636
Views
24
CrossRef citations to date
0
Altmetric
Review Article

Predictive markers in traumatic brain injury: opportunities for a serum biosignature

, , &
Pages 8-15 | Received 14 Nov 2012, Accepted 09 Jun 2013, Published online: 15 Jul 2013

References

  • Faul M, Xu L, Wald MM, Coronado VG. Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002–2006. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, 2010.
  • Berger RP. The use of serum biomarkers to predict outcome after traumatic brain injury in adults and children. J Head Traum Rehabil 2006;21:315–33.
  • Pelinka LE, Kroepfl A, Leixnering M, et al. GFAP versus S100b in serum after traumatic brain injury: relationship to brain damage and outcome. J Neurotrauma 2004;21:1553–61.
  • Petzold A, Green AJ, Keir G, et al. Role of serum S100B as an early predictor of high intracranial pressure and mortality in brain injury: a pilot study. Crit Care Med 2002;30:2705–10.
  • Bandyopadhyay S, Hennes H, Gorelick MH, Wells RG, Walsh-Kelly CM. Serum neuron-specific enolase as a predictor of short-term outcome in children with closed traumatic brain injury. Acad Emerg Med 2005;12:732–8.
  • Vos PE, Lamers KJ, Hendriks JC, et al. Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury. Neurology 2004;62:1303–10.
  • Lima JE, Takayanagui OM, Garcia LV, Leite JP. Use of neuron-specific enolase for assessing the severity and outcome of neurological disorders in patients. Braz J Med Biol Res 2004;37:19–26.
  • Thomas DG, Palfreyman JW, Ratcliffe JG. Serum-myelin-basic-protein assay in diagnosis and prognosis of patients with head injury. Lancet 1978;1:113–5.
  • Tran HT, Sanchez L, Esparza TJ, Brody DL. Distinct temporal and anatomical distributions of amyloid-β and tau abnormalities following controlled cortical impact in transgenic mice. PLoSOne 2011;6:e25475.
  • Galindo LT, Filippo TR, Semedo P, et al. Mesenchymal stem cell therapy modulates the inflammatory response in experimental traumatic brain injury. Neurol Res Int 2011;2011:564089.
  • Ley EJ, Srour MK, Clond MA, et al. Diabetic patients with traumatic brain injury: insulin deficiency is associated with increased mortality. J Trauma 2011;70:1141–4.
  • Wagner AK, McCullough EH, Niyonkuru C, et al. Acute serum hormone levels: characterization and prognosis after severe traumatic brain injury. J Neurotrauma 2011;28:871–88.
  • Mondello S, Linnet A, Buki A, et al. Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury. Neurosurgery 2011. [Epub ahead of print].
  • Xiong Z, O’Hanlon D, Becker LE, et al. Enhanced calcium transients in glial cells in neonatal cerebellar cultures derived from S100B null mice. Exp Cell Res 2000;257:281–9.
  • Nishiyama H, Knopfel T, Endo S, Itohara S. Glial protein S100B modulates long-term neuronal synaptic plasticity. ProcNatlSci USA 2002;99:4037–42.
  • Zurek J, Fedora M. Dynamics of glial fibrillary acidic protein during traumatic brain injury in children. J Trauma 2011;71:854–9.
  • Zurek J, Fedora M. The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury. Acta Neurochir (Wien) 2012;154:93–103.
  • Unden J, Romner B. Can low serum levels of S100B predict normal CT findings after minor head injury in adults: an evidence-based review and meta-analysis?. J Head Trauma Rehabil 2010;25: 228–40.
  • Morochovic R, Rácz O, Kitka M, et al. Serum S100B protein in early management of patients after mild traumatic brain injury. Eur J Neurol 2009;16:1112–7.
  • Berger RP, Dulani T, Adelson PD, et al. Identification of inflicted traumatic brain injury in well-appearing infants using serum and cerebrospinal markers, a possible screening tool. Pediatrics 2006;117:325–32.
  • Piazza O, Storti MP, Cotena S, et al. S100B is not a reliable prognostic index in paediatric TBI.Pediatr Neurosurg 2007; 43:258–64.
  • Bechtel K, Frasure S, Marshall C, Dziura J, Simpson C. Relationship of serum S100B levels and intracranial injury in children with closed head trauma. Pediatrics 2009;124:e697–704.
  • Filippidis AS, Papadopoulos DC, Kapsalaki EZ, Fountas KN. Role of the S100B serum biomarker in the treatment of children suffering from mild traumatic brain injury. Neurosurg Focus 2010;29:E2.
  • Hasselblatt M, Mooren FC, von Ahsen N, et al. Serum S100beta increases in marathon runners reflect extracranial release rather than glial damage. Neurology 2004;62:1634–6.
