A potential immunopathogenic role for reduced IL-35 expression in allergic asthma

References

• Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA), 2014. Available from: www.ginasthma.org
   Google Scholar
• Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 2008;118:3546–3556
   PubMed Web of Science ®Google Scholar
• Kay AB. The role of T lymphocytes in asthma. Chem Immunol Allergy 2006;91:59–75
   PubMedGoogle Scholar
• Zhao Y, Yang J, Gao YD, Guo W. Th17 immunity in patients with allergic asthma. Int Arch Allergy Immunol 2010;151:297–307
   PubMed Web of Science ®Google Scholar
• Cosmi L, Liotta F, Maggi E, Romagnani S, Annunziato F. Th17 cells: new players in asthma pathogenesis. Allergy 2011;66:989–998
   PubMed Web of Science ®Google Scholar
• Robinson DS. Regulatory T cells and asthma. Clin Exp Allergy 2009;39:1314–1323
   PubMed Web of Science ®Google Scholar
• Kearley J, Barker JE, Robinson DS, Lloyd CM. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25 + regulatory T cells is interleukin 10 dependent. J Exp Med 2005;202:1539–1547
   PubMed Web of Science ®Google Scholar
• Kearley J, Robinson DS, Lloyd CM. CD4+CD25 + regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol 2008;122:617–624 e616
   PubMed Web of Science ®Google Scholar
• Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol 2008;8:523–532
   PubMed Web of Science ®Google Scholar
• Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007;450:566–569
   PubMed Web of Science ®Google Scholar
• Vignali DA, Kuchroo VK. IL-12 family cytokines: immunological playmakers. Nat Immunol 2012;13:722–728
   PubMed Web of Science ®Google Scholar
• Liu JQ, Liu Z, Zhang X, Shi Y, Talebian F, Carl JW Jr, Yu C, et al. Increased Th17 and regulatory T cell responses in EBV-induced gene 3-deficient mice lead to marginally enhanced development of autoimmune encephalomyelitis. J Immunol 2012;188:3099–3106
   PubMed Web of Science ®Google Scholar
• Collison LW, Chaturvedi V, Henderson AL, Giacomin PR, Guy C, Bankoti J, Finkelstein D, et al. IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol 2010;11:1093–1101
   PubMed Web of Science ®Google Scholar
• Kochetkova I, Golden S, Holderness K, Callis G, Pascual DW. IL-35 stimulation of CD39 + regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10. J Immunol 2010;184:7144–7153
   PubMed Web of Science ®Google Scholar
• Huang CH, Loo EX, Kuo IC, Soh GH, Goh DL, Lee BW, Chua KY. Airway inflammation and IgE production induced by dust mite allergen-specific memory/effector Th2 cell line can be effectively attenuated by IL-35. J Immunol 2011;187:462–471
   PubMed Web of Science ®Google Scholar
• Whitehead GS, Wilson RH, Nakano K, Burch LH, Nakano H, Cook DN. IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease. J Allergy Clin Immunol 2012;129:207–215 e201–205
   Web of Science ®Google Scholar
• Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014;43:343–373
   PubMed Web of Science ®Google Scholar
• Strauss L, Bergmann C, Gooding W, Johnson JT, Whiteside TL. The frequency and suppressor function of CD4+CD25highFoxp3 + T cells in the circulation of patients with squamous cell carcinoma of the head and neck. Clin Cancer Res 2007;13:6301–6311
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001;25:402–408
   PubMed Web of Science ®Google Scholar
• Liu F, Tong F, He Y, Liu H. Detectable expression of IL-35 in CD4 + T cells from peripheral blood of chronic hepatitis B patients. Clin Immunol 2011;139:1–5
   PubMed Web of Science ®Google Scholar
• Cui G, Goll R, Olsen T, Steigen SE, Husebekk A, Vonen B, Florholmen J. Reduced expression of microenvironmental Th1 cytokines accompanies adenomas-carcinomas sequence of colorectum. Cancer Immunol Immunother 2007;56:985–995
   PubMed Web of Science ®Google Scholar
• Chen X, Gao YD, Yang J. Elevated interferon regulatory factor 4 levels in patients with allergic asthma. J Asthma 2012;49:441–449
   PubMed Web of Science ®Google Scholar
• Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature 2008;454:445–454
   PubMed Web of Science ®Google Scholar
• Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol 2007;37:3021–3029
   PubMed Web of Science ®Google Scholar
• Ouyang YH, Nakao A, Fan EZ, Li Y, Zhao LP, Zhang W, Han DM, Zhang L. Decreased expression of EBI3 and Foxp3 in CD4+CD25 + regulatory T cells in murine experimental allergic rhinitis. Orl J Oto-Rhino-Lary Relat Spec 2011;73:313–320
   PubMed Web of Science ®Google Scholar
• Bai J, Qiu SL, Zhong XN, Huang QP, He ZY, Zhang JQ, Liu GN, et al. Erythromycin enhances CD4+Foxp3 + regulatory T-cell responses in a rat model of smoke-induced lung inflammation. Mediators Inflamm 2012;2012:410232
   PubMed Web of Science ®Google Scholar
• Ma Y, Liu X, Wei Z, Wang X, Xu D, Dai S, Li Y, et al. The expression of a novel anti-inflammatory cytokine IL-35 and its possible significance in childhood asthma. Immunol Lett 2014;162:11–17
   PubMed Web of Science ®Google Scholar
• Karagiannidis C, Akdis M, Holopainen P, Woolley NJ, Hense G, Ruckert B, Mantel PY, et al. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol 2004;114:1425–1433
   PubMed Web of Science ®Google Scholar
• Achkova D, Chung FW, Leyhadi JA, Scadding GW, Charlesworth J, Phippard D, Durham S, Shamji MH. Interleukin-35 suppresses allergen-specific Th2 response in patients with grass pollen induced seasonal allergic rhinitis. J Allergy Clin Immunol 2012;129:AB208
   Web of Science ®Google Scholar
• Collison LW, Delgoffe GM, Guy CS, Vignali KM, Chaturvedi V, Fairweather D, Satoskar AR, et al. The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol 2012;13:290–299
   PubMed Web of Science ®Google Scholar
• Hawrylowicz CM, O'Garra A. Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nat Rev Immunol 2005;5:271–283
   PubMed Web of Science ®Google Scholar
• Faith A, Singh N, Farooque S, Dimeloe S, Richards DF, Lu H, Roberts D, et al. T cells producing the anti-inflammatory cytokine IL-10 regulate allergen-specific Th2 responses in human airways. Allergy 2012;67:1007–1013
   PubMed Web of Science ®Google Scholar