An Italian population study on 600 persons in vegetative state and minimally conscious state

References

• Laureys S, Owen AM, Schiff ND. Brain function in coma, vegetative state, and related disorders. Lancet Neurology 2004; 3: 537–546
   PubMed Web of Science ®Google Scholar
• Jennet B. The vegetative state. Journal of Neurology, Neurosurgery & Psychiatry 2002; 73: 355–357
   PubMed Web of Science ®Google Scholar
• The Multi-Society Task Force on PVS. Medical aspects of the persistent vegetative state (first of two parts). New England Journal of Medicine 1994; 330: 1499–1508
   PubMed Web of Science ®Google Scholar
• Giacino JT. The minimally conscious state: Defining the borders of consciousness. Progress in Brain Research 2005; 150: 381–395
   PubMed Web of Science ®Google Scholar
• Bernat JL. Chronic disorders of consciousness. Lancet 2006; 367: 1181–1192
   PubMed Web of Science ®Google Scholar
• Fins JJ, Master MG, Gerber LM, Giacino JT. The minimally conscious state: A diagnosis in search of an epidemiology. Archives of Neurology 2007; 64: 1400–1405
   PubMed Web of Science ®Google Scholar
• The Multi-Society Task Force on PVS. Medical aspects of the persistent vegetative state (second of two parts). New England Journal of Medicine 1994; 330: 1572–1529
   PubMed Web of Science ®Google Scholar
• Working Party of the Royal College of Physicians. The vegetative state: Guidance on diagnosis and management. Clinical Medicine 2003; 3: 249–254
   PubMed Web of Science ®Google Scholar
• Beaumont JG, Kenealy PM. Incidence and prevalence of the vegetative and minimally conscious states. Neuropsychological Rehabiliation 2005; 15: 184–189
   PubMed Web of Science ®Google Scholar
• Stepan CH, Haidinger G, Binder H. Prevalence of persistent vegetative state/apallic syndrome in Vienna. European Journal of Neurology 2004; 11: 461–466
   PubMed Web of Science ®Google Scholar
• Engberg AW, Teasdale TW. A population-based study of survival and discharge status for survivors after head injury. Acta Neurologica Scandinavica 2004; 110: 281–290
   PubMed Web of Science ®Google Scholar
• Wilson FC, Harpur J, Watson T, Morrow JI. Vegetative state and minimally responsive patients-regional survey, long-term case outcomes and service recommendations. NeuroRehabilitation 2002; 17: 231–236
   PubMed Web of Science ®Google Scholar
• World Health Organization. International Classification of Disease, 9th revision – Clinical modification. WHO, Geneve 2002
   Google Scholar
• Avesani R, Gambini MG, Albertini G. The vegetative state: A report of two cases with a long-term follow-up. Brain Injury 2006; 20: 333–338
   PubMed Web of Science ®Google Scholar
• Voss HU, Uluç AM, Dyke JP, Watts R, Kobylarz EJ, McCandliss BD, Heier LA, Beattie BJ, Hamacher KA, Vallabhajosula S, et al. Possible axonal regrowth in late recovery from the minimally conscious state. Journal of Clinical Investigation 2006; 116: 2005–2011
   PubMed Web of Science ®Google Scholar
• Saoût V, Ombredane MP, Mouillie JM, Marteau C, Mathé JF, Richard I. Patients in a permanent vegetative state or minimally conscious state in the Maine-et-Loire county of France: A cross-sectional, descriptive study. Annals of Physical and Rehabilitation Medicine 2010; 53: 96–104
   PubMedGoogle Scholar
• Lin LC, Hsieh PC, Wu SC. Prevalence and associated factors of pneumonia in patients with vegetative state in Taiwan. Journal of Clinical Nursing 2008; 17: 861–868
   PubMedGoogle Scholar
• Harrison-Felix CL, Whiteneck GG, Jha A, DeVivo MJ, Hammond FM, Hart DM. Mortality over four decades after traumatic brain injury rehabilitation: A retrospective cohort study. Archives of Physical Medicine and Rehabilitation 2009; 90: 1506–1513
   PubMed Web of Science ®Google Scholar
