The ageing population is neglected in research studies of traumatic brain injury

References

• Cornwell J. The care of frail older people with complex needs: time for a revolution. London: The King’s Fund; 2012.
   Google Scholar
• Conti M, Merlani P, Ricou B. Prognosis and quality of life of elderly patients after intensive care. Swiss Med Wkly 2012;142:w13671.
   PubMed Web of Science ®Google Scholar
• Angus DC, Barnato AE, Linde-Zwirble WT, et al. Use of intensive care at the end of life in the United States: an epidemiologic study. Crit Care Med 2004;32:638–43.
   PubMed Web of Science ®Google Scholar
• Appleby J. Spending on health and social care over the next 50 years: why think long term? London: The King’s Fund; 2013.
   Google Scholar
• Patel HC, Bouamra O, Woodford M, Yates DW, Lecky FE. Clinical article: mortality associated with severe head injury in the elderly. Acta Neurochir (Wien) 2010;152:1353–7 (discussion 1357).
   PubMed Web of Science ®Google Scholar
• Ross AM, Pitts LH, Kobayashi S. Prognosticators of outcome after major head injury in the elderly. J Neurosci Nurs 1992;24:88–93.
   PubMedGoogle Scholar
• Taylor MD, Tracy JK, Meyer W, Pasquale M, Napolitano LM. Trauma in the elderly: intensive care unit resource use and outcome. J Trauma 2002;53:407–14.
   PubMedGoogle Scholar
• Newcombe VF, Outtrim JG, Chatfield DA, et al. Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury. Brain 2011;134:759–68.
   PubMed Web of Science ®Google Scholar
• Patel HC, Menon DK, Tebbs S, Hawker R, Hutchinson PJ, Kirkpatrick PJ. Specialist neurocritical care and outcome from head injury. Intensive Care Med 2002;28:547–53.
   PubMed Web of Science ®Google Scholar
• Menon DK. Cerebral protection in severe brain injury: physiological determinants of outcome and their optimisation. Br Med Bull 1999;55:226–58.
   PubMed Web of Science ®Google Scholar
• Harrison DA, Prabhu G, Grieve R, et al. Risk Adjustment In Neurocritical care (RAIN) – prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study. Health Technol Assess 2013;17:vii–i.
   PubMed Web of Science ®Google Scholar
• Haynes RB, McKibbon KA, Wilczynski NL, Walter SD, Werre SR, Hedges Team. Optimal search strategies for retrieving scientifically strong studies of treatment from Medline: analytical survey. BMJ 2005;330:1179.
   PubMed Web of Science ®Google Scholar
• Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 2005;5:13.
   PubMedGoogle Scholar
• Bagshaw SM, Webb SA, Delaney A, et al. Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis. Crit Care 2009;13:R45.
   PubMed Web of Science ®Google Scholar
• Boumendil A, Guidet B. Elderly patients and intensive care medicine. Intensive Care Med 2006;32:965–7.
   PubMed Web of Science ®Google Scholar
• Pearson W, Sugerman DE, McGuire LC, Coronado VG. Emergency department visits for traumatic brain injury in older adults in the United States: 2006–08. West J Emerg Med 2012;13:289–93.
   PubMedGoogle Scholar
• Harrison DA, Parry GJ, Carpenter JR, Short A, Rowan K. A new risk prediction model for critical care: the Intensive Care National Audit & Research Centre (ICNARC) model. Crit Care Med 2007;35:1091–8.
   PubMed Web of Science ®Google Scholar
• Senaratne DN, Veenith T. Age influences the predictive value of Acute Physiology and Chronic Health Evaluation II and Intensive Care National Audit and Research Centre scoring models in patients admitted to Intensive Care Units after in-hospital cardiac arrest. Indian J Crit Care Med 2015;19:155–8.
   PubMedGoogle Scholar
• Hyam JA, Welch CA, Harrison DA, Menon DK. Case mix, outcomes and comparison of risk prediction models for admissions to adult, general and specialist critical care units for head injury: a secondary analysis of the ICNARC Case Mix Programme Database. Crit Care 2006;10:S2.
   PubMed Web of Science ®Google Scholar
• Hampshire PA, Welch CA, McCrossan LA, Francis K, Harrison DA. Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database. Crit Care 2009;13:R137.
