Conservative antibiotic policy in patients undergoing non-trauma cranial surgery does not result in higher rates of postoperative meningitis: An audit of nine years of narrow-spectrum prophylaxis

References

• Barker FG II. Efficacy of prophylactic antibiotics for craniotomy: a meta-analysis. Neurosurgery 1994;35:484–90.
   PubMed Web of Science ®Google Scholar
• Barker FG II. Efficacy of prophylactic antibiotics against meningitis after craniotomy: a meta analysis. Neurosurgery 2007; 60:887–94.
   PubMed Web of Science ®Google Scholar
• Blomstedt GC, Kytta J. Results of a randomized trial of vancomycin prophylaxis in craniotomy. J Neurosurg 1988;69:216–20.
   PubMed Web of Science ®Google Scholar
• Bullock R, van Dellen JR, Ketelbey W, Reinach SG. A double-blind placebo-controlled trial of perioperative prophylactic antibiotics for elective neurosurgery. J Neurosurg 1988;69:687–91.
   PubMed Web of Science ®Google Scholar
• Djindjian M, Lepresle E, Homs JB. Antibiotic prophylaxis during prolonged clean neurosurgery. Results of a randomized double-blind study using oxacillin. J Neurosurg 1990;73:383–6.
   Google Scholar
• Gaillard T, Gilsback JM. Intra-operative antibiotic prophylaxis in neurosurgery. A prospective, randomized, controlled study on Cefotiam. Acta Neurochir (Wein) 1991;113:103–9.
   PubMedGoogle Scholar
• Geraghty J, Feely MJ. Antibiotic prophylaxis in neurosurgery. A randomized controlled trial. Neurosurgery 1994;60:720–6.
   Google Scholar
• Korinek AM, Golmard JL, Elcheick A, et al. Risk factors for neurosurgical site infections after craniotomy: a critical reappraisal of antibiotic prophylaxis on 4578 patients. Br J Neurosurg 2005; 19:155–62.
   PubMed Web of Science ®Google Scholar
• Korinek AM, Baugnon T, Golmard JL, van Effenterre R, Coriat P, Puybasset L. Risk factors for adult nosocomial meningitis after craniotomy: role of antibiotic prophylaxis. Neurosurgery 2006; 59:126–33.
   PubMed Web of Science ®Google Scholar
• Kourbeti IS, Jacobs AV, Koslow M, Karabetsos D, Holzman RS. Risk factors associated with postcraniotomy meningitis. Neurosurgery 2007;60:317–25.
   PubMed Web of Science ®Google Scholar
• Malis LI. Prevention of neurosurgical infection by intraoperative antibiotics. Neurosurgery 1979;5:339–43.
   PubMed Web of Science ®Google Scholar
• Mollman HD, Haines SJ. Risk factors for postoperative neurosurgical wond infection. A case-control study. J Neurosurg 1986;64:902–6.
   PubMed Web of Science ®Google Scholar
• Sharma MS, Vohra A, Thomas P, et al. Effect of risk-stratified, protocol based perioperative chemoprophylaxis on nosocomial infection rates in a series of 31927 consecutive neurosurgical procedures (1994–2006). Neurosurgery 2009;64:1123–30.
   PubMedGoogle Scholar
• Wright RL. A survey of possible etiologic agents in postoperative craniotomy infections. J Neurosurg 1966;25:125–32.
   PubMedGoogle Scholar
• van Ek B, Dijkmans BA, van Dulken H, van Furth R. Antibiotic prophylaxis in craniotomy: a prospective double-blind placebo-controlled study. Scand J Infect Dis 1988;20:633–9.
   PubMedGoogle Scholar
• Young RF, Lawner PM. Perioperative antibiotic prophylaxis for prevention of postoperative neurosurgical infections. A randomized clinical trial. J Neurosurg 1987;66:701–5.
   PubMed Web of Science ®Google Scholar
• Medeiros AC, Aeiros-Neto T, Azevedas GV, Vilar MJP, Pinheiro LAM, Brandao-Neto J. Surgical site infection in a University Hospital in northeast Brazil. Br J Infect Dis 2005;9: 310–4.
   PubMedGoogle Scholar
• Thu LTA, Dibley MJ, Nho VV, Archibald L, Jarvis WR, Sohn AH. Reduction in surgical site infections in neurosurgical patients associated with bedside hand hygiene programme in Vietnam. Infect Control Hosp Epidemiol 2007;28:583–8.
   PubMedGoogle Scholar
• Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992 : A modification of CDC definitions of surgical wound infections. Am J Infect Control 1992;20:271–4.
   PubMed Web of Science ®Google Scholar
• Erdem I, Hakan T, Ceran N, et al. Clinical features, laboratory data, management and the risk factors that affect the mortality in patients with postoperative meningitis. Neurol India 2008; 56:433–7.
   PubMed Web of Science ®Google Scholar
• Erman T, Demirhindi H, Gocer AI, Tuna M, Ildan F, Boyar B. Risk factors for surgical site infections in neurosurgery patients with antibiotic prophylaxis. Surg Neurol 2005;63:107–13.
