Effects of Thymoquinone on STZ-induced Diabetic Nephropathy: An Immunohistochemical Study

References

• Sharma S, Anjaneyulu M, Kulkarni SK, Chopra K. Resveratrol, a polyphenolic phytoalexin, attenuates diabetic nephropathy in rats. Pharmacology 2006;76: 69–75
   PubMed Web of Science ®Google Scholar
• Li Y, Kang YS, Dai C, et al. Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria. Am J Pathol 2008;172: 299–308
   PubMed Web of Science ®Google Scholar
• Yamaguchi Y, Iwano M, Suzuki D, et al. Epithelial–mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy. Am J Kidney Dis 2009;54: 653–64
   PubMed Web of Science ®Google Scholar
• Tan RJ, Liu Y. Matrix metalloproteinases in kidney homeostasis and diseases. Am J Physiol Renal Physiol 2012;302: F1351–61
   PubMed Web of Science ®Google Scholar
• Thrailkill KM, Clay Bunn R, Fowlkes JL. Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy. Endocrine 2009;35: 1–10
   PubMed Web of Science ®Google Scholar
• Srichai MB, Colleta H, Gewin L, et al. Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice. PLoS One 2011;6: e17099
   Google Scholar
• Gross ML, Ritz E, Schoof A, et al. Comparison of renal morphology in the streptozotocin and the SHR/N-cp models of diabetes. Lab Invest 2004;84: 452–64
   PubMed Web of Science ®Google Scholar
• Lee SE, Ma W, Rattigan EM, et al. Ultrastructural features of retinal capillary basement membrane thickening in diabetic swine. Ultrastruct Pathol 2010;34: 35–41
   PubMed Web of Science ®Google Scholar
• Omran OM. Histopathological study of evening primrose oil effects on experimental diabetic neuropathy. Ultrastruct Pathol 2012;36: 222–7
   Web of Science ®Google Scholar
• Kanter M. Protective effects of thymoquinone on streptozotocin-induced diabetic nephropathy. J Mol Histol 2009;40: 107–15
   Google Scholar
• Khan MA, Sattar MA, Abdullah NA, et al. Functional subtypes of renal alpha1-adrenoceptor in spontaneously hypertensive rats with streptozotocin-induced experimental diabetic nephropathy. Kidney Blood Press Res 2009;32: 349–59
   PubMed Web of Science ®Google Scholar
• Gali-Muhtasib H, Diab-Assaf M, Boltze C, et al. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol 2004;25: 857–66
   PubMed Web of Science ®Google Scholar
• Haider S, Ahmed S, Tabassum S, et al. Streptozotocin-induced insulin deficiency leads to development of behavioral deficits in rats. Acta Neurol Belg 2013;113: 35–41
   PubMed Web of Science ®Google Scholar
• Kanter M, Coskun O, Uysal H. The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone, on ethanol-induced gastric mucosal damage. Arch Toxicol 2006;80: 217–24
   PubMed Web of Science ®Google Scholar
• Schena FP, Gesualdo L. Pathogenetic mechanisms of diabetic nephropathy. J Am Soc Nephrol 2005;16: S30–3. Review
   PubMed Web of Science ®Google Scholar
• Rossing P. Diabetic nephropathy: worldwide epidemic and effects of current treatment on natural history. Curr Diab Rep 2006;6: 479–83. Review
   PubMedGoogle Scholar
• Carpenter L, Cordery D, Biden TJ. Inhibition of protein kinase C delta protects rat INS-1 cells against interleukin-1beta and streptozotocin-induced apoptosis. Diabetes 2002;51: 317–24
   PubMed Web of Science ®Google Scholar
• Bendayan M. Immunocytochemical detection of advanced glycated end products in rat renal tissue as a function of age and diabetes. Kidney Int 1998;54: 438–47
   PubMed Web of Science ®Google Scholar
• Makino H, Miyamoto Y, Sawai K, et al. Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone. Diabetes 2006;55: 2747–56
   PubMed Web of Science ®Google Scholar
• Zhou G, Li C, Cai L. Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway. Am J Pathol 2004;165: 2033–43
   PubMed Web of Science ®Google Scholar
• Alsaad KO, Herzenberg AM. Distinguishing diabetic nephropathy from other causes of glomerulosclerosis: an update. J Clin Pathol 2007;60: 18–26. Review
   PubMed Web of Science ®Google Scholar
• Benzing T. Signaling at the slit diaphragm. J Am Soc Nephrol 2004;15: 1382–91. Review
   PubMed Web of Science ®Google Scholar
• Shankland SJ. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 2006;69: 2131–47
   PubMed Web of Science ®Google Scholar
• Nishitani Y, Iwano M, Yamaguchi Y, et al. Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN. Kidney Int 2005;68: 1078–85
   PubMed Web of Science ®Google Scholar
• Horster MF, Braun GS, Huber SM. Embryonic renal epithelia: induction, nephrogenesis, and cell differentiation. Physiol Rev 1999;79: 1157–91. Review
   PubMed Web of Science ®Google Scholar
• Kuhlmann A, Haas CS, Gross ML, et al. 1,25-Dihydroxyvitamin D3 decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat. Am J Physiol Renal Physiol 2004;286: F526–33
   PubMed Web of Science ®Google Scholar
• Zou J, Yaoita E, Watanabe Y, et al. Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury. Virchows Arch 2006;448: 485–92
   Google Scholar
• Wolf G, Chen S, Ziyadeh FN. From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. Diabetes 2005;54: 1626–34
   PubMed Web of Science ®Google Scholar
• Sun SZ, Wang Y, Li Q, et al. Effects of benazepril on renal function and kidney expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in diabetic rats. Chin Med J (Engl) 2006;119: 814–21
   Google Scholar
• Makino H, Miyamoto Y, Sawai K, et al. Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone. Diabetes 2006;55: 2747–56
   PubMed Web of Science ®Google Scholar
• Guhua Z, Cai L, Lu C. Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor b-independent pathway. Am J Pathol 2004;165: 2033–43
   Google Scholar
• Alsaad KO, Herzenberg AM. Distinguishing diabetic nephropathy from other causes of glomerulosclerosis: an update. J Clin Pathol 2007;60: 18–26
   PubMed Web of Science ®Google Scholar
• Koya D, Hayashi K, Kitada M, et al. Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats. J Am Soc Nephrol 2003;14: S250–3
   PubMed Web of Science ®Google Scholar
• Prabhakar S, Starnes J, Shi S, et al. Diabetic nephropathy is associated with oxidative stress and decreased renal nitric oxide production. J Am Soc Nephrol 2007;18: 2945–52
   PubMed Web of Science ®Google Scholar
• Lin CC, Lin LT, Yen MH, et al. Renal protective effect of xiao-chai-hu-tang on diabetic nephropathy of type 1-diabetic mice. Evid Based Complement Alternat Med 2012;2012: 984024
   PubMed Web of Science ®Google Scholar
• Fararh KM, Shimizu Y, Shiina T, et al. Thymoquinone reduces hepatic glucose production in diabetic hamsters. Res Vet Sci 2005;79: 219–23
   PubMed Web of Science ®Google Scholar
• El-Dakhakhny M, Madi NJ, Lembert N, Ammon HP. Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. J Ethnopharmacol 2002;81: 161–4
   PubMed Web of Science ®Google Scholar