494
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Hyperthermia worsens ischaemic brain injury through destruction of microvessels in an embolic model in rats

, , &
Pages 24-32 | Received 28 Jun 2011, Accepted 10 Oct 2011, Published online: 11 Jan 2012

References

  • Zaremba J. Hyperthermia in ischemic stroke. Med Sci Monit 2004; 10: 148–153
  • Reith J, Jorgensen HS, Pedersen PM, Nakayama H, Raaschou HO, Jeppesen LL, Olsen TS. Body temperature in acute stroke: Relation to stroke severity, infarct size, mortality and outcome. Lancet 1996; 347: 422–425
  • Wang Y, Lim LL, Levi C, Heller RF, Fisher J. Influence of admission body temperature on stroke mortality. Stroke 2000; 31: 404–409
  • Castillo J, Dávalos A, Marrugat J, Noya M. Timing for fever-related brain damage in acute ischemic stroke. Stroke 1998; 29: 2455–2460
  • Reglodi D, Somogyvari-Vigh A, Maderdrut JL, Vigh S, Arimura A. Postischemic spontaneous hyperthermia and its effects in middle cerebral artery occlusion in the rat. Exp Neurol 2000; 163: 399–407
  • Chen H, Chopp M, Welch KM. Effect of mild hyperthermia on the ischemic infarct volume after middle cerebral artery occlusion in the rat. Neurology 1991; 41: 1133–1135
  • Baena RC, Busto R, Dietrich WD, Globus MY, Ginsberg MD. Hyperthermia delayed by 24 hours aggravates neuronal damage in rat hippocampus following global ischemia. Neurology 1997; 48: 768–773
  • Minamisawa H, Smith ML, Siesjö BK. The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia. Ann Neurol 1990; 28: 26–33
  • Noor R, Wang CX, Shuaib A. Effects of hyperthermia on infarct volume in focal embolic model of cerebral ischemia in rats. Neurosci Lett 2003; 349: 130–132
  • Noor R, Wang CX, Shuaib A. Hyperthermia masks the neuroprotective effects of tissue plasminogen activator. Stroke 2005; 36: 665–669
  • Meden P, Overgaard K, Pedersen H, Boysen GBR. The influence of body temperature on infarct volume and thrombolytic therapy in a rat embolic stoke model. Brain Res 1994; 647: 131–138
  • del Zoppo GJ, Mabuchi T. Cerebral microvessel responses to focal ischemia. J Cereb Blood Flow Metab 2003; 23: 879–894
  • Wang CX, Yang T, Shuaib A. An improved version of embolic model of brain ischemic injury in the rat. J Neurosci Methods 2001; 109: 147–151
  • Shabanzadeh AP, Shuaib A, Wang CX. Reduction of ischemic brain injury in rats with normothermic and hyperthermic conditions. J Neurosurg 2008; 109: 522–529
  • Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination. Stroke 1986; 17: 472–476
  • Shuaib A, Wang C, Yang T, Noor R. Effects of nonpeptide V(1) vasopressin receptor antagonist SR-49059 on infarction volume and recovery of function in a focal embolic stroke model. Stroke 2002; 33: 3033–3037
  • Hamann GF, Okada Y, Fitridge R, del Zoppo GJ. Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion. Stroke 1995; 26: 2120–2126
  • Wang CX, Ding X, Noor R, Pegg C, He C, Shuaib A. Rosiglitazone alone or in combination with tissue plasminogen activator improves ischemic brain injury in an embolic model in rats. J Cereb Blood Flow Metab 2009; 29: 1683–1694
  • Romanic AM, White RF, Arleth AJ, Ohlstein EH, Barone FC. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: Inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke 1998; 29: 1020–1030
  • Rosenberg GA, Navratil M, Barone F, Feuerstein G. Proteolytic cascade enzymes increase in focal cerebral ischemia in rat. J Cereb Blood Flow Metab 1996; 16: 360–366
