2,837
Views
83
CrossRef citations to date
0
Altmetric
Pharmacotherapy

Effectiveness of Omalizumab in Severe Allergic Asthma: A Retrospective UK Real-World Study

, FRCP., , PH.D., FRCP., , PH.D., FRCP., , M.B.B.S. (HONS)., M.D., MRCP., FRCPCH., , B.PHARM. (HONS)., M.A., , M.A., MB BCHIR., MFPM. & , MBCHB., M.D., FRCP. show all
Pages 529-536 | Published online: 14 May 2013

References

  • Holgate ST, Chuchalin AG, Hébert J, Lötvall J, Persson GB, Chung KF, Bousquet J, Kerstjens HA, Fox H, Thirlwell J, Cioppa GD; Omalizumab 011 International Study Group. Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma. Clin Exp Allergy 2004; 34:632–638.
  • Humbert M, Beasley R, Ayres J, Slavin R, Hébert J, Bousquet J, Beeh K-M, Ramos S, Canonica G W, Hedgecock S, Fox H, Blogg M, Surrey K. Benefits of omalizumab as add on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy 2005; 60:309–316.
  • Fritscher L, Chapman KR. Omalizumab for asthma: Pharmacology and clinical profile. Expert Rev Resp Med 2009; 3(2):119–127.
  • Bousquet J, Cabrera P, Berkman N, Buhl R, Holgate S, Wenzel S, Fox H, Hedgecock S, Blogg M, Cioppa GD. The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma. Allergy 2005; 60:302–308.
  • Scottish Medicines Consortium. Omalizumab 150mg powder and solvent for injection (Xolair®) (No. 259/06). 2007. Available at: http://www.scottishmedicines.org.uk/SMC_Advice/Advice/Omalizumab__Xolair_/omalizumab_150mg_powder_and_solvent_for_injection__Xolair_1.Accessed April 24, 2013.
  • Scottish Medicines Consortium. Omalizumab 150 mg powder and solvent for solution for injection (Xolair®) (No: 611/10). 2010 Product Update. Available at: http://www.scottishmedicines.org.uk/files/OmalizumabXolair_Abbreviated_Mar2010.pdf. Accessed April 24, 2013.
  • National Institute for Health and Clinical Excellence. Omalizumab for severe persistent allergic asthma. NICE technology appraisal TA133. Available at: http://guidance.nice.org.uk/TA133. Accessed May 11, 2012.
  • Lewis LD, Cochrane GM. Systemic steroids in chronic severe asthma. Br Med J (Clin Res Ed) 1986; 292:1289–1290.
  • Yuen P Office of Health Economics. Compendium of Health Statistics 2003–2004, Office of Health Economics, London 2003.
  • Brusselle G, Michils A, Louis R, Dupont L, Van de Maele B, Delobbe A, Pilette C, Lee CS, Gurdain S, Vancayzeele S, Lecomte P, Hermans C, MacDonald K, Song M, Abraham I.“Real-life” effectiveness of omalizumab in patients with severe persistent allergic asthma: The PERSIST study. Respir Med 2009; 103:1633–1642.
  • Molimard M, de Blay F, Didier A, Le Gros V. Effectiveness of omalizumab (Xolair®) in the first patients treated in real-life practice in France. Respir Med 2008; 102:71–76.
  • Zureik M, Molimard M, Aubier M, Levy J, Humbert M, Grimaldi-Bensouda L, Abenhaim L; Pharmacoepidemiology of Asthma and Xolair (PAX) Study Group. Effect of omalizumab on the risk of hospitalisation in patients with uncontrolled severe asthma in real-life. The PAX-LASER cohort. European Respiratory Society (ERS) Congress 18–22 September 2010, Barcelona, Spain.
  • Korn S, Thielen A, Seyfried S, Taube C, Kornmann O, Buhl R.Omalizumab in patients with severe persistent allergic asthma in a real-life setting in Germany. Respir Med 2009; 103:1725–1731.
  • Vennera MDC, De Llano LP, Bardagi S, Ausin P, Sanjuas C, González H, Gullón JA, Martínez-Moragón E, Carretero JA, Vera E, Medina JF, Álvarez FJ, Entrenas LM, Padilla A, Irigaray R, Picado C, on behalf of the Spanish Registry. Omalizumab therapy in severe asthma: Experience from the Spanish Registry—Some new approaches. J Asthma 2012; 49:416–422.
