Randomized controlled trials in adult traumatic brain injury

References

• Faul M, Xu L, Wald MM, Coronado VG. Traumatic brain injury in the United States: Emergency department visits, hospitalizations and deaths 2002–2006. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, Atlanta, GA 2010
   Google Scholar
• Coronado VG, Xu L, Basavaraju SV, McGuire LC, Wald MM, Faul MD, Guzman BR, Hemphill JD, Centers for Disease Control and Prevention (CDC). Surveillance for traumatic brain injury-related deaths–united states, 1997–2007. MMWR Surveillance Summaries 2011; 60: 1–32
   PubMedGoogle Scholar
• Thurman D. The epidemiology and economics of head trauma. Head trauma: Basic, preclinical: Clinical directions, L Miller, R Ayes. John Wiley and Sons, New York 2001; 327–347
   Google Scholar
• Finkelstein EA, Corso PS, Miller TR, editors. The incidence and economic burden of injuries in the United States. Oxford University Press, New York 2006; 97–122
   Google Scholar
• Thornhill S, Teasdale GM, Murray GD, McEwen J, Roy CW, Penny KI. Disability in young people and adults one year after head injury: Prospective cohort study. British Medical Journal 2000; 320: 1631–1635
   PubMed Web of Science ®Google Scholar
• Maas AI, Roozenbeek B, Manley GT. Clinical trials in traumatic brain injury: Past experience and current developments. Neurotherapeutics 2010; 7: 115–126
   PubMed Web of Science ®Google Scholar
• Gordon WA, Zafonte R, Cicerone K, Cantor J, Brown M, Lombard L, Goldsmith R, Chandna T. Traumatic brain injury rehabilitation: State of the science. American Journal of Physical Medicine and Rehabilitation 2006; 85: 343–382
   PubMed Web of Science ®Google Scholar
• Cernich AN, Kurtz SM, Mordecai KL, Ryan PB. Cognitive rehabilitation in traumatic brain injury. Current Treatment Options in Neurology 2010; 12: 412–423
   PubMed Web of Science ®Google Scholar
• Yurkewicz L, Weaver J, Bullock MR, Marshall LF. The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury. Journal of Neurotrauma 2005; 22: 1428–1443
   PubMed Web of Science ®Google Scholar
• Morris GF, Bullock R, Marshall SB, Marmarou A, Maas A, Marshall LF. Failure of the competitive N-methyl-D-aspartate antagonist selfotel (CGS 19755) in the treatment of severe head injury: Results of two phase III clinical trials. The Selfotel Investigators. Journal of Neurosurgery 1999; 91: 737–743
   PubMed Web of Science ®Google Scholar
• Coester A, Neumann CR, Schmidt MI. Intensive insulin therapy in severe traumatic brain injury: A randomized trial. Journal of Trauma 2010; 68: 904–911
   PubMedGoogle Scholar
• Yang M, Guo Q, Zhang X, Sun S, Wang Y, Zhao L, Hu E, Li C. Intensive insulin therapy on infection rate, days in NICU, in-hospital mortality and neurological outcome in severe traumatic brain injury patients: A randomized controlled trial. International Journal of Nursing Studies 2009; 46: 753–758
   PubMedGoogle Scholar
• Bilotta F, Caramia R, Cernak I, Paoloni FP, Doronzio A, Cuzzone V, Santoro A, Rosa G. Intensive insulin therapy after severe traumatic brain injury: A randomized clinical trial. Neurocritical Care 2008; 9: 159–166
   PubMed Web of Science ®Google Scholar
• Temkin NR, Anderson GD, Winn HR, Ellenbogen RG, Britz GW, Schuster J, Lucas T, Newell DW, Mansfield PN, Machamer JE, et al. Magnesium sulfate for neuroprotection after traumatic brain injury: A randomised controlled trial. Lancet Neurology 2007; 6: 29–38
   PubMed Web of Science ®Google Scholar
• Maas AI, Murray G, Henney H, 3rd, Kassem N, Legrand V, Mangelus M, Muizelaar JP, Stocchetti N, Knoller N, Pharmos TBI investigators. Efficacy and safety of dexanabinol in severe traumatic brain injury: Results of a phase III randomised, placebo-controlled, clinical trial. Lancet Neurology 2006; 5: 38–45
   PubMed Web of Science ®Google Scholar
