Current Issues on Asthma Drugs: Impact on Clinical Trial Methodology

References

• Sly R M. Mortality from asthma. J Allergy Clin Immunol 1989; 84: 421–434
   PubMed Web of Science ®Google Scholar
• Sly R M. Effects of treatment on mortality from asthma. Ann Allergy 1986; 56: 207–212
   PubMedGoogle Scholar
• Evans R, Mullally D I, Wilson R W, et al. National trends in the morbidity and mortality of asthma in the US. Chest 1987; 91: 655–745
   Web of Science ®Google Scholar
• Storr J, Barrell E, Lenney W. Rising asthma admissions and self referral. Arch Dis Child 1988; 83: 744–779
   Google Scholar
• Buist A S. Asthma mortality: trends and determinants. Am Rev Respir Dis 1987; 136: 1037–1039
   Google Scholar
• Robin E D. Death from bronchial asthma. Chest 1988; 93: 614–618
   PubMed Web of Science ®Google Scholar
• Buist A S. Is asthma mortality increasing?. Chest 1988; 93: 449–450
   PubMed Web of Science ®Google Scholar
• Jackson R T, Beaglehole R, Rea H H, et al. Mortality from asthma: a new epidemic in New Zealand. Br Med J 1982; 285: 771–774
   PubMed Web of Science ®Google Scholar
• Sears M R, Rea H H, Beaglehole R, et al. Asthma mortality in New Zealand: a two year national study. N Z Med J 1985; 98: 271–175
   PubMedGoogle Scholar
• Sears M R. Why are deaths from asthma increasing?. Eur J Respir Dis 1986; 69(suppl 147)175–181
   PubMedGoogle Scholar
• Rea H H, Soagg R, Jackson R, et al. A case control study of deaths from asthma. Thorax 1986; 41: 833–839
   PubMed Web of Science ®Google Scholar
• Windom H H, Burgess C D, Crane J, et al. The self-administration of inhaled beta agonists drugs during severe asthma. N Z Med J 1990; 103: 205
   PubMedGoogle Scholar
• Nicklas R A. Perspective on asthma mortality-1989. Ann Allergy 1989; 63: 578–584
   PubMedGoogle Scholar
• Spitzer W. Preliminary report of the Saskatchewan Asthma Epidemiologic Project. 1991
   Google Scholar
• Nicklas R A, Balazs T. Adverse effects of theophyl-line-beta agonists interactions. J Allergy Clin Immunol 1986; 78: 806–810
   PubMedGoogle Scholar
• Whitehurst V E, Joseph X, Hohmann J R, et al. Cardiotoxic effects in rats and rabbits treated with terbutaline alone and in combination with aminophylline. J Am Coll Toxicol 1983; 2: 147
   Google Scholar
• Nicklas R A, Whitehurst V E, Donohoe R F, Balazs T. Concomitant use of beta adrenergic agonists and methylxanthines. J Allergy Clin Immunol 1984; 79: 20
   Google Scholar
• Barger L W, Vollmer W M, Felt R W, et al. Further investigation into the recent increase in asthma deaths: A review of 41 asthma deaths in Oregon in 1982. Ann Allergy 1988; 60: 34
   Google Scholar
• Cocchetto D M, Sykes R S, Spector S L. Paradoxical bronchospasm after use of inhalation aerosols: A review of the literature. J Asthma 1991; 28: 49–53
   PubMed Web of Science ®Google Scholar
• Sears M R, Taylor D R, Print C G, et al. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet 1990; 33: 1391–1396
   Google Scholar
• Vathenen A S, Higgins B C, Knox A J, et al. Rebound increase in bronchial responsiveness after treatment with inhaled terbutaline. Lancet 1988; 1: 554–557
   PubMed Web of Science ®Google Scholar
• Kraan J, Koeter G H, Mark T W, et al. Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: A comparison between budesonide and terbutaline. J Allergy Clin Immunol 1985; 76: 628
   PubMed Web of Science ®Google Scholar
• Kerrebijn K F, van Essen-Zandvliet E EM, Neijens H J. Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma. J Allergy Clin Immunol 1987; 79: 653–655
   PubMed Web of Science ®Google Scholar
