Human Non-Pigmented Ciliary Epithelium Bradykinin B₂-Receptors: Receptor Localization, Pharmacological Characterization of Intracellular Ca²⁺ Mobilization, and Prostaglandin Secretion

References

• Stone RA, Kuwayama Y, Laties AM. Regulatory peptides in the eye. Experentia 1987;43:791–800
   PubMedGoogle Scholar
• Kuwayama Y, Stone RA. Distinct substance P and calcitonin gene-related peptide immunoreactive nerves in the guinea pig eye. Invest Ophthalmol Vis Sci 1987;28:1947–1954
   PubMed Web of Science ®Google Scholar
• Stone RA, Wilson CM, Glembotski CC. Chromatographic characterization of vasoactive intestinal polypeptide in guinea pig and rhesus monkey eyes. Curr Eye Res 1990;9:287–291
   PubMed Web of Science ®Google Scholar
• Rittig MG, Licht K, Funk RH. Innervation of the ciliary process vasculature and epithelium by nerve fibers containing catecholamines and neuropeptide Y. Ophthal Res 1993;25:108–118
   PubMedGoogle Scholar
• Grimes PA, McGlinn AM, Koeberlein B, Stone RA. Galanin immunoreactivity in autonomic innervations of the cat eye. J Comp Neurol 1994;348:234–243
   PubMedGoogle Scholar
• Ghosh S, Choritz L, Geibel J, Coca-Prados M. Somatostatin modulates PI3K-AKT, eNOS and NHE activity in the ciliary epithelium. Mol Cell Endocrinol 2006;253:63–75
   PubMedGoogle Scholar
• Katoli P, Sharif NA, Sule A, Dimitrijevich SD. NPR-B natriuretic peptide receptors in human corneal epithelium: mRNA, immunohistochemistochemical, protein and biochemical pharmacology studies. Mol Vis 2010;16:1241–1252
   PubMed Web of Science ®Google Scholar
• Ortego J, Coca-Prados M. Molecular characterization and differential gene induction of the neuroendocrine-specific genes neurotensin, neurotensin receptor, PC1, PC2 and 7B2 in the human ocular ciliary epithelium. J Neurochem 1996;66:787–796
   PubMedGoogle Scholar
• Crook RB, Polansky JR. Neurotransmitters and neuropeptides stimulate inositol phosphates and intracellular calcium in cultured human nonpigmented ciliary epithelium. Invest Ophthalmol Vis Sci 1992;33:1706–1716
   PubMed Web of Science ®Google Scholar
• Sharif NA, Xu SX. Pharmacological characterization of bradykinin receptors coupled to phosphoinositide turnover in SV40-immortalized human trabecular meshwork cells. Exp Eye Res 1996;63:631–637
   PubMedGoogle Scholar
• Wiernas TK, Griffin BW, Sharif NA. The expression of functionally-coupled bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists. Br J Pharmacol 1997;121:649–656
   PubMedGoogle Scholar
• Wiernas TK, Davis TL, Griffin BW, Sharif NA. Effects of bradykinin on signal transduction, cell proliferation, and cytokine, prostaglandin E2 and collagenase-1 release from human corneal epithelial cells. Br J Pharmacol 1998;123:1127–1137
   PubMed Web of Science ®Google Scholar
• Igic R. Kallikrein and kininases in ocular tissues. Exp Eye Res 1985;41:117–120
   PubMedGoogle Scholar
• Leeb-lundberg LM, Marceau F, Muller-Esteri W, Pettibone DJ, Zuraw B. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev 2005;57:27–77
   PubMed Web of Science ®Google Scholar
• Ma JX, Song Q, Hatcher HC, Crouch RK, Chao L, Chao J. Expression and cellular localization of the kallikrein-kinin system in human ocular tissues. Exp Eye Res 1996;63:19–26
   PubMed Web of Science ®Google Scholar
• Chowdhury UR, Madden BJ, Charlesworth MC, Fautch MP. Proteome analysis of human aqueous humor. Invest Ophthalmol Vis Sci 2010;51:4921–4931
   PubMed Web of Science ®Google Scholar