• Wright DW, Kellermann AL, Hertzberg VS, Clark PL, Frankel M, Goldstein FC, Salomone JP, Dent LL, Harris OA, Ander DS, et al. ProTECT: A randomized clinical trial of progesterone for acute traumatic brain injury. Annals of Emergency Medicine 2007; 49: 391, 402, 402.e1-2
   PubMed Web of Science ®Google Scholar
• Xiao G, Wei J, Yan W, Wang W, Lu Z. Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: A randomized controlled trial. Critical Care 2008; 12: R61
   PubMed Web of Science ®Google Scholar
• Moein H, Khalili HA, Keramatian K. Effect of methylphenidate on ICU and hospital length of stay in patients with severe and moderate traumatic brain injury. Clinical Neurology & Neurosurgery 2006; 108: 539–542
   PubMed Web of Science ®Google Scholar
• Harders A, Kakarieka A, Braakman R. Traumatic subarachnoid hemorrhage and its treatment with nimodipine. German tSAH study group. Journal of Neurosurgery 1996; 85: 82–89
   PubMed Web of Science ®Google Scholar
• The European study group on nimodipine in severe head injury. A multicenter trial of the efficacy of nimodipine on outcome after severe head injury. Journal of Neurosurgery 1994; 80: 797–804
   PubMed Web of Science ®Google Scholar
• Bailey I, Bell A, Gray J, Gullan R, Heiskanan O, Marks PV, Marsh H, Mendelow DA, Murray G, Ohman J. A trial of the effect of nimodipine on outcome after head injury. Acta Neurochirurgica (Wien) 1991; 110: 97–105
   PubMed Web of Science ®Google Scholar
• Grumme T, Baethmann A, Kolodziejczyk D, Krimmer J, Fischer M, von Eisenhart Rothe B, Pelka R, Bennefeld H, Pollauer E, Kostron H. Treatment of patients with severe head injury by triamcinolone: A prospective, controlled multicenter clinical trial of 396 cases. Research in Experimental Medicine (Berlin) 1995; 195: 217–229
   PubMedGoogle Scholar
• Gaab MR, Trost HA, Alcantara A, Karimi-Nejad A, Moskopp D, Schultheiss R, Bock WJ, Piek J, Klinge H, Scheil F. “Ultrahigh” dexamethasone in acute brain injury. Results from a prospective randomized double-blind multicenter trial (GUDHIS). German ultrahigh dexamethasone head injury study group. Zentralblatt fur Neurochirurgica 1994; 55: 135–143
   PubMedGoogle Scholar
• Dearden NM, Gibson JS, McDowall DG, Gibson RM, Cameron MM. Effect of high-dose dexamethasone on outcome from severe head injury. Journal of Neurosurgery 1986; 64: 81–88
   PubMed Web of Science ®Google Scholar
• Braakman R, Schouten HJ, Blaauw-van Dishoeck M, Minderhoud JM. Megadose steroids in severe head injury. Results of a prospective double-blind clinical trial. Journal of Neurosurgery 1983; 58: 326–330
   PubMed Web of Science ®Google Scholar
• Saul TG, Ducker TB, Salcman M, Carro E. Steroids in severe head injury: A prospective randomized clinical trial. Journal of Neurosurgery 1981; 54: 596–600
   PubMed Web of Science ®Google Scholar
• Edwards P, Arango M, Balica L, Cottingham R, El-Sayed H, Farrell B, Fernandes J, Gogichaisvili T, Golden N, Hartzenberg B, et al. Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. Lancet 2005; 365: 1957–1959
   PubMed Web of Science ®Google Scholar
• Marshall LF, Maas AI, Marshall SB, Bricolo A, Fearnside M, Iannotti F, Klauber MR, Lagarrigue J, Lobato R, Persson L, et al. A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury. Journal of Neurosurgery 1998; 89: 519–525
   PubMed Web of Science ®Google Scholar
• Young B, Runge JW, Waxman KS, Harrington T, Wilberger J, Muizelaar JP, Boddy A, Kupiec JW. Effects of pegorgotein on neurologic outcome of patients with severe head injury. A multicenter, randomized controlled trial. Journal of the American Medical Assocation 1996; 276: 538–543
   PubMed Web of Science ®Google Scholar
• Marmarou A, Nichols J, Burgess J, Newell D, Troha J, Burnham D, Pitts L. Effects of the bradykinin antagonist bradycor (deltibant, CP-1027) in severe traumatic brain injury: Results of a multi-center, randomized, placebo-controlled trial. American brain injury consortium study group. Journal of Neurotrauma 1999; 16: 431–444
   PubMed Web of Science ®Google Scholar
