Kallikrein-related peptidase 6: A biomarker for traumatic brain injury in the rat

References

• Faul M, Xu L, Wald MM, Coronado V, Dellinger AM. Traumatic Brain Injury in the United States: National estimates of prevalence and incidence, 2002–2006. Injury Prevention 2010;16:A268–A268
   Web of Science ®Google Scholar
• Communications MOoS. DoD numbers for traumatic brain injury. Defense Medical Surveillance System (DMSS) TMDST, editor. 2012, Silver Spring, MD; Available online at: http://www.dvbic.org/dod-worldwide-numbers-tbi, accessed 22 Jan 2013
   Google Scholar
• Shigemori M, Abe T, Aruga T, Ogawa T, Okudera H, Ono J, Onuma T, Katayama Y, Kawai N, Kawamata T, et al. Guidelines for the Management of Severe Head Injury, 2nd ed. Guidelines from the Guidelines Committee on the Management of Severe Head Injury, the Japan Society of Neurotraumatology. Neurologia Medico Chirurgica (Tokyo) 2012;52:1–30
   PubMed Web of Science ®Google Scholar
• Lingsma HF, Roozenbeek B, Steyerberg EW, Murray GD, Maas AI. Early prognosis in traumatic brain injury: From prophecies to predictions. Lancet Neurology 2010;9:543–554
   PubMed Web of Science ®Google Scholar
• Carney NA, Ghajar J. Guidelines for the Management of Severe Traumatic Brain Injury. Journal of Neurotrauma 2007;24:S1--S2
   PubMed Web of Science ®Google Scholar
• Picton TW, Taylor MJ. Electrophysiological evaluation of human brain development. Developemental Neuropsychology 2007;31:249–278
   PubMed Web of Science ®Google Scholar
• Yuan XQ, Prough DS, Smith TL, Dewitt DS. The effects of traumatic brain injury on regional cerebral blood flow in rats. Journal of Neurotrauma 1988;5:289–301
   PubMed Web of Science ®Google Scholar
• Vagnozzi R, Signoretti S, Cristofori L, Alessandrini F, Floris R, Isgro E, Ria A, Marziale S, Zoccatelli G, Tavazzi B, et al. Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients. Brain 2010;133:3232–3242
   PubMed Web of Science ®Google Scholar
• Bergsneider M, Hovda DA, Shalmon E, Kelly DF, Vespa PM, Martin NA, Phelps ME, McArthur DL, Caron MJ, Kraus JF. Cerebral hyperglycolysis following severe traumatic brain injury in humans: A positron emission tomography study. Journal of Neurosurgery 1997;86:241–251
   PubMed Web of Science ®Google Scholar
• Hovda D, Lee S, Smith M, Von Stuck S, Bergsneider M, Kelly D, Shalmon E, Martin N, Caron M, Mazziotta J. The neurochemical and metabolic cascade following brain injury: Moving from animal models to man. Journal of Neurotrauma 1995;12:903–906
   PubMed Web of Science ®Google Scholar
• Werner C, Engelhard K. Pathophysiology of traumatic brain injury. British Journal of Anaesthesia 2007;99:4–9
   PubMed Web of Science ®Google Scholar
• Bouma GJ, Muizelaar JP, Choi SC, Newlon PG, Young HF. Cerebral circulation and metabolism after severe traumatic brain injury: The elusive role of ischemia. Journal of Neurosurgery 1991;75:685–693
   PubMed Web of Science ®Google Scholar
• Vespa P, Bergsneider M, Hattori N, Wu H-M, Huang S-C, Martin NA, Glenn TC, McArthur DL, Hovda DA. Metabolic crisis without brain ischemia is common after traumatic brain injury: A combined microdialysis and positron emission tomography study. Journal of Cerebral Blood Flow & Metabolism 2005;25:763–774
   PubMed Web of Science ®Google Scholar
• Palmer AM, Marion DW, Botscheller ML, Swedlow PE, Styren SD, DeKosky ST. Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model. Journal of Neurochemistry 2006;61:2015–2024
   Google Scholar
• Bullock R, Zauner A, Woodward JJ, Myseros J, Choi SC, Ward JD, Marmarou A, Young HF. Factors affecting excitatory amino acid release following severe human head injury. Journal of Neurosurgery 1998;89:507–518
   PubMed Web of Science ®Google Scholar
• Marklund N, Bakshi A, Castelbuono DJ, Conte V, McIntosh TK. Evaluation of pharmacological treatment strategies in traumatic brain injury. Current Pharmaceutical Design 2006;12:1645–1680
   PubMed Web of Science ®Google Scholar
