Ventilation heterogeneity in asthma

References

• West JB. Ventilation/blood flow and gas exchange. 3rd ed. Oxford: Blackwell Scientific Publications; 1980
   Google Scholar
• Bryan AC, Bentivoglio LG, Beerel F, MacLeish H, Zidulka A, Bates DV. Factors affecting regional distribution of ventilation and perfusion in the lung. J Appl Physiol 1964;19:395–402
   PubMed Web of Science ®Google Scholar
• Milic-Emili J, Henderson JAM, Dolovich MB, Trop D, Kaneko P. Regional distribution of inspired gas in the lung. J Appl Physiol 1966;21:749–759
   PubMed Web of Science ®Google Scholar
• West JB. Pulmonary pathophysiology – the essentials. Baltimore: Williams and Wilkins; 1981
   Google Scholar
• Colebatch HJH, Finucane KE, Smith MM. Pulmonary conductance and elastic recoil relationships in asthma and emphysema. J Appl Physiol 1973;34:143–153
   PubMed Web of Science ®Google Scholar
• Bates DV, Macklem PT, Christie RV. Respiratory function in disease. 2nd ed. Philadelphia: WB Saunders; 1971
   Google Scholar
• Engel LA, Landau L, Taussig L, Martin RR, Sybrecht G. Influence of bronchomotor tone on regional ventilation distribution at residual volume. J Appl Physiol 1976;40:411–416
   PubMed Web of Science ®Google Scholar
• Altes T, Powers P, Knight-Scott J, Rakes G, Platts-Mills T, Lange E, Alford BA, et al. Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findings. J Magn Reson Imaging 2001;13:378–384
   PubMed Web of Science ®Google Scholar
• De Lange EE, Mugler JP III, Brookeman JR, Knight-Scott J, Truwit JD, Teates CD, Daniel TM, et al. Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas. Radiology 1999;210:851–857
   Google Scholar
• Tustison NJ, Altes TA, Song G, de Lange EE, Mugler JP, Gee JC. Feature analysis of hyperpolarized helium-3 MRI: a study of asthmatics versus non-asthmatics. Magn Reson Med 2010;63:1448–1455
   Google Scholar
• Winkler T, Venegas JG. Self-organized patterns or airway narrowing. J Appl Physiol 2011;110:1482–1486
   Google Scholar
• Wagner PD, Laravuso RB, Uhl RR, West JB. Continuous distributions of ventilation-perfusion ratios in normal subjects breathing air and 100% O2. J Clin Invest 1974;54:54–68
   PubMed Web of Science ®Google Scholar
• Harris RS, Winkler T, Tgavelekos N, Musch G, Melo MCFV, Schroeder T, Chang Y, Venegas JG. Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma. Am J Respir Crit Care Med 2006;174:245–253
   PubMed Web of Science ®Google Scholar
• Coulen C, Drews C, Morgan K, Cohen A, Washington G, Teague WG. Risk factors for prolonged hospital admission in children with status asthmaticus: role of β-agonist exposure. Am J Respir Crit Care Med 2002;165:A746
   Google Scholar
• Moore BJ, Verburgt LM, King GG, Pare PD. The effect of deep inspiration on methacholine dose-response curves in normal subjects. Am J Respir Crit Care Med 1997;156:1278–1281
   Google Scholar
• Overbeek SE, Rijnbeek PR, Vons C, Mulder PG, Hoogsteden HC, Bogaard JM. Effects of fluticasone propionate on methacholine dose-response curves in nonsmoking atopic asthmatics. Eur Respir J 1996;9:2256–2262
   Google Scholar
• Sumino K, Sugar EA, Irvin CG, Kaminsky DA, Shade D, Wei CY, Holbrook JT, et al. Methacholine challenge test: diagnostic characteristics in asthmatic patients receiving controller medications. J Allergy Clin Immunol 2012;130:69–75
   PubMed Web of Science ®Google Scholar
• Filuk RB, Berezanski DJ, Anthonisen NR. Airway closure with methacholine-bronchoconstriction. J Appl Physiol 1987;63:2223–2230
   Google Scholar
• Siegler D, Fukuchi Y, Engel L. Influence of bronchomotor tone on ventilation distribution and airway closure in asymptomatic asthma. Am Rev Respir Dis 1976;114:123–130