• Ward JD, Becker DP, Miller JD, Choi SC, Marmarou A, Wood C, Newlon PG, Keenan R. Failure of prophylactic barbiturate coma in the treatment of severe head injury. Journal of Neurosurgery 1985; 62: 383–388
   PubMed Web of Science ®Google Scholar
• Eisenberg HM, Frankowski RF, Contant CF, Marshall LF, Walker MD. High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury. Journal of Neurosurgery 1988; 69: 15–23
   PubMed Web of Science ®Google Scholar
• Chen L, Zeng F, Yang L, Chai J, Li K, Lu M, Kuang Y. Curative effect of wilsonii injecta on severe head injury. Chinese Journal of Traumatology 2002; 5: 82–85
   PubMedGoogle Scholar
• Jiang JY, Xu W, Li WP, Xu WH, Zhang J, Bao YH, Ying YH, Luo QZ. Efficacy of standard trauma craniectomy for refractory intracranial hypertension with severe traumatic brain injury: A multicenter, prospective, randomized controlled study. Journal of Neurotrauma 2005; 22: 623–628
   PubMed Web of Science ®Google Scholar
• Lu LQ, Jiang JY, Yu MK, Hou LJ, Chen ZG, Zhang GJ, Zhu C. Standard large trauma craniotomy for severe traumatic brain injury. Chinese Journal of Traumatology 2003; 6: 302–304
   PubMedGoogle Scholar
• Cooper DJ, Rosenfeld JV, Murray L, Arabi YM, Davies AR, D'Urso P, Kossmann T, Ponsford J, Seppelt I, Reilly P, et al. Decompressive craniectomy in diffuse traumatic brain injury. New England Journal of Medicine 2011; 364: 1493–1502
   PubMed Web of Science ®Google Scholar
• Young B, Ott L, Kasarskis E, Rapp R, Moles K, Dempsey RJ, Tibbs PA, Kryscio R, McClain C. Zinc supplementation is associated with improved neurologic recovery rate and visceral protein levels of patients with severe closed head injury. Journal of Neurotrauma 1996; 13: 25–34
   PubMed Web of Science ®Google Scholar
• Young B, Ott L, Haack D, Twyman D, Combs D, Oexmann JB, Tibbs P, Dempsey R. Effect of total parenteral nutrition upon intracranial pressure in severe head injury. Journal of Neurosurgery 1987; 67: 76–80
   PubMedGoogle Scholar
• Artru F, Chacornac R, Deleuze R. Hyperbaric oxygenation for severe head injuries. preliminary results of a controlled study. European Neurology 1976; 14: 310–318
   PubMed Web of Science ®Google Scholar
• Rockswold GL, Ford SE, Anderson DC, Bergman TA, Sherman RE. Results of a prospective randomized trial for treatment of severely brain-injured patients with hyperbaric oxygen. Journal of Neurosurgery 1992; 76: 929–934
   PubMed Web of Science ®Google Scholar
• Muizelaar JP, Marmarou A, Ward JD, Kontos HA, Choi SC, Becker DP, Gruemer H, Young HF. Adverse effects of prolonged hyperventilation in patients with severe head injury: A randomized clinical trial. Journal of Neurosurgery 1991; 75: 731–739
   PubMed Web of Science ®Google Scholar
• Bulger EM, May S, Brasel KJ, Schreiber M, Kerby JD, Tisherman SA, Newgard C, Slutsky A, Coimbra R, Emerson S, et al. Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: A randomized controlled trial. Journal of the American Medical Association 2010; 304: 1455–1464
   PubMed Web of Science ®Google Scholar
• Cooper DJ, Myles PS, McDermott FT, Murray LJ, Laidlaw J, Cooper G, Tremayne AB, Bernard SS, Ponsford J, Study Investigators HTS. Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: A randomized controlled trial. Journal of the American Medical Association 2004; 291: 1350–1357
   PubMed Web of Science ®Google Scholar
• Cruz J, Minoja G, Okuchi K. Major clinical and physiological benefits of early high doses of mannitol for intraparenchymal temporal lobe hemorrhages with abnormal pupillary widening: A randomized trial. Neurosurgery 2002; 51: 628, 37; discussion 637–638
   PubMed Web of Science ®Google Scholar
• Cruz J, Minoja G, Okuchi K. Improving clinical outcomes from acute subdural hematomas with the emergency preoperative administration of high doses of mannitol: A randomized trial. Neurosurgery 2001; 49: 864–871
   PubMed Web of Science ®Google Scholar
