Protein kinase C epsilon is important in modulating organic-dust-induced airway inflammation

REFERENCES

• Poole JA, Romberger DJ: Immunological and inflammatory responses to organic dust in agriculture. Curr Opin Allergy Clin Immunol. 2012;12:126–132.
   PubMed Web of Science ®Google Scholar
• Schwartz DA, Landas SK, Lassise DL, Burmeister LF, Hunninghake GW, Merchant JA: Airway injury in swine confinement workers. Ann Intern Med. 1992;116:630–635.
   PubMed Web of Science ®Google Scholar
• Sundblad BM, Larsson BM, Palmberg L, Larsson K: Exhaled nitric oxide and bronchial responsiveness in healthy subjects exposed to organic dust. Eur Respir J. 2002;20:426–431.
   PubMed Web of Science ®Google Scholar
• Zhiping W, Malmberg P, Larsson BM, Larsson K, Larsson L, Saraf A: Exposure to bacteria in swine-house dust and acute inflammatory reactions in humans. Am J Respir Crit Care Med. 1996;154:1261–1266.
   PubMed Web of Science ®Google Scholar
• Palmberg L, Larssson BM, Malmberg P, Larsson K: Airway responses of healthy farmers and nonfarmers to exposure in a swine confinement building. Scand J Work Environ Health. 2002;28:256–263.
   PubMed Web of Science ®Google Scholar
• Sundblad BM, von Scheele I, Palmberg L, Olsson M, Larsson K: Repeated exposure to organic material alters inflammatory and physiological airway responses. Eur Respir J. 2009;34:80–88.
   PubMed Web of Science ®Google Scholar
• Poole JA, Wyatt TA, Oldenburg PJ, Elliott MK, West WW, Sisson JH, Von Essen SG, Romberger DJ: Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice. Am J Physiol Lung Cell Mol Physiol. 2009;296:L1085–L1095.
   PubMed Web of Science ®Google Scholar
• Charavaryamath C, Janardhan KS, Townsend HG, Willson P, Singh B: Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness. Respir Res. 2005;6:50–63.
   PubMed Web of Science ®Google Scholar
• Wyatt TA, Slager RE, Heires AJ, Devasure JM, Vonessen SG, Poole JA, Romberger DJ: Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor. Am J Respir Cell Mol Biol. 2010;42:706–715.
   PubMed Web of Science ®Google Scholar
• Wyatt TA, Slager RE, Devasure J, Auvermann BW, Mulhern ML, Von Essen S, Mathisen T, Floreani AA, Romberger DJ: Feedlot dust stimulation of interleukin-6 and -8 requires protein kinase C epsilon in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007;293:L1163–L1170.
   PubMed Web of Science ®Google Scholar
• Romberger DJ, Bodlak V, Von Essen SG, Mathisen T, Wyatt TA: Hog barn dust extract stimulates IL-8 and IL-6 release in human bronchial epithelial cells via PKC activation. J Appl Physiol. 2002;93:289–296.
   PubMed Web of Science ®Google Scholar
• Poole JA, Wyatt TA, Von Essen SG, Hervert J, Parks C, Mathisen T, Romberger DJ: Repeat organic dust exposure-induced monocyte inflammation is associated with protein kinase C activity. J Allergy Clin Immunol. 2007;120:366–373.
   PubMed Web of Science ®Google Scholar
• Castrillo A, Pennington DJ, Otto F, Parker PJ, Owen MJ, Bosca L. Protein kinase C epsilon is required for macrophage activation and defense against bacterial infection. J Exp Med. 2001;194:1231–1242.
   PubMed Web of Science ®Google Scholar
• Littler CM, Wehling CA, Wick MJ, Fagan KA, Cool CD, Messing RO, Dempsey EC: Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2005;289:L1083–L1093.
   PubMed Web of Science ®Google Scholar
• Poole JA, Wyatt TA, Kielian T, Oldenburg P, Gleason AM, Bauer A, Golden G, West WW, Sisson JH, Romberger DJ: Toll-like receptor 2 (TLR2) regulates organic dust-induced airway inflammation. Am J Respir Cell Mol Biol. 2011;45:711–719
   PubMed Web of Science ®Google Scholar
• Wyatt TA, Kharbanda KK, McCaskill ML, Tuma DJ, Yanov D, Devasure J, Sisson JH: Malondialdehyde-acetaldehyde-adducted protein inhalation causes lung injury. Alcohol. 2012;46:51–59.
   PubMed Web of Science ®Google Scholar
• Sanderson MJ: Exploring lung physiology in health and disease with lung slices. Pulm Pharmacol Ther. 2011;24:452–465.
   PubMed Web of Science ®Google Scholar
• Poole JA, Kielian T, Wyatt TA, Gleason AM, Stone J, Palm K, West WW, Romberger DJ: Organic dust augments nucleotide-binding oligomerization domain (NOD2) expression via an NF-kappa B pathway to negatively regulate inflammatory responses. Am J Physiol Lung Cell Mol Physiol. 2011;301: L296–L306.
   PubMed Web of Science ®Google Scholar
• Ward JM, Erexson CR, Faucette LJ, Foley JF, Dijkstra C, Cattoretti G: Immunohistochemical markers for the rodent immune system. Toxicol Pathol. 2006;34:616–630.
