83
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Formulation optimization of transdermal meloxicam potassium-loaded mesomorphic phases containing ethanol, oleic acid and mixture surfactant using the statistical experimental design methodology

, , , , &
Pages 508-514 | Received 15 Nov 2010, Accepted 09 May 2011, Published online: 04 Jul 2011

References

  • Azeem A, Khan ZI, Aqil M, Ahmad FJ, Khar RK, Talegaonkar S. Microemulsions as a surrogate carrier for dermal drug delivery. Drug Dev Ind Pharm 2009; 35: 525–47
  • Betz G, Aeppli A, Menshutina N, Leuenberger H. In vivo comparison of various liposome formulations for cosmetic application. Int J Pharm 2005; 296: 44–54
  • Busch U, Schmid J, Heinzel G, Schmaus H, Baierl J, Huber C, Roth W. Pharmacokinetics of meloxicam in animals and the relevance to humans. Drug Metab Dispos 1998; 26: 576–84
  • Chang JS, Huang YB, Hou SS, Wang RJ, Wu PC, Tsai YH. Formulation optimization of meloxicam sodium gel using response surface methodology. Int J Pharm 2007; 338: 48–54
  • Chen H, Chang X, Weng T, Zhao X, Gao Z, Yang Y, Xu H, Yang X. A study of microemulsion systems for transdermal delivery of triptolide. J Control Release 2004; 98: 427–36
  • Chien YW. Novel drug delivery system. Marcel Dekker, New York, NY 1992
  • Dreher F, Walde P, Luisi PL, Elsner P. Human skin irritation studies of a lecithin microemulsion gel and of lecithin liposomes. Skin Pharmacol 1996; 9: 124–9
  • El Maghraby GM. Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: Effects of cosurfactants. Int J Pharm 2008; 355: 285–92
  • Fang JY, Leu YL, Chang CC, Lin CH, Tsai YH. Lipid nano/submicron emulsions as vehicles for topical flurbiprofen delivery. Drug Deliv 2004; 11: 97–105
  • Fang JY, Yu SY, Wu PC, Huang YB, Tsai YH. In vitro skin permeation of estradiol from various proniosome formulations. Int J Pharm 2001; 215: 91–9
  • Fang YP, Huang YB, Wu PC, Tsai YH. Topical delivery of 5-aminolevulinic acid-encapsulated ethosomes in a hyperproliferative skin animal model using the CLSM technique to evaluate the penetration behavior. Eur J Pharm Biopharm 2009; 73: 391–8
  • Gonzalez-Rodriguez ML, Barros LB, Palma J, Gonzalez-Rodriguez PL, Rabasco AM. Application of statistical experimental design to study the formulation variables influencing the coating process of lidocaine liposomes. Int J Pharm 2007; 337: 336–45
  • Gupta SK, Bansal P, Bhardwaj RK, Jaiswal J, Velpandian T. Comparison of analgesic and anti-inflammatory activity of meloxicam gel with diclofenac and piroxicam gels in animal models: Pharmacokinetic parameters after topical application. Skin Pharmacol Appl Skin Physiol 2002; 15: 105–11
  • Halbaut L, Barbé C, del Pozo A. An investigation into physical and chemical properties of semi-solid self-emulsifying systems for hard gelatin capsules. Int J Pharm 1996; 130: 203–12
  • Heurtault B, Saulnier P, Pech B, Venier-Julienne MC, Proust JE, Phan-Tan-Luu R, Benoit JP. The influence of lipid nanocapsule composition on their size distribution. Eur J Pharm Sci 2003; 18: 55–61
  • Huang YB, Tsai YH, Yang WC, Chang JS, Wu PC, Takayama K. Once-daily propranolol extended-release tablet dosage form: Formulation design and in vitro/in vivo investigation. Eur J Pharm Biopharm 2004; 58: 607–14
  • Kaplan-Machlis B, Klostermeyer BS. The cyclooxygenase-2 inhibitors: Safety and effectiveness. Ann Pharmacother 1999; 33: 979–88
  • Kibbe AH. Handbook of pharmaceutical excipients, 3rd. Pharmaceutical Press, LondonUK 2000
