Serum biomarkers in elderly asthma

References

• Yorgancioglu A, Sakar Coskun A. Is the diagnosis of asthma different in elderly? Tuberk Toraks 2012;60:81–85
   PubMedGoogle Scholar
• Lindner K, Panaszek B, Machaj Z. Asthma in the elderly. Pol Arch Med Wewn 2007;117:350–354
   PubMedGoogle Scholar
• O'Neil SE, Lundback B, Lotvall J. Proteomics in asthma and COPD phenotypes and endotypes for biomarker discovery and improved understanding of disease entities. J Proteomics 2011;75:192–201
   PubMed Web of Science ®Google Scholar
• Bom AT, Pinto AM. Allergic respiratory diseases in the elderly. Respir Med 2009;103:1614–1622
   PubMed Web of Science ®Google Scholar
• Harik-Khan RI, Wise RA, Fozard JL. Determinants of maximal inspiratory pressure. The Baltimore Longitudinal Study of Aging. Am J Respir Crit Care Med 1998;158:1459–1464
   PubMed Web of Science ®Google Scholar
• Fahy JV. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc 2009;6:256–259
   PubMedGoogle Scholar
• Kim HY, DeKruyff RH, Umetsu DT. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol 2010;11:577–584
   PubMed Web of Science ®Google Scholar
• Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298–304
   PubMed Web of Science ®Google Scholar
• Holgate ST, Polosa R. Treatment strategies for allergy and asthma. Nat Rev Immunol 2008;8:218–230
   PubMed Web of Science ®Google Scholar
• Knudsen TB, Thomsen SF, Nolte H, Backer V. A population-based clinical study of allergic and non-allergic asthma. J Asthma: J Assoc Care Asthma 2009;46:91–94
   PubMed Web of Science ®Google Scholar
• Green RH, Brightling CE, Woltmann G, Parker D, Wardlaw AJ, Pavord ID. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002;57:875–879
   PubMed Web of Science ®Google Scholar
• Janeway CA, Jr., Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002;20:197–216
   PubMed Web of Science ®Google Scholar
• Simpson JL, Grissell TV, Douwes J, Scott RJ, Boyle MJ, Gibson PG. Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax 2007;62:211–218
   PubMed Web of Science ®Google Scholar
• Baines KJ, Simpson JL, Bowden NA, Scott RJ, Gibson PG. Differential gene expression and cytokine production from neutrophils in asthma phenotypes. Eur Resp J: Off J Eur Soc Clin Resp Physiol 2010;35:522–531
   PubMed Web of Science ®Google Scholar
• Scichilone N, Callari A, Augugliaro G, Marchese M, Togias A, Bellia V. The impact of age on prevalence of positive skin prick tests and specific IgE tests. Respir Med 2011;105:651–658
   PubMed Web of Science ®Google Scholar
• Bafadhel M, Clark TW, Reid C, Medina MJ, Batham S, Barer MR, Nicholson KG, Brightling CE. Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD. Chest 2011;139:1410–1418
   PubMed Web of Science ®Google Scholar
• Tinkelman DG, Price DB, Nordyke RJ, Halbert RJ, Isonaka S, Nonikov D, Juniper EF, et al. Symptom-based questionnaire for differentiating COPD and asthma. Respiration 2006;73:296–305
   PubMed Web of Science ®Google Scholar
• Fortuna AM, Feixas T, Gonzalez M, Casan P. Diagnostic utility of inflammatory biomarkers in asthma: exhaled nitric oxide and induced sputum eosinophil count. Respir Med 2007;101:2416–2421
   PubMed Web of Science ®Google Scholar
• Munakata M. Exhaled nitric oxide (FeNO) as a non-invasive marker of airway inflammation. Allergol Int: Off J Jpn Soc Allergol 2012;61:365–372
   Google Scholar
• Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143--178
   Google Scholar
• Patelis A, Gunnbjornsdottir M, Malinovschi A, Matsson P, Onell A, Hogman M, Alving K, Janson C. Population-based study of multiplexed IgE sensitization in relation to asthma, exhaled nitric oxide, and bronchial responsiveness. J Allerg Clin Immunol 2012;130:397–402
   PubMed Web of Science ®Google Scholar