• Strauss DJ, Ashwal S, Day SM, Shavelle RM. Life expectancy of children in vegetative and minimally conscious states. Pediatric Neurology 2000; 23: 312–319
   PubMed Web of Science ®Google Scholar
• Ashwal S. Recovery of consciousness and life expectancy of children in a vegetative state. Neuropsychological Rehabiliation 2005; 15: 190–197
   PubMed Web of Science ®Google Scholar
• Strauss DJ, Shavelle RM, Ashwal S. Life expectancy and median survival time in the permanent vegetative state. Pediatric Neurology 1999; 21: 626–631
   PubMed Web of Science ®Google Scholar
• Tresch DD, Sims FH, Duthie EH, Goldstein MD, Lane PS. Clinical characteristics of patients in the persistent vegetative state. Archives of Internal Medicine 1991; 151: 930–932
   PubMedGoogle Scholar
• Fabbri G, Fantini MP, Buggi F, Carretta E, Lorenzini L, Piperno R, Matera N, Leo MR, Coulter DL. The Morfeo Study: A 1-year follow-up of complications of vegetative state in a dedicated facility. Brain Injury 2010; 24: 620–624
   PubMed Web of Science ®Google Scholar
• Krimchansky BZ, Sazbon L, Heller L, Kosteff H, Luttwak Z. Bladder tone in patients in post-traumatic vegetative state. Brain Injury 1999; 13: 899–903
   PubMed Web of Science ®Google Scholar
• Ng YS, Chua KS. States of severely altered consciousness: Clinical characteristics, medical complications and functional outcome after rehabilitation. NeuroRehabilitation 2005; 20: 97–105
   PubMed Web of Science ®Google Scholar
• O'Neil-Pirozzi TM, Momose KJ, Mello J, Lepak P, McCabe M, Connors JJ, Lisiecki DJ. Feasibility of swallowing interventions for tracheostomized individuals with severely disordered consciousness following traumatic brain injury. Brain Injury 2003; 17: 389–399
   PubMed Web of Science ®Google Scholar
• Tan M, Zhu JC, Yin HH. Enteral nutrition in patients with severe traumatic brain injury: Reasons for intolerance and medical management. British Journal of Neurosurgery 2011; 25: 2–8
   PubMed Web of Science ®Google Scholar
• Krakau K, Omne-Pontén M, Karlsson T, Borg J. Metabolism and nutrition in patients with moderate and severe traumatic brain injury: A systematic review. Brain Injury 2006; 20: 345–367
   PubMed Web of Science ®Google Scholar
• Leong B. The vegetative and minimally conscious states in children: Spasticity, muscle contracture and issues for physiotherapy treatment. Brain Injury 2002; 16: 217–230
   PubMed Web of Science ®Google Scholar
• Leong B. Critical review of passive muscle stretch: Implications for the treatment of children in vegetative and minimally conscious states. Brain Injury 2002; 16: 169–183
   PubMed Web of Science ®Google Scholar
• Ashford S. Management of a patient diagnosed as PVS. Physiotherapy Research International 2000; 5: 202–206
   PubMedGoogle Scholar
• Georgiopoulos M, Katsakiori P, Kefalopoulou Z, Ellul J, Chroni E, Constantoyannis C. Vegetative state and minimally conscious state: A review of the therapeutic interventions. Stereotactic and Functional Neurosurgery 2010; 88: 199–207
   PubMed Web of Science ®Google Scholar
• Pistoia F, Mura E, Govoni S, Fini M, Sarà M. Awakenings and awareness recovery in disorders of consciousness: Is there a role for drugs?. CNS Drugs 2010; 24: 625–638
   PubMed Web of Science ®Google Scholar
• Oliveira L, Fregni F. Pharmacological and electrical stimulation in chronic disorders of consciousness: New insights and future directions. Brain Injury 2011; 25: 315–27
   PubMed Web of Science ®Google Scholar
• Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. New England Journal of Medicine 2012; 366: 819–826
   PubMed Web of Science ®Google Scholar
• McMahon MA, Vargus-Adams JN, Michaud LJ, Bean J. Effects of amantadine in children with impaired consciousness caused by acquired brain injury: A pilot study. American Journal of Physical Medicine and Rehabilitation 2009; 88: 525–532
