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Original Article

High Glucose Induced Differential Expression of Lysyl Oxidase and Its Isoform in ARPE-19 Cells

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Pages 194-203 | Received 10 Jul 2011, Accepted 07 Aug 2012, Published online: 11 Sep 2012

REFERENCES

  • Kagan HM, Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem 2003;88:660–672.
  • Csiszar K. Lysyl oxidases: a novel multifunctional amine oxidase family. Prog Nucleic Acid Res Mol Biol 2001;70:1–32.
  • Frank RN. Diabetic retinopathy. N Engl J Med 2004;350:48–58.
  • Decanini A, Karunadharma PR, Nordgaard CL, Feng X, Olsen TW, Ferrington DA. Human retinal pigment epithelium proteome changes in early diabetes. Diabetologia 2008;51:1051–1061.
  • Simó R, Villarroel M, Corraliza L, Hernández C, Garcia-Ramírez M. The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier–implications for the pathogenesis of diabetic retinopathy. J Biomed Biotechnol 2010;2010:190724.
  • Kim DI, Lim SK, Park MJ, Han HJ, Kim GY, Park SH. The involvement of phosphatidylinositol 3-kinase /Akt signaling in high glucose-induced downregulation of GLUT-1 expression in ARPE cells. Life Sci 2007;80:626–632.
  • Villarroel M, García-Ramírez M, Corraliza L, Hernández C, Simó R. Effects of high glucose concentration on the barrier function and the expression of tight junction proteins in human retinal pigment epithelial cells. Exp Eye Res 2009;89:913–920.
  • Crider JY, Yorio T, Sharif NA, Griffin BW. The effects of elevated glucose on Na+/K(+)-ATPase of cultured bovine retinal pigment epithelial cells measured by a new nonradioactive rubidium uptake assay. J Ocul Pharmacol Ther 1997;13:337–352.
  • Yao Y, Guan M, Zhao XQ, Huang YF. [Downregulation of the pigment epithelium derived factor by hypoxia and elevated glucose concentration in cultured human retinal pigment epithelial cells]. Zhonghua Yi Xue Za Zhi 2003;83:1989–1992.
  • Ljubimov AV, Burgeson RE, Butkowski RJ, Couchman JR, Zardi L, Ninomiya Y et al. Basement membrane abnormalities in human eyes with diabetic retinopathy. J Histochem Cytochem 1996;44:1469–1479.
  • Coral K, Angayarkanni N, Madhavan J, Bharathselvi M, Ramakrishnan S, Nandi K et al. Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment. Invest Ophthalmol Vis Sci 2008;49:4746–4752.
  • Das A, McGuire PG, Eriqat C, Ober RR, DeJuan E Jr, Williams GA et al. Human diabetic neovascular membranes contain high levels of urokinase and metalloproteinase enzymes. Invest Ophthalmol Vis Sci 1999;40:809–813.
  • Noda K, Ishida S, Inoue M, Obata K, Oguchi Y, Okada Y et al. Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 2003;44:2163–2170.
  • Heimsath EG Jr, Unda R, Vidro E, Muniz A, Villazana-Espinoza ET, Tsin A. ARPE-19 cell growth and cell functions in euglycemic culture media. Curr Eye Res 2006;31:1073–1080.
  • Senanayake P, Calabro A, Hu JG, Bonilha VL, Darr A, Bok D. Glucose utilization by the retinal pigment epithelium: evidence for rapid uptake and storage in glycogen, followed by glycogen utilization. Exp Eye Res 2006;83:235–246.
  • Palamakumbura AH, Trackman PC. A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples. Anal Biochem 2002;300:245–251.
  • Bustin SA, Benes V, Nolan T, Pfaffl MW. Quantitative real-time RT-PCR–a perspective. J Mol Endocrinol 2005;34:597–601.
  • Notari L, Miller A, Martínez A, Amaral J, Ju M, Robinson G. Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia. Invest Ophthalmol Vis Sci 2005;46:2736–2747.
  • Campochiaro PA, Jerdon JA, Glaser BM. The extracellular matrix of human retinal pigment epithelial cells in vivo and its synthesis in vitro. Invest Ophthalmol Vis Sci 1986;27:1615–1621.
  • Rodríguez C, Martínez-González J, Raposo B, Alcudia JF, Guadall A, Badimon L. Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases. Cardiovasc Res 2008;79:7–13.
  • Jansen MK, Csiszar K. Intracellular localization of the matrix enzyme lysyl oxidase in polarized epithelial cells. Matrix Biol 2007;26:136–139.
  • Omori K, Fujiseki Y, Omori K, Suzukawa J, Inagaki C. Regulation of the expression of lysyl oxidase mRNA in cultured rabbit retinal pigment epithelium cells. Matrix Biol 2002;21:337–348.
  • Wachi H, Sato F, Murata H, Nakazawa J, Starcher BC, Seyama Y. Development of a new in vitro model of elastic fiber assembly in human pigmented epithelial cells. Clin Biochem 2005;38:643–653.
  • Sumual S, Saad S, Tang O, Yong R, McGinn S, Chen XM et al. Differential regulation of Snail by hypoxia and hyperglycemia in human proximal tubule cells. Int J Biochem Cell Biol 2010;42:1689–1697.
  • López B, González A, Hermida N, Valencia F, de Teresa E, Díez J et al. Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects. Am J Physiol Heart Circ Physiol 2010;299:H1–H9.
