Alveolar Oxygen Tension and Angio-architecture of the Distal Adult Lung

References

• Jones RC, Capen DE, Petersen B, et al. A protocol for a lung neovascularization model in rodents. Nat Protoc 2008;3: 378–87
   PubMed Web of Science ®Google Scholar
• Jones R, Zapol WM, Reid L. Oxygen toxicity and restructuring of pulmonary arteries—a morphometric study: the response to 4 weeks' exposure to hyperoxia and return to breathing air. Am J Pathol 1985;121: 212–23
   PubMed Web of Science ®Google Scholar
• Hu LM, Jones R. Injury and remodeling of pulmonary veins by high oxygen: a morphometric study. Am J Pathol 1989;134: 253–62
   PubMed Web of Science ®Google Scholar
• Jones R. Ultrastructural analysis of contractile cell development in lung microvessels in hyperoxic pulmonary hypertension: fibroblasts and intermediate cells selectively reorganize nonmuscular segments. Am J Pathol 1992;141: 1491–505
   PubMed Web of Science ®Google Scholar
• Jones R, Jacobson M, Steudel W. alpha-smooth-muscle actin and microvascular precursor smooth-muscle cells in pulmonary hypertension. Am J Respir Cell Mol Biol 1999;20: 582–94
   PubMed Web of Science ®Google Scholar
• Jones R, Capen D, Jacobson M. PDGF and microvessel wall remodeling in adult lung: imaging PDGF-Rbeta and PDGF-BB molecules in progenitor smooth muscle cells developing in pulmonary hypertension. Ultrastruct Pathol 2006;30: 267–81
   PubMed Web of Science ®Google Scholar
• Jones R, Capen D, Jacobson M, Munn L. PDGF and microvessel wall remodeling in adult rat lung: imaging PDGF-AA and PDGFR-alpha molecules in progenitor smooth muscle cells developing in experimental pulmonary hypertension. Cell Tissue Res 2006;326: 759–69
   PubMed Web of Science ®Google Scholar
• Jones R, Capen D. Pulmonary vascular remodeling by high oxygen. In: Yuan JXJ, et al, eds. Textbook of Pulmonary Vascular Disease. New York: Springer Science & Business Media; 2011:733–58
   Google Scholar
• Jones R, Adler C, Farber F. Lung vascular cell proliferation in hyperoxic pulmonary hypertension and on return to air: [3H]thymidine pulse-labeling of intimal, medial, and adventitial cells in microvessels and at the hilum. Am Rev Respir Dis 1989;140: 1471–7
   PubMed Web of Science ®Google Scholar
• Jones RC, Jacobson M. Angiogenesis in the hypertensive lung: response to ambient oxygen tension. Cell Tissue Res 2000;300: 263–84
   PubMed Web of Science ®Google Scholar
• Jones R, Zapol WM, Reid L. Pulmonary artery remodeling and pulmonary hypertension after exposure to hyperoxia for 7 days. A morphometric and hemodynamic study. Am J Pathol 1984;117: 273–85
   PubMed Web of Science ®Google Scholar
• Jones R, Capen DE, Jacobson M, et al. VEGFR2+PDGFRbeta+ circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI). J Cell Mol Med 2009;13: 3720–9
   PubMed Web of Science ®Google Scholar
• Jones RC, Capen DE. A quantitative ultrastructural study of circulating (monocytic) cells interacting with endothelial cells in high oxygen-injured and spontaneously re-forming (FVB) mouse lung capillaries. Ultrastruct Pathol 2012;36: 260–79
   PubMed Web of Science ®Google Scholar
• Jones R, Reid L. Development of the pulmonary vasculature. In: Harding R, Pinkerton K, Plopper C, eds. The Lung: Development, Aging and the Environment. London: Elsevier Academic; 2004:81–103
   Google Scholar
• Lazarus A, Keshet E. Vascular endothelial growth factor and vascular homeostasis. Proc Am Thorac Soc 2011;8: 508–11
   PubMedGoogle Scholar
• Klekamp JG, Jarzecka K, Perkett EA. Exposure to hyperoxia decreases the expression of vascular endothelial growth factor and its receptors in adult rat lungs. Am J Pathol 1999;154: 823–31
   PubMed Web of Science ®Google Scholar
• Maniscalco WM, Watkins RH, Finkelstein JN, Campbell MH. Vascular endothelial growth factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury. Am J Respir Cell Mol Biol 1995;13: 377–86
   PubMed Web of Science ®Google Scholar
• Watkins RH, D'Angio CT, Ryan RM, et al. Differential expression of VEGF mRNA splice variants in newborn and adult hyperoxic lung injury. Am J Physiol 1999;276: L858–L67
   PubMed Web of Science ®Google Scholar
• Dor Y, Porat R, Keshet E. Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis. Am J Physiol Cell Physiol 2001;280: C1367–C74
   PubMed Web of Science ®Google Scholar
• Motoike T, Loughna S, Perens E, et al. Universal GFP reporter for the study of vascular development. Genesis 2000;28: 75–81
   PubMed Web of Science ®Google Scholar
