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Case Reports

Zolpidem induces paradoxical metabolic and vascular changes in a patient with PVS

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Pages 1320-1329 | Received 18 Nov 2011, Accepted 06 Apr 2013, Published online: 07 Aug 2013

References

  • Clauss R, Sathekge M, Nel W. Transient improvement of spinocerebellar ataxia with zolpidem. New England Journal of Medicine 2004;351:511–512
  • Clauss R, Nel W. Drug induced arousal from the permanent vegetative state. NeuroRehabilitation 2006;21:23–28
  • Singh R, McDonald C, Dawson K, Lewis S, Pringle AM, Smith S, Pentland B. Zolpidem in a minimally conscious state. Brain Injury 2008;22:103–106
  • Whyte J, Myers R. Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: A preliminary placebo controlled trial. American Journal of Physical Medicine & Rehabilitation 2009;88:410–418
  • Staner C, Joly F, Jacquot N, Vlasova ID, Nehlin M, Lundqvist T, Edenius C, Staner L. Sublingual zolpidem in early onset of sleep compared to oral zolpidem: Polysomnographic study in patients with primary insomnia. Current Medical Research and Opinion 2010;26:1423–1431
  • Clauss RP. Neurotransmitters in coma, vegetative and minimally conscious states, pharmacological interventions. Medical Hypotheses 2010;75:287–290
  • Clauss RP, van der Merwe CE, Nel HW. Arousal from a semi-comatose state on zolpidem. South African Medical Journal 2001;91:788–789
  • Clauss RP, Nel WH. Effect of zolpidem on brain injury and diaschisis as detected by 99mTc HMPAO brain SPECT in humans. Arzneimittelforschung 2004;54:641–646
  • Brefel-Courbon Ch, Payoux P, Ory F, Sommet A, Slaoui T, Raboyeau G, Lemesle B, Puel M, Montastruc JL, Demonet JF, et al. Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy. Annals of Neurology 2007;62:102–105
  • Machado C, Estevez M, Perez-Nellar J, Gutierrez J, Rodriguez-Rojas R, Carballo-Barreda M, Chinchilla M, Machado A, Portela L, García-Roca MC. Autonomic, EEG, and behavioural arousal signs in a PVS case after Zolpidem intake. Canadian Journal of Neurological Sciences 2011;38:341–344
  • Nyakale NE, Clauss RP, Nel W, Sathekge M. Clinical and brain SPECT scan response to zolpidem in patients after brain damage. Arzneimittelforschung 2010;60:177–181
  • Hoque R, Chesson AL. Zolpidem-induced sleepwalking, sleep related eating disorder, and sleep-driving: Fluorine-18-flourodeoxyglucose positron emission tomography analysis, and a literature review of other unexpected clinical effects of zolpidem. Journal of Clinical Sleep Medicine 2009;5:471–476
  • Coleman MR, Davis MH, Rodd JM, Robson T, Ali A, Owen AM, Pickard JD. Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness. Brain 2009;132:2541–2552
  • Ances BM, Leontiev O, Perthen JE, Liang C, Lansing AE, Buxton RB. Regional differences in the coupling of cerebral blood flow and oxygen metabolism changes in response to activation: Implications for BOLD-fMRI. Neuroimage 2008;39:1510–1521
  • Buckner RL, Vincent JL. Unrest at rest: Default activity and spontaneous network correlations. Neuroimage 2007;37:1091–1096
  • Greicius MD, Krasnow B, Reiss AL, Menon V. Functional connectivity in the resting brain: A network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences 2003;100:253–258
  • Vanhaudenhuyse A, Noirhomme Q, Tshibanda L, Bruno MA, Boveroux P, Schnakers C, Soddu A, Perlbarg V, Ledoux D, Brichant JF, et al. Default network connectivity reflects the level of consciousness in non-communicative braindamaged patients. Brain 2010;133:161–171
  • Tracey I, Wise RG. Pharmacological fMRI: A new tool for drug development in humans. Journal of Pharmacy Practice 2001;14:368–371
  • Wise RG, Tracey I. The Role of fMRI in drug discovery. Journal of Magnetic Resonance Imaging 2006;23:862–876
  • Lee SK, Kim J, Kim HD, Lee JS, Lee YM. Initial experiences with proton MR spectroscopy in treatment monitoring of mitochondrial encephalopathy. Yonsei Medical Journal 2010;51:672–675