• Burch RM, Axelrod J. Dissociation of bradykinin-stimulated arachidonic acid release from inositol phosphate formation in Swiss 3T3 fibroblasts. Evidence for a G protein-coupled phospholipase A2. Proc Natl Acad Sci USA 1987;84:6374–6378
   PubMed Web of Science ®Google Scholar
• Polansky JR, Kurtz RM, Alvarado JA, Weinreb RN, Mitchell MD. Eicosanoid production and glucocorticoid regulatory mechanisms in cultured human trabecular meshwork cells. Prog Clin Biol Res 1989;312:113–138
   PubMedGoogle Scholar
• Proud D, Sweet J, Stein P, Settipane RA, Kagey-Sobotka A, Freidlaender MH, Lichtenstein LM. Inflammatory mediator release on conjunctival provocation of allergic subjects with allergen. J Allergy Clin Immunol 1990;85:896–905
   PubMed Web of Science ®Google Scholar
• Chiang TS. Effects of intravenous infusions of histamine 5-hydroxytryptamine, bradykinin and prostaglandins on intraocular pressure. Arch Int Pharmacodyn 1974;207:131–138
   PubMedGoogle Scholar
• Kaufman PL, Barany EH, Erickson KA. Effect of serotonin, histamine and bradykinin on outflow facility following ciliary muscle retrodisplacement in the Cynomolgus monkey. Exp Eye Res 1982;35:191–199
   PubMedGoogle Scholar
• Cole DF, Unger WG. Action of bradykinin on intraocular pressure and papillary diameter. Ophthal Res 1974;6:308–314
   Google Scholar
• Zeller EA, Shoch D, Czerner TB, Hsu MY, Knepper PA. Enzymology of the refractory media of the eye. X. effect of topically administered bradykinin, amine releasers, and pargyline on aqueous humor dynamics. Invest Ophthalmol 1971;10:274–281
   PubMedGoogle Scholar
• Yokoyama K, Awaya S, Mizumura K, Kumazawa T. Implication of polymodal receptor activities in intraocular pressure elevation by neurogenic inflammation. Jpn J Ophthalmol 1990;34:245–255
   PubMedGoogle Scholar
• Green K, Elijah D. Drug effects on aqueous humor formation and pseudofacility in normal rabbit eyes. Exp Eye Res 1981;33:239–245
   PubMed Web of Science ®Google Scholar
• Bynke G, Hakanson R, Horig J, Leander S. Bradykinin contracts the papillary sphincter and evokes ocular inflammation through release of neuronal substance P. Eur J Pharmacol 1983;91:469–475
   PubMed Web of Science ®Google Scholar
• Llobet A, Gual A, Pales J, Barraquar R, Tobias E, Nicolas JM. Bradykinin decreases outflow facility in perfuaed anterior segments and induces shape changes in passaged BTM cells in vitro. Invest Ophthalmol Vis Sci 1999;40:113–125
   PubMedGoogle Scholar
• Webb JG, Husain S, Yates PW, Crosson CE. Kinin modulation of conventional outflow facility in bovine eye. J Ocular Pharmacol Ther 2006;22:310–316
   PubMed Web of Science ®Google Scholar
• Weinreb RN, Mitchell MD, Polansky JR. Prostaglandin production by human trabecular cells: in vitro inhibition by dexamethasone. Invest Ophthalmol Vis Sci 1983;24:1541–1545
   PubMed Web of Science ®Google Scholar
• Webb JG, Shearer TW, Yates PW, Mukhin TV, Crosson CE. Bradykinin enhancement of PGE2 signalling in bovine trabecular meshwork cells. Exp Eye Res 2003;76:283–289
   PubMedGoogle Scholar
• Webb JG, Yang X, Crosson CE. Bradykinin activation of extracellular signal-regulated kinases in human trabecular meshwork cells. Exp Eye Res 2011;92:495–501
   PubMed Web of Science ®Google Scholar
• Jacob TJ, Civan MM. Role of ion channels in aqueous humor formation. Am J Physiol 1996;271:C703–C720
   Google Scholar
