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Research Article

Decoy oligodeoxynucleotide against STAT transcription factors decreases allergic inflammation in a rat asthma model

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Pages 85-93 | Received 31 Oct 2008, Accepted 25 Jun 2009, Published online: 05 Mar 2010

REFERENCES

  • Umetsu DT, DeKruyff RH: Immune dysregulation in asthma. Curr Opin Immunol. 2006;18:727–732.
  • Akdis CA: Allergy and hypersensitivity: mechanisms of allergic disease. Curr Opin Immunol. 2006;18:718–726.
  • Crameri R, Rhyner C: Novel vaccines and adjuvants for allergen-specific immunotherapy. Curr Opin Immunol. 2006;18:761–768.
  • Darnell JE Jr, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 1994;264:1415–1421.
  • Chen W, Khurana Hershey GK: Signal transducer and activator of transcription signals in allergic disease. J Allergy Clin Immunol. 2007;119:529–541.
  • Akimoto T, Numata F, Tamura M, Takata Y, Higashida N, Takashi T, Takeda K, Akira S: Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J Exp Med. 1998;187:1537–1542.
  • Mathew A, MacLean JA, DeHaan E, Tager AM, Green FH, Luster AD: Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J Exp Med. 2001;193:1087–1096.
  • Tomkinson A, Kanehiro A, Rabinovitch N, Joetham A, Cieslewicz G, Gelfand EW: The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5. Am J Respir Crit Care Med. 1999;160:1283–1291.
  • Sampath D, Castro M, Look DC, Holtzman MJ: Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. J Clin Invest. 1999;103:1353–1361.
  • Wagner AH, Gebauer M, Pollok-Kopp B, Hecker M: Cytokine-inducible CD40 expression in human endothelial cells is mediated by interferon regulatory factor-1. Blood. 2002;99:520–525.
  • Lei XF, Ohkawara Y, Stampfli MR, Mastruzzo C, Marr RA, Snider D, Xing Z, Jordana M: Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice. J Clin Invest. 1998;101:1342–1353.
  • Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR: Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma. J Immunol. 2007;178:6191–6199.
  • Desmet C, Gosset P, Pajak B, Cataldo D, Bentires-Alj M, Lekeux P, Bureau F: Selective blockade of NF-kappa B activity in airway immune cells inhibits the effector phase of experimental asthma. J Immunol. 2004;173:5766–5775.
  • Desmet C, Gosset P, Henry E, Garze V, Faisca P, Vos N, Jaspar F, Melotte D, Lambrecht B, Desmecht D, Pajak B, Moser M, Lekeux P, Bureau F: Treatment of experimental asthma by decoy-mediated local inhibition of activator protein-1. Am J Respir Crit Care Med. 2005;172:671–678.
  • Quarcoo D, Weixler S, Groneberg D, Joachim R, Ahrens B, Wagner AH, Hecker M, Hamelmann E: Inhibition of signal transducer and activator of transcription 1 attenuates allergen-induced airway inflammation and hyperreactivity. J Allergy Clin Immunol. 2004;114:288–295.
  • Wagner AH, Wittjen I, Stojanovic T, Middel P, Meingassner JG, Hecker M: Signal transducer and activator of transcription 1 decoy oligodeoxynucleotide suppression of contact hypersensitivity. J Allergy Clin Immunol. 2008;121:158–165.
  • Hückel M, Schurigt U, Wagner AH, Stöckigt R, Petrow PK, Thoss K, Gajda M, Henzgen S, Hecker M, Bräuer R: Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1). Arthritis Res Ther. 2006;8:R17.
  • Krzesz R, Wagner AH, Cattaruzza M, Hecker M: Cytokine-inducible CD40 gene expression in vascular smooth muscle cells is mediated by nuclear factor kappa B and signal transducer and activatior of transcription-1. FEBS Lett. 1999;453:191–196.
  • Lührmann A, Deiters U, Skokowa J, Hanke M, Gessner JE, Mühlradt P, Pabst R, Tschernig T: In vivo effects of a synthetic 2-kilodalton macrophage-activating lipopeptide of Mycoplasma fermentans after pulmonary application. Infect Immun. 2002;70:3785–3792.
  • Stojanovic T, Scheele L, Wagner AH, Middel P, Bedke J, Lautenschläger I, Leister I, Panzner S, Hecker M: STAT-1 decoy oligonucleotide improves microcirculation and reduces acute rejection in allogeneic rat small bowel transplants. Gene Ther. 2007;14:883–90.
  • Agertoft L, Pedersen S: Effect of long-term treatment with inhaled budesonide on adult height in children with asthma. N Engl J Med. 2000;343:1064–1069.
  • Tschernig T, Neumann D, Pich A, Dorsch M, Pabst R: Experimental bronchial asthma—the strength of the species rat. Curr Drug Targets. 2008;9:466–469.
  • Roth M, Black JL: Transcription factors in asthma: are transcription factors a new target for asthma therapy?? Curr Drug Targets. 2006;7:589–595.
  • Cagnoni F, Oddera S, Giron-Michel J, Riccio AM, Olsson S, Dellacasa P, Melioli G, Canonica GW, Azzarone B: CD40 on adult human airway epithelial cells: expression and proinflammatory effects. J Immunol. 2004;172:3205–3214.
  • Barnes PJ, Adcock IM: Transcription factors and asthma. Eur Respir J. 1998,12;221–234.
  • Baraldo S, Lokar Oliani K, Turato G, Zuin R, Saetta M: The role of lymphocytes in the pathogenesis of asthma and COPD. Curr Med Chem. 2007;14:2250–2256.
  • Renauld JC: New insights into the role of cytokines in asthma. J Clin Pathol. 2001;54:577–589.
  • Heinecke JW: Eosinophil-dependent bromination in the pathogenesis of asthma. J Clin Invest. 2000;105:1331–1332.
  • Lee NA, Gelfand EW, Lee JJ: Pulmonary T cells and eosinophils: coconspirators or independent triggers of allergic respiratory pathology?? J Allergy Clin Immunol. 2001;107:945–957.
  • Barnes PJ: Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 2008;8:183–192.
  • Goleva E, Kisich KO, Leung DY: A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance. J Immunol. 2002;169:5934–5940.
  • Underwood SL, Raeburn D, Lawrence C, Foster M, Webber S, Karlsson JA: RPR 106541, a novel, airways-selective glucocorticoid: effects against antigen-induced CD4++ T lymphocyte accumulation and cytokine gene expression in the Brown Norway rat lung. Br J Pharmacol. 1997;122:439–446.
  • Adcock IM, Barnes PJ: Molecular mechanisms of corticosteroid resistance. Chest. 2008;134:394–401.
  • Tjandra K, Le T, Swain MG: Glucocorticoid receptors are downregulated in hepatic T lymphocytes in rats with experimental cholangitis. Gut. 2003;52:1363–1370.
  • Li LB, Leung DY, Hall CF, Goleva E: Divergent expression and function of glucocorticoid receptor beta in human monocytes and T cells. J Leukoc Biol. 2006;79:818–827.

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