4,885
Views
35
CrossRef citations to date
0
Altmetric
Research Article

Short-course adjuvant trastuzumab therapy in early stage breast cancer in Finland: Cost-effectiveness and value of information analysis based on the 5-year follow-up results of the FinHer Trial

, , , &
Pages 344-352 | Received 23 Nov 2010, Accepted 05 Jan 2011, Published online: 08 Feb 2011

References

  • Finnish Cancer Registry [Internet]. Helsinki: Institute for Statistical and Epidemiological Cancer Research; 2010. [cited 2010 Oct 2]. Available from: http://www.cancerregistry.fi
  • Mäklin S, Rissanen P. Cost of cancer – Treatment and productivity costs in 1996–2004 and forecast to year 2015. Finnish Cancer Organizations Publication no. 67. Helsinki, Finland: Finnish Cancer Organization; 2006. Finnish.
  • Joensuu H, Isola J, Lundin M, Salminen T, Holli K, Kataja V, . Amplification of erbB2 and erbB2 expression are superior to estrogen receptor status as risk factors for distant recurrence in pT1N0M0 breast cancer: A nationwide population based study. Clin Cancer Res 2003;9:923–30.
  • Owens MA, Horten BC, Da Silva MM. Her2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemisty in a cohort of 6556 breast cancer tissues. Clin Breast Cancer 2004;5:63–9.
  • Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, . Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707–12.
  • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, Untch M, Smith I, . Herceptin Adjuvant (HERA) Trial Study Team. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353:1659–72.
  • Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE Jr, Davidson NE, . Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005;353:1673–84.
  • Slamon D, Eiermann W, Robert N, Pienkowski T, Martin M, Rolski J, . Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC→T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC→TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients: BCIRG 006 Study (abstract 62). Cancer Res 2009;69:500s.
  • Smith I, Procter M, Gelber RD, Guillaume S, Feyereislova A, Dowsett M, . HERA study team. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: A randomised controlled trial. Lancet 2007; 369(9555):29–36.
  • Joensuu H, Kellokumpu-Lehtinen PL, Bono P, Alanko T, Kataja V, Asola R, . FinHer Study Investigators. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 2006;354:809–20.
  • Joensuu H, Bono P, Kataja V, Alanko T, Kokko R, Asola R, . Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: Final results of the FinHer Trial. J Clin Oncol 2009;27:5685–92.
  • The Synergism Or Long Duration (SOLD) Study. ClinicalTrials.gov Identifier: NCT00593697.
  • Chan AL, Leung HW, Lu CL, Lin SJ. Cost-effectiveness of trastuzumab as adjuvant therapy for early breast cancer: A systematic review. Ann Pharmacother 2009;43:296–303.
  • Reed SD, Schulman KA. Cost utility of sequential adjuvant trastuzumab for HER2/Neu-positive breast cancer. Value Health 2009;12:637–40.
  • Dedes KJ, Szucs TD, Imesch P, Fedier A, Fehr MK, Fink D. Cost-effectiveness of trastuzumab in the adjuvant treatment of early breast cancer: A model-based analysis of the HERA and FinHer trial. Ann Oncol 2007;18:1493–9.
  • Millar JA, Millward MJ. Cost effectiveness of trastuzumab in the adjuvant treatment of early breast cancer: A lifetime model. Pharmacoeconomics 2007;25:429–42.
  • Neyt M, Huybrechts M, Hulstaert F, Vrijens F, Ramaekers D. Trastuzumab in early stage breast cancer: A cost-effectiveness analysis for Belgium. Health Policy 2008;87:146–59.
  • Briggs A, Sculpher M. An introduction to Markov modelling for economic evaluation. Pharmacoeconomics 1998;13:397–409.
  • Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, . Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783–92.
  • Statistics Finland. Statistical yearbook of Finland 2008 – The official statistics of Finland. Helsinki: Statistics Finland; 2008.
  • Lidgren M, Wilking N, Jönsson B, Rehnberg C. Health related quality of life in different states of breast cancer. Qual Life Res 2007;16:1073–81.
  • Purmonen T, Auvinen PK, Martikainen JA. Budget impact analysis of trastuzumab in early breast cancer: A hospital district perspective. Int J Technol Assess Health Care 2010;26:163–9.
  • Clarke M, Collins R, Darby S, Davies C, Evans E, Godwin J. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005;365(9472):1687–717.
  • Hall PS, Hulme C, McCabe C, Oluboyede Y, Round J, Cameron DA. Updated cost-effectiveness analysis of trastuzumab for early breast cancer: A UK perspective considering long-term toxicity and pattern of recurrence. Leeds Institute of Health Sciences, Working Paper. June 2010.
  • Norum J, Olsen JA, Wist EA, Lønning PE. Trastuzumab in adjuvant breast cancer therapy. A model based cost-effectiveness analysis. Acta Oncol 2007;46:153–64.
  • Wilking U, Jönsson B, Wilking N, Bergh J. Trastuzumab use in breast cancer patients in the six Health Care Regions in Sweden. Acta Oncol 2010;49:844–50.
  • Lidgren M, Jönsson B, Rehnberg C, Willking N, Bergh J. Cost-effectiveness of HER2 testing and 1-year adjuvant trastuzumab therapy for early breast cancer. Ann Oncol 2008;19:487–95.
  • Telli ML, Hunt SA, Carlson RW, Guardino AE. Trastuzumab-related cardiotoxicity: Calling into question the concept of reversibility. J Clin Oncol 2007;25:3525–33.
  • Drummond M, Evans B, LeLorier J, Karakiewicz P, Martin D, Tugwell P, . Evidence and values: Requirements for public reimbursement of drugs for rare diseases – a case study in oncology. Can J Clin Pharmacol 2009;16:e273–81.
  • Metcalfe S, Evans J, Priest G. PHARMAC funding of 9-week concurrent trastuzumab (Herceptin) for HER2-positive early breast cancer. N Z Med J 2007;120(1256):U2593.
  • Herceptin now an election issue. [cited 2010 Nov 2]. Available from: http://www.stuff.co.nz/national/herceptin-debate/569826/Herceptin-now-an-election-issue
  • The Pharmaceutical Management Agency of New Zealand [Internet]. [updated 2011 Jan 26; cited 2010 Nov 2]. Wellington: PHARMAC; 2008. Available from: http://www.pharmac.govt.nz/herceptin#gov

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.