• Tilemann L, Gindner L, Meyer F, Szecsenyi J, Schneider A. Differences in local and systemic inflammatory markers in patients with obstructive airways disease. Prim Care Respir J 2011;20:407–414
   PubMedGoogle Scholar
• Fajraoui N, Charfi MR, Khouani H, Abouda M, Kerkenil Y, Zouari B. Contribution of serum total immunoglobulin E measurement in the diagnosis of respiratory allergic diseases. Tunis Med 2008;86:32–37
   PubMedGoogle Scholar
• Urban JF, Jr., Katona IM, Dean DA, Finkleman FD. The cellular IgE response of rodents to infection with Nippostrongylus brasiliensis, Trichinella spiralis and Schistosoma mansoni. Vet Parasitol 1984;14:193–208
   PubMed Web of Science ®Google Scholar
• van den Biggelaar AH, Rodrigues LC, van Ree R, van der Zee JS, Hoeksma-Kruize YC, Souverijn JH, Missinou MA, et al. Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. J Infect Dis 2004;189:892–900
   PubMed Web of Science ®Google Scholar
• Mandelin JM, Remitz A, Virtanen HM, Malmberg LP, Haahtela T, Reitamo S. A 10-year open follow-up of eczema and respiratory symptoms in patients with atopic dermatitis treated with topical tacrolimus for the first 4 years. J Dermatolog Treat 2010;21:167–170
   PubMed Web of Science ®Google Scholar
• Wood RA, Phipatanakul W, Hamilton RG, Eggleston PA. A comparison of skin prick tests, intradermal skin tests, and RASTs in the diagnosis of cat allergy. J Allerg Clin Immunol 1999;103:773–779
   PubMed Web of Science ®Google Scholar
• Szefler SJ, Wenzel S, Brown R, Erzurum SC, Fahy JV, Hamilton RG, Hunt JF, et al. Asthma outcomes: biomarkers. J Allergy Clin Immunol 2012;129:S9–S23
   PubMed Web of Science ®Google Scholar
• King MJ, Bukantz SC, Phillips S, Mohapatra SS, Tamulis T, Lockey RF. Serum total IgE and specific IgE to dermatophagoides pteronyssinus, but not eosinophil cationic protein, are more likely to be elevated in elderly asthmatic patients. Allerg Asthma Proc: Off J Reg State Allergy Soc 2004;25:321–325
   PubMed Web of Science ®Google Scholar
• Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999;340:448–454
   PubMed Web of Science ®Google Scholar
• Buyukozturk S, Gelincik AA, Genc S, Kocak H, Oneriyidogan Y, Erden S, Dal M, Colakoglu B. Acute phase reactants in allergic airway disease. Tohoku J Exp Med 2004;204:209–213
   PubMed Web of Science ®Google Scholar
• Allam MH, Said AF, El Samie Omran AA, Abd El-Reheim DM, Kasem AH. High sensitivity C-reactive protein: its correlation with sputum cell counts in bronchial asthma. Respir Med 2009;103:1878–1884
   PubMed Web of Science ®Google Scholar
• Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG. The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma. Chest 2012;142:86--93
   PubMed Web of Science ®Google Scholar
• Denburg JA, Keith PK. Eosinophil progenitors in airway diseases: clinical implications. Chest 2008;134:1037–1043
   PubMed Web of Science ®Google Scholar
• Venge P. Monitoring the allergic inflammation. Allergy 2004;59:26–32
   PubMed Web of Science ®Google Scholar
• Peona V, De Amici M, Quaglini S, Bellaviti G, Castellazzi AM, Marseglia G, Ciprandi G. Serum eosinophilic cationic protein: is there a role in respiratory disorders? J Asthma: Off J Assoc Care Asthma 2010;47:131–134
   PubMed Web of Science ®Google Scholar
• Ozseker F, Buyukozturk S, Depboylu B, Yilmazbayhan D, Karayigit E, Gelincik A, Genc C, et al. Serum amyloid A (SAA) in induced sputum of asthmatics: a new look to an old marker. Int Immunopharmacol 2006;6:1569–1576
   PubMed Web of Science ®Google Scholar
• Koh GC, Shek LP, Goh DY, Van Bever H, Koh DS. Eosinophil cationic protein: is it useful in asthma? A systematic review. Respir Med 2007;101:696–705
   PubMed Web of Science ®Google Scholar
• Greenfield EA, Nguyen KA, Kuchroo VK. CD28/B7 costimulation: a review. Crit Rev Immunol 1998;18:389–418