  • Machado C, Rodriguez R, Carballo M, Perez J, Korein J. Results of proton MRS studies in PVS and MCS patients. Canadian Journal of Neurological Sciences 2009;36:365–369
  • Giacino JT, Kalmar K, Whyte J. The JFK Coma Recovery Scale-Revised: Measurement characteristics and diagnostic utility. Archives of Physical Medicine & Rehabilitation 2004;85:2020–2029
  • Friston KJ, Mechelli A, Turner R, Price CJ. Nonlinear responses in fMRI: The Balloon Model, volterra kernels, and other hemodynamics. Neuroimage 2000;12:466–477
  • Friston KJ. Bayesian estimation of dynamical systems: An application to fMRI. Neuroimage 2002;16:513–530
  • Machado C, Estévez M, Rodríguez R, Pérez-Nellar J, Chinchilla M, Carrick FR, Leisman G, Melillo R, Gutiérrez J, Carballo M, et al. Zolpidem arousing effect in persistent vegetative state patients. Submitted for publication
  • Salva P, Costa J. Clinical pharmacokinetics and pharmacodynamics of zolpidem: Therapeutic implications. Clinical Pharmacokinetics 1995;29:142–153
  • Vlase L, Popa A, Neag M, Muntean D, Baldea I, Leucuta SE. Pharmacokinetic interaction between zolpidem and carbamazepine in healthy volunteers. Journal of Clinical Pharmacology 2010;51:1233–1236
  • Walusinski O, Deputte B. The phylogeny, ethology and nosology of yawning. Revue Neurologique (Paris) 2004;160:1011–1121
  • Guggisberg A, Mathis J, Herrmann U, Hess C. The functional relationship between yawning and vigilance. Behavioural Brain Research 2007;179:159–166
  • Cattaneo L, Cucurachi L, Chierici E, Pavesi G. Pathological yawning as a presenting symptom of brain stem ischaemia in two patients. Journal of Neurology, Neurosurgery & Psychiatry 2006;77:98–100
  • Hajek M, Dezortova M. Introduction to clinical in vivo MR spectroscopy. European Journal of Radiology 2008;67:185–193
  • Clark JF, Doepke A, Filosa JA, Wardle RL, Lu A, Meeker TJ, Pyne-Geithman GJ. N-acetylaspartate as a reservoir for glutamate. Medical Hypotheses 2006;67:506–512
  • Magistretti PJ. Role of glutamate in neuron-glia metabolic coupling. American Journal of Clinical Nutrition 2009;90:875S–880S
  • Magistretti PJ. Neuroscience. Low-cost travel in neurons. Science 2009;325:1349–1351
  • Pellerin L, Bouzier-Sore AK, Aubert A, Serres S, Merle M, Costalat R, Magistretti PJ. Activity-dependent regulation of energy metabolism by astrocytes: An update. Glia 2007;55:1251–1262
  • Boly M, Tshibanda L, Noirhomme Q, Vanhaudenhuyse A, Schnakers C, Ledoux D. Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient. Human Brain Mapping 2009;30:2393–2400
  • Noirhomme Q, Soddu A, Lehembre R, Vanhaudenhuyse A, Boveroux P, Boly M, Laureys S. Brain connectivity in pathological and pharmacological coma. Frontiers in System Neurosciences 2010
  • Licata SC, Lowen SB, Trksak GH, Maclean RR, Lukas SE. Zolpidem reduces the blood oxygen level-dependent signal during visual system stimulation. Progress in Neuropsychopharmacology & Biological Psychiatry 2011;35:1645–1652
  • Prichard J, Rothman D, Novotny E, Petroff O, Kuwabara T, Avison M, Howseman A, Hanstock C, Shulman R. Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Proceedings of the National Academy of Sciences USA 1991;88:5829–5831
  • Mangia S, Tka I, Logothetis NK, Gruetter R, Van de Moortele PF, Ugurbil K. Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli. Journal of Neuroscience Research 2007;85:3340–3346
  • Kuwabara T, Watanabe H, Tsuji S, Yuasa T. Lactate rise in the basal ganglia accompanying finger movements: A localized 1H-MRS study. Brain Research 1995;670:326–328
  • Urrila AS, Hakkarainen A, Heikkinen S, Vuori K, Stenberg D, Hakkinen AM. Metabolic imaging of human cognition: An fMRI/1H-MRS study of brain lactate response to silent word generation. Journal of Cerebral Blood Flow & Metabolism 2003;23:942–948
  • Mountford CE, Stanwell P, Lin A, Ramadan S, Ross B. Neurospectroscopy: The past, present and future. Chemical Reviews 2010;110:3060–3086

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