The Effect of Oral Tolerance on the Allergic Airway Response in Younger and Aged Mice

References

• Wu HY, Weiner HL. Oral tolerance. Immunol Res 2003; 28(3):265–284.
   PubMedGoogle Scholar
• Mayer L, Shao L. Therapeutic potential of oral tolerance. Nat Rev Immunol 2004; 4(6):407–419.
   PubMed Web of Science ®Google Scholar
• Weiner HL. Oral tolerance: Immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect 2001; 3(11):947–954.
   PubMedGoogle Scholar
• Samsom JN. Regulation of antigen-specific regulatory T-cell induction via nasal and oral mucosa. Crit Rev Immunol 2004; 24(3):157–177.
   PubMedGoogle Scholar
• Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 1995; 376(6536):177–180.
   PubMed Web of Science ®Google Scholar
• Samsom JN, van Berkel LA, van Helvoort JM, Unger WW, Jansen W, Thepen T, Mebius RE, Verbeek SS, Kroal G. Fc gamma RIIB regulates nasal and oral tolerance: A role for dendritic cells. J Immunol 2005; 174(9):5279–5287.
   PubMedGoogle Scholar
• Fitzgerald DC, Zhang GX, Yu S, Cullimore ML, Zhao Z, Rostami A. Intravenous tolerance effectively overcomes enhanced pro-inflammatory responses and experimental autoimmune encephalomyelitis severity in the absence of IL-12 receptor signaling. J Neuroimmunol 2012; 247(1–2):32–37.
   PubMedGoogle Scholar
• Matta B, Jha P, Bora PS, Bora NS. Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4 + CD25+ T-regulatory cells. Immunol Cell Biol 2010; 88(2):187–196.
   PubMedGoogle Scholar
• Keller AC, Mucida D, Gomes E, Faquim-Mauro E, Faria AM, Rodriguez D, Russo M. Hierarchical suppression of asthma-like responses by mucosal tolerance. J Allergy Clin Immunol 2006; 117(2):283–290.
   PubMedGoogle Scholar
• Berin MC. Mechanisms of allergic sensitization to foods: Bypassing immune tolerance pathways. Immunol Allergy Clin North Am 2012; 32(1):1–10.
   PubMed Web of Science ®Google Scholar
• Zhang X, Izikson L, Liu L, Weiner HL. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol 2001; 167(8):4245–4253.
   PubMedGoogle Scholar
• Faria AM, Garcia G, Rios MJ, Michalaros CL, Vaz NM. Decrease in susceptibility to oral tolerance induction and occurrence of oral immunization to ovalbumin in 20–38-week-old mice. The effect of interval between oral exposures and rate of antigen intake in the oral immunization. Immunology 1993; 78(1):147–151.
   PubMedGoogle Scholar
• de Faria AM, Ficker SM, Speziali E, Menezes JS, Stransky B, Silva Rodrigues V, Vaz NM. Aging affects oral tolerance induction but not its maintenance in mice. Mech Ageing Dev 1998; 102(1):67–80.
   PubMedGoogle Scholar
• Russo M, Nahori MA, Lefort J, Gomes E, de Castro Keller A, Rodriguez D, Ribeiro OG, Adriouch S, Gallois V, de Faria AM, Vargaftig BB. Suppression of asthma-like responses in different mouse strains by oral tolerance. Am J Respir Cell Mol Biol 2001; 24(5):518–526.
   PubMedGoogle Scholar
• Zureik M, Orehek J. Diagnosis and severity of asthma in the elderly: Results of a large survey in 1,485 asthmatics recruited by lung specialists. Respiration 2002; 69(3):223–228.
   PubMedGoogle Scholar
• King MJ, Bukantz SC, Phillips S, Mohapatra SS, Tamulis T, Lockey RF. Serum total IgE and specific IgE to Dermatophagoides pteronyssinus, but not eosinophil cationic protein, are more likely to be elevated in elderly asthmatic patients. Allergy Asthma Proc 2004; 25(5):321–325.
   PubMedGoogle Scholar
• Huss K, Naumann PL, Mason PJ, Nanda JP, Huss RW, Smith CM, Hamilton RG. Asthma severity, atopic status, allergen exposure and quality of life in elderly persons. Ann Allergy Asthma Immunol 2001; 86(5):524–530.
   PubMedGoogle Scholar
• Burrows B, Barbee RA, Cline MG, Knudson RJ, Lebowitz MD. Characteristics of asthma among elderly adults in a sample of the general population. Chest 1991; 100(4):935–942.
