1,25-Dihydroxyvitamin D₃ (1,25-(OH)₂D₃) Attenuates Airway Remodeling in a Murine Model of Chronic Asthma

References

• An SS, Bai TR, Bates JH, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Fairbank NJ, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gosens R, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Paré PD, Pellegrino R, Sanderson MJ, Schellenberg RR, Seow CY, Silveira PS, Smith PG, Solway J, Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, Tran T, Wang L. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J 2007; 29(5):834–860.
   PubMedGoogle Scholar
• Bai TR, Knight DA. Structural changes in the airways in asthma: observations and consequences. Clin Sci (Lond) 2005; 108(6):463–477.
   PubMedGoogle Scholar
• O’Byrne PM, Pedersen S, Busse WW, Tan WC, Chen YZ, Ohlsson SV, Ullman A, Lamm CJ, Pauwels RA. Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma. Chest 2006; 129(6):1478–1485.
   PubMed Web of Science ®Google Scholar
• Taher YA, van Esch BC, Hofman GA, Henricks PA, van Oosterhout AJ. 1alpha,25-dihydroxyvitamin D3 potentiates the beneficial effects of allergen immunotherapy in a mouse model of allergic asthma: role for IL-10 and TGF-beta. J Immunol 2008; 180(8):5211–5221.
   PubMedGoogle Scholar
• Gorman S, Judge MA, Burchell JT, Turner DJ, Hart PH. 1,25-Dihydroxyvitamin D3 enhances the ability of transferred CD4 + CD25+ cells to modulate T helper type 2-driven asthmatic responses. Immunology 2010; 130(2):181–192.
   PubMed Web of Science ®Google Scholar
• Song Y, Qi H, Wu C. Effect of 1,25-(OH)2D3 (a vitamin D analoge) on passively sensitized human airway smooth muscle cells. Respirology 2007; 12(4):486–494.
   PubMed Web of Science ®Google Scholar
• Sundar IK, Hwang JW, Wu S, Sun J, Rahman I. Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation. Biochem Biophys Res Commun 2011; 406(1):127–133.
   PubMed Web of Science ®Google Scholar
• Ramirez AM, Wongtrakool C, Welch T, Steinmeyer A, Zügel U, Roman J. Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells. J Steroid Biochem Mol Biol 2010; 118(3):142–150.
   PubMedGoogle Scholar
• Charokopos N, Apostolopoulos N, Kalapodi M, Leotsinidis M, Karamanos N, Mouzaki A. Bronchial asthma, chronic obstructive pulmonary disease and NF- kappaB. Curr Med Chem 2009; 16(17):867–883.
   PubMedGoogle Scholar
• Birrell MA, Hardaker E, Wong S, McCluskie K, Catley M, De Alba J, Newton R, Haj-Yahia S, Pun KT, Watts CJ, Shaw RJ, Savage TJ, Belvisi MG. Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. Am J Respir Crit Care Med 2005; 172(8):962–971.
   PubMedGoogle Scholar
• Matheu V, Bäck O, Mondoc E, Issazadeh-Navikas S. Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J Allergy Clin Immunol 2003; 112(3):585–592.
   PubMed Web of Science ®Google Scholar
• Wittke A, Weaver V, Mahon BD, August A, Cantorna MT. Vitamin D receptor-deficient mice fail to develop experimental allergic asthma. J Immunol 2004; 173(15):3432–3436.
   PubMedGoogle Scholar
• Wittke A, Chang A, Froicu M, Harandi OF, Weaver V, August A, Paulson RF, Cantorna MT. Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation. Arch Biochem Biophys 2007; 460(2):306–313.
   PubMedGoogle Scholar
• Hoffmann A, Levchenko A, Scott ML, Baltimore D. The IκB-NF-κ B signaling module: temporal control and selective gene activation. Science 2002; 298(5596):1241–1245.
   PubMed Web of Science ®Google Scholar
• Holgate ST, Holloway J, Wilson S, Bucchieri F, Puddicombe S, Davies DE. Epithelial-mesenchymal communicationin the pathogenesis of chronic asthma. Proc Am Thorac Soc 2004; 1(2):93–98.
   PubMedGoogle Scholar
• Temelkovski J, Hogan SP, Shepherd DP, Foster PS, Kumar RK. An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Thorax 1998; 53(10):849–856.
   PubMed Web of Science ®Google Scholar
• Tan X, Li Y, Liu Y. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy. J Am Soc Nephrol 2006; 17(12):3382–3393.
   PubMed Web of Science ®Google Scholar
• Koshiishi I, Mitani H, Sumita T, Imanari T. 1,25-Dihydroxyvitamin D3 prevents the conversion of adipose tissue into fibrous tissue in skin exposed to chronic UV irradiation. Toxicol Appl Pharmacol 2001; 173(2):99–104.
   PubMedGoogle Scholar
• Fahy JV. Remodeling of the airway epithelium in asthma. Am J Respir Crit Care Med 2001; 164(10 Pt 2):S46–S51.
   Google Scholar
• Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, Carter R, Wong HH, Cadbury PS, Fahy JV. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med 2004; 169(9):1001–1006.
   PubMed Web of Science ®Google Scholar
• Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003; 167(10):1360–1368.
   PubMed Web of Science ®Google Scholar
• Regamey N, Ochs M, Hilliard TN, Mühlfeld C, Cornish N, Fleming L, Saglani S, Alton EW, Bush A, Jeffery PK, Davies JC. Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non–cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2008; 177(8):837–843.