   PubMedGoogle Scholar
• Schnakers C, Hustinx R, Vandewalle G, Majerus S, Moonen G, Boly M, Vanhaudenhuyse A, Laureys S. Measuring the effect of amantadine in chronic anoxic minimally conscious state. Journal of Neurology, Neurosurgery & Psychiatry 2008; 79: 225–227
   PubMed Web of Science ®Google Scholar
• Singh R, McDonald C, Dawson K, Lewis S, Pringle AM, Smith S, Pentland B. Zolpidem in a minimally conscious state. Brain Injury 2008; 22: 103–106
   PubMed Web of Science ®Google Scholar
• Machado C, Estévez M, Pérez-Nellar J, Gutiérrez J, Rodríguez R, Carballo M, Chinchilla M, Machado A, Portela L, García-Roca MC, et al. Autonomic, EEG, and behavioral arousal signs in a PVS case after Zolpidem intake. Canadian Journal of Neurological Sciences 2011; 38: 341–344
   PubMed Web of Science ®Google Scholar
• Snyman N, Egan JR, London K, Howman-Giles R, Gill D, Gillis J, Scheinberg A. Zolpidem for persistent vegetative state–a placebo-controlled trial in pediatrics. Neuropediatrics 2010; 41: 223–227
   PubMed Web of Science ®Google Scholar
• Weeks DL, Greer CL, Bray BS, Schwartz CR, White JR, Jr. Association of antidepressant medication therapy with inpatient rehabilitation outcomes for stroke, traumatic brain injury, or traumatic spinal cord injury. Archives of Physical Medicine and Rehabilitation 2011; 92: 683–695
   PubMedGoogle Scholar
• Reinhard DL, Whyte J, Sandel ME. Improved arousal and initiation following tricyclic antidepressant use in severe brain injury. Archives of Physical Medicine and Rehabilitation 1996; 77: 80–83
   PubMed Web of Science ®Google Scholar
• Kaelin DL, Cifu DX, Matthies B. Methylphenidate effect on attention deficit in the acutely brain-injured adult. Archives of Physical Medicine and Rehabilitation 1996; 77: 6–9
   PubMed Web of Science ®Google Scholar
• Passler MA, Riggs RV. Positive outcomes in traumatic brain injury-vegetative state: Patients treated with bromocriptine. Archives of Physical Medicine and Rehabilitation 2001; 82: 311–315
   PubMed Web of Science ®Google Scholar
• Müller U, von Cramon DY. The therapeutic potential of bromocriptine in neuropsychological rehabilitation of patients with acquired brain damage. Progress in Neuropsychopharmacology & Biological Psychiatry 1994; 18: 1103–1120
   PubMed Web of Science ®Google Scholar
• Schnakers C, Chatelle C, Demertzi A, Majerus S, Laureys S. What about pain in disorders of consciousness?. AAPS Journal 2012; 14: 437–444
   PubMed Web of Science ®Google Scholar
• Demertzi A, Schnakers C, Ledoux D, Chatelle C, Bruno MA, Vanhaudenhuyse A, Boly M, Moonen G, Laureys S. Different beliefs about pain perception in the vegetative and minimally conscious states: A European survey of medical and paramedical professionals. Progress in Brain Research 2009; 177: 329–338
   PubMed Web of Science ®Google Scholar
• Laureys S, Owen A, Schiff N. Coma science: Clinical and ethical implications. Preface. Progress in Brain Research 2009; 177: xiii–xiv
   PubMedGoogle Scholar
• Giacino JT, Ashwal S, Childs N, Cranford R, Jennett B, Katz DI, Kelly JP, Rosenberg JH, Whyte J, Zafonte RD, et al. The minimally conscious state: Definition and diagnostic criteria. Neurology 2002; 58: 349–353
   PubMed Web of Science ®Google Scholar
• Giacino JT, Zasler ND, Katz DI, Kelly JP, Rosenberg JH, Filley CM. Development of practice guidelines for assessment and management of the vegetative and minimally conscious states. Journal of Head Trauma Rehabilitation 1997; 12: 79–89
   Web of Science ®Google Scholar
• World Health Organization Collaborating Centre for Drug Statistics Methodology. Anatomical Therapeutic Chemical (ATC) classification system ATC classification index with DDDs, 2012. WHO Collaborating Centre for Drug Statistics Methodology, Oslo 2011
   Google Scholar