• McIntosh TK, Saatman KE, Raghupathi R, Graham DI, Smith DH, Lee VM, Trojanowski JQ. The Dorothy Russell Memorial Lecture. The molecular and cellular sequelae of experimental traumatic brain injury: Pathogenetic mechanisms. Neuropathology and Applied Neurobiology 1998;24:251–267
   PubMed Web of Science ®Google Scholar
• Baydas G, Tuzcu M. Protective effects of melatonin against ethanol-induced reactive gliosis in hippocampus and cortex of young and aged rats. Experimental Neurology 2005;194:175–181
   PubMed Web of Science ®Google Scholar
• Wang KKW. Calpain and caspase: can you tell the difference? Trends in Neurosciences 2000;23:20–26
   PubMed Web of Science ®Google Scholar
• Woehrling EK, Hill EJ, Coleman MD. Development of a neurotoxicity test-system, using human post-mitotic, astrocytic and neuronal cell lines in co-culture. Toxicol In Vitro 2007;21:1241–1246
   PubMedGoogle Scholar
• Hergenroeder GW, Redell JB, Moore AN, Dash PK. Biomarkers in the clinical diagnosis and management of traumatic brain injury. Molecular Diagnosis & Therapy 2008;12:345–358
   PubMed Web of Science ®Google Scholar
• Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, et al. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Biological Chemistry 2006;387:637–641
   PubMed Web of Science ®Google Scholar
• Scarisbrick IA, Blaber SI, Lucchinetti CF, Genain CP, Blaber M, Rodriguez M. Activity of a newly identified serine protease in CNS demyelination. Brain 2002;125:1283–1296
   PubMed Web of Science ®Google Scholar
• Shaw JL, Diamandis EP. Distribution of 15 human kallikreins in tissues and biological fluids. Clinical Chemistry 2007;53:1423–1432
   PubMed Web of Science ®Google Scholar
• Lu J, Goh SJ, Tng PY, Deng YY, Ling EA, Moochhala S. Systemic inflammatory response following acute traumatic brain injury. Frontiers on Bioscience 2009;14:3795–3813
   PubMed Web of Science ®Google Scholar
• Rascher G, Fischmann A, Kroger S, Duffner F, Grote EH, Wolburg H. Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: Spatial segregation of tenascin and agrin. Acta Neuropathologie 2002;104:85–91
   PubMed Web of Science ®Google Scholar
• Rosenberg GA, Estrada E, Kelley RO, Kornfeld M. Bacterial collagenase disrupts extracellular matrix and opens blood-brain barrier in rat. Neuroscience Letters 1993;160:117–119
   PubMedGoogle Scholar
• Scarisbrick IA, Towner MD, Isackson PJ. Nervous system-specific expression of a novel serine protease: Regulation in the adult rat spinal cord by excitotoxic injury. Journal of Neuroscience 1997;17:8156–8168
   PubMed Web of Science ®Google Scholar
• Scarisbrick IA, Sabharwal P, Cruz H, Larsen N, Vandell AG, Blaber SI, Ameenuddin S, Papke LM, Fehlings MG, Reeves RK, et al. Dynamic role of kallikrein 6 in traumatic spinal cord injury. European Journal of Neuroscience 2006;24:1457–1469
   PubMedGoogle Scholar
• Dietrich WD, Alonso O, Halley M. Early microvascular and neuronal consequences of traumatic brain injury: A light and electron microscopic study in rats. Journal of Neurotrauma 1994;11:289–301
   PubMed Web of Science ®Google Scholar
• Raabe A, Grolms C, Sorge O, Zimmermann M, Seifert V. Serum S-100B protein in severe head injury. Neurosurgery 1999;45:477–483
   PubMed Web of Science ®Google Scholar
• Habgood MD, Bye N, Dziegielewska KM, Ek CJ, Lane MA, Potter A, Morganti-Kossmann C, Saunders NR. Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice. European Journal of Neurosciene 2007;25:231–238
   PubMed Web of Science ®Google Scholar
• Fukuda K, Tanno H, Okimura Y, Nakamura M, Yamaura A. The blood-brain barrier disruption to circulating proteins in the early period after fluid percussion brain injury in rats. Journal of Neurotrauma 1995;12:315–324
   PubMedGoogle Scholar
• Hoffman SW, Fulop Z, Stein DG. Bilateral frontal cortical contusion in rats: behavioral and anatomic consequences. Journal of Neurotrauma 1994;11:417–431
   PubMed Web of Science ®Google Scholar
• Blaber SI, Scarisbrick IA, Bernett MJ, Dhanarajan P, Seavy MA, Jin Y, Schwartz MA, Rodriguez M, Blaber M. Enzymatic properties of rat myelencephalon-specific protease. Biochemistry 2002;41:1165–1173
   PubMed Web of Science ®Google Scholar
