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Journal of Microencapsulation
Micro and Nano Carriers
Volume 3, 1986 - Issue 2
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Research Article

The effect of niosomes and polysorbate 80 on the metabolism and excretion of methotrexate in the mouse

M. N. Azmin Department of Pharmacy, University of Strathclyde, Glasgow, Gl 1XW, UK
,
A. T. Florence Department of Pharmacy, University of Strathclyde, Glasgow, Gl 1XW, UK
,
R. M. Handjani-Vila Oreal, Department of Advanced Research, 93601, Aulnay sous Bois, France
,
J. F. B. Stuart Department of Pharmacy, University of Strathclyde, Glasgow, Gl 1XW, UK; Faculty of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia
,
G. Vanlerberghe Oreal, Department of Advanced Research, 93601, Aulnay sous Bois, France; Redhall Lodge, 557 Parkhouse Road, Glasgow, G78, UK
&
J. S. Whittaker L'Oreal, Centre Eugene Schueller, 922117, Clichy Cedex, France
Pages 95-100 | Received 06 Feb 1986, Accepted 24 Feb 1986, Published online: 27 Sep 2008

References

  • Andren L., Theander G. Emptying effect on the gall bladder of Tween 80 and some related compounds. Gastroenterology 1961; 40: 636–640
  • Attwood D., Florence A. T. Surfactant Systems: Their Chemistry, Pharmacy and Biology. Chapman and Hall, London 1983
  • Azmin M. N., Florence A. T., Handjani-Vila R. M., Stuart J. F. B., Vanlerberghe G., Whittaker J. S. The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. Journal of Pharmacy and Pharmacology 1985a; 37: 237–242
  • Azmin M. N., Stuart J. F. B., Calman K. C., Florence A. T. Effects of polysorbate 80 on the absorption and distribution of oral methotrexate in mice. Cancer Chemotherapy and Pharmacology 1982; 9: 161–164
  • Azmin M. N., Stuart J. F. B., Florence A. T. The distribution and elimination of methotrexate in mouse blood and brain after concurrent administration of polysorbate 80. Cancer Chemotherapy and Pharmacology 1985b; 14: 238–242
  • Baillie A. J., Florence A. T., Hume L., Muirhead G., Rogerson A. Preparation and properties of niosomes—non-ionic surfactant vesicles. Journal of Pharmacy and Pharmacology 1985; 37: 863–868
  • Gaukroger J. M., Wilson L. Protection of cells from methotrexate toxicity by 7-hydroxymethotrexate. British Journal of Cancer 1984; 50: 327–333
  • Handjani-Vila R. M., Ribier A., Rondot A., Vanlerberghe G. Dispersion of lamellar phases of non-ionic lipid in cosmetic products. International Journal of Cosmetic Science 1979; 1: 303–314
  • Jacobs S. A., Stoller R. G., Chabner B. A., Johns D. G. 7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate. Journal of Clinical Investigation 1976; 57: 534–538
  • Kimelberg H. K., Atchison M. L. Effect of entrapment in liposomes on the distribution, degradation and effectiveness of methotrexate in vivo. Annals of the New York Academy of Sciences 1978; 308: 395–409
  • Sweeney E. F., Fujimoto J. M. Effect of intrabiliary administration of Triton X100 on biliary excretory function in the rat. Biochemical Pharmacology 1984; 33: 2309–2313
  • Willmott N., Cummings J., Stuart J. F. B., Florence A. T. Adriamycinloaded microspheres: preparation, in vivo distribution and release in the rat. Biopharmaceutics and Drug Disposition 1985; 6: 91–104

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