   PubMed Web of Science ®Google Scholar
• Rogers L, Cassino C, Berger KI, Goldring RM, Norman RG, Klugh T, Reibman J. Asthma in the elderly: Cockroach sensitization and severity of airway obstruction in elderly nonsmokers. Chest 2002; 122(5): 1580–1586.
   PubMedGoogle Scholar
• Busse PJ, Lurslurchachai L, Sampson HA, Halm EA, Wisnivesky J. Perennial allergen-specific immunoglobulin E levels among inner-city elderly asthmatics. J Asthma 2010; 47(7):781–5.
   PubMed Web of Science ®Google Scholar
• Ariano R, Panzani RC, Augeri G. Late onset asthma clinical and immunological data: Importance of allergy. J Investig Allergol Clin Immunol 1998; 8(1):35–41.
   PubMed Web of Science ®Google Scholar
• Bellia V, Pedone C, Catalano F, Zito A, Davi E, Palange S, Forastiere F, Incalzi RA. Asthma in the elderly: Mortality rate and associated risk factors for mortality. Chest 2007; 132(4):1175–1182.
   PubMed Web of Science ®Google Scholar
• Moorman JERR, Johnson CA, King M, Minor P, Bailey C, Scalia MR, Akinbami LJ. Centers for Disease Control and Prevention (CDC). National surveillance for asthma – United States, 1980–2004. MMWR Surveill Summ 2007; 56(SS08):1–14, 8–54.
   PubMedGoogle Scholar
• Diette GBKJ, Dominici F eds. Why do older adults have higher rates of hospitalization for asthma than younger adults? American Thoracic Society International Conference; 2000; Toronto, Canada.
   Google Scholar
• NAEPP Working Group Report: Considerations for Diagnosis and Managing Asthma in the Elderly 1996. Report No/NIH Publication No. 96-3662.
   Google Scholar
• Eyles J, Brimacombe M, Chaulk P, Stoddart G, Pranger T, Moase O. What determines health? To where should we shift resources? Attitudes towards the determinants of health among multiple stakeholder groups in Prince Edward Island, Canada. Soc Sci Med 2001; 53(12):1611–1619.
   PubMedGoogle Scholar
• Busse PJ, Zhang TF, Srivastava K, Schofield B, Li XM. Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice. Clin Exp Allergy 2007; 37(9):1392–1403.
   PubMed Web of Science ®Google Scholar
• Busse PJ, Zhang TF, Srivastava K, Lin BP, Schofield B, Sealfon SC, Li XM. Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo. J Allergy Clin Immunol 2005; 116(6):1256–1263.
   PubMed Web of Science ®Google Scholar
• Busse PJ, Zhang TF, Schofield B, Kilaru S, Patil S, Li XM. Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor alpha in a murine model of allergic asthma. Ann Allergy Asthma Immunol 2009; 103(4):295–303.
   PubMedGoogle Scholar
• Carson WFt, Guernsey LA, Singh A, Vella AT, Schramm CM, Thrall RS. Accumulation of regulatory T cells in local draining lymph nodes of the lung correlates with spontaneous resolution of chronic asthma in a murine model. Int Arch Allergy Immunol 2008; 145(3):231–243.
   PubMedGoogle Scholar
• Bochner BS, Busse WW. Allergy and asthma. J Allergy Clin Immunol 2005; 115(5):953–959.
   PubMedGoogle Scholar
• Ci X, Chu X, Wei M, Yang X, Cai Q, Deng X. Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury. PLoS One 2012; 7(4):e34634.
   PubMed Web of Science ®Google Scholar
• Simarro M, Giannattasio G, Xing W, Lundequist EM, Stewart S, Stevens RL, Orduña A, Boyce JA, Anderson PJ. The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite. Immunol Lett 2012; 146(1–2):8–14.
   PubMedGoogle Scholar
• Olson N, Kasahara DI, Hristova M, Bernstein R, Janssen-Heininger Y, van der Vliet A. Modulation of NF-{kappa}B and HIF-1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice. Am J Respir Cell Mol Biol 2011; 44(6):813–23.
   PubMedGoogle Scholar
• Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noël A, Cataldo DD. Mouse models of asthma: A comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production. Inflamm Res 2009; 58(12):845–854.