• Ziegler U, Groscurth P. Morphological features of cell death. News in Physiological Sciences 2004;19:124–128
   PubMedGoogle Scholar
• Swets JA. Measuring the accuracy of diagnostic systems. Science 1988;240:1285–1293
   PubMed Web of Science ®Google Scholar
• Greiner M, Pfeiffer D, Smith RD. Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests. Preventive Veterinary Medicine 2000;45:23–41
   PubMed Web of Science ®Google Scholar
• Nye SH, Pelfrey CM, Burkwit JJ, Voskuhl RR, Lenardo MJ, Mueller JP. Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein. Molecular Immunology 1995;32:1131–1141
   PubMed Web of Science ®Google Scholar
• Shiryaev SA, Savinov AY, Cieplak P, Ratnikov BI, Motamedchaboki K, Smith JW, Strongin AY. Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis. PLoS One 2009;4:e4952
   PubMed Web of Science ®Google Scholar
• Scarisbrick IA, Epstein B, Cloud BA, Yoon H, Wu J, Renner DN, Blaber SI, Blaber M, Vandell AG, Bryson AL. Functional role of kallikrein 6 in regulating immune cell survival. PLoS One 2011;6:e18376
   PubMedGoogle Scholar
• Scarisbrick IA, Linbo R, Vandell AG, Keegan M, Blaber SI, Blaber M, Sneve D, Lucchinetti CF, Rodriguez M, Diamandis EP. Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration. Biological Chemistry 2008;389:739–745
   PubMed Web of Science ®Google Scholar
• Beers MH, Berkow R, Bogin RM, Fletcher AJ, Nace BA, Moy DE; Merck Research Laboratories. The Merck manual of diagnosis and therapy. 17th ed. Whitehouse Station, NJ: Merck; 1999
   Google Scholar
• Kang JH, Lin HC. Increased risk of multiple sclerosis after traumatic brain injury: A nationwide population-based study. Journal of Neurotrauma 2012;29:90–95
   PubMed Web of Science ®Google Scholar
• Liu MC, Akle V, Zheng WR, Kitlen J, O'Steen B, Larner SF, Dave JR, Tortella FC, Hayes RL, Wang KKW. Extensive degradation of myelin basic protein isoforms by calpain following traumatic brain injury. Journal of Neurochemistry 2006;98:700–712
   PubMed Web of Science ®Google Scholar
• He J, Evans CO, Hoffman SW, Oyesiku NM, Stein DG. Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury. Experimental Neurology 2004;189:404–412
   PubMed Web of Science ®Google Scholar
• Ledeen RW, Chakraborty G. Cytokines, signal transduction, and inflammatory demyelination: Review and hypothesis. Neurochemical Research 1998;23:277–289
   PubMed Web of Science ®Google Scholar
• Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, Kollias G, Probert L. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: mModels for multiple sclerosis with primary oligodendrogliopathy. American Journal of Pathology 1998;153:801–813
   PubMed Web of Science ®Google Scholar
• Feuerstein GZ, Liu T, Barone FC. Cytokines, inflammation, and brain injury: Role of tumor necrosis factor-alpha. Cerebrovascular and Brain Metabolism Reviews 1994;6:341–360
   PubMedGoogle Scholar
• Gahring LC, Carlson NG, Kulmar RA, Rogers SW. Neuronal expression of tumor necrosis factor alpha in the murine brain. Neuroimmunomodulation 1996;3:289–303
   PubMed Web of Science ®Google Scholar
• von Gertten C, Flores Morales A, Holmin S, Mathiesen T, Nordqvist AC. Genomic responses in rat cerebral cortex after traumatic brain injury. BMC Neuroscience 2005;6:69
   PubMed Web of Science ®Google Scholar
• Yoon H, Blaber SI, Evans DM, Trim J, Juliano MA, Scarisbrick IA, Blaber M. Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis. Protein Science 2008;17:1998–2007
   PubMed Web of Science ®Google Scholar
• Gingrich MB, Traynelis SF. Serine proteases and brain damage - is there a link? Trends in Neurosciences 2000;23:399–407
   PubMed Web of Science ®Google Scholar
• Xiong Y, Peterson PL, Lee CP. Alterations in cerebral energy metabolism induced by traumatic brain injury. Neurological Research 2001;23:129–138
   PubMed Web of Science ®Google Scholar
• Kaku DA, Giffard RG, Choi DW. Neuroprotective effects of glutamate antagonists and extracellular acidity. Science 1993;260:1516–1518
   PubMed Web of Science ®Google Scholar
• Nedergaard M, Kraig RP, Tanabe J, Pulsinelli WA. Dynamics of interstitial and intracellular pH in evolving brain infarct. American Journal of Physiology 1991;260:R581–588