• van Schayck C P, Visch M B, van Herwaarden C LA, et al. Increased bronchial hyperresponsiveness after inhaling salbutamol during one year is not caused by desensitization to salbutamol. J Allergy Clin Immunol 1990; 86: 793–800
   PubMed Web of Science ®Google Scholar
• Gundel R H, Gerritsen M E, Gleich G J, et al. Repeated antigen inhalation results in a prolonged airway eosinophilia and airway hyperresponsiveness in primates. J Appl Physiol 1990; 68: 779–788
   PubMed Web of Science ®Google Scholar
• O'Hollaren M T, Yunginger J W, Offord K P, et al. Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N Engl J Med 1991; 324: 359–363
   PubMed Web of Science ®Google Scholar
• Page C P. One explanation of the asthma paradox: inhibition of natural anti-inflammatory mechanism by B2-agonists. Lancet 1991; 337: 717–720
   PubMed Web of Science ®Google Scholar
• Nicklas R A. Paradoxical bronchospasm associated with the use of inhaled beta agonists. J Allergy Clin Immunol 1990; 65: 959–964
   Google Scholar
• Reed C E. Basic mechanism of asthma. Role of inflammation. Chest 1988; 94: 175
   PubMedGoogle Scholar
• Platts-Mills T AE, Mitchell E B, Nock P, et al. Reduction of bronchial hyperreactivity during prolonged allergen avoidance. Lancet 1982; 2: 675–677
   PubMed Web of Science ®Google Scholar
• Brusasco V, Crimi E, Gianiorio P, et al. Allergen-induced increase in airway responsiveness and inflammation in mild asthma. J Apply Physiol 1990; 69: 2209–2214
   PubMed Web of Science ®Google Scholar
• Lal C KW, Twentyman O P, Holgate S T. The effect of an increase in inhaled allergen dose after inhaled rimeterol hydrobromide and the occurrence and magnitude of the late asthmatic response and the associated changes in non-specific bronchial responsiveness. Am Rev Respir Dis 1987; 140: 917–923
   Google Scholar
• Tsiu S J, Self T H, Burns R. Theophylline toxicity: update. Ann Allergy 1990; 64: 241–257
   PubMedGoogle Scholar
• Sykes R S, Cocchetto D M. Anti-asthma drugs: Key issues in clinical trial methology. J Asthma 1992; 29(2)77–88
   Google Scholar
• Nicklas R A. Treatment of the elderly asthmatic patient with heart disease. Immunol Allergy Clin North Am 1991; 11: 183–199
   Google Scholar
• Robertson C F, Rubinfeld A R, Bowes G. Deaths from asthma in Victoria: a 12 month survey. Med JAust 1990; 152: 511–517
   Google Scholar
• Robin E D, Lewiston N. Unexpected, unexplained sudden death in young asthmatic subjects. Chest 1989; 98: 790–793
   Google Scholar
• Birkhead G, Attaway N J, Strumk R C, et al. Investigation of a cluster of deaths of adolescents from asthma: evidence implicating inadequate treatment and poor patient adherence with medication. J Allergy Clin Immunol 1989; 84: 484–491
   PubMed Web of Science ®Google Scholar
• Weiss K B, Wagener O K. Changing patterns of asthma mortality-identifying target populations at high risk. JAMA 1990; 264: 1683–1687
   PubMed Web of Science ®Google Scholar
• Bernstein I L. Report of the American Academy of Allergy and Immunology Task Force of guidelines for clinical investigation of nonbronchodilator anti-asthma drugs. J Allergy Clin Immunol 1986; 78: 489
   PubMedGoogle Scholar
• Juniper E F, Kline P A, Vanzieleghem M A, Hargreave F E. Reduction of budesonide after a year of increased use: A randomized controlled trial to evaluate whether improvements in airway responsiveness and clinical asthma are maintained. J Allergy Clin Immunol 1991; 87: 483–489
   PubMed Web of Science ®Google Scholar
• Rachelefsky G S. Review of asthma self-management programs. J Allergy Clin Immunol 1987; 80(3)506–511, pt 2
   PubMed Web of Science ®Google Scholar