Microencapsulated drug delivery: a new approach to pro-inflammatory cytokine inhibition

References

• Akhavein N, Oettinger C, Gayakawad S, Addo R, Bejugam N, Bauer J, Pollock S, D'souza M. Treatment of adjuvant arthritis using microencapsulated antisense to NF-κB oligonucleotides. J Microencapsulation 2008; 18: 1–12
   Google Scholar
• Andreakos ET, Feldman M. Autoimmunity and cytokines: Pathogenesis and therapy. The cytokine handbook4th, AW Thomsom, MT Lotze. Academic Press, San Diego, CA 2003; II: 1189–211
   Google Scholar
• Bagby G, Plessala K, Wilson L, Thompson J, Nelson S. Divergent efficacy of antibody to tumor necrosis factor-α in intravascular and peritonitis models of sepsis. J Infect Dis 1991; 163: 83–8
   PubMed Web of Science ®Google Scholar
• Bender A, Schafer V, Steffan AM, Royer C, Kreuter J, Rubsamen-Waigmann H, von Briesen H. Inhibition of HIV in-vitro by antiviral drug-targeting using nanoparticles. Res Virol 1994; 145: 215–20
   PubMedGoogle Scholar
• Bianchi M, Bloom O, Raabe T, Cohen PS, Chesney J, Sherry B, Schmidtmayerova H, Calandra T, Zhang X, Bukrinsky M. Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone. J Exp Med 1996; 183: 927–36
   PubMed Web of Science ®Google Scholar
• Bianchi M, Ulrich P, Bloom O, Meistral III M, Zimmerman GA, Schmidtmayerova H, Bukrinsky M, Donnelley T, Bucala R, Sherry B. An inhibitor of macrophage arginine transport and nitric oxide production (CNI-1493) prevents acute inflammation and endotoxin lethality. Mol Med 1995; 1: 254–66
   PubMed Web of Science ®Google Scholar
• Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 2001; 344: 907–15
   PubMed Web of Science ®Google Scholar
• De Bosscher K, Schmitz ML, Vanden Berghe W, Plaisance S, Fiers W, Haegeman G. Glucocorticoid mediated repression of nuclear factor-κB dependent transcription involves direct interference with transactivation. Proc Natl Acad Sci USA 1997; 94: 13504–9
   PubMed Web of Science ®Google Scholar
• de Oliveira-Marques V, Cyrne L, Marinho HS, Antunes F. A quantitative study of NF-κB activation by H2O2: Relevance in inflammation and synergy with TNF-α. J Immunol 2007; 178: 3893–902
   PubMed Web of Science ®Google Scholar
• Dinarello CA. Introduction: Cytokine biology relevant to infectious diseases. Cytokines and chemokines. Cytokines and chemokines in infectious diseases handbook2nd, M Kotb, T Calandra. Humana Press, Totowa, NJ 2010; 1–92
   Google Scholar
• Doi K, Leelahavanichkul A, Yuen PSTG, Star RA. Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest 2009; 119: 2868–78
   PubMed Web of Science ®Google Scholar
• D'souza MJ, DeSouza P. Site specific microencapsulated drug targeting strategies-liver and gastro-intestinal tract targeting. Adv Drug Delivery Rev 1995; 17: 247–54
   Web of Science ®Google Scholar
• D'souza M, Jin Z, Oettinger C. Treatment of experimental septic shock with microencapsulated antisense oligomers to NF-κB. J Interferon Cytokine Res 2005; 25: 311–20
   PubMed Web of Science ®Google Scholar
• D'souza MJ, Oettinger CW, Milton GW. Microspheres containing neutralizing antibodies to tumor necrosis factor-α and interleukin-1β protect rats form Staphloccus aureus-induced peritonitis. J Interferon Cytokine Res 2000; 20: 907–13
   PubMed Web of Science ®Google Scholar
• D'souza M, Oettinger C, Milton G, Tracey K. Prevention of lethality and suppression of proinflammatory cytokines in experimental septic shock by microencapsulated CNI-1493. J Interferon Cytokine Res 1999; 19: 1125–33
   PubMed Web of Science ®Google Scholar
• D'souza MJ, Oettinger CW, Shah A, Tipping PG, Huang XR, Milton GV. Macrophage depletion by albumin microencapsulated clodronate: Attenuation of cytokine release in macrophage-dependent glomerulonephritis. Drug Dev Ind Pharm 1999; 25: 591–6
   PubMed Web of Science ®Google Scholar
• Gayakwad SG, Bejugam NK, Akhavein N, Uddin NA, Oettinger CW, D'souza MJ. Formulation and in vitro characterization of spray-dried antisense oligonucleotide to NF-κB encapsulated microspheres. J Microencapsulation 2009; 26: 692–700
   PubMed Web of Science ®Google Scholar
• Iles KE, Forman HJ. Macrophage signaling and respiratory burst. Immun Res 2002; 26: 95–105
   Google Scholar
• Leonard EJ, Yoshimura T. Human Monocyte chemoattractant Protein-1(MCP-1). Immunol Today 1990; 11: 97–101
   PubMedGoogle Scholar
• Ma A, Qi S, Chen H. Antioxidant therapy for prevention of inflammation, ischemic reperfusion injuries and allograft rejection. Cardiovasc Hematol Agents Med Chem 2008; 6: 20–43
   PubMedGoogle Scholar