   PubMed Web of Science ®Google Scholar
• Kato H, Fujihashi K, Kato R, Dohi T, Hagiwara Y, Kataoka K, Kobayashi R, MgGhee JR. Lack of oral tolerance in aging is due to sequential loss of Peyer’s patch cell interactions. Int Immunol 2003; 15(2):145–158.
   PubMedGoogle Scholar
• Faria AM, Maron R, Ficker SM, Slavin AJ, Spahn T, Weiner HL. Oral tolerance induced by continuous feeding: Enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis. J Autoimmun 2003; 20(2):135–145.
   PubMedGoogle Scholar
• Wakabayashi A, Utsuyama M, Hosoda T, Sato K, Takahashi H, Hirokawa K. Induction of immunological tolerance by oral, but not intravenous and intraportal, administration of ovalbumin and the difference between young and old mice. J Nutr Health Aging 2006; 10(3):183–191.
   PubMedGoogle Scholar
• Bulati M, Buffa S, Candore G, Caruso C, Dunn-Walters DK, Pellicano M, Wu YC, Colonna Romano  G. B cells and immunosenescence: A focus on IgG + IgD-CD27- (DN) B cells in aged humans. Ageing Res Rev 2011; 10(2):274–284.
   PubMed Web of Science ®Google Scholar
• Koga T, McGhee JR, Kato H, Kato R, Kiyono H, Fujihashi K. Evidence for early aging in the mucosal immune system. J Immunol 2000; 165(9):5352–5359.
   PubMedGoogle Scholar
• Speziali E, Santiago AF, Fernandes RM, Vaz NM, Menezes JS, Faria AM. Specific immune responses but not basal functions of B and T cells are impaired in aged mice. Cell Immunol 2009; 256(1–2):1–5.
   PubMedGoogle Scholar
• Frasca D, Riley RL, Blomberg BB. Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF. Exp Gerontol 2007; 42(3):192–203.
   PubMedGoogle Scholar
• Faria AM, Weiner HL. Oral tolerance: Therapeutic implications for autoimmune diseases. Clin Dev Immunol 2006; 13(2–4):143–157.
   PubMedGoogle Scholar
• Kraal G, Samsom JN, Mebius RE. The importance of regional lymph nodes for mucosal tolerance. Immunol Rev 2006; 213:119–130.
   PubMedGoogle Scholar
• Zhao L, Sun L, Wang H, Ma H, Liu G, Zhao Y. Changes of CD4 + CD25 + Foxp3+ regulatory T cells in aged Balb/c mice. J Leukoc Biol 2007; 81(6):1386–1394.
   PubMedGoogle Scholar
• Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, Belkaid Y, Chougnet C. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol 2008; 181(3):1835–1848.
   PubMedGoogle Scholar
• Chiu BC, Stolberg VR, Zhang H, Chensue SW. Increased Foxp3(+) Treg cell activity reduces dendritic cell co-stimulatory molecule expression in aged mice. Mech Ageing Dev 2007; 128(11–12):618–627.
   PubMed Web of Science ®Google Scholar
• Gregg R, Smith CM, Clark FJ, Dunnion D, Khan N, Chakraverty R, Nayak L, Moss PA. The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age. Clin Exp Immunol 2005; 140(3):540–546.
   PubMed Web of Science ®Google Scholar
• Hwang KA, Kim HR, Kang I. Aging and human CD4(+) regulatory T cells. Mech Ageing Dev 2009; 130(8):509–517.
   PubMedGoogle Scholar
• Robinson DS. Regulatory T cells and asthma. Clin Exp Allergy 2009; 39(9):1314–1323.
   PubMedGoogle Scholar
• Nishioka T, Shimizu J, Iida R, Yamazaki S, Sakaguchi S. CD4 + CD25 + Foxp3+ T cells and CD4 + CD25-Foxp3+ T cells in aged mice. J Immunol 2006; 176(11):6586–6593.
   PubMed Web of Science ®Google Scholar
• Nagatani K, Dohi M, To Y, Tanaka R, Okunishi K, Nakagome K, Sagawa K, Tanno Y, Komagata Y, Yamamoto K. Splenic dendritic cells induced by oral antigen administration are important for the transfer of oral tolerance in an experimental model of asthma. J Immunol 2006; 176(3):1481–1489.
   PubMedGoogle Scholar
• Burchell JT, Wikstrom ME, Stumbles PA, Sly PD, Turner DJ. Attenuation of allergen-induced airway hyperresponsiveness is mediated by airway regulatory T cells. Am J Physiol Lung Cell Mol Physiol 2009; 296(3):L307–L319.
