MAP Kinase Pathway is Involved in IGF-1-Stimulated Proliferation of Human Retinal Pigment Epithelial Cells (hRPE)

References

• Slomiany MG, Rosenzweig SA. IGF-1-Induced VEGF and IGFBP-3 Secretion Correlates with Increased HIF-1α Expression and Activity in Retinal Pigment Epithelial Cell Line D407. Invest. Ophthal. & Vis. Science 2004;45:2838–2847.
   PubMedGoogle Scholar
• Sall JW, Klisovic DD, O’Dorisio MS, Katz SE. Somatostatin inhibits IGF-1 mediated induction of VEGF in human retinal pigment epithelial cells. Exp. Eye Research 2004;79:465–476.
   PubMed Web of Science ®Google Scholar
• Takagi H, Yoshimura N, Tanihara H, Honda Y. Insulin-Like Growth Factor-Related Genes, Receptors, and Binding Proteins in Cultured Human Retinal Pigment Epithelial Cells. Invest. Ophthal. & Vis. Science 1994;35:916–923.
   PubMed Web of Science ®Google Scholar
• Zapf J, Schmid C, Froesch ER. Biological and immunological properties of insulin-like growth factors (IGF) I and II. Clin. Endocrinol. Metab. 1984;13:3–30.
   PubMedGoogle Scholar
• Guan J, Bennet L, Gluckman PD, Gunn AJ. Insulin-like growth factor-1 and post-ischemic brain injury. Prog. Neurobiol. 2003;70:443–462.
   PubMed Web of Science ®Google Scholar
• Slomiany MG, Rosenzweig SA. Autocrine effects of IGF-1-induced VEGF and IGFBP-3 secretion in retinal pigment epithelial cell line ARPE-19. Am. J. Physiol. Cell Physiol. 2004;287:746–753.
   PubMed Web of Science ®Google Scholar
• Cui Q, Almazan G. IGF-1-induced oligodendrocyte progenitor proliferation requires PI3K/Akt, MEK/ERK, and Src-like tyrosine kinases. J. Neurochem. 2007;100:1480–1493.
   PubMed Web of Science ®Google Scholar
• LeRoith D, Werner H, Bietner-Johnson D, Roberts CT Jr. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr. Rev. 1995;16:143–163.
   PubMed Web of Science ®Google Scholar
• Gronborg M, Wulff BS, Rasmussen JS, Kjeldsen T, Gammeltoft S. Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase. J. Biol. Chem. 1993;268:23435–23440.
   PubMed Web of Science ®Google Scholar
• Hernandez-Sanchez C, Blakesley V, Kalebic T, Helman L, LeRoith D. The role of tyrosine kinase domain of the insulin-like growth factor-1 receptor in intracellular signaling, cellular proliferation, and tumorigenesis. J. Biol. Chem. 1995;270:29176–29181.
   PubMed Web of Science ®Google Scholar
• Danis RP, Bingaman DP. Insulin-like growth factor-1 retinal microangiopathy in the pig eye. Ophthalmology 1997;104:1661–1669.
   PubMed Web of Science ®Google Scholar
• Baudouin C, Fredj-Reygrobellet D, Brignole F, Negre F, Lapalus P, Gastaud P. Growth factors in vitreous and subretinal fluid cells from patients with proliferative vitreoretinopathy. Ophthal. Res. 1993;25:52–59.
   PubMed Web of Science ®Google Scholar
• Merimee TJ, Zapf J, Froesch ER. Insulin-like growth factors. Studies in diabetics with and without retinopathy. N. Engl. J. Med. 1983;309:527–530.
   PubMed Web of Science ®Google Scholar
• Pfeiffer A, Spranger J, Meyer-Schwickerath R, Schatz H. Growth factor alterations in advanced diabetic retinopathy: a possible role of blood retina barrier breakdown. Diabetes 1997;46:S26-S30.
   PubMed Web of Science ®Google Scholar
• Punglia RS, Lu M, Hsu J, Kuroki M, Tolentino MS, Keough K, Levy AP, Levy NS, Goldberg MA, D’Amato RJ, Adamis AP. Regulation of vascular endothelial growth factor expression by insulin-like growth factor I. Diabetes 1997;46:1619–1626.
   PubMed Web of Science ®Google Scholar
• Lu M, Amano S, Miyamoto K, Garland R, Keough K, Qin W, Adamis AP. Insulin-induced vascular endothelial growth factor expression in retina. Invest. Ophthalmol. Vis. Sci. 1999;40:3281–3286.
