Potential Association of DDR1 Genetic Variant with FEV₁ Decline by Aspirin Provocation in Asthmatics

References

• Fanta CH. Asthma. N Engl J Med 2009; 360:1002–1014.
   Web of Science ®Google Scholar
• Lee RU, Stevenson DD. Aspirin-exacerbated respiratory disease: evaluation and management. Allergy Asthma Immunol Res 2011; 3:3–10.
   PubMed Web of Science ®Google Scholar
• Jenkins C, Costello J, Hodge L. Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice. BMJ 2004; 328:434.
   Google Scholar
• Stevenson DD, Szczeklik A. Clinical and pathologic perspectives on aspirin sensitivity and asthma. J Allergy Clin Immunol 2006; 118: 773–786.
   PubMed Web of Science ®Google Scholar
• Widal F, Abrami P, Lermoyez J. Anaphylaxie et idiosyncrasie. 1992 [Anaphylaxis and idiosyncrasy. 1992]. Allergy Proc 1993; 14:373–376.
   PubMedGoogle Scholar
• Babu KS, Salvi SS. Aspirin and asthma. Chest 2000; 118:1470–1476.
   PubMed Web of Science ®Google Scholar
• Kim SH, Hur GY, Choi JH, Park HS. Pharmacogenetics of aspirin-intolerant asthma. Pharmacogenomics 2008; 9:85–91.
   PubMedGoogle Scholar
• Kim SH, Kim YK, Park HW, Kim SH, Ye YM, Min KU, Park HS. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. Respir Med 2009; 103:356–363.
   PubMedGoogle Scholar
• Kim SH, Ye YM, Hur GY, Lee SK, Sampson AP, Lee HY, Park HS. CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients. Pharmacogenomics 2007; 8:1143–1150.
   PubMed Web of Science ®Google Scholar
• Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 2006; 368:780–793.
   PubMed Web of Science ®Google Scholar
• Djukanovic R, Roche WR, Wilson JW, Beasley CR, Twentyman OP, Howarth RH, Holgate ST. Mucosal inflammation in asthma. Am Rev Respir Dis 1990; 142:434–457.
   PubMed Web of Science ®Google Scholar
• Kamohara H, Yamashiro S, Galligan C, Yoshimura T. Discoidin domain receptor 1 isoform-a (DDR1alpha) promotes migration of leukocytes in three-dimensional collagen lattices. Faseb J 2001; 15:2724–2726.
   PubMedGoogle Scholar
• Sakamoto O, Suga M, Suda T, Ando M. Expression of discoidin domain receptor 1 tyrosine kinase on the human bronchial epithelium. Eur Respir J 2001; 17:969–974.
   PubMedGoogle Scholar
• Matsuyama W, Wang L, Farrar WL, Faure M, Yoshimura T. Activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: role of p38 mitogen-activated protein kinase and NF-kappa B. J Immunol 2004; 172:2332–2340.
   PubMed Web of Science ®Google Scholar
• Avivi-Green C, Singal M, Vogel WF. Discoidin domain receptor 1-deficient mice are resistant to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med 2006; 174:420–427.
   PubMed Web of Science ®Google Scholar
• Camara J, Jarai G. Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha. Fibrogenesis Tissue Repair 2010; 3:2.
   PubMedGoogle Scholar
• Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, O’Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31:143–178.
   PubMed Web of Science ®Google Scholar
• Macy E, Bernstein JA, Castells MC, Gawchik SM, Lee TH, Settipane RA, Simon RA, Wald J, Woessner KM. Aspirin challenge and desensitization for aspirin-exacerbated respiratory disease: a practice paper. Ann Allergy Asthma Immunol 2007; 98:172–174.
   PubMed Web of Science ®Google Scholar
• Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, MacIntyre NR, McKay RT, Wanger JS, Anderson SD, Cockcroft DW, Fish JE, Sterk PJ. Guidelines for methacholine and exercise challenge testing-1999. Am J Respir Crit Care Med 2000; 161:309–329.
   PubMed Web of Science ®Google Scholar
• Kim TH, Chang HS, Park SM, Nam BY, Park JS, Rhim T, Park HS, Kim MK, Choi IS, Cho SH, Chung IY, Park BL, Park CS, Shin HD. Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics. Clin Exp Allergy 2008; 38:1727–1737.
   PubMed Web of Science ®Google Scholar
• Cormican LJ, Farooque S, Altmann DR, Lee TH. Improvements in an oral aspirin challenge protocol for the diagnosis of aspirin hypersensitivity. Clin Exp Allergy 2005; 35:717–722.
   PubMedGoogle Scholar
• Kim JH, Cha JY, Cheong HS, Park JS, Jang AS, Uh ST, Kim MK, Choi IS, Cho SH, Park BL, Bae JS, Park CS, Shin HD. KIF3A, a Cilia Structural Gene on Chromosome 5q31, and Its Polymorphisms Show an Association with Aspirin Hypersensitivity in Asthma. J Clin Immunol 2011; 31:112–121.
   PubMedGoogle Scholar
• Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263–265.