  • Eisner MD, Zazzali JL, Miller MK, Bradley MS, Schatz M. Longitudinal changes in asthma control with Omalizumab: 2 year interim data from the EXCELS study. J Asthma 2012; 49:642–648.
  • Dal Negro RW, Tognella S, Pradelli LA. 36 month study on the cost/utility of add-on omalizumab in persistent difficult-to-treat atopic7asthma in Italy. J Asthma 2012; 49:843–848.
  • Niven R, McBryan D. A UK survey of oral corticosteroid use in patients treated with omalizumab. Thorax 2007; 62(suppl. 3):A98 ( Abstract P91).
  • Simons S, Regan K, Aziz A, Saralaya D. Real-life effectiveness of omalizumab in patients with severe persistent allergic (IgE-mediated) asthma at a single UK hospital. Am J Respir Crit Care Med 2010; 181:A1336.
  • Knowles V, Nordstrom M, Britton M. Real-life effectiveness of omalizumab in patients with severe persistent allergic (IgE-mediated) asthma at a single UK hospital. Eur Respir J 2009;34(suppl. 53): 315s, E1875 (Abstract).
  • Gibeon D, Campbell DA, Regan SE, Menzies-Gow A. The effectiveness of omalizumab in severe allergic asthma is comparable in patients selected by NICE or SMC criteria. Am J Respir Crit Care Med 2009; 179:A2812 (Abstract).
  • Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, Murray JJ, Pendergraft TB. Development of the asthma control test: A survey for assessing asthma control. J Allergy Clin Immunol 2004; 113:59–65.
  • Juniper EF, Guyatt GH, Epstein RS, Ferrie PJ, Jaeschke R, Hiller TK. Evaluation of impairment of health-related quality of life in asthma: Development of a questionnaire for use in clinical trials. Thorax 1992; 47:76–83.
  • Joint Formulary Committee. British National Formulary. 64th ed. London: BMJ Group and Pharmaceutical Press, 2012.
  • European Medicines Agency. Xolair 150 mg powder and solvent for solution for injection summary of product characteristics [online]. Available at: http://www.medicines.org.uk/emc/medicine/17029#POSOLOGY. Accessed May 11, 2012.
  • Walsh L, Wong C, Oborne J, Cooper S, Lewis SA, Pringle M, Hubbard R, Tattersfield AE. Adverse effects of oral corticosteroids in relation to dose in patients with lung disease. Thorax 2001; 56: 279–284.
  • Covar RA, Leung DYM, McCormick D, Steelman J, Zeitler P, Spahn JD. Risk factors associated with glucocorticoid-induced adverse effects in children with severe asthma. The Journal of Allergy and Clinical Immunology 2000; 106: 651–9.
  • Molimard M, Chanez P, Pison C, Tétu L, Le Gros V. Long term follow-up of patients under omalizumab initiated during the pre-approval period in France. European Respiratory Society Annual Congress 2010 (Abstract #250607)
  • Costello RW, Long DAA, Gaine S, Mc Donnell T, Gilmartin JJ, Lane SJ. Therapy with omalizumab for patients with severe allergic asthma improves asthma control and reduces overall healthcare costs. Ir J Med Sci 2011; 180:637–641.
  • Schatz M, Camargo CA Jr. The relationship of sex to asthma prevalence, health care utilization and medications in a large managed care organization. Ann Allergy Asthma Immunol 2003; 91:553–558.
  • Cazzola M, Camiciottoli G, Bonavia M, . Italian real-life experience of omalizumab. Respir Med 2010; 104:1410–1416.
  • Braunstahl GJ, Leo J, Chen CW, Maykut R, Georgiou P, Peachey G. The eXpeRience registry: Monitoring the ‘real-world’ effectiveness of omalizumab in allergic asthma. Poster presentation (P3953) at the European Respiratory Society Annual Congress 2011, Amsterdam, NL.