• Smith HP, Kelly DL, Jr, McWhorter JM, Armstrong D, Johnson R, Transou C, Howard G. Comparison of mannitol regimens in patients with severe head injury undergoing intracranial monitoring. Journal of Neurosurgery 1986; 65: 820–824
   PubMed Web of Science ®Google Scholar
• Qiu W, Zhang Y, Sheng H, Zhang J, Wang W, Liu W, Chen K, Zhou J, Xu Z. Effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy. Journal of Critical Care 2007; 22: 229–235
   PubMed Web of Science ®Google Scholar
• Qiu WS, Liu WG, Shen H, Wang WM, Hang ZL, Zhang Y, Jiang SJ, Yang XF. Therapeutic effect of mild hypothermia on severe traumatic head injury. Chinese Journal of Traumatology 2005; 8: 27–32
   PubMedGoogle Scholar
• Zhi D, Zhang S, Lin X. Study on therapeutic mechanism and clinical effect of mild hypothermia in patients with severe head injury. Surgical Neurology 2003; 59: 381–385
   PubMedGoogle Scholar
• Jiang JY, Xu W, Li WP, Gao GY, Bao YH, Liang YM, Luo QZ. Effect of long-term mild hypothermia or short-term mild hypothermia on outcome of patients with severe traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism 2006; 26: 771–776
   PubMed Web of Science ®Google Scholar
• Clifton GL, Miller ER, Choi SC, Levin HS, McCauley S, Smith KR, Jr, Muizelaar JP, Marion DW, Luerssen TG. Hypothermia on admission in patients with severe brain injury. Journal of Neurotrauma 2002; 19: 293–301
   PubMed Web of Science ®Google Scholar
• Harris OA, Muh CR, Surles MC, Pan Y, Rozycki G, Macleod J, Easley K. Discrete cerebral hypothermia in the management of traumatic brain injury: A randomized controlled trial. Journal of Neurosurgery 2009; 110: 1256–1264
   PubMed Web of Science ®Google Scholar
• Marion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM, Palmer AM, Wisniewski SR, DeKosky ST. Treatment of traumatic brain injury with moderate hypothermia. New England Journal of Medicine 1997; 3368: 540–546
   Google Scholar
• Clifton GL, Valadka A, Zygun D, Coffey CS, Drever P, Fourwinds S, Janis LS, Wilde E, Taylor P, Harshman K, et al. Very early hypothermia induction in patients with severe brain injury (the national acute brain injury study: Hypothermia II): A randomised trial. Lancet Neurology 2011; 10: 131–139
   PubMed Web of Science ®Google Scholar
• Shiozaki T, Hayakata T, Taneda M, Nakajima Y, Hashiguchi N, Fujimi S, Nakamori Y, Tanaka H, Shimazu T, Sugimoto H. A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. Mild hypothermia study group in japan. Journal of Neurosurgery 2001; 94: 50–54
   PubMed Web of Science ®Google Scholar
• Bernard SA, Nguyen V, Cameron P, Masci K, Fitzgerald M, Cooper DJ, Walker T, Std BP, Myles P, Murray L, et al. Prehospital rapid sequence intubation improves functional outcome for patients with severe traumatic brain injury: A randomized controlled trial. Annals of Surgery 2010; 252: 959–965
   PubMed Web of Science ®Google Scholar
• Elgmark Andersson EE, Emanuelson I, Bjorklund R, Stalhammar DA. Mild traumatic brain injuries: The impact of early intervention on late sequelae. A randomized controlled trial. Acta Neurochirurgica (Wien) 2007; 149: 151, 9; discussion 160
   PubMed Web of Science ®Google Scholar
• Constantinidou F, Thomas RD, Robinson L. Benefits of categorization training in patients with traumatic brain injury during post-acute rehabilitation: Additional evidence from a randomized controlled trial. Journal of Head Trauma Rehabilitation 2008; 23: 312–328
   PubMed Web of Science ®Google Scholar
• Vanderploeg RD, Schwab K, Walker WC, Fraser JA, Sigford BJ, Date ES, Scott SG, Curtiss G, Salazar AM, Warden DL, et al. Rehabilitation of traumatic brain injury in active duty military personnel and veterans: Defense and veterans brain injury center randomized controlled trial of two rehabilitation approaches. Archives of Physical Medicine and Rehabilitation 2008; 89: 2227–2238
   PubMed Web of Science ®Google Scholar
