Serotonin inhibits apoptosis of pulmonary artery smooth muscle cells through 5-HT_2A receptors involved in the pulmonary artery remodeling of pulmonary artery hypertension

REFERENCES

• Goyal R, Papamatheakis DG, Loftin M, Vrancken K, Dawson AS, Osman NJ, Blood AB, Pearce WJ, Longo LD, Wilson SM: Long-term maternal hypoxia: the role of extracellular Ca2+ entry during serotonin-mediated contractility in fetal ovine pulmonary arteries. Reprod Sci. 2011;18:948–962.
   PubMed Web of Science ®Google Scholar
• McLaughlin VV, Davis M, Cornwell W: Pulmonary arterial hypertension. Curr Probl Cardiol. 2011;36:461–517.
   PubMed Web of Science ®Google Scholar
• Humbert M, Morrell NW, Archer SL, Stenmark KR, MacLean MR, Lang IM, Christman BW, Weir EK, Eickelberg O, Voelkel NF, Rabinovitch M: Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol. 2004;43:13S–24S.
   PubMed Web of Science ®Google Scholar
• Yeager ME, Belchenko DD, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR: Endothelin-1, the unfolded protein response, and persistent inflammation role of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 2012;46:14–22.
   PubMed Web of Science ®Google Scholar
• Gurbanov E, Xiao S: The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension. Eur J Cardiothorac Surg. 2006;30:499–507.
   PubMed Web of Science ®Google Scholar
• Lambert CM, Roy M, Robitaille GA, Richard DE, Bonnet S: HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism. Cardiovasc Res. 2010;88:196–204.
   PubMed Web of Science ®Google Scholar
• Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JXJ: Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol-Lung Cell Mol Physiol. 2003;285:L740–L754.
   PubMed Web of Science ®Google Scholar
• Xia S, Tai X, Wang Y, An X, Qian G, Dong J, Wang X, Sha B, Wang D, Murthi P, Kalionis B, Wang X, Bai C: Involvement of gax gene in hypoxia-induced pulmonary hypertension, proliferation, and apoptosis of arterial smooth muscle cells. Am J Respir Cell Mol Biol. 2011;44:66–73.
   PubMed Web of Science ®Google Scholar
• Nakamura K, Akagi S, Ogawa A, Kusano KF, Matsubara H, Miura D, Fuke S, Nishii N, Nagase S, Kohno K, Morita H, Oto T, Yamanaka R, Otsuka F, Miura A, Yutani C, Ohe T, Ito H: Pro-apoptotic effects of imatinib on PDGF-stimulated pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Int J Cardiol. 2012;159:100–106.
   PubMed Web of Science ®Google Scholar
• Long L, MacLean MR, Jeffery TK, Morecroft I, Yang X, Rudarakanchana N, Southwood M, James V, Trembath RC, Morrell NW: Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ Res. 2006;98:818–827.
   PubMed Web of Science ®Google Scholar
• MacLean MR, Dempsie Y: Serotonin and pulmonary hypertension-from bench to bedside? Curr. Opin. Pharmacol. 2009;9:281–286.
   PubMed Web of Science ®Google Scholar
• Delaney C, Gien J, Grover TR, Roe G, Abman SH: Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus. Am J Physiol Lung Cell Mol Physiol. 2011;301:L937–L944.
   PubMed Web of Science ®Google Scholar
• Shaw AM, Brown C, Irvine J, Bunton DC, MacDonald A: Role of the 5-HT2A receptor and alpha(1)-adrenoceptor in the contractile response of rat pulmonary artery to 5-HT in the presence and absence of nitric oxide. Pulm Pharmacol Ther. 2000;13:277–285.
   PubMed Web of Science ®Google Scholar
• Ni W, Fink GD, Watts SW: The 5-hydroxytryptamine(2A) receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007;321:485–491.
   PubMed Web of Science ®Google Scholar
• Liu Y, Fanburg BL: Phospholipase D signaling in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells. Am J Physiol 2008;295:L471–L478.
   Web of Science ®Google Scholar
• Welsh DJ, Harnett M, MacLean M, Peacock AJ: Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter. Am J Respir Crit Care Med. 2004;170:252–259.
   PubMed Web of Science ®Google Scholar
• Hironaka E, Hongo M, Sakai A, Mawatari E, Terasawa F, Okumura N, Yamazaki A, Ushiyama Y, Yazaki Y, Kinoshita O: Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats. Cardiovasc Res. 2003;60:692–699.
   PubMed Web of Science ®Google Scholar
• Cogolludo A, Moreno L, Lodi F, Frazziano G, Cobeno L, Tamargo J, Perez-Vizcaino F: Serotonin inhibits voltage-gated K +currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization. Circ Res. 2006;98:931–938.