   Google Scholar
• Castro M, Fain SB, Hoffman EA, Gierada D, Erzurum SC, Wenzel S. Lung imaging in asthma: the picture is clearer. J Allergy Clin Immunol 2011;128:467–478
   PubMed Web of Science ®Google Scholar
• Hoffman E, Sinak L, Robb R, Ritman E. Noninvasive quantitative imaging of shape and volume of lungs. J Appl Physiol 1983;54:1414–1421
   PubMed Web of Science ®Google Scholar
• Newman KB, Lynch DA, Newman LS, Ellegood D, Newell JD. Quantitative computed tomography detects air trapping due to asthma. Chest 1994;106:105–109
   PubMed Web of Science ®Google Scholar
• Hoshino M, Matsuoka S, Handa H, Miyazawa T, Yagihashi K. Correlation between airflow limitation and airway dimensions assessed by multidetector CT in asthma. Respir Med 2010;104:794–800
   PubMed Web of Science ®Google Scholar
• Jung JW, Kwon JW, Kim TW, Lee SH, Kim KM, Kang HR, Park HW, et al. New insight into the assessment of asthma using xenon ventilation computed tomography. Ann Allergy Asthma Immunol 2013;111:90–95
   Google Scholar
• De Lange EE, Altes TA, Patrie JT, Gaare JD, Knake JJ, Mugler JP, Platts-Mills TA. Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry. Chest 2006;130:1055–1062
   PubMed Web of Science ®Google Scholar
• De Lange EE, Altes TA, Patrie JT, Battiston JJ, Juersivich AP, Mugler JP III, Platts-Mills TA. Changes in regional airflow obstruction over time in the lungs of patients with asthma: evaluation with 3He MR imaging. Radiology 2009;250:567–575
   Google Scholar
• Svenningsen S, Kirby M, Starr D, Coxson HO, Paterson NA, McCormack DG, Parraga G. What are ventilation defects in asthma? Thorax 2014;69:63–71
   PubMed Web of Science ®Google Scholar
• Altes TA, Mata J, de Lange EE, Brookeman JR, Mugler JP. Assessment of lung development using hyperpolarized helium-3 diffusion MR imaging. J Magn Reson Imaging 2006;24:1277–1283
   PubMed Web of Science ®Google Scholar
• Wang C, Altes TA, Mugler JP, Miller GW, Ruppert K, Mata JF, Cates GD Jr, et al. Assessment of the lung microstructure in patients with asthma using hyperpolarized 3He diffusion MRI at two time scales: comparison with healthy subjects and patients with COPD. J Magn Reson Imaging 2008;28:80–88
   PubMed Web of Science ®Google Scholar
• Narayanan M, Beardsmore CS, Owers-Bradley J, Dogaru CM, Mada M, Ball L, Garipov RR, et al. Catch up alveolarization in ex-preterm children” Evidence from 3He magnetic resonance. Am J Respir Crit Care Med 2013;187:1104–1109
   Google Scholar
• Narayanan M, Owers-Bradley J, Beardsmore CS, Mada M, Ball I, Garipov R, Panesar KS, et al. Alveolarization continues during childhood and adolescence: new evidence from helium-3 magnetic resonance. Am J Respir Crit Care Med 2012;185:186–191
   PubMed Web of Science ®Google Scholar
• Cadman RV, Lemanske RF, Evans MD, Jackson DJ, Gern JE, Sorkness RL, Fain SB. Pulmonary 3He magnetic resonance imaging of childhood asthma. J Allergy Clin Immunol 2013;131:369–376
   PubMed Web of Science ®Google Scholar
• Mugler JP, Altes TA. Hyperpolarized 129Xe MRI of the human lung. J Magn Reson Imaging 2013;37:313–331
   PubMed Web of Science ®Google Scholar
• Qing K, Ruppert K, Jiang Y, Mata JF, Miller GW, Shim YM, Wang C, et al. Regional mapping of gas uptake by blood and tissue in the human lung using hyperpolarized xenon-129 MRI. J Magnetic Reson Imaging 2014;39:346–359
   Google Scholar
• Fain SB, Gonzalez-Fernandez G, Peterson ET, Evans MD, Sorkness RL, Jarjour NN, Busse WW, Kuhlman JE. Evaluation of structure-function relationships in asthma using multi-detector CT (MDCT) and hyperpolarized (HP) He-3 MRI. Acad Radiol 2008;15:753–762
   PubMed Web of Science ®Google Scholar
