Evaluation of a Common Variant of the Gene Encoding Clara Cell 10 kd Protein (CC10) as a Candidate Determinant for Asthma Severity and Steroid Responsiveness Among Chinese Children

References

• Rabe K, Adachi M, Lai C, Soriano J, Vermeire P, Weiss K, Weiss S. Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol 2004; 114:40–47.
   PubMed Web of Science ®Google Scholar
• Pearce N, Aït-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E, Robertson C; and the ISAAC Phase Three Study Group. World-wide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2007; 62:758–766.
   PubMed Web of Science ®Google Scholar
• Tsuang HC, Su HJ, Kao FF, Shih HC. Effects of changing risk factors on increasing asthma prevalence in southern Taiwan. Paediatr Perinat Epidemiol 2003; 17:3–9.
   PubMed Web of Science ®Google Scholar
• Kao CC, Huang JL, Ou LS, See LC. The prevalence, severity and seasonal variations of asthma, rhinitis and eczema in Taiwanese schoolchildren. Pediatr Allergy Immunol 2005; 16:408–415.
   PubMed Web of Science ®Google Scholar
• Yan DC, Ou LS, Tsai TL, Wu WF, Huang JL. Prevalence and severity of symptoms of asthma, rhinitis, and eczema in 13-to 14-year-old children in Taipei, Taiwan. Ann Allergy Asthma Immunol 2005; 95:579–585.
   PubMed Web of Science ®Google Scholar
• Mukherjee AB, Zhang Z, Chilton BS. Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily. Endocr Rev 2007; 28:707–725.
   PubMed Web of Science ®Google Scholar
• Shijubo N, Kawabata I, Sato N, Itoh Y. Clinical aspects of Clara cell 10-kDa protein/uteroglobin (secretoglobin 1A1). Curr Pharm Des 2003; 9:1139–1149.
   PubMed Web of Science ®Google Scholar
• Hayashida S, Harrod KS, Whitsett JA. Regulation and function of CCSP during pulmonary Pseudomonas aeruginosa infection in vivo. Am J Physiol Lung Cell Mol Physiol 2000; 279:452–459.
   PubMed Web of Science ®Google Scholar
• Chen LC, Zhang Z, Myers AC, Huang SK. Cutting edge: altered pulmonary eosinophilic inflammation in mice deficient for Clara cell secretory 10-kDa protein. J Immunol 2001; 340(167): 3025–3028.
   Google Scholar
• Mandal AK, Zhang Z, Ray R, Choi MS, Chowdhury B, Pattabiraman N, Mukherjee AB. Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions. J Exp Med 2004; 199:1317–1330.
   PubMed Web of Science ®Google Scholar
• Wang SZ, Rosenberger CL, Espindola TM, Barrett EG, Tesfaigzi Y, Bice DE, Harrod KS. CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model. Am J Physiol Lung Cell Mol Physiol 2001; 281:L1303–L1311.
   PubMed Web of Science ®Google Scholar
• Laing IA, Hermans C, Bernard A, Burton PR, Goldblatt J, Le Souef PN. Association between plasma CC16 levels, the A38G polymorphism, and asthma. Am J Respir Crit Care Med 2000; 16:124–127.
   Google Scholar
• Candelaria PV, Backer V, Laing IA, Porsbjerg C, Nepper-Christensen S, de Klerk N, Goldblatt J, Le Souëf PN. Association between asthma-related phenotypes and the CC16 A38G polymorphism in an unselected population of young adult Danes. Immunogenetics 2005; 57:25–32.
   PubMed Web of Science ®Google Scholar
• Gao PS, Mao XQ, Kawai M, Enomoto T, Sasaki S, Tanabe O, Yoshimura K, Shaldon SR, Dake Y, Kitano H, Coull P, Shirakawa T, Hopkin JM. Negative association between asthma and variants of CC16 (CC10) on chromosome 11q13 in British and Japanese populations. Hum Genet 1998; 103:57–59.
   PubMedGoogle Scholar
• Mansur AH, Fryer AA, Hepple M, Strange RC, Spiteri MA. An association study between the Clara cell secretory protein CC16 A38G polymorphism and asthma phenotypes. Clin Exp Allergy 2002; 32:994–999.
   PubMedGoogle Scholar
• Sharma S, Ghosh B. Association of an intragenic microsatellite marker in the CC16 gene with asthma in the Indian population. J Hum Genet 2004; 49:677–683.
   PubMedGoogle Scholar
• Van Vyve T, Chanez P, Bernard A, Bousquet J, Godard P, Lauwerijs R, Sibille Y. Protein content in bronchoalveolar lavage fluid of patients with asthma and control subjects. J Allergy Clin Immunol 1995; 95:60–68.
   PubMed Web of Science ®Google Scholar
• Shijubo N, Itoh Y, Yamaguchi T, Sugaya F, Hirasawa M, Yamada T, Kawai T, Abe S. Serum levels of Clara cell 10-kDa protein are decreased in patients with asthma. Lung 1999; 177:45–52.
   PubMed Web of Science ®Google Scholar
• Yang KD, Ou CY, Chang JC, Chen RF, Liu CA, Liang HM, Hsu TY, Chen LC, Huang SK. Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. J Allergy Clin Immunol 2007; 120:842–848.
   PubMed Web of Science ®Google Scholar
• Benson M, Fransson M, Martinsson T, Naluai AT, Uddman R, Cardell LO. Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen-challenged patients with intermittent allergic rhinitis. Allergy 2007; 62:178–183.
