Microencapsulation of insulin using a W/O/W double emulsion followed by complex coacervation to provide protection in the gastrointestinal tract

References

• Ameri M, Maa Y. Spray drying of biopharmaceuticals: Stability and process considerations. Drying Tech, 2006;24:763–8
   Web of Science ®Google Scholar
• Babu VR, Patel P, Mundargi RC, Ragaswamy V, Aminabhavi TM. Developments in polymeric devices for oral insulin delivery. Exp Opin Drug Deliv, 2008;5:403–15
   PubMed Web of Science ®Google Scholar
• Benichou A, Aserin A, Garti N. Polyols, high pressure, and refractive indices equalization for improved stability of W/O emulsions for food applications. J Disp Sci Technol, 2001;22(2–3):269–80
   Web of Science ®Google Scholar
• Bowey K, Swift BE, Flynn LE, Neufeld RJ. Characterization of biologically active insulin-loaded alginate microparticles prepared by spray drying. Drug Dev Ind Pharm, 2013;39(3):457–65
   PubMed Web of Science ®Google Scholar
• Cárdenas-Bailón F, Osorio-Revilla G, Gallardo-Velazquez T. Microencapsulation techniques to develop formulations of insulin for oral delivery: A review. J Microencasul, 2013;30(5):409–24
   PubMed Web of Science ®Google Scholar
• Chaturvedi K, Ganguly K, Nadagouda MN, Aminabhavi TM. Polymeric hydrogels for oral insulin delivery. J Control Release, 2013;165:129–38
   PubMed Web of Science ®Google Scholar
• Cournarie F, Rosilio V, Cherón M, Vauthier C, Lacour V, Grossiord JL, Seiller M. Improved formulation of W/OW/multiple emulsion for insulin encapsulation. Influence of the chemical structure of insulin. Colloid Polym Sci, 2004;282:562–8
   Web of Science ®Google Scholar
• Cunha AS, Cherón M, Grossiord JL, Puisieux F, Seiller M. W/O/W multiple emulsions of insulin containing a protease inhibitor and an absorption enhancer: Biological activity after oral administration to normal and diabetic rats. Int J Pharm, 1998;169:33–44
   Web of Science ®Google Scholar
• Cunha AS, Grossiord JL, Puisieux F, Seiller M. Insulin in w/o/w multiple emulsions: Preparation characterization and determination of stability towards proteases in vitro. J Microencapsul, 1997;14(39):311–19
   PubMed Web of Science ®Google Scholar
• Damgé C, Maincent P, Ubrich N. Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J Control Release, 2007;117:163–70
   PubMed Web of Science ®Google Scholar
• Dong Z, Ma Y, Hayar K, Jia C, Xia S, Zhang X. Morphology and release profile of microcapsules encapsulating peppermint oil by complex coacervation. J Food Eng, 2011;104(3):455–60
   Web of Science ®Google Scholar
• Eastman JE, Moore CO. 1984. Cold water soluble granular starch for gelled food composition. US Patent 4465702
   Google Scholar
• Foss AC, Goto T, Morishita M, Peppas NA. Development of acrylic-based copolymers for oral insulin delivery. Eur J Pharm Biopharm, 2004;57:163–9
   PubMed Web of Science ®Google Scholar
• Ganguly K, Chaturvedi K, More UA, Nadagouda MN, Aminabhavi TM. Polysaccharide based micro/nanohydrogels for delivering macromolecular therapeutics. J Control Release, 2014;193:162–73
   PubMed Web of Science ®Google Scholar
• Gouin S. Microencapsulation: Industrial appraisal of existing technologies. Food Sci Tech, 2004;15:330–47
   Web of Science ®Google Scholar
• Herrero EP, Alonso MJ, Csaba N. Polymer based oral peptide nanomedicines. Ther Deliv, 2012;3(5):657–68
   PubMedGoogle Scholar
• Jelvehgari M, Milani PZ, Shadbad MRS, Loveymi BD, Nokhodchi A, Azari Z, Valizadeh H. Development of pH-sensitive insulin nanoparticles using Eudragit L100-55 and chitosan with different molecular weights. AAPS PharmSciTech, 2010;11(3):1237–42
   PubMed Web of Science ®Google Scholar
• Khan AY, Talegaonkar S, Iqbal Z, Ahmed FJ, Khar RK. Multiple emulsions: An overview. Curr Drug Deliv, 2006;3:429–43
   PubMedGoogle Scholar
• Klein M, Aserin A, Ishai PB, Garti N. Interactions between whey protein isolate and gum Arabic. Colloids Surf B, 2010;79:377–83
   PubMed Web of Science ®Google Scholar
• Lowman AM, Morishita M, Kajita M, Nagai T, Peppas NA. Oral delivery of insulin using pH-responsive complexation gels. J Pharm Sci, 1999;88(9):933–7
   PubMed Web of Science ®Google Scholar
• Makhlof A, Tozuka Y, Takeuchi H. Design and evaluation of novel pH sensitive chitosan nanoparticles for oral insulin delivery. Eur J Pharm Sci, 2011;42:445–51
   PubMed Web of Science ®Google Scholar
• Maltesen MJ, Bjerregaard S, Hovgaard L, Havelund S, Van de Weert M. Quality by design – Spray drying of insulin intended for inhalation. Eur J Pharm Biopharm, 2008;70:828–38
   PubMed Web of Science ®Google Scholar
• Mathiowitz E, Furtado S, Abramson D, Burril R, Olivier G, Gourd C, Bubbers E. Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres. Int J Pharm, 2008;347:149–55
   PubMed Web of Science ®Google Scholar