• Zhu XL, Poon WS, Chan CC, Chan SS. Does intensive rehabilitation improve the functional outcome of patients with traumatic brain injury (TBI)? A randomized controlled trial. Brain Injury 2007; 21: 681–690
   PubMed Web of Science ®Google Scholar
• Powell J, Heslin J, Greenwood R. Community based rehabilitation after severe traumatic brain injury: A randomised controlled trial. Journal of Neurology, Neurosurgery & Psychiatry 2002; 72: 193–202
   PubMed Web of Science ®Google Scholar
• Shiel A, Burn JP, Henry D, Clark J, Wilson BA, Burnett ME, McLellan DL. The effects of increased rehabilitation therapy after brain injury: Results of a prospective controlled trial. Clinical Rehabilitation 2001; 15: 501–514
   PubMed Web of Science ®Google Scholar
• Salazar AM, Warden DL, Schwab K, Spector J, Braverman S, Walter J, Cole R, Rosner MM, Martin EM, Ecklund J, et al. Cognitive rehabilitation for traumatic brain injury: A randomized trial. Defense and veterans head injury program (DVHIP) study group. Journal of the American Medical Association 2000; 283: 3075–3081
   PubMed Web of Science ®Google Scholar
• Bombardier CH, Bell KR, Temkin NR, Fann JR, Hoffman J, Dikmen S. The efficacy of a scheduled telephone intervention for ameliorating depressive symptoms during the first year after traumatic brain injury. Journal of Head Trauma Rehabilitation 2009; 24: 230–238
   PubMed Web of Science ®Google Scholar
• Cicerone KD, Mott T, Azulay J, Sharlow-Galella MA, Ellmo WJ, Paradise S, Friel JC. A randomized controlled trial of holistic neuropsychologic rehabilitation after traumatic brain injury. Archives of Physical Medicine and Rehabilitation 2008; 89: 2239–2249
   PubMed Web of Science ®Google Scholar
• Ruff RM, Niemann H. Cognitive rehabilitation versus day treatment in head-injured adults: Is there an impact on emotional and psychosocial adjustment?. Brain Injury 1990; 4: 339–347
   PubMedGoogle Scholar
• Levine B, Robertson IH, Clare L, Carter G, Hong J, Wilson BA, Duncan J, Stuss DT. Rehabilitation of executive functioning: An experimental-clinical validation of goal management training. Journal of the International Neuropsychological Society 2000; 6: 299–312
   PubMed Web of Science ®Google Scholar
• Dahlberg CA, Cusick CP, Hawley LA, Newman JK, Morey CE, Harrison-Felix CL, Whiteneck GG. Treatment efficacy of social communication skills training after traumatic brain injury: A randomized treatment and deferred treatment controlled trial. Archives of Physical Medicine and Rehabilitation 2007; 88: 1561–1573
   PubMed Web of Science ®Google Scholar
• Shum D, Fleming J, Gill H, Gullo MJ, Strong J. A randomized controlled trial of prospective memory rehabilitation in adults with traumatic brain injury. Journal of Rehabilitation Medicine 2011; 43: 216–223
   PubMed Web of Science ®Google Scholar
• Wilson BA, Emslie H, Quirk K, Evans J, Watson P. A randomized control trial to evaluate a paging system for people with traumatic brain injury. Brain Injury 2005; 19: 891–894
   PubMed Web of Science ®Google Scholar
• Dirette DK, Hinojosa J, Carnevale GJ. Comparison of remedial and compensatory interventions for adults with acquired brain injuries. Journal of Head Trauma Rehabilitation 1999; 14: 595–601
   PubMed Web of Science ®Google Scholar
• Niemann H, Ruff RM, Baser CA. Computer-assisted attention retraining in head-injured individuals: A controlled efficacy study of an outpatient program. Journal of Consulting and Clinical Psychology 1990; 58: 811–817
   PubMed Web of Science ®Google Scholar
• Paniak C, Toller-Lobe G, Durand A, Nagy J. A randomized trial of two treatments for mild traumatic brain injury. Brain Injury 1998; 12: 1011–1023
   PubMed Web of Science ®Google Scholar
• Paniak C, Toller-Lobe G, Reynolds S, Melnyk A, Nagy J. A randomized trial of two treatments for mild traumatic brain injury: 1 year follow-up. Brain Injury 2000; 14: 219–226
   PubMed Web of Science ®Google Scholar