   PubMedGoogle Scholar
• Gioldassi XM, Papadimitriou H, Mikraki V, Karamanos NK. Clara cell secretory protein: determination of serum levels by an enzyme immunoassay and its importance as an indicator of bronchial asthma in children. J Pharm Biomed Anal 2004; 34:823–826.
   PubMedGoogle Scholar
• Chen J, Lam S, Pilon A, McWilliams A, Macaulay C, Szabo E. Higher levels of the anti-inflammatory protein CC10 are associated with improvement in bronchial dysplasia and sputum cytometric assessment in individuals at high risk for lung cancer. Clin Cancer Res 2008; 14:1590–1597.
   PubMed Web of Science ®Google Scholar
• Broeckaert F, Arsalane K, Hermans C, Bergamaschi E, Brustolin A, Mutti A, Serum BA. Clara cell protein: a sensitive biomarker of increased lung epithelium permeability caused by ambient ozone. Environ Health Perspect 2000; 108:533–537.
   PubMed Web of Science ®Google Scholar
• Lakind JS, Holgate ST, Ownby DR, Mansur AH, Helms PJ, Pyatt D, Hays SM. A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects. Biomarkers 2007; 12:445–467.
   PubMed Web of Science ®Google Scholar
• Hallstrand TS, Fahy JV. Practical management of acute asthma in adults. Respir Care 2002; 47:171–182.
   PubMedGoogle Scholar
• Robinson D, Hamid Q, Ying S, Bentley A, Assoufi B, Durham S. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. Am Rev Respir Dis 1993; 148:401–406.
   PubMed Web of Science ®Google Scholar
• Schwiebert LM, Beck LA, Stellato C, Bickel CA, Bochner BS, Schleimer RP. Glucocorticosteroid inhibition of cytokine production relevance to anti-allergic actions. J Allergy Clin Immunol 1996; 97:143–152.
   PubMed Web of Science ®Google Scholar
• Goleva E, Li LB, Eves PT, Strand MJ, Martin RJ, Leung DY. Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 2006; 173:607–616.
   PubMed Web of Science ®Google Scholar
• Berg T, Cassel TN, Schwarze PE, Nord M. Glucocorticoids regulate the CCSP and CYP2B1 promoters via C/EBPbeta and delta in lung cells. Biochem Biophys Res Commun 2002; 293:907–912.
   PubMedGoogle Scholar
• Kim S, Shim JJ, Burgel PR, Ueki IF, Dao-Pick T, Tam DC, Nadel JA. IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway. Am J Physiol Lung Cell Mol Physiol 2002; 283:L67–L75.
   PubMed Web of Science ®Google Scholar
• Yao TC, Kuo ML, See LC, Chen LC, Yan DC, Ou LS, Shaw CK, Huang JL. The RANTES promoter polymorphism: a genetic risk factor for near-fatal asthma in Chinese children. J Allergy Clin Immunol 2003; 111(6): 1285–1292.
   PubMed Web of Science ®Google Scholar
• Huang JL, Wang SY, Hsieh KH. Effect of short-term exposure to low levels of SO2 and NOx on pulmonary function and methacholine and allergen bronchial sensitivities in asthmatic children. Arch Environ Health 1991; 46:296–299.
   PubMed Web of Science ®Google Scholar
• Tsaprouni LG, Ito K, Adcock IM, Punchard N. Suppression of lipopolysaccharide-and tumor necrosis factor-alpha-induced interleukin(IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation. Clin Exp Immunol 2007; 150:151–157.
   PubMed Web of Science ®Google Scholar
• Neale BM, Sham PC. The future of association studies: gene-based analysis and replication. Am J Hum Genet 2004; 75(3): 353–362.
   PubMed Web of Science ®Google Scholar
• Zhu M, Zhao S. Candidate gene identification approach: progress and challenges. Int J Biol Sci 2007; 3(7): 420–427.
   PubMed Web of Science ®Google Scholar
• Sengler C, Heinzmann A, Jerkic SP, Haider A, Sommerfeld C, Niggemann B, Lau S, Forster J, Schuster A, Kamin W, Bauer C, Laing I, LeSouef P, Wahn U, Deichmann K, Nickel R. Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children. J Allergy Clin Immunol 2003; 111:515–519.
   PubMedGoogle Scholar
• Boldt K, Rist W, Weiss SM, Weith A, Lenter MC. FPRL-1 induces modifications of migration-associated proteins in human neutrophils. Proteomics 2006; 6(17): 4790–4799.
   PubMedGoogle Scholar
• Hung CH, Chen LC, Zhang Z, Chowdhury B, Lee WL, Plunkett B, Chen CH, Myers AC, Huang SK. Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein. J Allergy Clin Immunol 2004; 114(3): 664–670.
   PubMed Web of Science ®Google Scholar
• Snyder JC, Reynolds SD, Hollingsworth JW, Li Z, Kaminski N, Stripp BR. Clara cells attenuate the inflammatory response through regulation of macrophage behavior. Am J Respir Cell Mol Biol 2010; 42(2): 161–171.
   PubMedGoogle Scholar
• Martin AC, Laing IA, Khoo SK, Zhang G, Rueter K, Teoh L, Taheri S, Hayden CM, Geelhoed GC, Goldblatt J, LeSouëf PN. Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity. Am J Respir Crit Care Med 2006; 173:617–622.
   PubMedGoogle Scholar
• Sawaya PL, Stripp BR, Whitsett JA, Luse DS. The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families. Mol Cell Biol 1993; 13:3860–3871.
   PubMed Web of Science ®Google Scholar