   PubMed Web of Science ®Google Scholar
• Wang Z, Larsson K, Palmberg L, Malmberg P, Larsson P, Larsson L: Inhalation of swine dust induces cytokine release in the upper and lower airways. Eur Respir J. 1997;10:381–387.
   PubMed Web of Science ®Google Scholar
• Von Essen SG, Scheppers LA, Robbins RA, Donham KJ. Respiratory tract inflammation in swine confinement workers studied using induced sputum and exhaled nitric oxide. J Toxicol Clin Toxicol. 1998;36:557–365.
   PubMed Web of Science ®Google Scholar
• Wyatt TA, Sisson JH, Von Essen SG, Poole JA, Romberger DJ: Exposure to hog barn dust alters airway epithelial ciliary beating. Eur Respir J. 2008;31:1249–1255.
   PubMed Web of Science ®Google Scholar
• Meier M, Menne J, Park JK, Holtz M, Gueler F, Kirsch T, Schiffer M, Mengel M, Lindschau C, Leitges M, Haller H: Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo. J Am Soc Nephrol. 2007;18:1190–1198.
   PubMed Web of Science ®Google Scholar
• Grommes J, Soehnlein O: Contribution of neutrophils to acute lung injury. Mol Med. 2011;17:293–307.
   PubMed Web of Science ®Google Scholar
• Poole JA, Dooley GP, Saito R, Burrell AM, Bailey KL, Romberger DJ, Mehaffy J, Reynolds SJ: Muramic acid, endotoxin, 3-hydroxy fatty acids, and ergosterol content explain monocyte and epithelial cell inflammatory responses to agricultural dusts. J Toxicol Environ Health A. 2010;73:684–700.
   PubMed Web of Science ®Google Scholar
• Nehme B, Gilbert Y, Letourneau V, Forster RJ, Veillette M, Villemur R, Duchaine C: Culture-independent characterization of archaeal biodiversity in swine confinement building bioaerosols. Appl Environ Microbiol. 2009;75:5445–5450.
   PubMed Web of Science ®Google Scholar
• Wagner JG, Roth RA: Neutrophil migration during endotoxemia. J Leukoc Biol. 1999;66:10–24.
   PubMed Web of Science ®Google Scholar
• Sperry JF, Burns JM: Polymorphonuclear neutrophil chemotaxis modulated by bacteroides fragilis peptidoglycan. Infect Immun. 1987;55:1725–1727.
   PubMed Web of Science ®Google Scholar
• Buck MG, Schachter EN, Fick RB, Merrill WW, Cooper JA, Jr, Keirns JJ, Oliver J, Wall JH: Biologic activity of purified cotton bract extracts in man and guinea pig. Environ Health Perspect. 1986;66:37–44.
   PubMed Web of Science ®Google Scholar
• Von Essen SG, O'Neill DP, Robbins RA, Rennard SI. Neutrophil chemotaxis to extracts of grain plant components. Am J Ind Med. 1994;25:85–88.
   PubMed Web of Science ®Google Scholar
• Von Essen SG, Robbins RA, Thompson AB, Ertl RF, Linder J, Rennard S: Mechanisms of neutrophil recruitment to the lung by grain dust exposure. Am Rev Respir Dis. 1988;138:921–927.
   PubMed Web of Science ®Google Scholar
• Fagan KA, Tyler RC, Sato K, Fouty BW, Morris KG, Jr, Huang PL, McMurtry IF, Rodman DM: Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation. Am J Physiol. 1999;277:L472–L478.
   PubMed Web of Science ®Google Scholar
• Charavaryamath C, Juneau V, Suri SS, Janardhan KS, Townsend H, Singh B: Role of Toll-like receptor 4 in lung inflammation following exposure to swine barn air. Exp Lung Res. 2008;34:19–35.
   PubMed Web of Science ®Google Scholar
• Pennings HJ, Kramer K, Bast A, Buurman WA, Wouters EF: Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro. Eur Respir J. 1998;12:45–49.
   PubMed Web of Science ®Google Scholar
• Savov JD, Gavett SH, Brass DM, Costa DL, Schwartz DA: Neutrophils play a critical role in development of LPS-induced airway disease. Am J Physiol Lung Cell Mol Physiol. 2002;283:L952–L962.
   PubMed Web of Science ®Google Scholar
• Lefort J, Singer M, Leduc D, Renesto P, Nahori MA, Huerre M, Creminon C, Chignard M, Vargaftig BB: Systemic administration of endotoxin induces bronchopulmonary hyperreactivity dissociated from TNF-alpha formation and neutrophil sequestration into the murine lungs. J Immunol. 1998;161:474–480.
   PubMed Web of Science ®Google Scholar
• Oldenburg PJ, Poole JA, Sisson JH: Alcohol reduces airway hyperresponsiveness (AHR) and allergic airway inflammation in mice. Am J Physiol Lung Cell Mol Physiol. 2012;302:L308–L315.
   PubMed Web of Science ®Google Scholar
• Loegering DJ, Lennartz MR: Protein kinase C and Toll-like receptor signaling. Enzyme Res. 2011;2011: article ID: 537821.
   PubMedGoogle Scholar
• Faisal A, Saurin A, Gregory B, Foxwell B, Parker PJ: The scaffold MyD88 acts to couple protein kinase C epsilon to toll-like receptors. J Biol Chem. 2008;283:18591–18600.
   PubMed Web of Science ®Google Scholar