• Duda DG, Cohen KS, Kozin SV, et al. Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. Blood 2006;107: 2774–6
   PubMed Web of Science ®Google Scholar
• Keshet E. Preventing pathological regression of blood vessels. J Clin Invest 2003;112: 27–9
   PubMed Web of Science ®Google Scholar
• Howell K, Preston RJ, McLoughlin P. Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol 2003;547: 133–45
   PubMed Web of Science ®Google Scholar
• Reinke C, Bevans-Fonti S, Grigoryev DN, et al. Chronic intermittent hypoxia induces lung growth in adult mice. Am J Physiol Lung Cell Mol Physiol 2011;300: L266–73
   Web of Science ®Google Scholar
• Cahill E, Rowan SC, Sands M, et al. The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally. Exp Physiol 2012;97: 796–806
   PubMed Web of Science ®Google Scholar
• Stenmark KR, Abman SH. Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia. Annu Rev Physiol 2005;67: 623–61
   PubMed Web of Science ®Google Scholar
• Oury TD, Schaefer LM, Fattman CL, et al. Depletion of pulmonary EC-SOD after exposure to hyperoxia. Am J Physiol Lung Cell Mol Physiol 2002;283: L777–84
   PubMed Web of Science ®Google Scholar
• Lee PJ, Choi AM. Pathways of cell signaling in hyperoxia. Free Radic Biol Med 2003;35: 341–50
   PubMed Web of Science ®Google Scholar
• Browning EA, Chatterjee S, Fisher AB. Stop the flow: a paradigm for cell signaling mediated by reactive oxygen species in the pulmonary endothelium. Annu Rev Physiol 2012;74: 403–24
   PubMed Web of Science ®Google Scholar
• Kazzaz JA, Xu J, Palaia TA, et al. Cellular oxygen toxicity. Oxidant injury without apoptosis. J Biol Chem 1996;271: 15182–6
   PubMed Web of Science ®Google Scholar
• Barrazzone C, Horowitz S, Donati YR, et al. Oxygen toxicity in mouse lung: pathways to cell death. Am J Respir Cell Mol Biol 1998;19: 573–81
   PubMed Web of Science ®Google Scholar
• Bhandari V, Choo-Wing R, Lee CG, et al. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med 2006;12: 1286–93
   PubMed Web of Science ®Google Scholar
• Tang PS, Mura M, Seth R, Liu M, et al. Acute lung injury and cell death: how many ways can cells die? Am J Physiol Lung Cell Mol Physiol 2008;294: L632–L41
   PubMed Web of Science ®Google Scholar
• Crapo JD, Barry BE, Foscue HA, Shelbourne J. Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen. Am Rev Respir Dis 1980;122: 123–43
   PubMed Web of Science ®Google Scholar
• Yang W, de Bono DP. A new role for vascular endothelial growth factor and fibroblast growth factors: increasing endothelial resistance to oxidative stress. FEBS Lett 1997;403: 139–42
   PubMed Web of Science ®Google Scholar
• Baffert F, Le T, Sennino B, et al. Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling. Am J Physiol Heart Circ Physiol 2006;290: H547–9
   PubMed Web of Science ®Google Scholar
• Hlushchuk R, Ehrbar M, Reichmuth P, et al. Decrease in VEGF expression induces intussusceptive vascular pruning. Arterioscler Thromb Vasc Biol 2011;31: 2836–44
   PubMed Web of Science ®Google Scholar
• Burri PH. Structural aspects of postnatal lung development–alveolar formation and growth. Biol Neonate 2006;89: 313–22
   PubMedGoogle Scholar
• Keeley EC, Mehrad B, Strieter RM. The role of fibrocytes in fibrotic diseases of the lungs and heart. Fibrogenesis Tissue Repair 2011;4: 2
   PubMedGoogle Scholar
• Fujiwara A, Kobayashi H, Masuya M, et al. Correlation between circulating fibrocytes, and activity and progression of interstitial lung diseases. Respirology 2012;17: 693–8
   PubMed Web of Science ®Google Scholar
• Konig MF, Lucocq JM, Weibel ER. Demonstration of pulmonary vascular perfusion by electron and light microscopy. J Appl Physiol 1993;75: 1877–83
   PubMedGoogle Scholar
• Alvarez DF, Huang L, King JA, et al. Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity. Am J Physiol Lung Cell Mol Physiol 2008;294: L419–L30
   PubMed Web of Science ®Google Scholar
• Schniedermann J, Rennecke M, Buttler K, et al. Mouse lung contains endothelial progenitors with high capacity to form blood and lymphatic vessels. BMC Cell Biol 2010;11: 50
   PubMedGoogle Scholar
• Jones RC and Capen DE. Mechanisms of growth in a pulmonary capillary network in adult lung. Ultrastruct Pathol. 2013; in press
   Google Scholar
• Burri PH, Tarek MR. A novel mechanism of capillary growth in the rat pulmonary microcirculation. Anat Rec 1990;228: 35–45
   PubMedGoogle Scholar
• Grunewald M, Avraham I, Dor Y, et al. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 2006;124: 175–89
   PubMed Web of Science ®Google Scholar