Is a Single Blood Eosinophil Count a Reliable Marker for “Eosinophilic Asthma?”

References

• Fahy JV. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc 2009; 6:256–259.
   PubMedGoogle Scholar
• Lemière C, Ernst P, Olivenstein R, Yamauchi Y, Govindaraju K, Ludwig MS, Martin JG, Hamid Q. Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes. J Allergy Clin Immunol 2006; 118: 1033–1039.
   PubMed Web of Science ®Google Scholar
• Lovett CJ, Whitehead BF, Gibson PG. Eosinophilic airway inflammation and the prognosis of childhood asthma. Clin Exp Allergy 2007; 37:1594–1601.
   PubMed Web of Science ®Google Scholar
• Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, Wardlaw AJ, Pavord ID. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002; 360:1715–1721.
   PubMed Web of Science ®Google Scholar
• Castro M, Mathur S, Hargreave F, Boulet LP, Xie F, Young J, Wilkins HJ, Henkel T, Nair P; Res-5-0010 Study Group. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med. 2011 Nov 15;184(10):1125–32.
   Google Scholar
• Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, Marshall RP, Bradding P, Green RH, Wardlaw AJ, Pavord ID. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360: 973–984.
   PubMed Web of Science ®Google Scholar
• Simpson JL, McElduff P, Gibson PG. Assessment and reproducibility of non-eosinophilic asthma using induced sputum. Respiration 2010; 79:147–151.
   PubMed Web of Science ®Google Scholar
• Petsky HL, Cates CJ, Lasserson TJ, Li AM, Turner C, Kynaston JA, Chang AB. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils). Thorax. 2012 Mar;67(3):199–208.
   Google Scholar
• American Thoracic Society. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 2000; 162:2341–2351.
   PubMedGoogle Scholar
• Horn BR, Robin ED, Theodore J, Van Kessel A. Total eosinophil counts in the management of bronchial asthma. N Engl J Med 1975; 292: 1152–1155.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Chanez P, Lacoste JY, Barnéon G, Ghavanian N, Enander I, Venge P, Ahlstedt S, Simony-Lafontaine J, Godard P, . Eosinophilic inflammation in asthma. N Engl J Med 1990; 323:1033–1039.
   PubMed Web of Science ®Google Scholar
• Ulrik CS. Peripheral eosinophil counts as a marker of disease activity in intrinsic and extrinsic asthma. Clin Exp Allergy 1995; 25:820–827.
   PubMed Web of Science ®Google Scholar
• Szefler SJ, Wenzel S, Brown R, Erzurum SC, Fahy JV, Hamilton RG, Hunt JF, Kita H, Liu AH, Panettieri RA Jr, Schleimer RP, Minnicozzi M. Asthma outcomes: biomarkers. J Allergy Clin Immunol 2012; 129:S9–S23.
   PubMed Web of Science ®Google Scholar
• Adkinson NF, Middleton E. Middleton’s Allergy: Principles & Practice. 7th ed. Philadelphia: Mosby/Elsevier, 2009.
   Google Scholar
• Halberg F, Visscher MB. Regular diurnal physiological variation in eosinophil levels in five stocks of mice. Proc Soc Exp Biol Med 1950; 75:846–847.
   PubMed Web of Science ®Google Scholar
• Maklad MK, Ahmed MM, Hussein HM, el-Wakil MR, el-Wakil HS. Time factor and eosinophil count in relation to experimental Schistosoma mansoni infection. J Egypt Soc Parasitol 1994; 24: 591–596.
   PubMedGoogle Scholar
• Stein HJ, Bader RA, Lemle A, . Hormonal alterations in men exposed to heat and cold stress. J Clin Endocrinol Metab 1949; 9: 529–547.
   PubMed Web of Science ®Google Scholar
• Donato RA, Strumia MM. An exact method for the chamber count of eosinophils in capillary blood and its application to the study of the diurnal cycle. Blood 1952; 7:1020–1029.
   PubMed Web of Science ®Google Scholar
• Tatai K, Ogawa S. A study of diurnal variation in circulating eosinophils especially with reference to sleep in healthy individuals. Jpn J Physiol 1951; 1:328–331.
   PubMedGoogle Scholar
• Acland JD, Gould AH. Normal variation in the count of circulating eosinophils in man. J Physiol 1956; 133:456–466.
   PubMed Web of Science ®Google Scholar
• Blumberg MZ, Buckley JM. The total eosinophil count and adrenal function in asthmatic children. Ann Allergy 1975; 35:377–381.
   PubMedGoogle Scholar
• Blumberg MZ, Buckley JM. The total eosinophil count in asthmatic children. J Allergy Clin Immunol 1976; 57:493–498.
   PubMed Web of Science ®Google Scholar
• Singh RK, Chandra R, Narang RK, Singh SK, Katiyar SK, Singh RP, Pandey HN, Joshi LD. Circadian variations of the absolute eosinophil count and serum histaminase activity in tropical pulmonary eosinophilia. Trop Geogr Med 1987; 39:49–52.
   PubMedGoogle Scholar
• Winkel P, Statland BE, Saunders AM, Osborn H, Kupperman H. Within-day physiologic variation of leukocyte types in healthy subjects as assayed by two automated leukocyte differential analyzers. Am J Clin Pathol 1981; 75:693–700.
   PubMed Web of Science ®Google Scholar
• Steinbach KH, Schick P, Trepel F, Raffler H, Döhrmann J, Heilgeist G, Heltzel W, Li K, Past W, van der Woerd-de Lange JA, Theml H, Fliedner TM, Begemann H. Estimation of kinetic parameters of neutrophilic, eosinophilic, and basophilic granulocytes in human blood. Blut 1979; 39:27–38.
   PubMedGoogle Scholar
• Martin JR, Pattee CJ. Correlation of the eosinophil count with the clinical course during cortisone and ACTH therapy. Can Med Assoc J 1953; 68:564–569.
   PubMed Web of Science ®Google Scholar