• Prost ND, Costa EL, Wellman T, Musch G, Tucci MR, Winkler T, Harris RS, et al. Effects of ventilation strategy on distribution of lung inflammatory cell activity. Crit Care 2013;17:R175
   Google Scholar
• Costella S, Kirby M, Maksym GN, McCormack DG, Paterson NA, Parraga G. Regional pulmonary response to a methacholine challenge using hyperpolarized 3He magnetic resonance imaging. Respirology 2012;17:1237–1246
   PubMed Web of Science ®Google Scholar
• Harris RS, Fujii-Rios H, Winkler T, Musch G, Melo MFV, Venegas JG. Ventilation defect formation in healthy and asthma subjects is determined by lung inflation. PLoS One 2012;7:e53216
   Google Scholar
• Venegas JG, Winkler T, Musch G, Melo MF, Layfield D, Tgavalekos N, Fischman AJ, et al. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature 2005;434:777–782
   PubMed Web of Science ®Google Scholar
• Robinson PD, Latzin P, Verbanck S, Hall GL, Horsley A, Gappa M, Thamrin C, et al. Consensus statement for inert gas washout measurement using multiple- and single-breath tests. Eur Respir J 2013;41:507–522
   PubMed Web of Science ®Google Scholar
• Verbanck S, Schuermans D, Noppen M, Van Muylem A, Paiva M, Vincken W. Evidence of acinar airway involvement in asthma. Am J Respir Crit Care Med 1999;159:1545–1550
   PubMed Web of Science ®Google Scholar
• Macleod KA, Horsley AR, Bell NJ, Greening AP, Innes JA, Cunningham S. Ventilation heterogeneity in children with well controlled asthma with normal spirometry indicates residual airways disease. Thorax 2009;64:33–37
   PubMed Web of Science ®Google Scholar
• Thompson BR, Douglass JA, Ellis MJ, Kelly VJ, O'Hehir RE, King GG, Verbanck S. Peripheral lung function in patients with stable and unstable asthma. J Allergy Clin Immunol 2013;131:1322–1328
   PubMed Web of Science ®Google Scholar
• Verbanck S, Schuermans D, Paiva M, Vincken W. Nonreversible conductive airway ventilation heterogeneity in mild asthma. J Appl Physiol 2003;94:1380–1386
   Web of Science ®Google Scholar
• Downie SR, Salome CM, Verbanck S, Thompson B, Berend N, King GG. Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation. Thorax 2007;62:684–689
   PubMed Web of Science ®Google Scholar
• Verbanck S, Schuermans D, Vincken W. Inflammation and airway function in the lung periphery of patients with stable asthma. J Allergy Clin Immunol 2010;125:611–616
   PubMed Web of Science ®Google Scholar
• Berend N, Salome CM, King GG. Mechanisms of airway hyperresponsiveness in asthma. Respirology 2008;13:624–631
   Google Scholar
• Hardaker KM, Downie SR, Kermode JA, Farah CS, Brown NJ, King GG, Salome CM. Predictors of airway hyperresponsiveness differ between old and young patients with asthma. Chest 2011;139:1395–1401
   Google Scholar
• Chapman DG, Berend N, Horlyck KR, King GG, Salome CM. Does increased ventilation heterogeneity following chest wall strapping predispose to airway hyperresponsiveness? J Appl Physiol 2012;113:25–30
   Google Scholar
• Farah CS, King GG, Brown NJ, Downie SR, Kermode JA, Hardaker KM, Peters MJ, et al. The role of the small airways in the clinical expression of asthma in adults. J Allergy Clin Immunol 2012;129:381–387
   PubMed Web of Science ®Google Scholar
• Farah CS, King GG, Brown NJ, Peters MJ, Berend N, Salome CM. Ventilation heterogeneity predicts asthma control in adults following inhaled corticosteroid dose titration. J Allergy Clin Immunol 2012;130:61–68
   PubMed Web of Science ®Google Scholar
• Castro M, Rubin AS, Laviolette M, Fiterman J, Lima MDA, Shah PL, Fiss E, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma. Am J Respir Crit Care Med 2010;181:116–124
   PubMed Web of Science ®Google Scholar