Amplification of the Epidermal Growth Factor Receptor Gene in Biopsy Specimens from Human Intracranial Tumours

References

• Green A R, Wyke J A. Anti-oncogenes. A subset of regulatory genes involved in carcinogenesis?. Lancet 1985; 2: 475–7
   PubMed Web of Science ®Google Scholar
• Mäkelä T P, Alitalo K. Proto-oncogene amplification: role in tumour progression. Annals Clin Res 1986; 18: 290–6
   PubMedGoogle Scholar
• Seeger R C, Brodeur G M, Sather H, Dalton A, Siegel S E, Wong K Y, Hammond D. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. New Eng J Med 1985; 313: 1111–6
   PubMed Web of Science ®Google Scholar
• Slamon D J, Clark G M, Wong S G, Levin W J, Ullrich A, McGuire W L. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177–82
   PubMed Web of Science ®Google Scholar
• Wong A J, Ruppert J M, Eggleston J, Hamilton S R, Baylin S B, Vogelstein B. Gene amplification of c-myc and N-myc in small cell carcinoma of the lung. Science 1986; 233: 461–4
   PubMed Web of Science ®Google Scholar
• Spurr N K, Solomon E, Jansson M, Sheer D, Goodfel-low P N, Bodmer W F, Vennstrom B. Chromosomal localisation of the human homologues to the oncogenes erbA and B. EMBO Journal 1984; 3: 159–63
   PubMedGoogle Scholar
• Gill G N, Bertics P J, Santon J B. Epidermal growth factor and its receptor. Mol Cell Endocrinol 1987; 51: 169–86
   PubMed Web of Science ®Google Scholar
• Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield M D. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 1984; 307: 521–7
   PubMed Web of Science ®Google Scholar
• Libermann T A, Razon N, Bartal A D, Yarden Y, Schlessinger J, Soreq H. Expression of epidermal growth factor receptors in human brain tumours. Cancer Research 1984; 44: 753–60
   PubMed Web of Science ®Google Scholar
• Filmus J, Trent J M, Pollak M N, Buick R N. Epidermal growth factor receptor gene-amplified MDA-468 breast cancer cell line and its nonamplified variants. Mol Cell Biol 1987; 7: 251–7
   PubMed Web of Science ®Google Scholar
• Wong A J, Bigner S H, Bigner D D, Kinzler K W, Hamilton S R, Vogelstein B. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA 1987; 84: 6899–903
   PubMed Web of Science ®Google Scholar
• Kamata N, Chida K, Rikimaru K, Horikoshi M, Enomoto S, Kuroki T. Growth-inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinomas in culture. Cancer Res 1986; 46: 1648–53
   PubMed Web of Science ®Google Scholar
• Veale D, Ashcroft T, Marsh C, Gibson G J, Harris A L. Epidermal growth factor receptors in non-small cell lung cancer. Br J Cancer 1987; 55: 513–6
   PubMed Web of Science ®Google Scholar
• Neal D E, Marsh C, Bennett M K, Abel P D, Hall R R, Sainsbury J RC, Harris A L. Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours. Lancet 1985; 1: 366–8
   PubMed Web of Science ®Google Scholar
• Sainsbury J RC, Farndon J R, Sherbet G V, Harris A L. Epidermal-growth-factor receptors and oestrogen receptors in human breast cancer. Lancet 1985; 1: 364–6
   PubMed Web of Science ®Google Scholar
• Libermann T A, Nusbaum H R, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield M D, Ullrich A, Schlessinger J. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 1985; 313: 144–7
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Ikawa S, Akiyama T, Semba K, Nomura N, Miyajima N, Saito T, Toyoshima K. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature 1986; 319: 230–4
   PubMed Web of Science ®Google Scholar
