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Journal of Asthma Volume 22, 1985 - Issue 2
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Original Article

Decreased Theophylline Clearance Causing Toxicity in Children during Viral Epidemics

Gideon Koren The Division of Clinical Pharmacology, The Research Institute, The Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; The Departments of Pharmacology and Pediatrics, University of Toronto, Toronto, Canada
&
Mark Greenwald The Division of Clinical Pharmacology, The Research Institute, The Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; The Departments of Pharmacology and Pediatrics, University of Toronto, Toronto, Canada
Pages 75-79 | Published online: 02 Jul 2009

Reference

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  • Anolik R, Kolski GB, Schaible DH, Ratner J: Transient alteration of thedphylline half life: Possible association with herpes simplex infection. Ann Allergy 49:109, 1982.
  • Kraemer MJ, Furukawa CT, Koup JR, Shapiro GG, Pierson WE, Bierman CW: Altered theophylline clearance during an influenza B outbreak. Pediatrics 69:476, 1982.
  • Weinberger M: Theophylline toxicity and viral infections. Pediatrics 70:508, 1982.
  • Gibaldi M, Perrier D: Pharrnacokinetics, Marcel Dekker, Inc., New York, 1982, p 199.
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  • Renton KW, Gray JD, Hall RI: Decreased elimination of theophylline after influenza vaccination. Can Med Assoc 1 123:288, 1980.
  • Walker SB, Middlekamp JN: Theophylline toxicity and viral infection. Pediatrics 70:508, 1982.
  • Franko TG, Powell DA, Nahata MC. Pharmacokinetics of theophylline in infants with bronchiolitis. Eur J Clin Pharmaco1 23:123, 1982.
  • Weinberger M, Hendeles L, Abrens R: Clinical pharmacology of drugs used for asthma. In Pediatric Clinics of North America. Cohen SW, Kaufman RE, Eds: Philadelphia, WB Saunders Co., 1981, p 47.
  • Hendeles L, Weinberger M: Theophylline-A state of the art review. Pharmacotherapy 3:2, 1983.

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