• Matos M, Gutierrez G, Coca J, Pazos G. Preparation of water-in-oil-in-water (W1/O/W2) double emulsions containing trans-resveratrol. Colloids Surf A: Physicochem Eng Aspects, 2014;442:69–79
   Web of Science ®Google Scholar
• Morishita I, Morishita M, Takayama K, Mashida Y, Nagai T. Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats. Int J Pharm, 1992;92:9–16
   Web of Science ®Google Scholar
• Morishita M, Matsuzawa A, Takayama K, Isowa K, Nagai T. Improving insulin enteral absorption using water-in-oil-in-water emulsion. Int J Pharm, 1998;172:189–98
   Web of Science ®Google Scholar
• Morishita M, Goto T, Nakamura K, Lowman AM, Takayama K, Peppas NA. Novel oral insulin delivery systems based on complexation polymer hydrogels: Single and multiple administration studies in type 1 and 2 diabetic rats. J Control Release, 2006;110:587–94
   PubMed Web of Science ®Google Scholar
• Mun S, Choi Y, Rho S, Kang C, Park C, Kim Y. Preparation and characterization of water/oil/water emulsions stabilized by polyglycerol polyricinoleate and whey protein isolate. J Food Sci, 2010;75(2):116–25
   Web of Science ®Google Scholar
• Mundargi RC, Rangaswamy V, Aminabhavi TM. pH-sensitive oral insulin delivery systems using Eudragit microspheres. Drug Dev Ind Pharm, 2011a;37(8):977–85
   PubMed Web of Science ®Google Scholar
• Mundargi RC, Rangaswamy V, Aminabhavi TM. Poly(N-vinylcaprolactam-co-methacrylic acid) hydrogel microparticles for oral insulin delivery. J Microencapsul, 2011b;28(5):384–94
   PubMed Web of Science ®Google Scholar
• Mundargi RC, Babu VR, Rangaswamy V, Patel P, Aminabhavi TM. Nano/micro technologies for delivering macromolecular therapeutics using poly(d,l-lactide-co-glycolide) and its derivatives. J Control Release, 2008;125:193–209
   PubMed Web of Science ®Google Scholar
• Okochi H, Nakano M. Comparative study of two preparation methods of W/O/W emulsions: Stirring and membrane emulsification. Chem Pharm Bull, 1997;45:1323–6
   Web of Science ®Google Scholar
• Reis CP, Ribeiro AJ, Houngc S, Veigaa F, Neufeld RJ. Nanoparticulate delivery system for insulin: Design, characterization and in vitro/in vivo bioactivity. Eur J Pharm Sci, 2007;30:392–7
   PubMed Web of Science ®Google Scholar
• Rocha-Selmi GA, Bozza FT, Thomazini M, Bolini HMA, Fávaro-Trindade CS. Microencapsulation of aspartame by double emulsion followed by complex coacervation to provide protection and prolong sweetness. Food Chem, 2013;139:72–8
   PubMed Web of Science ®Google Scholar
• Roy SK, Prabhakar B. Bioadhesive polymeric platforms for transmucosa drug delivery systems – A review. Trop J Pharm Res, 2010;9(1):91–104
   Web of Science ®Google Scholar
• Sajeesh S, Sharma CP. Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery. Int J Pharm, 2006;325(1–2):147–54
   PubMed Web of Science ®Google Scholar
• Sarmento B, Ribeiro A, Veiga F, Ferreira D. Development and characterization of new insulin containing polysaccharide nanoparticles. Colloids Surf B – Biointerfaces, 2006;53:193–202
   PubMed Web of Science ®Google Scholar
• Schmidts T, Dobler D, Schlupp P, Nissing C, Garn H, Runkela F. Development of multiple W/O/W emulsions as dermal carrier system for oligonucleotides: Effect of additives on emulsion stability. Int J Pharm, 2010;398:107–13
   PubMed Web of Science ®Google Scholar
• Shima M, Tanaka M, Fujii T, Egawa K, Kimura Y, Adachi S, Matsuno R. Oral administration of insulin included in fine W/O/W emulsions to rats. Food Hydrocolloids, 2006;20:523–31
   Web of Science ®Google Scholar
• Silva CM, Ribeiro AJ, Ferreira D, Veiga F. Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation. Eur J Pharm Sci, 2006;29:148–59
   PubMed Web of Science ®Google Scholar
• Sonaje K, Lin KJ, Wey SP, Lin CK, Yeh TH, Nguyen HN, Hsu CW, Yen TC, Juang JH, Sung HW. Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: Oral delivery using pH – Responsive nanoparticles vs subcutaneous injection. Biomaterials, 2010;31:6849–58
   PubMed Web of Science ®Google Scholar
• Weiss J, Muschioli G. Factors affecting the droplet size of water-in-oil emulsions (W/O) and the oil globule size in water-in-oil-in-water emulsions (W/O/W). J Disp Sci Tech, 2007;28:703–26
   Web of Science ®Google Scholar
• Woitiski CB, Neufeld RJ, Veiga F, Carvalho RA, Figuereido IV. Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticle. Eur J Pharm Sci, 2010;41:556–63
   Google Scholar
• Yin L, Ding J, He C, Cui L, Tan C, Yin C. Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials, 2009;30:5691–700
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wu X, Meng L, Zhang Y, Ai R, Qi N, He H, Xu H, Tang X. Thiolated Eudragit nanoparticles for oral insulin delivery: Preparation, characterization and in vivo evaluation. Int J Pharm, 2012;436:341–50
   PubMed Web of Science ®Google Scholar