• Kadowaki T, Kasuga M, Tobe K, Takaku F, Nishida E, Sakai H, Koyasu S, Yahara I, Toyoshima K, Yamamoto T, Akiyama T. A Mr = 190,000 glycoprotein phosphorylated on tyrosine residues in epidermal growth factor stimulated KB cells is the product of the C-erbB-2 gene. Biochem Biophys Res Comm 1987; 144: 699–704
   PubMed Web of Science ®Google Scholar
• Neel B G, Jhanwar S C, Chaganti R SK, Hayward W S. Two human c-onc genes are located on the long arm of chromosome 8. Proc Natl Acad Sci USA 1982; 79: 7842–6
   PubMed Web of Science ®Google Scholar
• Ramsay G, Evan G I, Bishop J M. The protein encoded by the human proto-oncogene c-myc. Proc Natl Acad Sci USA 1984; 81: 7742–6
   PubMed Web of Science ®Google Scholar
• DePinho R, Mitsock L, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P, Kriz R, Alt F. Myc family of cellular ocogenes. J Cell Biochem 1987; 33: 257–66
   PubMed Web of Science ®Google Scholar
• Kelly K, Siebenlist U. The role of c-myc in the proliferation of normal and neoplastic cells. J Clin Immunol 1985; 5: 65–77
   PubMedGoogle Scholar
• Kahn P, Shin S-I. Cellular tumorigenicity in nude mice. Test of associations among loss of cell-surface fibronectin, anchorage independence, and tumor-forming ability. J Cell Biol 1979; 82: 1–16
   PubMed Web of Science ®Google Scholar
• Bøyum A. Isolation of lymphocytes, granulocytes and macrophages. Scand J Immunol 1976; 5(Suppl. 5)9–15
   PubMed Web of Science ®Google Scholar
• Xu Y-h, Ishii S, Clark A JL, Sullivan M, Wilson R K, Ma D P, Roe B A, Merlino G T, Pastan I. Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells. Nature 1984; 309: 806–10
   PubMed Web of Science ®Google Scholar
• Feinberg A P, Vogelstein B. A technique for radiolabel-ing DNA restriction endonuclease fragments to high specific activity. Analyt Biochem 1983; 132: 6–13
   PubMed Web of Science ®Google Scholar
• Southern E M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 1975; 98: 503–17
   PubMed Web of Science ®Google Scholar
• Unsgaard G, Larsen B, Dalen A, Vik R, Ringkjøb R. A new technique to register proliferation of clonogenic cells from brain tumors. J Neuro-Oncology 1985; 3: 203–9
   PubMed Web of Science ®Google Scholar
• Unsgaard G, Helseth E, Vik R, Dalen A. An isotope agarose assay for rapid testing of the sentitivity of glioma biopsies to chemotherapeutic drugs and biological response modifiers. Effects of BCNU, vincristine, lymphokines and the recombinant agents interferon alpha2C, interferon gamma and tumor necrosis factor. Acta Neurochir 1988, in press
   PubMed Web of Science ®Google Scholar
• Ullrich A, Coussens L, Hayflick J S, Dull T J, Gray A, Tarn A W, Lee J, Yarden Y, Libermann T A, Schles-singer J, Downward J, Mayes E LV, Whittle N, Waterfield M D, Seeburg P H. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 1984; 309: 418–25
   PubMed Web of Science ®Google Scholar
• Nowell P, Finan J, Favera R D, Gallo R C, ar-Rushdi A, Romanczuk H, Selden J R, Emanuel B S, Rovera G, Croce C M. Association of amplified oncogene c-myc with an abnormally banded chromosome 8 in a human leukaemia cell line. Nature 1983; 306: 494–7
   PubMed Web of Science ®Google Scholar
• Egan S E, Wright J A, Jarolim L, Yanagihara K, Bassin R H, Greenberg A H. Transformation by oncogenes encoding protein kinases induces the metastatic pheno-type. Science 1987; 238: 202–5
   PubMed Web of Science ®Google Scholar
• Santon J B, Cronin M T, MacLeod C L, Mendelsohn J, Masui H, Gill G N. Effects of epidermal growth factor receptor concentration of rumorigenicity of A431 cells in nude mice. Cancer Research 1986; 46: 4701–5
   PubMed Web of Science ®Google Scholar