   PubMed Web of Science ®Google Scholar
• Damera G, Fogle HW, Lim P, Goncharova EA, Zhao H, Banerjee A, Tliba O, Krymskaya VP, Panettieri RA Jr. Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retino-blastoma protein and checkpoint kinase 1. Br J Pharmacol 2009; 158(6):1429–1441.
   PubMed Web of Science ®Google Scholar
• Banerjee A, Damera G, Bhandare R, Gu S, Lopez-Boado Y, Panettieri R Jr, Tliba O. Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells. Br J Pharmacol 2008; 155(1):84–92.
   PubMed Web of Science ®Google Scholar
• Shiba K, Kasahara K, Nakajima H, Adachi M. Structural changes of the airway wall impair respiratory function, even in mild asthma. Chest 2002; 122(5):1622–1626.
   PubMed Web of Science ®Google Scholar
• Ward C, Johns DP, Bish R, Pais M, Reid DW, Ingram C, Feltis B, Walters EH. Reduced airway distensibility, fixed airflow limitation, and airway wall remodeling in asthma. Am J Respir Crit Care Med 2001; 164(9):1718–1721.
   PubMed Web of Science ®Google Scholar
• Gupta A, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, Saglani S. Relationship between serum Vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med 2011; 184(12):1342–1349.
   PubMed Web of Science ®Google Scholar
• Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest 2005; 128(6):3792–3798.
   PubMed Web of Science ®Google Scholar
• Zosky GR, Berry LJ, Elliot JG, James AL, Gorman S, Hart PH. Vitamin D deficiency causes deficits in lung function and alters lung structure. Am J Respir Crit Care Med 2011; 183(10):1336–1343.
   PubMed Web of Science ®Google Scholar
• Lu X, Farmer P, Rubin J, Nanes MS. Integration of the NF kappaB p65 subunit into the vitamin D receptor transcriptional complex: identification of p65 domains that inhibit 1,25-dihydroxyvitamin D3-stimulated transcription. J Cell Biochem 2004; 92(4):833–848.
   PubMedGoogle Scholar
• Chen Y, Kong J, Sun T, Li G, Szeto FL, Liu W, Deb DK, Wang Y, Zhao Q, Thadhani R, Li YC. 1,25-Dihydroxyvitamin D3 suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor-κB activation. Arch Biochem Biophys 2011; 507(2):241–247.
   PubMed Web of Science ®Google Scholar
• Geldmeyer-Hilt K, Heine G, Hartmann B, Baumgrass R, Radbruch A, Worm M. 1,25-Dihydroxyvitamin D3 impairs NF-κB activation in human naïve B cells. Biochem Biophys Res Commun 2011; 407(4):699–702.
   PubMedGoogle Scholar
• Wu S, Xia Y, Liu X, Sun J. Vitamin D receptor deletion leads to reduced level of IkappaBalpha protein through protein translation, protein-protein interaction, and post-translational modification. In J Biochem Cell Biol 2010; 42(2):329–336.
   PubMedGoogle Scholar
• Janjetovic Z, Brozyna AA, Tuckey RC, Kim TK, Nguyen MN, Jozwicki W, Pfeffer SR, Pfeffer LM, Slominski AT. High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives. Br J Cancer 2011; 105(12):1874–1884.
   PubMedGoogle Scholar
• Kwon HJ, Won YS, Nam KT, Yoon YD, Jee H, Yoon WK, Nam KH, Kang JS, Han SU, Choi IP, Kim DY, Kim HC. Vitamin D3 upregulated protein 1 deficiency promotes N-methyl-N-nitrosourea and Helicobacter pylori-induced gastric carcinogenesis in mice. Gut 2012; 61(1):53–63.
   PubMedGoogle Scholar
• Tachi K, Takami M, Zhao B, Mochizuki A, Yamada A, Miyamoto Y, Inoue T, Baba K, Kamijo R. Bone morphogenetic protein 2 enhances mouse osteoclast differentiation via increased levels of receptor activator of NF-κB ligand expression in osteoblasts. Cell Tissue Res 2010; 342(2):213–220.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Pardo V, Martin D, Gutkind JS, Verstuyf A, Bouillon R, de Boland AR, Boland RL. 1Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposisarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo. Endocrinology 2010; 151(1):23–31.
   PubMedGoogle Scholar
• Deb DK, Chen Y, Zhang Z, Zhang Y, Szeto FL, Wong KE, Kong J, Li YC. 1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-{kappa}B pathway. Am J Physiol Renal Physiol 2009; 296(5):F1212–F1218.
   PubMed Web of Science ®Google Scholar
• Tan X, Wen X, Liu Y. Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling. J Am Soc Nephrol 2008; 19(9):1741–1752.
   PubMed Web of Science ®Google Scholar
• Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, Adikibi T, Pridgeon C, Dallman M, Loke TK, Robinson DS, Barrat FJ, O’Garra A, Lavender P, Lee TH, Corrigan C, Hawrylowicz CM. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest 2006; 116(1):146–155.
   PubMed Web of Science ®Google Scholar
• Chikanza IC, Kozaci D, Chernajovsky Y. The molecular and cellular basis of corticosteroid resistance. J Endocrinol 2003; 179(3):301–310.
   PubMedGoogle Scholar
• Gagliardo R, Chanez P, Mathieu M, Bruno A, Costanzo G, Gougat C, Vachier I, Bousquet J, Bonsignore G, Vignola AM. Petsistent activation of nuclear factor- kappa B signaling pathway in severe uncontrolled asthma. Am J Respir Crit Care Med 2003; 168(10):1190–1198.
   PubMedGoogle Scholar