The peptide AF-16 decreases high interstitial fluid pressure in solid tumors

References

• Heldin CH, Rubin K, Pietras K, Östman A. High interstitial fluid pressure – an obstacle in cancer therapy. Nature Rev Cancer 2004;4:806–13.
   PubMed Web of Science ®Google Scholar
• Wiig H, Tveit E, Hultborn R, Reed RK, Weiss L. Interstitial fluid pressures in DMBA-induced rat mammary tumors. Scand J Clin Lab Invest 1982;42:159–64.
   PubMed Web of Science ®Google Scholar
• Flessner MF, Choi J, Credit K, Deverkadra R, Henderson K. Resistance of tumor interstitial pressure to the penetration of intraperitoneally delivered antibodies into metastatic ovarian tumors. Clin Cancer Res 2005;11:3117–25.
   PubMed Web of Science ®Google Scholar
• Jain RK, Duda DG. Vascular and interstitial biology of tumors. Abeloff's Clinical Oncology, 4th. London: Churchill Livingstone; 2008. 105–124.
   Google Scholar
• Rubin K, Sjöquist M, Gustafsson AM, Isaksson B, Salvesson G, Reed RK. Lowering of tumoral interstitial fluid pressure by prostaglandin E1 is paralleled by an increased uptake of 51Cr-EDTA. Int J Cancer 2000;86:636–43.
   PubMed Web of Science ®Google Scholar
• Salnikov AV, Iversen VV, Koisti M, Sundberg C, Johansson L, Stuhr LB, . Lowering of tumor interstitial fluid pressure specifically augments efficacy of chemotherapy. FASEB J 2003;17:1756–68.
   PubMed Web of Science ®Google Scholar
• Magzoub M, Jin S, Verkman AS. Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin. FASEB J 2008;22:276–84.
   PubMed Web of Science ®Google Scholar
• Nagano S, Perentes JY, Jain RK, Boucher Y. Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors. Cancer Res 2008;68:3795–802.
   PubMed Web of Science ®Google Scholar
• Reed RK, Rubin K. Transcapillary exchange: Role and importance of the interstitial fluid pressure and the extracellular matrix. Cardiovasc Res 2010;87:211–7.
   PubMed Web of Science ®Google Scholar
• Johansson E, Lange S, Lönnroth I. Identification of an active site in the Antisecretory Factor protein. Biochim Biophys Acta 1997;1362:177–82.
   PubMed Web of Science ®Google Scholar
• Johansson E, Lönnroth I, Lange S, Jonson I, Jennische E, Lönnroth C. Molecular cloning and expression of a pituitary gland protein modulating intestinal fluid secretion. J Biol Chem 1995;270:20615–20.
   PubMed Web of Science ®Google Scholar
• Jennische E, Bergström T, Johansson M, Nyström K, Tarkowski A, Hansson HA, . The peptide AF-16 abolishes sickness and death at experimental encephalitis by reducing increase of intracranial pressure. Brain Res 2008; 1227:189–97.
   PubMed Web of Science ®Google Scholar
• Krave U, Höjer S, Hansson HA. Transient, powerful pressures are generated in the brain by a rotational acceleration impulse to the head. Eur J Neurosci 2005;21:2876–82.
   PubMed Web of Science ®Google Scholar
• Ozerdem U. Measuring interstitial fluid pressure with fiberoptic pressure transducers. Microvasc Res 2009;77: 226–9.
   PubMed Web of Science ®Google Scholar
• Griffon-Etienne G, Boucher Y, Brekken C, Suit HD, Jain RK. Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: Clinical implications. Cancer Res 1999;59:3776–82.
   PubMed Web of Science ®Google Scholar
• Hofmann M, Schultz M, Bernd A, Bereiter-Hahn J, Kaufmann R, Kippenberger S. Long-term lowering of tumor interstitial fluid pressure reduces Ki-67 expression. J Biomech 2007;40:2324–9.
   PubMed Web of Science ®Google Scholar
• Hultborn R, Tveit E, Angerås M, Köpf I, Weiss L. Effects of oophorectomy on interstitial fluid pressure, blood flow and vascularity in rat mammary tumor. Anticancer Res 1997; 17:1877–80.
   PubMed Web of Science ®Google Scholar
• Brekken C, Hjelstuen MH, Bruland OS, de Lange Davies C. Hyaluronidase-induced periodic modulation of the interstitial fluid pressure increases selective antibody uptake in human osteosarcoma xenografts. Anticancer Res 2000; 20:3513–9.
   PubMed Web of Science ®Google Scholar
• Eikenes L, Bruland OS, Brekken C, de Lange Davies C. Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts. Cancer Res 2004;64:4768–73.
   PubMed Web of Science ®Google Scholar
• Deryugina EI, Quigley JP. Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions. Bioch Bioph Acta Mol Cell Res 2010;1803:103–20.
   PubMed Web of Science ®Google Scholar
• Pietras K, Östman A, Sjöquist M, Buchdunger E, Reed RK, Heldin CH, . Inhibition of PDGF receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res 2001;61:2929–34.
   PubMed Web of Science ®Google Scholar
• Svendsen ØS, Barczyk MM, Popova SN, Liden Å, Gullberg D, Wiig H. The α11β1 integrin has a mechanistic role in control of interstitial fluid pressure and edema formation in inflammation. Arterioscl Thromb Vasc Biol 2009;29:1864–70.
   PubMed Web of Science ®Google Scholar
• Björck S, Bosaeus I, Ek E, Jennische E, Lönnroth I, Johansson E, . Food induced stimulation of the antisecretory factor can improve symptoms in human inflammatory bowel disease: A study of a concept. Gut 2000;46:824–9.
   PubMed Web of Science ®Google Scholar
• Eriksson A, Shafazand M, Jennische E, Lange S. Effect of antisecretory factor in ulcerative colitis on histological and laborative outcome: A short period clinical trial. Scand J Gastroenterol 2003;38:1045–9.
   PubMed Web of Science ®Google Scholar
• Hanner P, Rask-Andersen H, Lange S, Jennische E. Antisecretory factor-inducing therapy improves the clinical outcome in patients with Meniere's disease. Acta Otolaryngol 2010;130:223–7.
   PubMed Web of Science ®Google Scholar
• Rappalino MV, Lange S, Lönnroth I, Cupello A. Antisecretory Factor peptide derivatives specificly inhibits (3H)-GABA/36Cl- out → in transport across the isolated rabbit Deiters´neuronal membrane. Acta Phys Scand 2003; 179:367–71.
   PubMedGoogle Scholar