   Web of Science ®Google Scholar
• Karnad DR, Lapsia V, Krishnan A, Salvi VS. Prognostic factors in obstetric patients admitted to an Indian intensive care unit. Crit Care Med 2004;32:1294–9.
   PubMed Web of Science ®Google Scholar
• Yap CH, Reid C, Yii M, et al. Validation of the EuroSCORE model in Australia. Eur J Cardiothorac Surg 2006;29:441–6 (discussion 446).
   PubMed Web of Science ®Google Scholar
• Lip GY, Skjøth F, Nielsen PB, Larsen TB. Non-valvular atrial fibrillation patients with none or one additional risk factor of the CHA2DS2-VASc score. A comprehensive net clinical benefit analysis for warfarin, aspirin, or no therapy. Thromb Haemost 2015;114:826–34.
   PubMed Web of Science ®Google Scholar
• Marcucci M, Nobili A, Tettamanti M, et al. Joint use of cardio-embolic and bleeding risk scores in elderly patients with atrial fibrillation. Eur J Intern Med 2013;24:800–6.
   PubMed Web of Science ®Google Scholar
• Batchelor JS, Grayson A. A meta-analysis to determine the effect of anticoagulation on mortality in patients with blunt head trauma. Br J Neurosurg 2012;26:525–30.
   PubMed Web of Science ®Google Scholar
• Batchelor JS, Grayson A. A meta-analysis to determine the effect of preinjury antiplatelet agents on mortality in patients with blunt head trauma. Br J Neurosurg 2013;27:12–18.
   PubMed Web of Science ®Google Scholar
• Yuh EL, Cooper SR, Mukherjee P, et al. Diffusion tensor imaging for outcome prediction in mild traumatic brain injury: a TRACK-TBI study. J Neurotrauma 2014;31:1457–77.
   PubMed Web of Science ®Google Scholar
• Lannoo E, Van Rietvelde F, Colardyn F, et al. Early predictors of mortality and morbidity after severe closed head injury. J Neurotrauma 2000;17:403–14.
   PubMed Web of Science ®Google Scholar
• Hong YT, Veenith T, Dewar D, et al. Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury. JAMA Neurol 2014;71:23–31.
   PubMed Web of Science ®Google Scholar
• Hesdorffer DC, Ghajar J. Marked improvement in adherence to traumatic brain injury guidelines in United States trauma centers. J Trauma 2007;63:841–7 (discussion 847).
   PubMedGoogle Scholar
• Timofeev I, Carpenter KL, Nortje J, et al. Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients. Brain 2011;134:484–94.
   PubMed Web of Science ®Google Scholar
• Griesdale DE, Örtenwall V, Norena M, et al. Adherence to guidelines for management of cerebral perfusion pressure and outcome in patients who have severe traumatic brain injury. J Crit Care 2015;30:111–15.
   PubMed Web of Science ®Google Scholar
• Allen BB, Chiu YL, Gerber LM, Ghajar J, Greenfield JP. Age-specific cerebral perfusion pressure thresholds and survival in children and adolescents with severe traumatic brain injury. Pediatr Crit Care Med 2014;15:62–70.
   PubMed Web of Science ®Google Scholar
• Andersen FH, Kvåle R. Do elderly intensive care unit patients receive less intensive care treatment and have higher mortality? Acta Anaesthesiol Scand 2012;56:1298–305.
   PubMed Web of Science ®Google Scholar
• Torres OH, Francia E, Longobardi V, Gich I, Benito S, Ruiz D. Short- and long-term outcomes of older patients in intermediate care units. Intensive Care Med 2006;32:1052–9.
   PubMed Web of Science ®Google Scholar
• de Rooij SE, Abu-Hanna A, Levi M, de Jonge E. Factors that predict outcome of intensive care treatment in very elderly patients: a review. Crit Care 2005;9:R307–14.
   PubMed Web of Science ®Google Scholar
• Bowling A. Ageism in cardiology. BMJ 1999;319:1353–5.
   PubMed Web of Science ®Google Scholar
• Gnavi R, Migliardi A, Demaria M, Petrelli A, Caprioglio A, Costa G. Statins prescribing for the secondary prevention of ischaemic heart disease in Torino, Italy. A case of ageism and social inequalities. Eur J Public Health 2007;17:492–6.
   PubMed Web of Science ®Google Scholar
• Witham MD, McMurdo ME. How to get older people included in clinical studies. Drugs Aging 2007;24:187–96.
   PubMed Web of Science ®Google Scholar