   PubMedGoogle Scholar
• Infection in Neurosurgery Working Party of the British Society for antimicrobial therapy. The management of neurosurgical patients with postoperative bacterial or aseptic meningitis or external ventricular drain-associated ventriculitis. Br J Neurosurg 2000;14:7–12.
   PubMed Web of Science ®Google Scholar
• Leitard C, Thebaud V, Besson G, Lejeune B. Risk factors for neurosurgical site infections: an 18-month prospective survey. J Neurosurg 2008;109:729–34.
   PubMedGoogle Scholar
• McClelland S III, Hall WA. Postoperative central nervous system infection: incidence and associated factors in 2111 neurosurgical procedures. Clin Infect Dis 2007;45:55–59.
   PubMed Web of Science ®Google Scholar
• Srinivas D, Kumari VBH, Somanna S, Bhagavatula I, Anandappa CB. The incidence of postoperative meningitis in neurosurgery: An institutional experience. Neurol India 2011; 59:195–9.
   PubMedGoogle Scholar
• Reichert MC, Medceros EA, Ferrez FA. Hospital-acquired meningitis in patients undergoing craniotomy: incidence, evolution and risk factors. Am J Infect Control 2002;30:158–64.
   PubMed Web of Science ®Google Scholar
• Kourbeti IS, Papadakis JA, Neophytou C, et al. Infections in patients with traumatic brain injury who undergo neurosurgery. Br J Neurosurg 2011;25:9–15.
   PubMed Web of Science ®Google Scholar
• Blomstedt GC. Infections in neurosurgery: a retrospective study of 1143 patients and 1517 operations. Acta Neurochir (Wein) 1985; 78:81–90.
   PubMed Web of Science ®Google Scholar
• Lu CH, Chang WN, Chuang YC, Chang HW. Gram-negative bacillary meningitis in adult post-neurosurgical patients. Surg Neurol 1999;52:438–44.
   PubMedGoogle Scholar
• Wang KW, Chang WN, Huang CR, et al. Post-neurosurgical nosocomial bacterial meningitis in adults: microbiology, clinical features, and outcomes. J Clin Neurosci 2005;12:647–50.
   PubMed Web of Science ®Google Scholar
• Palabiyikoglu I, Tekeli E, Cokea F, et al. Nosocomial meningitis in a university hospital between 1993 and 2002. J Hosp Infect 2006;62:94–7.
   PubMed Web of Science ®Google Scholar
• Wesfelt M, van de Beek D, Spanjaard L, de Gaus J. Nosocomial bacterial meningitis in adults: a prospective series of 50 cases. J Hosp Infect 2007;66:71–8.
   PubMedGoogle Scholar
• Federico G, Tumbarello M, Spann T, et al. Risk factors and prognostic indicators of bacterial meningitis in a cohort of 3580 postneurosurgical patients. Scand J Infect Dis 2001; 33:533–7.
   PubMedGoogle Scholar
• Krcmery V, Paradisi F. Pediatric Nosocomial meningitis study group. Nosocomial bacterial and fungal meningitis in children: An eight year national survey reporting 101 cases. Int J Antimicrobial Agents 2000;15:143–7.
   PubMedGoogle Scholar
• Simon B, Ellis Peglin RD, Raymond N, Thomas M, Wilkinson L. Gram negative bacillary meningitis after cranial surgery or trauma in adults. Scand J Infect Dis 2004;36:165–73.
   PubMedGoogle Scholar
• O’Neill E, Humphreys H, Phillips J, Smyth EG. Third-generation cephalosporin resistance among Gram-negative bacilli causing meningitis in neurosurgical patients: significant challenges in ensuring effective antibiotic therapy. J Antimicrobial Chemotherapy 2006;57:356–9.
   PubMedGoogle Scholar
• Farideh N, Tajlik P, Khasab M, Kazmi SS, Khotaei GT, Salahesh S. A randomized trial of ceftriaxone versus trimethoprim-sulfmethoxazole to prevent ventriculoperitoneal shunt infection. J Microbiol Immunol Infect 2008;41:112–17.
   PubMedGoogle Scholar
• Whitby M, Johnson BC, Atkinson RL, Stuart G. The comparative efficacy of intravenous cefotaxime and trimethoprim/sulfamethoxazole in preventing infection after neurosurgery: a prospective, randomized study. Brisbane Neurosurgical Infection group. Br J Neurosurg 2000;14:13–18.
   PubMedGoogle Scholar
• Baatrup G, Nilsen RM, Svensen R, Akselsen PE. Increased incidence of postoperative infections during prophylaxis with cephalothin compared to doxycycline in intestinal surgery. BMC Surg 2009;7:9–17.
   Google Scholar
• Price DJ, Sleigh JD. Control of infection due to Klebsiella aerogenes in a neurosurgical unit by withdrawal of all antibiotics. Lancet 1970;2:1213–5.
   PubMed Web of Science ®Google Scholar