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Original Article

Abbreviated levetiracetam treatment effects on behavioural and histological outcomes after experimental TBI

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Pages 78-85 | Received 30 Jan 2014, Accepted 13 Aug 2014, Published online: 25 Sep 2014

References

  • Garga N, Lowenstein DH. Posttraumatic epilepsy: A major problem in desperate need of major advances. Epilepsy Currents 2006;6:1–5
  • Gupta P, Ding K, Sayed N, Agostini M, Van Ness P, Madden C, Mickey B, D’Ambrosio R, Diaz-Arrastia RJ. Subtypes of post-traumatic epilepsy: clinical, electrophysiologic, and imaging features. Journal of Neurotrauma 2014;31:1439–1443
  • Diamond ML, Ritter A, Failla MD, Boles JA, Conley YP, Kochanek PM, Wagner AK. IL-1β influences on post-traumatic epilepsy development: A genetics and biomarker cohort Study. Epilepsia 2014;55:1109–1119
  • Darrah SD, Miller MA, Ren D, Hoh NZ, Scanlon JM, Conley YP, Wagner AK. Genetic variability in the glutamic acid decarboxylase gene: Associations with post-traumatic seizures after severe TBI. Epilepsy Research 2013;103:180–194
  • Wagner AK, Miller MA, Scanlon, J, Ren D, Kochanek PM, Conley YP. Adenosine A1 receptor gene variant associated with post-traumatic seizures after severe TBI. Epilepsy Research 2010;90:259–272
  • Pitkänen A, Immonen R. Epilepsy related to traumatic brain injury. Neurotherapeutics 2014;11:286–296
  • Chang BS, Lowenstein DH. Quality Standards Subcommittee of the American Academy of N: Practice parameter: Antiepileptic drug prophylaxis in severe traumatic brain injury: Report of the quality standards subcommittee of the American Academy of Neurology. Neurology 2003;60:10–16
  • Temkin NR, Dikmen SS, Wilensky AJ, Keihm J, Chabal S, Winn HR. A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. New England Journal of Medicine 1990;323:497–502
  • Frey LC. Epidemiology of posttraumatic epilepsy: A critical review. Epilepsia 2003;44:11–17
  • Dikmen SS, Temkin NR, Miller B, Machamer J, Winn HR. Neurobehavioural effects of phenytoin prophylaxis of posttraumatic seizures. Journal of the American Medical Association 1991;265:1271–1277
  • Darrah SD, Chuang J, Mohler LM, Chen X, Cummings EE, Burnett T, Reyes-Littaua MC, Galang GN, Wagner AK. Dilantin therapy in an experimental model of traumatic brain injury: Effects of limited versus daily treatment on neurological and behavioural recovery. Journal of Neurotrauma 2011;28:43–55
  • Nakamura H, Osawa M, Yokoyama T, Yoshida K, Suzuki A. Efficacy and safety of levetiracetam as adjunctive therapy in Japanese children with uncontrolled partial-onset seizures: Multicenter and open-label study (N01223), short term evaluation. Brain Nerve 2013;65:1083–1092
  • Jones KE, Puccio AM, Harshman KJ, Falcione B, Benedict N, Jankowitz BT, Stippler M, Fischer M, Sauber-Schatz EK, Fabio A, et al. Levetiracetam versus phenytoin for seizure prophylaxis in severe traumatic brain injury. Neurosurgical Focus 2008;25:E3
  • Szaflarski JP, Sangha KS, Lindsell CJ, Shutter LA. Prospective, randomized, single-blinded comparative trial of intravenous levetiracetam versus phenytoin for seizure prophylaxis. Neurocritical Care 2010;12:165–172
  • Zou H, Brayer SW, Hurwitz M, Niyonkuru C, Fowler LE, Wagner AK. Neuroprotective, neuroplastic, and neurobehavioural effects of daily treatment with levetiracetam in experimental traumatic brain injury. Neurorehabilitation Neural Repair 2013;27:878–888
  • Klein P, Herr D, Pearl PL, Natale J, Levine Z, Nogay C, Sandoval F, Trzcinski S, Atabaki SM, Tsuchida T, et al. Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy. Archives of Neurology 2012;69:1290–1295
  • Hwabejire JO, Imam AM, Jin G, Liu B, Li Y, Sillesen M, Jepsen CH, Lu J, deMoya MA, Alam HB. Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury. Journal of Trauma and Acute Care Surgery 2013;75:968–974; discussion 974–975
  • Cuomo O, Rispoli V, Leo A, Politi GB, Vinciguerra A, di Renzo G, Cataldi M. The antiepileptic drug levetiracetam suppresses non-convulsive seizure activity and reduces ischemic brain damage in rats subjected to permanent middle cerebral artery occlusion. PLOS ONE 2013;8:e80852
  • Hanon E, Klitgaard H. Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia. Seizure 2001;10:287–293
  • Folkersma H, Foster Dingley JC, van Berckel BN, Rozemuller A, Boellaard R, Huisman MC, Lammertsma AA, Vandertop WP, Molthoff CF. Increased cerebral(R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: A longitudinal pilot study. Journal of Neuroinflammation 2011;8:67
  • Thomale UW, Griebenow M, Mautes A, Beyer TF, Dohse NK, Stroop R, Sakowitz OW, Unterberg AW, Stover JF. Heterogeneous regional and temporal energetic impairment following controlled cortical impactinjury in rats. Neurological Research 2007;29:594–603