   PubMed Web of Science ®Google Scholar
• Smith LE, Shen W, Perruzzi C, Soker S, Kinose F, Xu X, Robinson G, Driver S, Bischoff J, Zhang B, Schaeffer JM, Senger DR. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat. Med. 1999;5:1390–1395.
   PubMed Web of Science ®Google Scholar
• Sone H, Kawakami Y, Okuda Y, Sekine Y, Honmura S, Matsuo K, Segawa T, Suzuki H, Yamashita K. Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes. Diabetologia 1997;40:726–730.
   PubMed Web of Science ®Google Scholar
• Schwesinger C, Yee C, Rohan RM, Joussen AM, Fernandez A, Meyer TN, Poulaki V, Ma JJ, Redmond TM, Liu S, Adamis AP, D’Amato RJ. Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium. Am. J. Pathol. 2001;154:1743–1753.
   Google Scholar
• Spilsbury K, Garrett KL, Shen WY, Constable IJ, Rakoczy PE. Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization. Am. J. Pathol. 2000;157:135–144.
   PubMed Web of Science ®Google Scholar
• Ozaki H, Seo MS, Ozaki K, Yamada H, Yamada E, Okamoto N, Hofmann F, Wood JM, Campochiaro PA. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am. J. Pathol. 2000;156:697–707.
   PubMed Web of Science ®Google Scholar
• Randolph A, Yee D, Feldman EL. Insulin-like growth factor binding protein expression in human retinal pigment epithelial cells. Annals NY Acad. Sci. 1993;692:265–267.
   PubMed Web of Science ®Google Scholar
• Higgins RD, Yan Y, Schrier BK. Somatostatin analogs inhibit neonatal retinal neovascularization. Exp. Eye Res. 2002;74:553–559.
   PubMed Web of Science ®Google Scholar
• Kothary PC, Lahiri R, Kee L, Sharma N, Chun E, Kuznia A, Del Monte MA. Pigment Epithelium-Derived Growth Factor Inhibits Fetal Bovine Serum Stimulated Vascular Endothelial Growth Factor Synthesis in Cultured Human Retinal Pigment Epithelial Cells. Retinal Degenerative Diseases 2006;71:513–518.
   Google Scholar
• Rosenthal R, Wohlleben H, Malek G, Schlichting L, Thieme H, Bowes Rickman C, Strauss O. Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration. Biochem. and Biophys. Research Comm. 2004;323:1203–1208.
   PubMed Web of Science ®Google Scholar
• Miele C, Rochford JJ, Filippa N, Giorgetti-Peraldi S, Van Obberghen E. Insulin and insulin-like growth factor-1 induce vascular endothelial growth factor mRNA expression via different signaling pathways. J. Biol. Chem. 2000;275:21695–21702.
   PubMed Web of Science ®Google Scholar
• Hecquet C, Lefevre G, Valtink M, Engelmann K, Mascarelli F. Activation and role of MAP kinase-dependent pathways in retinal pigment epithelial cells: ERK and RPE cell proliferation. Invest. Ophthalmol. Vis. Sci. 2002;43:3091–3098.
   PubMed Web of Science ®Google Scholar
• Kusaka K, Kothary PC, Del Monte MA. Modulation of basic fibroblast growth factor effect by retinoic acid in cultured retinal pigment epithelium. Curr. Eye Research 1998;17:524–530.
   PubMed Web of Science ®Google Scholar
• Siffroi-Fernandez S, Felder-Schmittbuhl M, Khanna H, Swaroop A, Hicks D. FGF19 Exhibits Neuroprotective Effects on Adult Mammalian Photoreceptors In Vitro. Invest. Ophthal. & Vis. Science 2008;49:1696–1704.
   PubMed Web of Science ®Google Scholar
• Kramer CY. Extension of multiple range tests to group unequal numbers of replications. Biometrics 1956;12:307–310.
   Google Scholar
• Tukey JW. The problem of multiple comparisons. Unpublished manuscript. 1953.
   Google Scholar
• Li C, Huang Z, Kingsley R, Zhou X, Li F, Parke III D, Cao W. Biochemical Alterations in the Retinas of Very Low-Density Lipoprotein Receptor Knockout Mice. Arch. Ophthalmol. 2007;125:795–803.
   PubMedGoogle Scholar
• Alejandro EU, Johnson JD. Inhibition of Raf-1 Alters Multiple Downstream Pathways to Induce Pancreatic β-Cell Apoptosis. J. Biol. Chem. 2008;283:2407–2417.
   PubMed Web of Science ®Google Scholar