  • Saini M, Saqqur M, Kamruzzaman A, Lees KR, Shuaib A. Effect of hyperthermia on prognosis after acute ischemic stroke. Stroke 2009; 40: 3051–3059
  • Risau W, Esser S, Engelhardt B. Differentiation of blood–brain barrier endothelial cells. Pathol Biol 1998; 46: 171–175
  • Yurchenco PD, Schittny JC. Molecular architecture of basement membranes. FASEB J 1990; 4: 1577–1590
  • Hamann GF, del Zoppo GJ, von Kummer R. Hemorrhagic transformation of cerebral infarction: Possible mechanisms. Thromb Haemost 1999; 82: S92–94
  • Gasche Y, Fujimura M, Morita-Fujimura Y, Copin JC, Kawase M, Massengale J, Chan PH. Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: A possible role in blood–brain barrier dysfunction. J Cereb Blood Flow Metab 1999; 19: 1020–1028
  • del Zoppo GJ, von Kummer R, Hamann GF. Ischaemic damage of brain microvessels: Inherent risks for thrombolytic treatment in stroke. J Neurol Neurosurg Psychiatry 1998; 65: 1–9
  • Heo JH, Lucero J, Abumiya T, Koziol JA, Copeland BR, del Zoppo GJ. Matrix metalloproteinases increase very early during experimental focal cerebral ischemia. J Cereb Blood Flow Metab 1999; 19: 624–633
  • Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab 2007; 27: 697–709
  • Lo EH, Wang X, Cuzner ML. Extracellular proteolysis in brain injury and inflammation: Role for plasminogen activators and matrix metalloproteinases. J Neurosci Res 2002; 69: 1–9
  • Cunningham LA, Wetzel M, Rosenberg GA. Multiple roles for MMPs and TIMPs in cerebral ischemia. Glia 2005; 50: 329–339
  • Fukuda S, Fini CA, Mabuchi T, Koziol JA, Eggleston LL, Jr, del Zoppo GJ. Focal cerebral ischemia induces active proteases that degrade microvascular matrix. Stroke 2004; 35: 998–1004
  • Noor R, Wang CX, Todd K, Elliott C, Wahr J, Shuaib A. Partial intra-aortic occlusion improves perfusion deficits and infarct size following focal cerebral ischemia. J Neuroimaging 2010; 20: 272–276
  • Hosomi N, Lucero J, Heo JH, Koziol JA, Copeland BR, del Zoppo GJ. Rapid differential endogenous plasminogen activator expression after acute middle cerebral artery occlusion. Stroke 2001; 32: 1341–1348
  • Ahn MY, Zhang ZG, Tsang W, Chopp M. Endogenous plasminogen activator expression after embolic focal cerebral ischemia in mice. Brain Res 1999; 837: 169–176
  • Lee SR, Guo SZ, Scannevin RH, Magliaro BC, Rhodes KJ, Wang XY, Lo EH. Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators. Neurosci Lett 2007; 417: 1–5
  • Duncan GW, Pessin M, Mohr JP. Relevance of duration of transient ischaemic attacks in carotid territory. Br Med J 1978; 2: 1020
  • Sloan MA. Thrombolysis and stroke. Past and future. Arch Neurol 1987; 44: 748–768
  • Petty GW, Brust JC, Tatemichi TK, Barr ML. Embolic stroke after smoking ‘crack’ cocaine. Stroke 1990; 21: 1632–1635
  • Kudo M, Aoyama A, Ichimori S, Fukunaga N. An animal model of cerebral infarction. Homologous blood clot emboli in rats. Stroke 1982; 13: 505–508
  • Wang CX, Yang Y, Yang T, Shuaib A. A focal embolic model of cerebral ischemia in rats: Introduction and evaluation. Brain Res Brain Res Protoc 2001; 7: 115–120
  • Wang CX, Yang T, Shuaib A. Clot fragments formed from original thrombus obstruct downstream arteries in the ischemic injured brain. Microcirculation 2006; 13(3)229–236

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.