• Wade DT, Crawford S, Wenden FJ, King NS, Moss NE. Does routine follow up after head injury help? A randomised controlled trial. Journal of Neurology, Neurosurgery & Psychiatry 1997; 62: 478–484
   PubMed Web of Science ®Google Scholar
• Bell KR, Hoffman JM, Temkin NR, Powell JM, Fraser RT, Esselman PC, Barber JK, Dikmen S. The effect of telephone counselling on reducing post-traumatic symptoms after mild traumatic brain injury: A randomised trial. Journal of Neurology, Neurosurgery & Psychiatry 2008; 79: 1275–1281
   PubMed Web of Science ®Google Scholar
• Wade DT, King NS, Wenden FJ, Crawford S, Caldwell FE. Routine follow up after head injury: A second randomised controlled trial. Journal of Neurology, Neurosurgery & Psychiatry 1998; 65: 177–183
   PubMed Web of Science ®Google Scholar
• Bell KR, Temkin NR, Esselman PC, Doctor JN, Bombardier CH, Fraser RT, Hoffman JM, Powell JM, Dikmen S. The effect of a scheduled telephone intervention on outcome after moderate to severe traumatic brain injury: A randomized trial. Archives of Physical Medicine and Rehabilitation 2005; 86: 851–856
   PubMed Web of Science ®Google Scholar
• Tiersky LA, Anselmi V, Johnston MV, Kurtyka J, Roosen E, Schwartz T, Deluca J. A trial of neuropsychologic rehabilitation in mild-spectrum traumatic brain injury. Archives of Physical Medicine and Rehabilitation 2005; 86: 1565–1574
   PubMed Web of Science ®Google Scholar
• McDonald S, Tate R, Togher L, Bornhofen C, Long E, Gertler P, Bowen R. Social skills treatment for people with severe, chronic acquired brain injuries: A multicenter trial. Archives of Physical Medicine and Rehabilitation 2008; 89: 1648–1659
   PubMed Web of Science ®Google Scholar
• Carnevale GJ, Anselmi V, Johnston MV, Busichio K, Walsh V. A natural setting behavior management program for persons with acquired brain injury: A randomized controlled trial. Archives of Physical Medicine and Rehabilitation 2006; 87: 1289–1297
   PubMed Web of Science ®Google Scholar
• Hoffman JM, Bell KR, Powell JM, Behr J, Dunn EC, Dikmen S, Bombardier CH. A randomized controlled trial of exercise to improve mood after traumatic brain injury. PM & R 2010; 2: 911–919
   PubMedGoogle Scholar
• Wilson DJ, Powell M, Gorham JL, Childers MK. Ambulation training with and without partial weight bearing after traumatic brain injury: Results of a randomized, controlled trial. American Journal of Physical Medicine and Rehabilitation 2006; 85: 68–74
   PubMed Web of Science ®Google Scholar
• Brown TH, Mount J, Rouland BL, Kautz KA, Barnes RM, Kim J. Body weight-supported treadmill training versus conventional gait training for people with chronic traumatic brain injury. Journal of Head Trauma Rehabilitation 2005; 20: 402–415
   PubMed Web of Science ®Google Scholar
• Bateman A, Culpan FJ, Pickering AD, Powell JH, Scott OM, Greenwood RJ. The effect of aerobic training on rehabilitation outcomes after recent severe brain injury: A randomized controlled evaluation. Archives of Physical Medicine and Rehabilitation 2001; 82: 174–182
   PubMed Web of Science ®Google Scholar
• de Kruijk JR, Leffers P, Meerhoff S, Rutten J, Twijnstra A. Effectiveness of bed rest after mild traumatic brain injury: A randomised trial of no versus six days of bed rest. Journal of Neurology, Neurosurgery & Psychiatry 2002; 73: 167–172
   PubMed Web of Science ®Google Scholar
• Hassett LM, Moseley AM, Tate RL, Harmer AR, Fairbairn TJ, Leung J. Efficacy of a fitness centre-based exercise programme compared with a home-based exercise programme in traumatic brain injury: A randomized controlled trial. Journal of Rehabilitation Medicine 2009; 41: 247–255
   PubMed Web of Science ®Google Scholar
• Neistadt ME. The effects of different treatment activities on functional fine motor coordination in adults with brain injury. American Journal of Occupational Therapy 1994; 48: 877–882
   PubMed Web of Science ®Google Scholar