   PubMed Web of Science ®Google Scholar
• Jeannin P, Magistrelli G, Aubry JP, Caron G, Gauchat JF, Renno T, Herbault N, et al. Soluble CD86 is a costimulatory molecule for human T lymphocytes. Immunity 2000;13:303–312
   PubMed Web of Science ®Google Scholar
• Tsuyuki S, Tsuyuki J, Einsle K, Kopf M, Coyle AJ. Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness. J Exp Med 1997;185:1671–1679
   PubMed Web of Science ®Google Scholar
• Burr JS, Kimzey SL, Randolph DR, Green JM. CD28 and CTLA4 coordinately regulate airway inflammatory cell recruitment and T-helper cell differentiation after inhaled allergen. Am J Respir Cell Mol Biol 2001;24:563–568
   PubMed Web of Science ®Google Scholar
• Shi HZ, Xie ZF, Deng JM, Chen YQ, Xiao CQ. Soluble CD86 protein in serum samples of patients with asthma. Thorax 2004;59:870–875
   PubMed Web of Science ®Google Scholar
• Urieli-Shoval S, Cohen P, Eisenberg S, Matzner Y. Widespread expression of serum amyloid A in histologically normal human tissues. Predominant localization to the epithelium. J Histochem Cytochem 1998;46:1377–1384
   PubMed Web of Science ®Google Scholar
• Braunstahl GJ, Fokkens WJ, Overbeek SE, KleinJan A, Hoogsteden HC, Prins JB. Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways. Clin Exp Allerg: J Br Soc Allerg Clin Immunol 2003;33:579–587
   PubMed Web of Science ®Google Scholar
• Kunkel SL, Standiford T, Kasahara K, Strieter RM. Interleukin-8 (IL-8): the major neutrophil chemotactic factor in the lung. Exp Lung Res 1991;17:17–23
   PubMed Web of Science ®Google Scholar
• Shute JK, Vrugt B, Lindley IJ, Holgate ST, Bron A, Aalbers R, Djukanovic R. Free and complexed interleukin-8 in blood and bronchial mucosa in asthma. Am J Respir Crit Care Med 1997;155:1877–1883
   PubMed Web of Science ®Google Scholar
• Silvestri M, Bontempelli M, Giacomelli M, Malerba M, Rossi GA, Di Stefano A, Rossi A, Ricciardolo FL. High serum levels of tumour necrosis factor-alpha and interleukin-8 in severe asthma: markers of systemic inflammation? Clin Exp Allerg: J Br Soc Allerg Clin Immunol 2006;36:1373–1381
   PubMed Web of Science ®Google Scholar
• Hollander C, Sitkauskiene B, Sakalauskas R, Westin U, Janciauskiene SM. Serum and bronchial lavage fluid concentrations of IL-8, SLPI, sCD14 and sICAM-1 in patients with COPD and asthma. Respir Med 2007;101:1947–1953
   PubMed Web of Science ®Google Scholar
• Yokoyama A, Kohno N, Sakai K, Kondo K, Hirasawa Y, Hiwada K. Circulating levels of soluble interleukin-6 receptor in patients with bronchial asthma. Am J Respir Crit Care Med 1997;156:1688–1691
   PubMed Web of Science ®Google Scholar
• Donaldson GC, Seemungal TA, Patel IS, Bhowmik A, Wilkinson TM, Hurst JR, Maccallum PK, Wedzicha JA. Airway and systemic inflammation and decline in lung function in patients with COPD. Chest 2005;128:1995–2004
   PubMed Web of Science ®Google Scholar
• Robinson DS. Regulatory T cells and asthma. Clin Exp Allerg: J Br Soc Allerg Clin Immunol 2009;39:1314–1323
   PubMed Web of Science ®Google Scholar
• Tato CM, O'Shea JJ. Immunology: what does it mean to be just 17? Nature 2006;441:166–168
   PubMed Web of Science ®Google Scholar
• Cazzola M, Matera MG. IL-17 in chronic obstructive pulmonary disease. Expert Rev Respir Med 2012;6:135–138
   PubMed Web of Science ®Google Scholar
• Milner JD. IL-17 producing cells in host defense and atopy. Curr Opin Immunol 2011;23:784–788
   PubMed Web of Science ®Google Scholar
• Milovanovic M, Drozdenko G, Weise C, Babina M, Worm M. Interleukin-17A promotes IgE production in human B cells. J Invest Dermatol 2010;130:2621–2628
   PubMed Web of Science ®Google Scholar
• Chang Y, Al-Alwan L, Risse PA, Roussel L, Rousseau S, Halayko AJ, Martin JG, et al. TH17 cytokines induce human airway smooth muscle cell migration. J Allerg Clin Immunol 2011;127:1046–1053