  • Kreilgaard M. Influence of microemulsions on cutaneous drug delivery. Adv Drug Deliv Rev 2002; 54(Suppl. 1): S77–98
  • Lehmann L, Keipert S, Gloor M. Effects of microemulsions on the stratum corneum and hydrocortisone penetration. Eur J Pharm Biopharm 2001; 52: 129–36
  • Lewis GA, Mathieu D, Phan-Tan-Luu R. Pharmaceutical experimental design. Dekker, New York, NY 1999
  • Lopez-Pinto JM, Gonzalez-Rodriguez ML, Rabasco AM. Effect of cholesterol and ethanol on dermal delivery from DPPC liposomes. Int J Pharm 2005; 298: 1–12
  • McNeill SC, Potts RO, Francoeur ML. Local enhanced topical delivery (LETD) of drugs: Does it truly exist?. Pharm Res 1992; 9: 1422–7
  • Noble S, Balfour JA. Meloxicam. Drugs 1996; 51: 424–30; discussion 431–2
  • Onuki Y, Morishita M, Takayama K. Formulation optimization of water-in-oil-water multiple emulsion for intestinal insulin delivery. J Control Release 2004; 97: 91–9
  • Padamwar MN, Pokharkar VB. Development of vitamin-loaded topical liposomal formulation using factorial design approach: Drug deposition and stability. Int J Pharm 2006; 320: 37–44
  • Paolino D, Ventura CA, Nistico S, Puglisi G, Fresta M. Lecithin microemulsions for the topical administration of ketoprofen: Percutaneous adsorption through human skin and in vivo human skin tolerability. Int J Pharm 2002; 244: 21–31
  • Peltola S, Saarinen-Savolainen P, Kiesvaara J, Suhonen TM, Urtti A. Microemulsions for topical delivery of estradiol. Int J Pharm 2003; 254: 99–107
  • Rhee YS, Chang SY, Park CW, Chi SC, Park ES. Optimization of ibuprofen gel formulations using experimental design technique for enhanced transdermal penetration. Int J Pharm 2008; 364: 14–20
  • Sintov AC, Botner S. Transdermal drug delivery using microemulsion and aqueous systems: Influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems. Int J Pharm 2006; 311: 55–62
  • Skjodt NM, Davies NM. Clinical pharmacokinetics and pharmacodynamics of bromfenac. Clin Pharmacokinet 1999; 36: 399–408
  • Stei P, Kruss B, Wiegleb J, Trach V. Local tissue tolerability of meloxicam, a new NSAID: Indications for parenteral, dermal and mucosal administration. Br J Rheumatol 1996; 35: 44–50
  • Trotta M, Gallarate M, Pattarino F, Carlotti ME. Investigation of the phase behaviour of systems containing lecithin and 2-acyl lysolecithin derivatives. Int J Pharm 1999; 190: 83–9
  • Trotta M, Gasco MR, Caputo O, Sancin P. Transcutasolutionsneous diffusion of hematoporphyrin in photodynamic therapy: In vitro release from microemulsions. STP Pharma Sci 1994; 4: 150–4
  • Tsai YH, Lee KF, Huang YB, Huang CT, Wu PC. In vitro permeation and in vivo whitening effect of topical hesperetin microemulsion delivery system. Int J Pharm 2010; 388: 257–62
  • Turck D, Busch U, Heinzel G, Narjes H. Clinical pharmacokinetics of meloxicam. Arzneimittelforschung 1997; 47: 253–8
  • Wang RJ, Wu PC, Huang YB, Tsai YH. The effects of iontophoresis and electroporation on transdermal delivery of meloxicam salts evaluated in vitro and in vivo. J Food Drug Anal 2008; 16: 39–46
  • Yuan Y, Li SM, Mo FK, Zhong DF. Investigation of microemulsion system for transdermal delivery of meloxicam. Int J Pharm 2006; 321: 117–23
  • Zidan AS, Sammour OA, Hammad MA, Megrab NA, Habib MJ, Khan MA. Quality by design: Understanding the product variability of a self-nanoemulsified drug delivery system of cyclosporine A. J Pharm Sci 2007; 96: 2409–23

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.