   PubMed Web of Science ®Google Scholar
• Burg ED, Remillard CV, Yuan JXJ: Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications. Br J Pharmacol. 2008;153:S99–S111.
   PubMed Web of Science ®Google Scholar
• Sanchez-Alcazar JA, Khodjakov A, Schneider E: Anticancer drugs induce increased mitochondrial cytochrome c expression that precedes cell death. Cancer Res. 2001;61:1038–1044.
   PubMed Web of Science ®Google Scholar
• Sarafian TA, Kouyoumjian S, Khoshaghideh F, Tashkin DP, Roth MD: Delta 9-Tetrahydrocannabinol disrupts mitochondrial function and cell energetics. Am J Physiol 2003;284:L298–L306.
   PubMed Web of Science ®Google Scholar
• Soga F, Katoh N, Inoue T, Kishimoto S: Serotonin activates human monocytes and prevents apoptosis. J Invest Dermatol. 2007;127:1947–1955.
   Google Scholar
• Nebigil CG, Jaffre F, Messaddeq N, Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy. Circulation. 2003;107:3223–3229.
   PubMed Web of Science ®Google Scholar
• Rajesh KG, Suzuki R, Maeda H, Murio Y, Sasaguri S: 5-HT2 receptor blocker sarpogrelate prevents downregulation of antiapoptotic protein Bcl-2 and protects the heart against ischemia-reperfusion injury. Life Sci. 2006;79:1749–1755.
   PubMed Web of Science ®Google Scholar
• Shen L, Shen J, Pu J, He B: Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels. Cell Biochem Biophys. 2011;61:23–31.
   PubMed Web of Science ®Google Scholar
• Kanai Y, Hori S, Tanaka T, Yasuoka M, Watanabe K, Aikawa N, Hosoda Y: Role of 5-hydroxytryptamine in the progression of monocrotaline-induced pulmonary-hypertension in rats. Cardiovasc Res. 1993;27:1619–1623.
   PubMed Web of Science ®Google Scholar
• Drozdov I, Kidd M, Gustafsson BI, Svejda B, Joseph R, Pfragner R, Modlin IM: Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines. Cancer. 2009;115:4934–4945.
   PubMed Web of Science ®Google Scholar
• Kekewska A, Goernemann T, Jantschak F, Glusa E, Pertz HH: Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012;340:369–376.
   PubMed Web of Science ®Google Scholar
• Chang CW, Poteet E, Schetz JA, Gumus ZH, Weinstein H: Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation. Neuropharmacology. 2009;56:213–225.
   PubMed Web of Science ®Google Scholar
• Watts SW, Yang PY, Banes AK, Baez M: Activation of Erk mitogen-activated protein kinase proteins by vascular serotonin receptors. J Cardiovasc Pharmacol. 2001;38:539–551.
   PubMed Web of Science ®Google Scholar
• Nebigil CG, Etienne N, Messaddeq N, Maroteaux L: Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling. FASEB J. 2003;17:1373–1375.
   PubMed Web of Science ®Google Scholar
• Rasola A, Sciacovelli M, Chiara F, Pantic B, Brusilow WS, Bernardi P: Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition. Proc Natl Acad Sci USA. 2010;107:726–731.
   PubMed Web of Science ®Google Scholar
• Monick MM, Powers LS, Barrett CW, Hinde S, Ashare A, Groskreutz DJ, Nyunoya T, Coleman M, Spitz DR, Hunninghake GW: Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity. J Immunol. 2008;180:7485–7496.
   PubMed Web of Science ®Google Scholar
• McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, Michelakis ED: Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res. 2004;95:830–840.
   PubMed Web of Science ®Google Scholar
• He K, Aizenman E: ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity. J Neurochem. 2010;114:452–461.
   PubMed Web of Science ®Google Scholar
• Gupta SC, Reuter S, Phromnoi K, Park B, Hema PS, Nair M, Aggarwal BB: Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent Up-regulation of death receptors, p53, and bax. J Biol Chem. 2011;286:1134–1146.
   PubMed Web of Science ®Google Scholar
• Subramanian M, Shaha C: Up-regulation of bcl-2 through ERK phosphorylation is associated with human macrophage survival in an estrogen microenvironment. J Immunol. 2007;179:2330–2338.
   PubMed Web of Science ®Google Scholar
• Ostrakhovitch EA, Cherian MG: Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: The lack of effect of ERK in p53 mediated copper induced apoptosis. J Cell Biochem. 2005;95:1120–1134.
   PubMed Web of Science ®Google Scholar