   PubMed Web of Science ®Google Scholar
• Agache I, Ciobanu C, Agache C, Anghel M. Increased serum IL-17 is an independent risk factor for severe asthma. Respir Med 2010;104:1131–1137
   PubMed Web of Science ®Google Scholar
• Kaski JC, Avanzas P, Arroyo-Espliguero R. Neopterin – a forgotten biomarker. J Am Coll Cardiol 2003;42:1142–1143
   PubMed Web of Science ®Google Scholar
• Mota Pinto A, Todo Bom A, Vale Pereira S, Alves V, Santos Rosa M. Elevated neopterin levels in non-allergic asthma. Pathophysiology 2006;14:35–39
   PubMedGoogle Scholar
• Frick B, Schroecksnadel K, Neurauter G, Leblhuber F, Fuchs D. Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. Clin Biochem 2004;37:684–687
   PubMed Web of Science ®Google Scholar
• Elias JA, Homer RJ, Hamid Q, Lee CG. Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma. J Allerg Clin Immunol 2005;116:497–500
   PubMed Web of Science ®Google Scholar
• Kawada M, Hachiya Y, Arihiro A, Mizoguchi E. Role of mammalian chitinases in inflammatory conditions. Keio J Med 2007;56:21–27
   PubMedGoogle Scholar
• Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, et al. A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med 2007;357:2016–2027
   PubMed Web of Science ®Google Scholar
• Tang H, Fang Z, Sun Y, Li B, Shi Z, Chen J, Ng T, Xiu Q. YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E. Eur Respir J: Off J Eur Soc Clin Respir Physiol 2010;35:757–760
   PubMed Web of Science ®Google Scholar
• Specjalski K, Jassem E. YKL-40 protein is a marker of asthma. J Asthma: Off J Assoc Care Asthma 2011;48:767–772
   PubMed Web of Science ®Google Scholar
• Bara I, Ozier A, Girodet PO, Carvalho G, Cattiaux J, Begueret H, Thumerel M, et al. Role of YKL-40 in bronchial smooth muscle remodeling in asthma. Am J Respir Crit Care Med 2012;185:715–722
   PubMed Web of Science ®Google Scholar
• Letuve S, Kozhich A, Arouche N, Grandsaigne M, Reed J, Dombret MC, Kiener PA, et al. YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages. J Immunol 2008;181:5167–5173
   PubMed Web of Science ®Google Scholar
• Batinic K, Hobaus C, Grujicic M, Steffan A, Jelic F, Lorant D, Hörtenhuber T, et al. YKL-40 is elevated in patients with peripheral arterial disease and diabetes or pre-diabetes. Atherosclerosis 2012;222:557–563
   PubMed Web of Science ®Google Scholar
• Sakamoto F, Katakami N, Kaneto H, Yasuda T, Takahara M, Miyashita K, Kuroda A, et al. Association of serum YKL-40 levels with urinary albumin excretion rate in young Japanese patients with type 1 diabetes mellitus. Endocr J 2013;60:73--79
   PubMed Web of Science ®Google Scholar
• Pei D. Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage. Cell Res 1999;9:291–303
   PubMed Web of Science ®Google Scholar
• Kang T, Yi J, Guo A, Wang X, Overall CM, Jiang W, Elde R, et al. Subcellular distribution and cytokine- and chemokine-regulated secretion of leukolysin/MT6-MMP/MMP-25 in neutrophils. J Biol Chem 2001;276:21960–21968
   PubMed Web of Science ®Google Scholar
• Blumenthal MN, Zhong W, Miller M, Wendt C, Connett JE, Pei D. Serum metalloproteinase leukolysin (MMP-25/MT-6): a potential metabolic marker for atopy-associated inflammation. Clin Exp Allerg: J Br Soc Allerg Clin Immunol 2010;40:859–866
   PubMed Web of Science ®Google Scholar
• Zieg G, Lack G, Harbeck RJ, Gelfand EW, Leung DY. In vivo effects of glucocorticoids on IgE production. J Allerg Clin Immunol 1994;94:222–230
   PubMed Web of Science ®Google Scholar
• Vijverberg SJ, Koenderman L, Koster ES, van der Ent CK, Raaijmakers JA, Maitland-van der Zee AH. Biomarkers of therapy responsiveness in asthma: pitfalls and promises. Clin Exp Allerg: J Br Soc Allerg Clin Immunol 2011;41:615–629
   PubMed Web of Science ®Google Scholar