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Current Eye Research Volume 3, 1984 - Issue 6
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Original Article

Vitamin A is present as retinol in the tears of humans and rabbits

John L. Ubels Department of Physiology and Ophthalmology, The Medical College of Wisconsin, Milwaukee, WI, 53226, USA
&
Scott M. Macrae Department of Physiology and Ophthalmology, The Medical College of Wisconsin, Milwaukee, WI, 53226, USA
Pages 815-822 | Received 15 Sep 1983, Accepted 27 Mar 1984, Published online: 02 Jul 2009

References

  • Sommer A. Effects of vitamin A deficiency in the ocular surface. Ophthalmol 1983; 90: 592–600
  • Wiggert B., Bergsma D. R., Helmsen R. J., Aligood J., Lewis M., Chader G. J. Retinol receptors in corneal epithelium, stroma, and endothelium. Biochim. Biophys. Acta. 1977; 491: 104–113
  • Wiggert B., Bergsma D. R., Helmsen R., Chader G. J. Vitamin A receptors: retinoic acid binding in ocular tissues. Biochem. J. 1978; 169: 87–94
  • Smith J. E., Goodman O. S. Retinol binding protein and the regulation of vitamin A transport. Fed. Proc. 1979; 38: 2504–2509
  • Rask L., Geiger C., Bill A., Peterson P. A. Vitamin A supply of the cornea. Exp. Eye Res. 1980; 31: 201–211
  • Sommer A. Treatment of corneal xerophthalmia with retinoic acid. Am. J. Ophthalmol. 1983; 95: 349–352
  • Ubels J. L., Edelhauser H. F., Austin K. H. Healing of experimental corneal wounds treated with topically applied reti-noids. Am. J. Ophthalmol. 1983; 95: 353–358
  • Carney L. G., Hill R. M. Human tear buffering capacity. Arch. Ophthalmol. 1979; 97: 951–952
  • McCormick A. M., Napoli J. L., DeLuca H. F. High pressure liquid chromatographic resolution of vitamin A compounds. Anal. Biochem. 1978; 86: 25–33
  • Van Horn D. L., Schutten W. H., Hyndiuk R. A., Kurz P. Xerophthalmia in vitamin A-deficient rabbits. Clinical and ultra-structural alterations in the cornea. Invest. Ophthalmol. Vis Sci. 1980; 19: 1067–1079
  • Johnson E. L., Stevenson R. Basic liquid chromatography. Varian, Palo Alto, CA. 1978; 227–228
  • Sporn M. B., Dunlop N. M., Newton D. L., Hinterson W. R. Relationship between structure and activity of retinoids. Nature 1976; 263: 110–113
  • Pirie A. Effects of locally applied retinoic acid on corneal xerophthalmia in the rat. Exp. Eye Res. 1977; 25: 297–302
  • Hatchell D. L., FaculJak M., Kubicek D. Treatment of xerophthalmia with retinol, retinoic acid and etretinate. Arch. Ophthalmol.
  • Ubels J. L., Edelhauser H. F. Retinoid permeability and uptake in corneas of normal and vitamin A deficient rabbits. Arch Ophthalmol. 1982; 100: 1828–1831
  • Tseng S. C.G., Huang J. W., Sun T. T., Hatchell D. L. A keratinization assay for xerophthalmia. Ophthalmol. (Suppl.) 1982; 89: 193

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