• Shahidulla M, Delamere NA. NO donors inhibit Na, K-ATPase activity by a protein kinase G-dependent mechanism in the non-pigmented ciliary epithelium of the porcine eye. Br J Pharmacol 2006;148:871–880
   PubMedGoogle Scholar
• Coca-prados M, Escribano J. New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland. Prog Retina Eye Res 2007;26:239–262
   PubMed Web of Science ®Google Scholar
• Coca-Prados M, Wax MB. Transformation of human ciliary epithelial cells by simian virus 40: induction of cell proliferation and retention of β2-adrenergic receptors. Proc Nat Acad Sci USA 1986;83:8754–8758
   PubMed Web of Science ®Google Scholar
• Coca-Prados M, Lopez-Briones LG. Human nonpigmented ciliary epithelail cells in culture: a comparison study between normal versus transformed and fetal versus adult cells. Invest Ophthalmol Vis Sci 1987;28:10
   Google Scholar
• Wax MB, Coca-Prados M. Receptor-mediated phosphoinositide hydrolysis in human ocular ciliary epithelial cells. Invest Ophthalmol Vis Sci 1989;30:1675–1679
   PubMed Web of Science ®Google Scholar
• Crider JY, Sharif NA. Functional pharmacological evidence for EP2 and EP4 prostanoid receptors in immortalized human trabecular meshwork and non-pigmented ciliary epithelial cells. J Ocular Pharmacol Ther 2001;17:35–46
   PubMed Web of Science ®Google Scholar
• Sharif NA, Senchyna M, Xu SX. Pharmacological and molecular biological (RT-PCR) characterization of functional TP prostanoid receptors in immortalized human non-pigmented ciliary epithelial cells. J Ocular Pharmacol Ther 2002;18:141–162
   PubMedGoogle Scholar
• Sharif NA, Whiting RL. Identification of B2-bradykinin receptors in guinea pig brain regions, spinal cord and peripheral tissues. Neurochem Int 1991;18:89–96
   PubMedGoogle Scholar
• Sharif NA, Hunter JC, Hill RG, Hughes J. Bradykinin-induced accumulation of [3H]inositol-1-phosphate in human embryonic pituitary tumor cells by activation of a B2-receptor. Neurosci Lett 1988;86:279–283
   PubMedGoogle Scholar
• Ransom J, Cherwinski HM, Dunne JF, Sharif NA. Flow cytometric analysis of internal calcium mobilization via a B2-bradykinin receptor in a subclone of PC12 cells. J Neurochem 1991;56:983–989
   PubMedGoogle Scholar
• Kelly CR, Williams GW, Sharif NA. Real-time intracellular Ca2+-mobilization by travoprost acid, bimatoprost, unoprostone and other analogs via endogenous mouse, rat and cloned human FP prostaglandin receptors. J Pharmacol Exp Ther 2003;304:238–245
   PubMedGoogle Scholar
• Kelly CR, Sharif NA. Pharmacological evidence for a functional serotonin-2B receptor subtype in a human uterine smooth muscle cell line. J Pharmacol Expt Ther 2006;317:1254–1261
   PubMedGoogle Scholar
• Sharif NA, Crider JY, Kelly CR, Davis TL. Serotonin-2 (5HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension. J Ocular Pharmacol Ther 2006;22:389–401
   PubMedGoogle Scholar
• Sharif NA, Kelly CR, McLaughlin MA. Human trabecular meshwork cells express functional serotonin-2 (5HT2) receptors: role in IOP reduction. Invest Ophthalmol Vis Sci 2006;47:4001–4010
   PubMedGoogle Scholar
• Busse R, Fleming I. Regulation and functional consequences of endothelial nitric oxide formation. Ann Med 1995;27:331–340
   PubMed Web of Science ®Google Scholar
• Tsutsuie M, Onoue H, Iida Y, Smith L, O’Brien T, Katusic ZS. B1 and B2 bradykinin receptors in adeventitial fibroblasts of cerebral arteries are coupled to recombinant eNOS. Am J Physiol Heart Circ Physiol 2000;278:H367–H372
   Google Scholar