• Croce R, Horvat M, Roswal G. Augmented feedback for enhanced skill acquisition in individuals with traumatic brain injury. Perceptual and Motor Skills 1996; 82: 507–514
   PubMed Web of Science ®Google Scholar
• Banos JH, Novack TA, Brunner R, Renfroe S, Lin HY, Meythaler J. Impact of early administration of sertraline on cognitive and behavioral recovery in the first year after moderate to severe traumatic brain injury. Journal of Head Trauma Rehabilitation 2010; 25: 357–361
   PubMed Web of Science ®Google Scholar
• Novack TA, Banos JH, Brunner R, Renfroe S, Meythaler JM. Impact of early administration of sertraline on depressive symptoms in the first year after traumatic brain injury. Journal of Neurotrauma 2009; 26: 1921–1928
   PubMed Web of Science ®Google Scholar
• Jha A, Weintraub A, Allshouse A, Morey C, Cusick C, Kittelson J, Harrison-Felix C, Whiteneck G, Gerber D. A randomized trial of modafinil for the treatment of fatigue and excessive daytime sleepiness in individuals with chronic traumatic brain injury. Journal of Head Trauma Rehabilitation 2008; 23: 52–63
   PubMed Web of Science ®Google Scholar
• Whyte J, Hart T, Vaccaro M, Grieb-Neff P, Risser A, Polansky M, Coslett HB. Effects of methylphenidate on attention deficits after traumatic brain injury: A multidimensional, randomized, controlled trial. American Journal of Physical Medicine and Rehabilitation 2004; 83: 401–420
   PubMed Web of Science ®Google Scholar
• Smith Jr KR, Goulding PM, Wilderman D, Goldfader PR, Holterman-Hommes P, Wei F. Neurobehavioral effects of phenytoin and carbamazepine in patients recovering from brain trauma: A comparative study. Archives of Neurology 1994; 51: 653–660
   PubMedGoogle Scholar
• Rapoport MJ, Mitchell RA, McCullagh S, Herrmann N, Chan F, Kiss A, Feinstein A, Lanctot KL. A randomized controlled trial of antidepressant continuation for major depression following traumatic brain injury. Journal of Clinical Psychiatry 2010; 71: 1125–1130
   PubMed Web of Science ®Google Scholar
• Tenovuo O, Alin J, Helenius H. A randomized controlled trial of rivastigmine for chronic sequels of traumatic brain injury-what it showed and taught?. Brain Injury 2009; 23: 548–558
   PubMed Web of Science ®Google Scholar
• Willmott C, Ponsford J. Efficacy of methylphenidate in the rehabilitation of attention following traumatic brain injury: A randomised, crossover, double blind, placebo controlled inpatient trial. Journal of Neurology, Neurosurgery & Psychiatry 2009; 80: 552–557
   PubMed Web of Science ®Google Scholar
• Lee H, Kim SW, Kim JM, Shin IS, Yang SJ, Yoon JS. Comparing effects of methylphenidate, sertraline and placebo on neuropsychiatric sequelae in patients with traumatic brain injury. Human Psychopharmacology 2005; 20: 97–104
   PubMed Web of Science ®Google Scholar
• Kitamura K. Therapeutic effect of pyritinol on sequelae of head injuries. Journal of International Medical Research 1981; 9: 215–221
   PubMedGoogle Scholar
• Calatayud Maldonado V, Calatayud Perez JB, Aso Escario J. Effects of CDP-choline on the recovery of patients with head injury. Journal of the Neurological Sciences 1991; 103(Suppl)S15–18
   Google Scholar
• Aquilani R, Iadarola P, Contardi A, Boselli M, Verri M, Pastoris O, Boschi F, Arcidiaco P, Viglio S. Branched-chain amino acids enhance the cognitive recovery of patients with severe traumatic brain injury. Archives of Physical Medicine and Rehabilitation 2005; 86: 1729–1735
   PubMedGoogle Scholar
• McFadden KL, Healy KM, Dettmann ML, Kaye JT, Ito TA, Hernandez TD. Acupressure as a non-pharmacological intervention for traumatic brain injury (TBI). Journal of Neurotrauma 2011; 28: 21–34
   PubMed Web of Science ®Google Scholar
• Wright DW, Ritchie JC, Mullins RE, Kellermann AL, Denson DD. Steady-state serum concentrations of progesterone following continuous intravenous infusion in patients with acute moderate to severe traumatic brain injury. Journal of Clinical Pharmacology 2005; 45: 640–648
