Heat shock proteins in breast cancer progression–A suitable case for treatment?

References

• Calderwood SK, Ciocca DR. Heat shock proteins: Stress proteins with Janus-like properties in cancer. Int J Hyperthermia 2008; 24: 31–39
   PubMed Web of Science ®Google Scholar
• Lindquist S, Craig EA. The heat shock proteins. Ann Rev Genet 1988; 22: 631–637
   PubMed Web of Science ®Google Scholar
• Bukau B, Weissman J, Horwich A. Molecular chaperones and protein quality control. Cell 2006; 125: 443–451
   PubMed Web of Science ®Google Scholar
• Subjeck JR, Sciandra JJ, Johnson RJ. Heat shock proteins and thermotolerance: A comparison of induction kinetics. Br J Radiol 1982; 55: 579–584
   PubMed Web of Science ®Google Scholar
• Landry J, Bernier D, Chretien P, Nicole LM, Tanguay RM, Marceau N. Synthesis and degradation of heat shock proteins during the development and decay of thermotolerance. Cancer Research 1982; 42: 2457–2461
   PubMed Web of Science ®Google Scholar
• Li GC, Werb Z. Correlation between the synthesis of heat shock proteins and the development of thermotolerance in CHO fibroblasts. Proc Natl Acad Sci USA 1982; 79: 3218–3222
   PubMed Web of Science ®Google Scholar
• Calderwood SK, Murshid A, Prince T. The shock of aging: Molecular chaperones and the heat shock response in longevity and aging–A mini-review. Gerontology 2009; 55: 550–558
   PubMed Web of Science ®Google Scholar
• Tang D, Khaleque MA, Jones EL, Theriault JR, Li C, Wong WH, Stevenson MA, Calderwood SK. Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo. Cell Stress Chaperones 2005; 10: 46–58
   PubMed Web of Science ®Google Scholar
• Jones EL, Zhao MJ, Stevenson MA, Calderwood SK. The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer. Int J Hyperthermia 2004; 20: 835–849
   PubMed Web of Science ®Google Scholar
• Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: Implications in apoptosis and aging. FEBS Lett 1998; 438: 1–4
   PubMed Web of Science ®Google Scholar
• Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G. Heat shock proteins 27 and 70: Anti-apoptotic proteins with tumorigenic properties. Cell Cycle 2006; 5: 2592–2601
   PubMed Web of Science ®Google Scholar
• Sorger PK, Pelham HRB. Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell 1988; 54: 855–864
   PubMed Web of Science ®Google Scholar
• Wu C. Heat shock transcription factors: Structure and regulation. Ann Rev Cell Dev Biol 1995; 11: 441–469
   PubMed Web of Science ®Google Scholar
• Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR. Heat shock proteins in cancer: Chaperones of tumorigenesis. Trends Biochem Sci 2006; 31: 164–172
   PubMed Web of Science ®Google Scholar
• Ciocca DR, Calderwood SK. Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 2005; 10: 86–103
   PubMed Web of Science ®Google Scholar
• Ciocca DR, Vargas-Roig LM. Hsp27 as a prognostic and predictive factor in cancer. Prog Mol Subcell Biol 2002; 28: 205–218
   PubMedGoogle Scholar
• Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC, Burrows FJ. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 2003; 425: 407–410
   PubMed Web of Science ®Google Scholar
• Neckers L, Lee YS. Cancer: The rules of attraction. Nature 2003; 425: 357–359
   PubMed Web of Science ®Google Scholar
• Rutherford SL, Lindquist S. Hsp90 as a capacitor for morphological evolution. Nature 1998; 396: 336–342
   PubMed Web of Science ®Google Scholar
• Sangster TA, Salathia N, Lee HN, Watanabe E, Schellenberg K, Morneau K, Wang H, Undurraga S, Queitsch C, Lindquist S. HSP90-buffered genetic variation is common in Arabidopsis thaliana. Proc Natl Acad Sci USA 2008; 105: 2969–2974
   PubMed Web of Science ®Google Scholar
• Khaleque MA, Bharti A, Sawyer D, Gong J, Benjamin IJ, Stevenson MA, Calderwood SK. Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene 2005; 24: 6564–6573
   PubMed Web of Science ®Google Scholar
• Leav I, Plescia J, Goel HL, Li J, Jiang Z, Cohen RJ, Languino LR, Altieri DC. Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am J Pathol, 176: 393–401
   PubMed Web of Science ®Google Scholar
• Wadhwa R, Taira K, Kaul SC. An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: What, when, and where?. Cell Stress Chaperones 2002; 7: 309–316
   PubMed Web of Science ®Google Scholar
• Khaleque MA, Bharti A, Gong J, Gray PJ, Sachdev V, Ciocca DR, Stati A, Fanelli M, Calderwood SK. Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1. Oncogene 2008; 27: 1886–1893
   PubMed Web of Science ®Google Scholar