   PubMedGoogle Scholar
• Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wei WL, MacDonald JF, Wemmie JA, Price MP, Welsh MJ, et al. Neuroprotection in ischemia: Blocking calcium-permeable acid-sensing ion channels. Cell 2004;118:687–698
   PubMed Web of Science ®Google Scholar
• Xu L, Glassford AJ, Giaccia AJ, Giffard RG. Acidosis reduces neuronal apoptosis. Neuroreport 1998;9:875–879
   PubMed Web of Science ®Google Scholar
• Blaber SI, Yoon H, Scarisbrick IA, Juliano MA, Blaber M. The autolytic regulation of human kallikrein-related peptidase 6. Biochemistry 2007;46:5209–5217
   PubMedGoogle Scholar
• Bernett MJ, Blaber SI, Scarisbrick IA, Dhanarajana P, Thomspon SM, Blaber M. Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system. Journal of Biological Chemistry 2002;277:24562–24570
   PubMed Web of Science ®Google Scholar
• Kozlowski S. FDA perspectives on biomarkers. In: Products OoB, editor. Workshop on Prognostic and Predictive Immunologic Biomarkers in Cancer. Bethesda, MD: Society for Immunotherapy of Cancer; 2009
   Google Scholar
• Liu MC, Akle V, Zheng W, Kitlen J, O'Steen B, Larner SF, Dave JR, Tortella FC, Hayes RL, Wang KK. Extensive degradation of myelin basic protein isoforms by calpain following traumatic brain injury. Journal of Neurochemistry 2006;98:700–712
   PubMed Web of Science ®Google Scholar
• Khuman J, Meehan WP 3rd, Zhu X, Qiu J, Hoffmann U, Zhang J, Giovannone E, Lo EH, Whalen MJ. Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice. Journal of Cerebral Blood Flow and Metabolism 2011;31:778–789
   PubMedGoogle Scholar
• Fassbender K, Schneider S, Bertsch T, Schlueter D, Fatar M, Ragoschke A, Kuhl S, Kischka U, Hennerici M. Temporal profile of release of interleukin-1beta in neurotrauma. Neuroscience Letters 2000;284:135–138
   PubMed Web of Science ®Google Scholar
• Kinoshita K, Chatzipanteli i K, Vitarbo E, Truettner JS, Alonso OF, Dietrich WD. Interleukin-1beta messenger ribonucleic acid and protein levels after fluid-percussion brain injury in rats: Importance of injury severity and brain temperature. Neurosurgery 2002;51:195–203; discussion 203
   PubMed Web of Science ®Google Scholar
• Dalgard CL, Cole JT, Kean WS, Lucky JJ, Sukumar G, McMullen DC, Pollard HB, Watson WD. The cytokine temporal profile in rat cortex after controlled cortical impact. Frontiers in Molecular Neuroscience 2012;5:6
   PubMed Web of Science ®Google Scholar
• Zhao X, Bausano B, Pike BR, Newcomb-Fernandez JK, Wang KK, Shohami E, Ringger NC, DeFord SM, Anderson DK, Hayes RL. TNF-alpha stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures. Journal of Neuroscience Research 2001;64:121–131
   PubMedGoogle Scholar
• Abrahamson EE, Ikonomovic MD, Ciallella JR, Hope CE, Paljug WR, Isanski BA, Flood DG, Clark RS, DeKosky ST. Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: Implications for clinical outcome. Experimental Neurology 2006;197:437–450
   PubMed Web of Science ®Google Scholar
• Saatman KE, Creed J, Raghupathi R. Calpain as a therapeutic target in traumatic brain injury. Neurotherapeutics 2010;7:31–42
   PubMed Web of Science ®Google Scholar
• Van Den Heuvel C, Thornton E, Vink R. Traumatic brain injury and Alzheimer's disease: A review. Progress in Brain Research 2007;161:303–316
   PubMed Web of Science ®Google Scholar
• Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: A brief overview. Journal of Head Trauma Rehabilitation 2006;21:375–378
   PubMed Web of Science ®Google Scholar
• Cekic M, Cutler SM, VanLandingham JW, Stein DG. Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats. Neurobiology of Aging 2011;32:864–874
   PubMed Web of Science ®Google Scholar
• Paxinos G, Watson C, Pennisi M, Topple A. Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight. Journal of Neuroscience Methods 1985;13:139–143
   PubMed Web of Science ®Google Scholar
• Bewick V, Cheek L, Ball J. Statistics review 13: receiver operating characteristic curves. Critical Care 2004;8:508–512
   PubMed Web of Science ®Google Scholar