• Offord E, Sharif NA, Mace K, Tromvoukis Y, Spillare E, Avanti OE, et al. Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies. Invest Ophthalmol Vis Sci 1999;40:1091–1101
   PubMed Web of Science ®Google Scholar
• Linder S, Marshall H. Immortalization of primary cells by DNA tumor viruses. Exp Cell Res 1990;191:1–7
   PubMedGoogle Scholar
• Sharif NA, McLaughlin MA, Kelly CR, Katoli P, Drace C, Husain S, et al. Cabergoline: pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in Cynomolgus monkey eyes. Exp Eye Res 2009;88:386–397
   PubMedGoogle Scholar
• Schild HO. pA2, a new scale for the measurement of drug antagonism. Br J Pharmacol 1947;2:189–206
   PubMed Web of Science ®Google Scholar
• Kenakin T. Pharmacologic Analysis of Drug-Receptor Interactions. 2nd Edn. New York: Lipincott-Raven. 1993
   Google Scholar
• Rang HP. The receptor concept: pharmacology’s big idea. Br J Pharmacol 2006;147:S9–S16
   PubMedGoogle Scholar
• Nahorski SR. Pharmacology of intracellular signaling pathways. Br J Pharmacol 2006;147:S38–S45
   Google Scholar
• Lands WEM. The biosynthesis and metabolism of prostaglandins. Ann Rev Physiol 1979;41:633–643
   PubMed Web of Science ®Google Scholar
• Taylor L, Menconi M, Leibowitz HM, Polgar P. The effect of ascorbate, hydroperoxides, and bradykinin on prostaglandin production by corneal and lens cells. Invest Ophthalmol Vis Sci 1982;23:378–383
   PubMed Web of Science ®Google Scholar
• Coleman AL, Miglior, S. Risk factors for glaucoma onset and progression. Surv Ophthalmol 2008;53:S3–S10
   PubMed Web of Science ®Google Scholar
• Buchan KW, Martin W. Bradykinin induces elevations of cytosolic calcium through mobilization of intracellular and extracellular pools in bovine aortic endothelial cells. Br J Pharmacol 1991;102:35–40
   PubMed Web of Science ®Google Scholar
• Lambert DG, Nahorski SR. Carbachol-stimulated calcium entry in SH-SY5Y human neuroblastoma cells: which route? J Physiol (Paris) 1992;86:77–82
   PubMedGoogle Scholar
• Tovell VE, Sanderson J. Distinct P2Y receptor subtypes regulate calcium signaling in human retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 2008;49:350–357
   PubMedGoogle Scholar
• Snider RM, Richelson E. Bradykinin receptor-mediated cyclic GMP formation in a nerve cell population (murine neuroblastoma clone N1E-115). J Neurochem 1984;43:1749–1754
   PubMedGoogle Scholar
• Shimuta S, Barbosa AMRB, Borges ACR, Paiva TB. Pharmacological characterization of RMP-7, a novel bradykinin agonist in smooth muscle. Immunopharmacol 1999;45:63–67
   PubMedGoogle Scholar
• Sharif NA, Whiting RL. The neuropeptide bradykinin stimulates phosphoinositide turnover in HSDM1C1 cells: B2-antagonist-sensitive responses and receptor binding studies. Neurochem Res 1993;12:1313–1320
   Google Scholar
• Sharif NA, Xu S, Li L, Katoli P, Kelly CR, Wang Y, et al. Protein expression, biochemical pharmacology of signal transduction, and relation to IOP modulation by bradykinin B2-receptors in ciliary muscle. Molecular Vision 2013;19:1356--1370
   Google Scholar
• Patil R, Li L, Sharif NA. Activation of ERK signaling pathway by bradykinin B2-receptor in isolated human ciliary muscle cells. ARVO 2012; Abstract # 1971
   Google Scholar
• Duke-Elder S, Cook C. Normal and abnormal development. In: Duke-Elder S, editor. System of ophthalmology. Vol. III, Part 1 Embryology. St. Louis, MO, USA: The C.V. Mosby Company; 1963. pp 103--125
   Google Scholar