   PubMed Web of Science ®Google Scholar
• Ott LG, Schmidt JJ, Young AB, Twyman DL, Rapp RP, Tibbs PA, Dempsey RJ, McClain CJ. Comparison of administration of two standard intravenous amino acid formulas to severely brain-injured patients. Drug Intelligence & Clinical Pharmacy 1988; 22: 763–768
   PubMedGoogle Scholar
• Faden AI. Neuroprotection and traumatic brain injury: Theoretical option or realistic proposition. Current Opinions in Neurology 2002; 15: 707–712
   PubMed Web of Science ®Google Scholar
• Narayan RK, Michel ME, Ansell B, Baethmann A, Biegon A, Bracken MB, Bullock MR, Choi SC, Clifton GL, Contant CF, et al. Clinical trials in head injury. Journal of Neurotrauma 2002; 19: 503–557
   PubMed Web of Science ®Google Scholar
• Doppenberg EM, Choi SC, Bullock R. Clinical trials in traumatic brain injury: Lessons for the future. Journal of Neurosurgical Anesthesiology 2004; 16: 87–94
   PubMed Web of Science ®Google Scholar
• Povlishock JT, Katz DI. Update of neuropathology and neurological recovery after traumatic brain injury. Journal of Head Trauma Rehabilitation 2005; 20: 76–94
   PubMed Web of Science ®Google Scholar
• Margulies S, Hicks R, Combination Therapies for Traumatic Brain Injury Workshop Leaders. Combination therapies for traumatic brain injury: Prospective considerations. Journal of Neurotrauma 2009; 26: 925–939
   PubMed Web of Science ®Google Scholar
• Maas AI, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurology 2008; 7: 728–741
   PubMed Web of Science ®Google Scholar
• Povlishock JT. The future of combinational therapy in the treatment of traumatic brain injury. Journal of Neurotrauma 2009; 26: 923
   PubMedGoogle Scholar
• Thurmond VA, Hicks R, Gleason T, Miller AC, Szuflita N, Orman J, Schwab K. Advancing integrated research in psychological health and traumatic brain injury: Common data elements. Archives of Physical Medicine and Rehabilitation 2010; 91: 1633–1636
   PubMed Web of Science ®Google Scholar
• Maas AI, Marmarou A, Murray GD, Teasdale SG, Steyerberg EW. Prognosis and clinical trial design in traumatic brain injury: The IMPACT study. Journal of Neurotrauma 2007; 24: 232–238
   PubMed Web of Science ®Google Scholar
• Mushkudiani NA, Engel DC, Steyerberg EW, Butcher I, Lu J, Marmarou A, Slieker F, McHugh GS, Murray GD, Maas AI. Prognostic value of demographic characteristics in traumatic brain injury: Results from the IMPACT study. Journal of Neurotrauma 2007; 24: 259–269
   PubMed Web of Science ®Google Scholar
• Staudenmayer KL, Diaz-Arrastia R, de Oliveira A, Gentilello LM, Shafi S. Ethnic disparities in long-term functional outcomes after traumatic brain injury. Journal of Trauma 2007; 63: 1364–1369
   PubMed Web of Science ®Google Scholar
• Arango-Lasprilla JC, Kreutzer JS. Racial and ethnic disparities in functional, psychosocial, and neurobehavioral outcomes after brain injury. Journal of Head Trauma Rehabilitation 2010; 25: 128–136
   PubMed Web of Science ®Google Scholar
• Consensus conference. Rehabilitation of persons with traumatic brain injury. NIH consensus development panel on rehabilitation of persons with traumatic brain injury. Journal of the American Medical Association 1999; 282: 974–983
   PubMedGoogle Scholar
• Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, Pitkin R, Rennie D, Schulz KF, Simel D, Stroup DF. Improving the quality of reporting of randomized controlled trials. The CONSORT Statement. Journal of the American Medical Association 1996; 276: 637–639
   PubMed Web of Science ®Google Scholar
• Moher D, Schulz KF, Altman DG. The CONSORT statement: Revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 2001; 357: 1191–1194
   PubMed Web of Science ®Google Scholar
• Simes RJ. Publication bias: The case for an international registry of clinical trials. Journal of Clinical Oncology 1986; 4: 1529–1541
   PubMed Web of Science ®Google Scholar