  • Ohrt-Nissen S, Friis-Hansen L, Dahl B, et al. How does extracerebral trauma affect the clinical value of S100B measurements?. Emerg Med J 2011;28:941–4.
  • Sandler SJ, Figaji AA, Adelson PD. Clinical applications of biomarkers in pediatric traumatic brain injury. Child Nerv Syst 2010;26:205–13.
  • Kövesdi E, Lückl J, Bukovics P, et al. Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics. Acta Neurochir (Wien) 2010;152:1–17.
  • Papa L, Lewis LM, Falk JL, et al. Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention. Ann Emerg Med 2011. [Epub ahead of print].
  • Dash PK, Zhao J, Hergenroeder G, Moore AN. Biomarkers for the diagnosis, prognosis, and evaluation of treatment efficacy for traumatic brain injury. Neurotherapeutics 2010;7:100–14.
  • Honda M, Tsuruta R, Kaneko T, et al. Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase. J Trauma 2010;69:104–9.
  • Böhmer AE, Oses JP, Schmidt AP, et al. Neuron-specific enolase, S100B, and glial fibrillary acidic protein levels as outcome predictors in patients with severe traumatic brain injury. Neurosurgery 2011;68:1624–30; discussion 1630-1.
  • Ross SA, Halliday MI, Campbell GC, Byrnes DP, Rowlands BJ. The presence of tumour necrosis factor in CSF and plasma after severe head injury. Br J Neurosurg 1994;8:419–25.
  • Crespo AR, Da Rocha AB, Jotz GP, et al. Increased serum sFas and TNFalpha following isolated severe head injury in males. Brain Inj 2007;21:441–7.
  • Melo JR, Di Rocco F, Blanot S, et al. Acute hyperglycemia is a reliable outcome predictor in children with severe traumatic brain injury. Acta Neurochir (Wien) 2010;152:1559–65.
  • Liu MC, Akle V, Zheng W, et al. Extensive degradation of myelin basic protein isoforms by calpain following traumatic brain injury. J Neurochem 2006;98:700–12.
  • Zemlan FP, Jauch EC, Mulcahey JJ, et al. C-tau biomarker of neuronal damage in severe brain injured patients: association with elevated intracranial pressure and clinical outcome. Brain Res 2002;947:131–9.
  • Kavalci C, Pekdemir M, Durukan P, et al. The value of serum tau protein for the diagnosis of intracranial injury in minor head trauma. Am J Emerg Med 2007;25:391–5.
  • Bazarian JJ, Zemlan FP, Mookerjee S, Stigbrand T. Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury. Brain Inj 2006;20:759–65.
  • Cooper EH. Neuron-specific enolase. Int J Biol Markers 1994;9: 205–10.
  • Bittigau P, Sifringer M, Pohl D, et al. Apoptotic neurodegeneration following trauma is markedly enhanced in the immature brain. Ann Neurol 1999;45:724–35.
  • Hergenroeder GW, Moore AN, McCoy JP Jr, et al. Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury. J Neuroinflammation 2010;7:19.
  • Singhal A, Baker AJ, Hare GM, et al. Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury. J Neurotrauma 2002;19:929–37.
  • Papa L, Akinyi L, Liu MC, et al. Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Crit Care Med 2010;38:138–44.
  • Berger RP, Hayes RL, Richichi R, Beers SR, Wang KK. Serum concentrations of ubiquitin C-terminal hydrolase-L1 and αII-spectrin breakdown product 145 kDa correlate with outcome after pediatric TBI. J Neurotrauma 2011. [Epub ahead of print].
  • Pineda JA, Lewis SB, Valadka AB, et al. Clinical significance of alpha II-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury. J Neurotrauma 2007;24: 354–66.
  • Mondello S, Robicsek SA, Gabrielli A, et al. αII-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients. J Neurotrauma 2010;27:1203–13.
  • Groswasser Z, Cohen M, Keren O. Female TBI patients recover better than males. Brain Inj 1998;12:805–8.
  • Bayir H, Marion DW, Puccio AM, et al. Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients. J Neurotrauma 2004;21:1–8.
  • Yeung JH, Mikocka-Walus AA, Cameron PA, et al. Protection from traumatic brain injury in hormonally active women vs men of a similar age: a retrospective international study. Arch Surg 2011;146:436–42.
  • Schwarz Z, Guest PC, Rahmoune H, et al. Identification of a blood-based biological signature in subjects with psychiatric disorders prior to clinical manifestation. World J Biol Psychiatry 2011. [Epub ahead of print].
  • Berger RP, Adelson PD, Pierce MC, Dulani T, Cassidy LD, Kochanek PM. Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children. J Neurosurg 2005;103 (1 Suppl):61–8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.