   PubMed Web of Science ®Google Scholar
• Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68:978–989.
   PubMed Web of Science ®Google Scholar
• Rioux JD, Goyette P, Vyse TJ, Hammarstrom L, Fernando MM, Green T, De Jager PL, Foisy S, Wang J, de Bakker PI, Leslie S, McVean G, Padyukov L, Alfredsson L, Annese V, Hafler DA, Pan-Hammarstrom Q, Matell R, Sawcer SJ, Compston AD, Cree BA, Mirel DB, Daly MJ, Behrens TW, Klareskog L, Gregersen PK, Oksenberg JR, Hauser SL. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A 2009; 106: 18680–18685.
   PubMed Web of Science ®Google Scholar
• Shiina T, Inoko H, Kulski JK. An update of the HLA genomic region, locus information and disease associations: 2004. Tissue Antigens 2004; 64:631–649.
   PubMedGoogle Scholar
• Santiago JL, Li W, Lee A, Martinez A, Chandrasekaran A, Fernandez-Arquero M, Khalili H, de la Concha EG, Urcelay E, Gregersen PK. Localization of Type 1 Diabetes susceptibility in the ancestral haplotype 18.2 by high density SNP mapping. Genomics 2009; 94:228–232.
   Google Scholar
• Silva de Castro CC, do Nascimento LM, Walker G, Werneck RI, Nogoceke E, Mira MT. Genetic variants of the DDR1 gene are associated with vitiligo in two independent Brazilian population samples. J Invest Dermatol 2010; 130:1813–1818.
   PubMed Web of Science ®Google Scholar
• Tantisira KG, Drazen JM. Genetics and pharmacogenetics of the leukotriene pathway. J Allergy Clin Immunol 2009; 124:422–427.
   PubMed Web of Science ®Google Scholar
• Park JS, Chang HS, Park CS, Lee JH, Lee YM, Choi JH, Park HS, Kim LH, Park BL, Choi YH, Shin HD. Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. Pharmacogenet Genomics 2005; 15:483–492.
   PubMed Web of Science ®Google Scholar
• Kim JY, Kim JH, Park TJ, Bae JS, Lee JS, Pasaje CF, Park BL, Cheong HS, Park JS, Park SW, Uh ST, Kim MK, Choi IS, Cho SH, Choi BW, Park CS, Shin HD. Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. BMC Pulm Med 2010; 10:34.
   PubMedGoogle Scholar
• Akahoshi M, Obara K, Hirota T, Matsuda A, Hasegawa K, Takahashi N, Shimizu M, Nakashima K, Cheng L, Doi S, Fujiwara H, Miyatake A, Fujita K, Higashi N, Taniguchi M, Enomoto T, Mao XQ, Nakashima H, Adra CN, Nakamura Y, Tamari M, Shirakawa T. Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Hum Genet 2005; 117:16–26.
   PubMed Web of Science ®Google Scholar
• Vogel W, Gish GD, Alves F, Pawson T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell 1997; 1:13–23.
   PubMed Web of Science ®Google Scholar
• Kim H, Uhm Y, Yun J, Im S, Yim S, Chung J, Shin M, Lee M. Association between polymorphisms of discoidin domain receptor tyrosine kinase 1 (DDR1) and non-segmental vitiligo in the Korean population. Eur J Dermatol. 2010; 20:231–232.
   PubMed Web of Science ®Google Scholar
• Shintani Y, Fukumoto Y, Chaika N, Svoboda R, Wheelock MJ, Johnson KR. Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol 2008; 180:1277–1289.
   PubMed Web of Science ®Google Scholar
• Kaarteenaho R, Lappi-Blanco E, Lehtonen S. Epithelial N-cadherin and nuclear beta-catenin are up-regulated during early development of human lung. BMC Dev Biol 2010; 10:113.
   PubMedGoogle Scholar
• Tregouet DA, Groop PH, McGinn S, Forsblom C, Hadjadj S, Marre M, Parving HH, Tarnow L, Telgmann R, Godefroy T, Nicaud V, Rousseau R, Parkkonen M, Hoverfalt A, Gut I, Heath S, Matsuda F, Cox R, Kazeem G, Farrall M, Gauguier D, Brand-Herrmann SM, Cambien F, Lathrop M, Vionnet N. G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes. Diabetes 2008; 57:2843–28450.
   PubMedGoogle Scholar
• Gu X, Qi P, Zhou F, Ji Q, Wang H, Dou T, Zhao Y, Gao C. An intronic polymorphism in the corticotropin-releasing hormone receptor 2 gene increases susceptibility to HBV-related hepatocellular carcinoma in Chinese population. Hum Genet 2010; 127:75–81.
   PubMedGoogle Scholar
• Pagani F, Baralle FE. Genomic variants in exons and introns: identifying the splicing spoilers. Nat Rev Genet 2004; 5:389–396.
   PubMed Web of Science ®Google Scholar
• Brinster RL, Allen JM, Behringer RR, Gelinas RE, Palmiter RD. Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci U S A 1988; 85:836–840.
   PubMed Web of Science ®Google Scholar