• International Organization for Standardization. Technical aids for persons with disabilities: Classification and terminology. ISO, Geneve 2002
   Google Scholar
• Dubroja I, Valent S, Miklic P, Kesak D. Outcome of post-traumatic unawareness persisting for more than a month. Journal of Neurology, Neurosurgery & Psychiatry 1995; 58: 465–466
   PubMedGoogle Scholar
• Kampfl A, Schumutzhard E, Franz G, Pfausler B, Haring HP, Ulmer H, Felber S, Golaszewski S, Aichner F. Prediction of recovery from post-traumatic vegetative state with cerebral magnetic resonance imaging. Lancet 1998; 351: 1763–1767
   PubMed Web of Science ®Google Scholar
• Lippert-Gruner M, Wedekind C, Klug N. Outcome of prolonged coma following severe traumatic brain injury. Brain Injury 2003; 17: 49–54
   PubMed Web of Science ®Google Scholar
• Di Carlo A, Baldereschi M, Gandolfo C. Stroke in an elderly population: Incidence and impact on survival and daily function. The Italian Longitudinal Study on Aging. Cerebrovascular Diseases 2003; 16: 141–150
   PubMed Web of Science ®Google Scholar
• Luautè J, Maucort-Boulch D, Tell L, Quelard F, Sarraf T, Iwaz J, Boisson D, Fischer C. Long-term outcomes of chronic minimally conscious and vegetative states. Neurology 2010; 75: 246–252
   PubMed Web of Science ®Google Scholar
• Tagliaferri F, Compagnone C, Korsic M, Servadei F, Kraus J. A systematic review of brain injury epidemiology in Europe. Acta Neurochirurgica (Wien) 2006; 148: 255–268
   PubMed Web of Science ®Google Scholar
• Maas AI, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurology 2008; 7: 728–741
   PubMed Web of Science ®Google Scholar
• Stocchetti N, Conte V, Ghisoni L, Canavesi K, Zanaboni C. Traumatic brain injury in pediatric patients. Minerva Anestesiologica 2010; 76: 1052–1059
   PubMedGoogle Scholar
• Wittenberg GF. Neural plasticity and treatment across the lifespan for motor deficits in cerebral palsy. Developmental Medicine & Child Neurology 2009; 51(Suppl 4)130–133
   PubMedGoogle Scholar
• Ministry of Health of Italy [Internet]. Report of the technical-scientific committee on Vegetative State and Minimally Conscious State. Rome, Italy: Ministry of Health; 2009. Available online at: http://www.salute.gov.it/imgs/C_17_pubblicazioni_1378_allegato.pdf, accessed 23 June 2012
   Google Scholar
• Boly M, Faymonville ME, Schnakers C, Peigneux P, Lambermont B, Phillips C, Lancellotti P, Luxen A, Lamy M, Moonen G, et al. Perception of pain in the minimally conscious state with PET activation: An observational study. Lancet Neurology 2008; 7: 1013–1020
   PubMed Web of Science ®Google Scholar
• Kassubek J, Juengling FD, Els T, Spreer J, Herpers M, Krause T, Moser E, Lücking CH. Activation of a residual cortical network during painful stimulation in long-term postanoxic vegetative state: A 15O-H2O PET study. Journal of Neurological Sciences 2003; 212: 85–91
   PubMed Web of Science ®Google Scholar
• Schnakers C, Zasler ND. Pain assessment and management in disorders of consciousness. Current Opinion in Neurology 2000; 20: 620–626
   Google Scholar
• Schnakers C, Vanhaudenhuyse A, Giacino J, Ventura M, Boly M, Majerus S, Moonen G, Laureys S. Diagnostic accuracy of the vegetative and minimally conscious state: Clinical consensus versus standardized neurobehavioral assessment. BMC Neurology 2009; 9: 35
   PubMed Web of Science ®Google Scholar
• Giacino J, Kalmar K, Whyte J. The JFK Coma Recovery Scale-Revised: Measurement characteristics and diagnostic utility. Archives of Physical Medicine and Rehabilitation 2004; 85: 2020–2029
   PubMed Web of Science ®Google Scholar
• Sacco S, Altobelli E, Pistarini C, Cerone D, Cazzulani B, Carolei A. Validation of the Italian version of the Coma Recovery Scale-Revised (CRS-R). Brain Injury 2011; 25: 488–495
   PubMed Web of Science ®Google Scholar