196
Views
11
CrossRef citations to date
0
Altmetric
Original Article

Evidence That ‘Brain-Specific’ Fox-1, Fox-2, and nPTB Alternatively Spliced Isoforms Are Produced in the Lens

, , , , , & show all
Pages 321-327 | Received 23 Feb 2010, Accepted 02 Jun 2010, Published online: 19 Oct 2010

REFERENCES

  • Ashiya M, Grabowski PJ. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart. RNA. 1997;3:996–1015.
  • Boutz PL, Stoilov P, Li Q, et al. A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev. 2007;21:1636–1652.
  • Kuroyanagi H. Fox-1 family of RNA-binding proteins. Cell Mol Life Sci. 2009;66:3895–3907.
  • Lee JA, Tang ZZ, Black DL. An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons. Genes Dev. 2009;23:2284–2293.
  • Spriggs KA, Cobbold LC, Ridley SH, et al. The human insulin receptor mRNA contains a functional internal ribosome entry segment. Nucleic Acids Res. 2009;37:5881–5893.
  • Castle JC, Zhang C, Shah JK, et al. Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines. Nat Genet. 2008;40:1416–1425.
  • Fairbrother WG, Lipscombe D. Repressing the neuron within. Bioessays. 2008;30:1–4.
  • Wang ET, Sandberg R, Luo S, et al. Alternative isoform regulation in human tissue transcriptomes. Nature. 2008;456:470–476.
  • Zhang C, Zhang Z, Castle J, et al. Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev. 2008;22:2550–2563.
  • Arnold JM. On the occurrence of microtubules in the developing lens of the squid Loligo pealii. J Ultrastruct Res. 1966;14:534–539.
  • Byers B, Porter KR. Oriented microtubules in elongating cells of the developing lens rudiment after induction. Proc Natl Acad Sci U S A. 1964;52:1091–1099.
  • Lo WK, Wen XJ, Zhou CJ. Microtubule configuration and membranous vesicle transport in elongating fiber cells of the rat lens. Exp Eye Res. 2003;77:615–626.
  • Hollenberg MJ, Wyse JP, Lewis BJ. Surface morphology of lens fibers from eyes of normal and microphthalmic (Browman) rats. Cell Tissue Res. 1976;167:425–438.
  • Zhou CJ, Lo WK. Association of clathrin, AP-2 adaptor and actin cytoskeleton with developing interlocking membrane domains of lens fibre cells. Exp Eye Res. 2003;77:423–432.
  • Lang RA. Which factors stimulate lens fiber cell differentiation in vivo? Invest Ophthalmol Vis Sci. 1999;40:3075–3078.
  • Frederikse PH, Yun E, Kao HT, et al. Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation. Mol Vis. 2004;10:794–804.
  • Bitel CL, Perrone-Bizzozero NI, Frederikse PH. HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens. Mol Vis. 16:2301–2316.
  • Rottinger E, Besnardeau L, Lepage T. Expression pattern of three putative RNA-binding proteins during early development of the sea urchin Paracentrotus lividus. Gene Expr Patterns. 2006;6:864–872.
  • Le Sommer C, Lesimple M, Mereau A, et al. PTB regulates the processing of a 3′-terminal exon by repressing both splicing and polyadenylation. Mol Cell Biol. 2005;25:9595–9607.
  • Revil T, Gaffney D, Dias C, et al. Alternative splicing is frequent during early embryonic development in mouse. BMC Genomics. 2010;11:399.
  • Shibayama M, Ohno S, Osaka T, et al. Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation. FEBS J. 2009;276:6658–6668.
  • Wang C, Norton JT, Ghosh S, et al. Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner. J Biol Chem. 2008;283:20277–20287.
  • Coutinho-Mansfield GC, Xue Y, Zhang Y, et al. PTB/nPTB switch: A post-transcriptional mechanism for programming neuronal differentiation. Genes Dev. 2007;21:1573–1577.
  • Nakahata S, Kawamoto S. Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities. Nucleic Acids Res. 2005;33:2078–2089.
  • Matsushita M, Tanaka S, Nakamura N, et al. A novel kinesin-like protein, KIF1Bbeta3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cells. Traffic. 2004;5:140–151.
  • Matsushita M, Yamamoto R, Mitsui K, et al. Altered motor activity of alternative splice variants of the mammalian kinesin-3 protein KIF1B. Traffic. 2009;10:1647–1654.
  • Galban S, Kuwano Y, Pullmann R Jr, et al. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol. 2008;28:93–107.
  • Ma S, Liu G, Sun Y, et al. Relocalization of the polypyrimidine tract-binding protein during PKA-induced neurite growth. Biochim Biophys Acta. 2007;1773:912–923.
  • Anthony K, Gallo JM. Aberrant RNA processing events in neurological disorders. Brain Res. 2010;1338:67–77.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.