   Google Scholar
• Kearley J, Barker JE, Robinson DS, Lloyd CM. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4 + CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med 2005; 202(11):1539–1547.
   PubMed Web of Science ®Google Scholar
• Kearley J, Robinson DS, Lloyd CM. CD4 + CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol 2008; 122(3):617–624.e6.
   PubMedGoogle Scholar
• Schaefer U, Machida T, Vorlova S, Strickland S, Levi R. The plasminogen activator system modulates sympathetic nerve function. J Exp Med 2006; 203(9):2191–2200.
   PubMedGoogle Scholar
• Lewkowich IP, Herman NS, Schleifer KW, Dance MP, Chen BL, Dienger KM, Sproles AA, Shah JS, Köhl J, Belkaid Y, Wills-Karp M. CD4 + CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med 2005; 202(11):1549–1561.
   PubMed Web of Science ®Google Scholar
• Hartl D, Koller B, Mehlhorn AT, Reinhardt D, Nicolai T, Schendel DJ, Griese M, Krauss-Etschmann S. Quantitative and functional impairment of pulmonary CD4 + CD25hi regulatory T cells in pediatric asthma. J Allergy Clin Immunol 2007; 119(5):1258–1266.
   PubMed Web of Science ®Google Scholar
• Provoost S, Maes T, van Durme YM, Gevaert P, Bachert C, Schmidt-Weber CB, Brusselle GG, Joos GF, Tournoy KG. Decreased FOXP3 protein expression in patients with asthma. Allergy 2009; 64(10): 1539–1546.
   PubMedGoogle Scholar
• Vale-Pereira S, Todo-Bom A, Geraldes L, Schmidt-Weber C, Akdis CA, FoxP M-PA. 3, GATA-3 and T-bet expression in elderly asthma. Clin Exp Allergy 2011; 41(4):490–496.
   PubMedGoogle Scholar
• Zhang TF, Srivastava K, Wen MC, Yang N, Cao J, Busse P, Birmingham N, Goldfarb J, Li XM. Pharmacology and immunological actions of a herbal medicine ASHMI (TM) on allergic asthma. Phytother Res 2010; 24(7):1047–1055.
   PubMedGoogle Scholar
• Burrows B, Lebowitz MD, Barbee RA, Cline MG. Findings before diagnoses of asthma among the elderly in a longitudinal study of a general population sample. J Allergy Clin Immunol 1991; 88(6): 870–877.
   PubMedGoogle Scholar
• Litonjua AA, Sparrow D, Weiss ST, O’Connor GT, Long AA, Ohman JL Jr. Sensitization to cat allergen is associated with asthma in older men and predicts new-onset airway hyperresponsiveness. The Normative Aging Study. Am J Respir Crit Care Med 1997; 156(1):23–27.
   PubMed Web of Science ®Google Scholar
• Parameswaran K, Hildreth AJ, Taylor IK, Keaney NP, Bansal SK. Predictors of asthma severity in the elderly: Results of a community survey in Northeast England. J Asthma 1999; 36(7):613–618.
   PubMed Web of Science ®Google Scholar
• Asero R. Efficacy of injection immunotherapy with ragweed and birch pollen in elderly patients. Int Arch Allergy Immunol 2004; 135(4):332–335.
   PubMed Web of Science ®Google Scholar
• Korn S, Schumann C, Kropf C, Stoiber K, Thielen A, Taube C, Buhl R. Effectiveness of omalizumab in patients 50 years and older with severe persistent allergic asthma. Ann Allergy Asthma Immunol 2010; 105(4):313–319.
   PubMed Web of Science ®Google Scholar
• Maykut RJ, Kianifard F, Geba GP. Response of older patients with IgE-mediated asthma to omalizumab: A pooled analysis. J Asthma 2008; 45(3):173–181.
   PubMed Web of Science ®Google Scholar
• Quadrelli SA, Roncoroni A. Features of asthma in the elderly. J Asthma 2001; 38(5):377–389.
   PubMed Web of Science ®Google Scholar
• Reed CE. Asthma in the elderly: Diagnosis and management. J Allergy Clin Immunol 2010; 126(4):681–7.
   PubMedGoogle Scholar
• Sin DD, Tu JV. Inhaled corticosteroid therapy reduces the risk of rehospitalization and all-cause mortality in elderly asthmatics. Eur Respir J 2001; 17(3):380–385.
   PubMedGoogle Scholar