  • Szauter KM, Cao T, Boyd CD, Csiszar K. Lysyl oxidase in development, aging and pathologies of the skin. Pathol Biol 2005;53:448–456.
  • Gilad GM, Kagan HM, Gilad VH. Evidence for increased lysyl oxidase, the extracellular matrix-forming enzyme, in Alzheimer’s disease brain. Neurosci Lett 2005;376:210–214.
  • Sharma S, Chataway T, Burdon KP, Jonavicius L, Klebe S, Hewitt AW et al. Identification of LOXL1 protein and Apolipoprotein E as components of surgically isolated pseudoexfoliation material by direct mass spectrometry. Exp Eye Res 2009;89:479–485.
  • Yu HG, Liu X, Kiss S, Connolly E, Gragoudas ES, Michaud NA et al. Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1. Invest Ophthalmol Vis Sci 2008;49:2599–2605.
  • Barry-Hamilton V, Spangler R, Marshall D, McCauley S, Rodriguez HM, Oyasu M et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med 2010;16:1009–1017.
  • Kim Y, Roh S, Park JY, Kim Y, Cho DH, Kim JC. Differential expression of the LOX family genes in human colorectal adenocarcinomas. Oncol Rep 2009;22:799–804.
  • Coral K, Angayarkanni N, Gomathy N, Bharathselvi M, Pukhraj R, Rupak R. Homocysteine levels in the vitreous of proliferative diabetic retinopathy and rhegmatogenous retinal detachment: its modulating role on lysyl oxidase. Invest Ophthalmol Vis Sci 2009;50:3607–3612.
  • Lien YH, Stern R, Fu JC, Siegel RC. Inhibition of collagen fibril formation in vitro and subsequent cross-linking by glucose. Science 1984;225:1489–1491.
  • Buckingham B, Reiser KM. Relationship between the content of lysyl oxidase-dependent cross-links in skin collagen, nonenzymatic glycosylation, and long-term complications in type I diabetes mellitus. J Clin Invest 1990;86:1046–1054.
  • Pischon N, Darbois LM, Palamakumbura AH, Kessler E, Trackman PC. Regulation of collagen deposition and lysyl oxidase by tumor necrosis factor-alpha in osteoblasts. J Biol Chem 2004;279:30060–30065.
  • Rodríguez C, Alcudia JF, Martínez-González J, Raposo B, Navarro MA, Badimon L. Lysyl oxidase (LOX) down-regulation by TNFalpha: a new mechanism underlying TNFalpha-induced endothelial dysfunction. Atherosclerosis 2008;196:558–564.
  • Oleggini R, Gastaldo N, Di Donato A. Regulation of elastin promoter by lysyl oxidase and growth factors: cross control of lysyl oxidase on TGF-beta1 effects. Matrix Biol 2007;26:494–505.
  • Nam DH, Oh J, Roh JH, Huh K. Different expression of vascular endothelial growth factor and pigment epithelium-derived factor between diabetic and non-diabetic epiretinal membranes. Ophthalmologica 2009;223:188–191.
  • Wang JJ, Zhang SX, Mott R, Knapp RR, Cao W, Lau K et al. Salutary effect of pigment epithelium-derived factor in diabetic nephropathy: evidence for antifibrogenic activities. Diabetes 2006;55:1678–1685.
  • Kim YS, Jung DH, Kim NH, Lee YM, Jang DS, Song GY et al. KIOM-79 inhibits high glucose or AGEs-induced VEGF expression in human retinal pigment epithelial cells. J Ethnopharmacol 2007;112:166–172.
  • Angayarkanni N, Selvi R, Pukhraj R, Biswas J, Bhavesh SJ, Tombran-Tink J et al. Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease. J Ocul Biol Dis Infor 2009;2:20–28.
  • Giebel SJ, Menicucci G, McGuire PG, Das A. Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier. Lab Invest 2005;85:597–607.
  • Maruhashi T, Kii I, Saito M, Kudo A. Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase. J Biol Chem 2010;285:13294–13303.
  • Uzel MI, Scott IC, Babakhanlou-Chase H, Palamakumbura AH, Pappano WN, Hong HH et al. Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. J Biol Chem 2001;276:22537–22543.
  • Madia AM, Rozovski SJ, Kagan HM. Changes in lung lysyl oxidase activity in streptozotocin-diabetes and in starvation. Biochim Biophys Acta 1979;585:481–487.
  • Chronopoulos A, Tang A, Beglova E, Trackman PC, Roy S. High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier function. Diabetes 2010;59:3159–3166.
  • Hewitt AW, Sharma S, Burdon KP, Wang JJ, Baird PN, Dimasi DP et al. Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people. Hum Mol Genet 2008;17:710–716.
  • Sethi A, Wordinger RJ, Clark AF. Focus on Molecules: Lysyl oxidase. Exp Eye Res 2012.
  • Barathi S, Angayarkanni N, Pasupathi A, Natarajan SK, Pukraj R, Dhupper M et al. Homocysteinethiolactone and paraoxonase: novel markers of diabetic retinopathy. Diabetes Care 2010;33:2031–2037.
  • Liu G, Nellaiappan K, Kagan HM. Irreversible inhibition of lysyl oxidase by homocysteine thiolactone and its selenium and oxygen analogues. Implications for homocystinuria. J Biol Chem 1997;272:32370–32377.
  • Raposo B, Rodríguez C, Martínez-González J, Badimon L. High levels of homocysteine inhibit lysyl oxidase (LOX) and downregulate LOX expression in vascular endothelial cells. Atherosclerosis 2004;177:1–8.

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