  • Hovda DA, Lee SM, Smith ML, Von Stuck S, Bergsneider M, Kelly D, Shalmon E, Martin N, Caron M, Mazziotta J, et al. The neurochemical and metabolic cascade following brain injury: Moving from animal models to man. Journal of Neurotrauma 1995;12:903–906
  • Wagner AK, Fabio A, Puccio AM, Hirschberg R, Li W, Zafonte RD, Marion DW. Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injury. Critical Care Medicine 2005;33:407–413
  • De Smedt T, Raedt R, Vonck K, Boon P. Levetiracetam: The profile of a novel anticonvulsant drug-part I: Preclinical data. CNS Drug Review 2007;13:43–56
  • Tong X, Patsalos PN. A microdialysis study of the novel antiepileptic drug levetiracetam: Extracellular pharmacokinetics and effect on taurine in rat brain. British Journal of Pharmacology 2001;133:867–874
  • De Smedt T, Raedt R, Vonck K, Boon P. Levetiracetam: Part II, the clinical profile of a novel anticonvulsant drug. CNS Drug Review 2007;13:57–78
  • Zweckberger K, Hackenberg K, Jung CS, Hertle DN, Kiening KL, Unterberg AW, Sakowitz OW. Cerebral metabolism after early decompression craniotomy following controlled cortical impact injury in rats. Neurological Research 2011;33:875–880
  • Kruer RM, Harris LH, Goodwin H, Kornbluth J, Thomas KP, Slater LA, Haut ER. Changing trends in the use of seizure prophylaxis after traumatic brain injury: A shift from phenytoin to levetiracetam. Journal of Critical Care 2013;28:883.e9–e13
  • Bales J, Wagner AK, Kline AE, Dixon CE. Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis. Neuroscience and Biobehavioral Reviews 2009;33:981–1003
  • Wagner AK, Hurwitz M, Brayer S, Zou H, Failla MD, Arenth PM, Skidmore E, Garman R, Thiels E. Non-spatial pre-training in the water maze as a clinically relevant model for evaluating learning and memory in experimental TBI. Neurobiology of Learning and Memory 2013;106:71–86
  • Tanaka S, Tanaka T. Levetiracetam add-on therapy in Japanese patients with refractory partial epilepsy. Epileptic Disorders 2013;15:132–141
  • Fonkem E, Bricker P, Mungall D, Aceves J, Ebwe E, Tang W, Kirmani B. The role of levetiracetam in treatment of seizures in brain tumor patients. Frontiers in Neurology 2013;4:153
  • Steinhoff BJ, Maren Staack A, Wisniewski I. Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre. Epileptic Disorders 2012;14:379–387
  • Pachet A, Friesen S, Winkelaar D, Gray S. Beneficial behavioural effects of lamotrigine in traumatic brain injury. Brain Injury 2003;17:715–722
  • Deb S, Crownshaw T. The role of pharmacotherapy in the management of behaviour disorders in traumatic brain injury patients. Brain Injury 2004;18:1–31
  • Wang H, Gao J, Lassiter TF, McDonagh DL, Sheng H, Warner DS, Lynch JR, Laskowitz DT. Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage. Neurocritical Care 2006;5:71–78
  • Smith GR, Brenneman DE, Zhang Y, Du Y, Reitz AB. Small-molecule anticonvulsant agents with potent in vitro neuroprotection and favorable drug-like properties. Journal of Molecular Neuroscience 2014;52:446–458
  • Tello I, Campos-Pena V, Montiel E, Rodriguez V, Aguirre-Moreno A, Leon-Rivera I, Del Rio-Portilla F, Herrera-Ruiz M, Villeda-Hernandez J. Anticonvulsant and neuroprotective effects of oligosaccharides from lingzhi or reishi medicinal mushroom, Ganoderma lucidum (higher basidiomycetes). International Journal of Medicinal Mushrooms 2013;15:555–568
  • Nowack A, Malarkey EB, Yao J, Bleckert A, Hill J, Bajjalieh SM. Levetiracetam reverses synaptic deficits produced by overexpression of SV2A. PLoS One 2011;6:e29560
  • Belcastro V, Pierguidi L, Tambasco N. Levetiracetam in brain ischemia: Clinical implications in neuroprotection and prevention of post-stroke epilepsy. Brain Development 2011;33:289–293
  • Loscher W, Honack D, Rundfeldt C. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. The Journal of Pharmaceutical and Experimental Therapy 1998;284:474–479
  • Benge JF, Phenis RA, Bernett A, Cruz-Laureano D, Kirmani BF. Neurobehavioural effects of levetiracetam in patients with traumatic brain injury. Frontiers in Neurology 2013;4:195
  • Ravizza T, Noe F, Zardoni D, Vaghi V, Sifringer M, Vezzani A. Interleukin converting enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production. Neurobiology of Disease 2008;31:327–333
  • Vezzani A, Conti M, De Luigi A, Ravizza T, Moneta D, Marchesi F, De Simoni MG. Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: Functional evidence for enhancement of electrographic seizures. Journal of Neuroscience 1999;19:5054–5065
  • Kumar R, Boles JA, Failla MD, Wagner AK. Chronic inflammation characterization after severe traumatic brain injury: Characterization and associations with outcome 6 and 12 months postinjury. Journal of Head Trauma Rehabilitation 2014. PMID: 24901329 [Epub ahead of print]

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