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Research Article

Toxicity and Pharmacokinetics of Intrastromal Injection of Amphotericin B in a Rabbit Model

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Pages 340-347 | Received 05 Jan 2013, Accepted 17 Sep 2013, Published online: 11 Nov 2013

References

  • Xie L, Zhong W, Shi W, Sun S. Spectrum of fungal keratitis in north China. Ophthalmology 2006;113:1943–1948
  • Xie L, Zhai H, Zhao J, Sun S, Shi W, Dong X. Antifungal susceptibility for common pathogens of fungal keratitis in Shandong Province, China. Am J Ophthalmol 2008;146:260–265
  • Hirose H, Terasaki H, Awaya S, Yasuma T. Treatment of fungal corneal ulcers with amphotercin B ointment. Am J Ophthalmol 1997;124:836–838
  • O’Day DM, Smith R, Stevens JB, Williams TE, Robinson RD, Head WS. Toxicity and pharmacokinetics of subconjunctival amphotericin B. Cornea 1991;10:411–417
  • Garcia-Valenzuela E, Song CD. Intracorneal injection of amphothericin B for recurrent fungal keratitis and endophthalmitis. Arch Ophthalmol 2005;123:1721–1723
  • Yavas GF, Oztürk F, Küsbeci T, Cetinkaya Z, Ermis SS, Kiraz N, et al. Antifungal efficacy of voriconazole, itraconazole and amphotericin b in experimental fusarium solani keratitis. Graefes Arch Clin Exp Ophthalmol 2008;246:275–279
  • Qu L, Li L, Xie H. Corneal and aqueous humor concentrations of amphotericin B using three different routes of administration in a rabbit model. Ophthalmic Res 2010; 43:153–158
  • Yoon KC, Jeong IY, Im SK, Chae HJ, Yang SY. Therapeutic effect of intracameral amphotericin B injection in the treatment of fungal keratitis. Cornea 2007;26:814–818
  • Yilmaz S, Ture M, Maden A. Efficacy of intracameral amphotericin B injection in the management of refractory keratomycosis and endophthalmitis. Cornea 2007;26:398–402
  • Foster JBT, Almeda E, Littman ML, Wilson ME. Some intraocular and conjunctival effects of amphotercin B in man and in rabbits. Arch Ophthalmol 1958;60:555–564
  • Donovick R, Gold W, Pagano JF, Stout HA. Amphotericins A and B, antifungal antibiotics produced by a streptomycete. I. In vitro studies. Antibiot Annu 1955–1956;3:579–586
  • Brajtburg J, Elberg S, Medoff J, Kobayashi GS, Schlessinger D, Medoff G. Stimulatory, permeabilizing, and toxic effects of amphotericin B on L cells. Antimicrob Agents Chemother 1984;26:892–897
  • Bolard J, Legrand P, Heitz F, Cybulska B. One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium. Biochemistry 1991;30:5707–5715
  • Perkhofer S, Blum G, Speth C, Mayr A, Dierich MP, Lass-Flörl C. Influence of amphotericin B and amphotericin B colloidal dispersion on the functions of human phagocytes in defence against Aspergillus species. Eur J Clin Microbiol Infect 2007;26:413–417
  • Kagan S, Ickowicz D, Shmuel M, Altschuler Y, Sionov E, Pitusi M, et al. Toxicity mechanisms of amphotericin B and its neutralization by conjugation with arabinogalactan. Antimicrob Agents Chemother 2012;56:5603–5611
  • Hashemian MN, Zare MA, Rahimi F, Mohammadpour M. Deep intrastromal bevacizumab injection for management of corneal stromal vascularization after deep anterior lamellar keratoplasty, a novel technique. Cornea 2011;30:215–218
  • Neoh CF, Leung L, Vajpayee RB, Stewart K, Kong DC. Treatment of Alternaria keratitis with intrastromal and topical caspofungin in combination with intrastromal, topical, and oral voriconazole. Ann Pharmacother 2011;45:e24
  • Sharma N, Agarwal P, Sinha R, Titiyal JS, Velpandian T, Vajpayee RB. Evaluation of intrastromal voriconazole injection in recalcitrant deep fungal keratitis: case series. Br J Ophthalmol 2011;95:1735–1737
  • Kaji Y, Yamamoto E, Hiraoka T, Oshika T. Toxicities and pharmacokinetics of subconjunctival injection of liposomal amphotericin B. Graefes Arch Clin Exp Ophthalmol 2009;247:549–553

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