J.D., Hwang, P.K., Brodsky, F.M. (2005). New faces of the familiar clathrin lattice. Traffic 6, 346–350.
   PubMedGoogle Scholar
• Wu, M.N., Fergestad, T., Lloyd, T.E., He, Y., Broadie, K., Bellen, H.J. (1999). Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo. Neuron 23, 593–605.
   PubMed Web of Science ®Google Scholar
• Yamada, M., Yamazaki, S., Takahashi, K., Nara, K., Ozawa, H., Yamada, S., Kiuchi, Y., Oguchi, K., Kamijima, K., Higuchi, T., Momose, K. (2001). Induction of cysteine string protein after chronic antidepressant treatment in rat frontal cortex. Neurosci. Lett. 301, 183–186.
   PubMedGoogle Scholar
• Young, J.C., Agashe, V.R., Siegers, K., Hartl, F.U. (2004). Pathways of chaperone-mediated protein folding in the cytosol. Nat. Rev. Mol. Cell Biol. 5, 781–791.
   PubMed Web of Science ®Google Scholar
• Young, J.C., Barral, J.M., Ulrich Hartl, F. (2003). More than folding: Localized functions of cytosolic chaperones. Trends Biochem. Sci. 28, 541–547.
   PubMed Web of Science ®Google Scholar
• Zhang, H., Kelley, W.L., Chamberlain, L.H., Burgoyne, R.D., Lang, J. (1999). Mutational analysis of cysteine-string protein function in insulin exocytosis. J. Cell Sci. 112, 1345–1351.
   PubMedGoogle Scholar
• Zhang, H., Kelley, W.L., Chamberlain, L.H., Burgoyne, R.D., Wollheim, C.B., Lang, J. (1998). Cysteine-string proteins regulate exocytosis of insulin independent from transmembrane ion fluxes. FEBS Lett, 437, 267–272.
   PubMed Web of Science ®Google Scholar
• Zhang, W., Khan, A., Ostenson, C.G., Berggren, P.O., Efendic, S., Meister, B. (2002). Down-regulated expression of exocytotic proteins in pancreatic islets of diabetic GK rats. Biochem. Biophys. Res. Commun. 291, 1038–1044.
   PubMed Web of Science ®Google Scholar
• Zhao, C.M., Jacobsson, G., Chen, D., Hakanson, R., Meister, B. (1997). Exocytotic proteins in enterochromaffin-like (ECL) cells of the rat stomach. Cell Tissue Res. 290, 539–551.
   PubMedGoogle Scholar
• Zhao, X., Braun, A.P., Braun, J.E. (2008). Biological roles of neural J proteins. Cell. Mol. Life Sci. 65, 2385–2396.
   PubMedGoogle Scholar
• Zinsmaier, K.E. (1997). Cysteine string proteins. M. J. Gething, Guidebook to molecular chaperones and protein folding catalysts. Oxford University Press, Oxford. (115–117).
   Google Scholar
• Zinsmaier, K.E., Bronk, P. (2001). Molecular chaperones and the regulation of neurotransmitter exocytosis. Biochem. Pharmacol. 62, 1–11.
   PubMed Web of Science ®Google Scholar
• Zinsmaier, K.E., Eberle, K.K., Buchner, E., Walter, N., Benzer, S. (1994). Paralysis and early death in cysteine string protein mutants of Drosophila. Science 263, 977–980.
   PubMedGoogle Scholar
• Zinsmaier, K.E., Hofbauer, A., Heimbeck, G., Pflugfelder, G.O., Buchner, S., Buchner, E. (1990). A cysteine-string protein is expressed in retina and brain of Drosophila. J. Neurogenet. 7, 15–29.
   PubMed Web of Science ®Google Scholar
• Zipursky, S.L., Venkatesh, T.R., Benzer, S. (1985). From monoclonal antibody to gene for a neuron-specific glycoprotein in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 82, 1855–1859.
   PubMed Web of Science ®Google Scholar