• Michie HR, Mangonogue KR, Spriggs DR, Revhaug A, O’Dwyer S, Dinarello CA, Cerami A, Wolff SM, Wilmore DW. Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 1988; 318: 1481–6
   PubMed Web of Science ®Google Scholar
• Moreland LW, Baumgartner SW, Schiff MH, Tindall EA, Fleischmann RM, Weaver AL, Ettlinger RE, Cohen S, Koopman WJ, Mohler K. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor (p75)-Fc fusion protein. N Engl J Med 1997; 337: 141–7
   PubMed Web of Science ®Google Scholar
• Oettinger CW, D'souza MJ. Microencapsulation of tumor necrosis factor oligomers: A new approach to pro-inflammatory cytokine inhibition. J Interferon Cytokine Res 2003; 23: 533–43
   PubMed Web of Science ®Google Scholar
• Oettinger CW, D'souza MJ. Synergism in survival to endotoxic shock in rats given microencapsulated CNI-1493 and antisense oligomers to NF-κB. J Microencapsulation 2010; 27: 372–6
   PubMed Web of Science ®Google Scholar
• Oettinger CW, D'souza M, Akhavein N, Peer G, Taylor F, Kinsaewitz G. Pro-inflammatory cytokine inhibition in the primate using microencapsulated antisense oligomers to NF-κB. J Microencapsulation 2007; 24: 337–48
   PubMed Web of Science ®Google Scholar
• Oettinger CW, D'souza M, Milton G. Targeting macrophages with microspheres containing cytokine-neutralizing antibodies prevents lethality in gram-negative peritonitis. J Interferon Cytokine Res 1999; 19: 33–40
   PubMed Web of Science ®Google Scholar
• Okusawa AS, Gelfand J, Ikejima T. Interleukin-1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest 1988; 81: 1162–72
   PubMed Web of Science ®Google Scholar
• Oliver JC, Bland LA, Oettinger CW, Arduino MJ, McAllister SK, Aguero SM, Favero MS. Cytokine kinectics in an in vitro whole blood model following an endotoxin challenge. Lymphokine Cytokine Res 1993; 12: 115–20
   PubMedGoogle Scholar
• Pantano C, Reynaert NL, van der Vliet A, Janssen-Heninger YM. Redox-sensitive kinases of the nuclear factor-κB signaling pathway. Antioxid Redox Signal 2006; 8: 1791–806
   PubMed Web of Science ®Google Scholar
• Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS. Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol Cell Biol 1995; 15: 943–53
   PubMed Web of Science ®Google Scholar
• Shafer V, Briesen HV, Rubsamen-Waigmann H, Steffan AM, Royer C, Kreuter J. Phagocytosis and degradation of human serum albumin microspheres and nanoparticles in human macrophages. J Microencapsulation 1994; 11: 261–9
   PubMed Web of Science ®Google Scholar
• Siwale RC, Oettinger CW, Addo R, Yeboah GK, D'souza MJ. The effect of intracellular antioxidant delivery (catalase) on hydrogen peroxide and proinflammatory cytokine synthesis: A new therapeutic horizon. J Drug Target 2009; 17: 710–18
   PubMed Web of Science ®Google Scholar
• Siwale RC, Oettinger CW, Pai SB, Addo R, Uddin N, Siddig A, D'souza MJ. Formulation and characterization of catalase in albumin microspheres. J Microencapsulation 2008; 26(5): 411–19
   Web of Science ®Google Scholar
• Smith-Oliver T, Noel L, Stimson S, Yarnall D, Connolly K. Elevated levels of TNF in the joints of adjuvant arthritic rats. Cytokine 1993; 5: 298–304
   PubMed Web of Science ®Google Scholar
• Szekanecz Z, Halloran M, Volin M, Woods J, Streiter R, Haines K, Kunkel S, Burdick M, Koch A. Temporal expression of inflammatory cytokines and chemokines in rat adjuvant-induced arthritis. Arthritis Rheum 2000; 43: 1266–77
   PubMed Web of Science ®Google Scholar
• Uddin MN, Siddig A, Oettinger CW, D'souza MJ. Potentiation of pro-inflammatory cytokine suppression and survival by microencapsulated dexamethasone in the treatment of experimental sepsis. J Drug Target 2011; 19(9): 752–60
   Web of Science ®Google Scholar
• Van Rooijen N, Kors N, Vander Ende M, Dikstra CD. Depletion and repopulation of macrophages in spleen and liver of the rat after intravenous treatment with liposome-encapsulated dichloromethelyne diphosphate. Cell Tissue Res 1990; 260: 215–22
   PubMed Web of Science ®Google Scholar
• Ward JH, Cloud RS. Comparative effect of anti-rheumatic drugs on adjuvant-induced polyarthritis in rats. J Pharm Exp Ther 1966; 152: 116–21
   PubMed Web of Science ®Google Scholar
• Zarjou A, Agarwal A. Sepsis and acute kidney injury. J Am Soc Nephrol 2011; 22: 999–1006
   PubMed Web of Science ®Google Scholar
• Zhaowei J, D'souza MJ, Oettinger CW. Reversal of LPS induced endothelial cell TNF synthesis and increased permeability with microencapsulated antisense oligomers to NF-κB. J Microencapsulation 2007; 24: 596–607
   PubMed Web of Science ®Google Scholar