• Wang Y, Theriault JR, He H, Gong J, Calderwood SK. Expression of a dominant negative heat shock factor-1 construct inhibits aneuploidy in prostate carcinoma cells. J Biol Chem 2004; 279: 32651–32659
   PubMed Web of Science ®Google Scholar
• Dai C, Whitesell L, Rogers AB, Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 2007; 130: 1005–1018
   PubMed Web of Science ®Google Scholar
• Kawabe M, Mandic M, Taylor JL, Vasquez CA, Wesa AK, Neckers LM, Storkus WJ. Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells. Cancer Res 2009; 69: 6995–7003
   PubMed Web of Science ®Google Scholar
• Tsutsumi S, Beebe K, Neckers L. Impact of heat-shock protein 90 on cancer metastasis. Future Oncol 2009; 5: 679–688
   PubMed Web of Science ®Google Scholar
• Neckers L, Ivy SP. Heat shock protein 90. Curr Opin Oncol 2003; 15: 419–424
   PubMed Web of Science ®Google Scholar
• Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nat Rev Cancer 2005; 5: 761–772
   PubMed Web of Science ®Google Scholar
• Kim YS, Alarcon SV, Lee S, Lee MJ, Giaccone G, Neckers L, Trepel JB. Update on Hsp90 inhibitors in clinical trial. Curr Top Med Chem 2009; 9: 1479–1492
   PubMed Web of Science ®Google Scholar
• Gray PJ, Jr, Stevenson MA, Calderwood SK. Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells. Cancer Res 2007; 67: 11942–11950
   PubMed Web of Science ®Google Scholar
• Gray PJ, Jr, Prince T, Cheng J, Stevenson MA, Calderwood SK. Targeting the oncogene and kinome chaperone CDC37. Nat Rev Cancer 2008; 8: 491–495
   PubMed Web of Science ®Google Scholar
• Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, et al. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene 2003; 22: 6669–6678
   PubMed Web of Science ®Google Scholar
• Schmitt E, Parcellier A, Gurbuxani S, Cande C, Hammann A, Morales MC, Hunt CR, Dix DJ, Kroemer RT, Giordanetto F, et al. Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Cancer Res 2003; 63: 8233–8240
   PubMed Web of Science ®Google Scholar
• Ciocca DR, Oesterreich S, Chamness GC, McGuire WL, Fuqua SA. Biological and clinical implications of heat shock protein 27,000 (Hsp27): A review. J Natl Cancer Inst 1993; 85: 1558–1570
   PubMed Web of Science ®Google Scholar
• Sherman MY, Gabai V, O'Callaghan C, Yaglom J. Molecular chaperones regulate p53 and suppress senescence programs. FEBS Lett 2007; 581: 3711–3715
   PubMed Web of Science ®Google Scholar
• Sherman MY, Goldberg AL. Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases. Neuron 2001; 29: 15–32
   PubMed Web of Science ®Google Scholar
• Brunet Simioni M, De Thonel A, Hammann A, Joly AL, Bossis G, Fourmaux E, Bouchot A, Landry J, Piechaczyk M, Garrido C. Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity. Oncogene 2009; 28: 3332–3344
   PubMed Web of Science ®Google Scholar
• Buchdunger E, Matter A, Druker BJ. Bcr-Abl inhibition as a modality of CML therapeutics. Biochim Biophys Acta 2001; 1551: M11–18
   PubMed Web of Science ®Google Scholar
• Min JN, Huang L, Zimonjic DB, Moskophidis D, Mivechi NF. Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors. Oncogene 2007; 26: 5086–5097
   PubMed Web of Science ®Google Scholar
• Asea A, Ara G, Teicher BA, Stevenson MA, Calderwood SK. Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo. Int J Hyperthermia 2001; 17: 347–356
   PubMed Web of Science ®Google Scholar
• Price BD, Calderwood SK. Ca2+ is essential for multistep activation of the heat shock factor in permeabilized cells. Mol Cell Biol 1991; 11: 3365–3368
   PubMed Web of Science ®Google Scholar
• Martin CA, Kurkowski DL, Valentino AM, Santiago-Schwarz F. Increased intracellular, cell surface, and secreted inducible heat shock protein 70 responses are triggered during the monocyte to dendritic cell (DC) transition by cytokines independently of heat stress and infection and may positively regulate DC growth. J Immunol 2009; 183: 388–399
   PubMed Web of Science ®Google Scholar
• Koishi M, Yokota S, Mae T, Nishimura Y, Kanamori S, Horii N, Shibuya K, Sasai K, Hiraoka M. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res 2001; 7: 215–219
   PubMed Web of Science ®Google Scholar
• Zaarur N, Gabai VL, Porco J, Calderwood SK, Sherman MY. Novel inhibitors of heat shock protein expression sensitize cancer cells to proteasome and hsp90 inhibitors. Cancer Res, 66: 1783–1791
   PubMed Web of Science ®Google Scholar
• Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005; 434: 843–850
   PubMed Web of Science ®Google Scholar
• Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105–111
   PubMed Web of Science ®Google Scholar